This document discusses several patterns of heredity in humans including simple dominant and recessive traits, incomplete dominance where the heterozygote phenotype is intermediate, codominance where both alleles are expressed, polygenic traits determined by multiple genes, and sex-linked traits located on the X or Y chromosomes. It provides examples like tongue rolling, cow coat color, and sickle cell anemia to illustrate these genetics concepts.
Chapter 15: Chromosomal Basis of InheritanceAngel Vega
KEY CONCEPTS
15.1 Morgan showed that Mendelian inheritance has its physical
basis in the behavior of chromosomes: Scientific inquiry
15.2 Sex-linked genes exhibit unique patterns of inheritance
15.3 Linked genes tend to be inherited together because they are located near each other on the same chromosome
15.4 Alterations of chromosome number or structure cause
some genetic disorders
15.5 Some inheritance patterns are exceptions to standard
Mendelian inheritance
It is a powerpoint presentation that discusses about the lesson or topic: Non-Mendelian Inheritance. It also talks about the definition, history and the laws included in the Non-Mendelian Inheritance or Non-Mendelian Genetics.
Chromosomal Basis of Inheritance
Be familiar with patterns of inheritance for autosomal and sex linked genes
Understand the concept of “Linked Genes”
Understand how traits affected by incomplete dominance and codominance differ from autosomal dominant and autosomal recessive traits
Understand how nondisjunction of chromosomes can lead to disorders.
Linked genes: are those that reside on the same chromosome and tend to be inherited together
Humans have 23 pairs of chromosomes
Autosomal genes reside on the autosomal chromosomes (pairs 1-22)
Sex-linked genes are found on the sex chromosomes
(pair 23, usually on the X)
Autosomal genes are usually represented by a pair of alleles
The phenotype of the gene reflects the dominant or recessive relationship of the alleles.
Most autosomal genetic diseases are autosomal recessive meaning the individual need to be homozygous recessive to exhibit the condition
(example: cystic fibrosis) Production of abnormmaly thick mucus. Leading to the blockage of panreatic duct, intestines and respiratory infection.
Huntington’s disease is an autosomal dominant disorder meaning that is a single Huntingtons allele is inherited, the individual will have the disease.
Some alleles do not show a dominance hierarchy
Incomplete dominance: the phenotype of a heterozygous genotype is intermediate in appearance
Codominance: each allele in the genotype for a particular gene will be expressed in the phenotype
Males and females differ in their sex chromosome combination
(females XX; males XY)
Because the X contains genes and the Y “does not”, inheritance patterns of sex-linked genes vary between the sexes
recessive traits more prevalent in males
Genetic disorders can also occur due to errors in the number of inherited chromosomes
This condition arises through a problem that occurs during meiosis
Although female mammals, including humans, inherit two X chromosomes, one X chromosome in each cell becomes almost completely inactivated during embryonic development.
Barr body
Nondisjunction:
Leads to aneuploidy:
Aneuploidy: is the condition of having less than or more than the normal diploid number of chromosomes, and is the most frequently observed type of cytogenetic abnormality.
Mendelian inheritance has its physical basis in the behavior of chromosomes during sexual life cycles.
Morgan traced a gene to a specific chromosome.
Sex-linked genes have unique patterns of inheritance.
Alterations of chromosome numbers or structure cause some genetic disorders.
Linked genes tend to be inherited together because they are located on the same chromosome.
Independent assortment of chromosomes and crossing over produce genetic variation (recombinants)
Geneticists can use recombination data to map a chromosomes genetic loci.
Chromosomal basis for sex is dependent upon the organism.
Chapter 15: Chromosomal Basis of InheritanceAngel Vega
KEY CONCEPTS
15.1 Morgan showed that Mendelian inheritance has its physical
basis in the behavior of chromosomes: Scientific inquiry
15.2 Sex-linked genes exhibit unique patterns of inheritance
15.3 Linked genes tend to be inherited together because they are located near each other on the same chromosome
15.4 Alterations of chromosome number or structure cause
some genetic disorders
15.5 Some inheritance patterns are exceptions to standard
Mendelian inheritance
It is a powerpoint presentation that discusses about the lesson or topic: Non-Mendelian Inheritance. It also talks about the definition, history and the laws included in the Non-Mendelian Inheritance or Non-Mendelian Genetics.
Chromosomal Basis of Inheritance
Be familiar with patterns of inheritance for autosomal and sex linked genes
Understand the concept of “Linked Genes”
Understand how traits affected by incomplete dominance and codominance differ from autosomal dominant and autosomal recessive traits
Understand how nondisjunction of chromosomes can lead to disorders.
Linked genes: are those that reside on the same chromosome and tend to be inherited together
Humans have 23 pairs of chromosomes
Autosomal genes reside on the autosomal chromosomes (pairs 1-22)
Sex-linked genes are found on the sex chromosomes
(pair 23, usually on the X)
Autosomal genes are usually represented by a pair of alleles
The phenotype of the gene reflects the dominant or recessive relationship of the alleles.
Most autosomal genetic diseases are autosomal recessive meaning the individual need to be homozygous recessive to exhibit the condition
(example: cystic fibrosis) Production of abnormmaly thick mucus. Leading to the blockage of panreatic duct, intestines and respiratory infection.
Huntington’s disease is an autosomal dominant disorder meaning that is a single Huntingtons allele is inherited, the individual will have the disease.
Some alleles do not show a dominance hierarchy
Incomplete dominance: the phenotype of a heterozygous genotype is intermediate in appearance
Codominance: each allele in the genotype for a particular gene will be expressed in the phenotype
Males and females differ in their sex chromosome combination
(females XX; males XY)
Because the X contains genes and the Y “does not”, inheritance patterns of sex-linked genes vary between the sexes
recessive traits more prevalent in males
Genetic disorders can also occur due to errors in the number of inherited chromosomes
This condition arises through a problem that occurs during meiosis
Although female mammals, including humans, inherit two X chromosomes, one X chromosome in each cell becomes almost completely inactivated during embryonic development.
Barr body
Nondisjunction:
Leads to aneuploidy:
Aneuploidy: is the condition of having less than or more than the normal diploid number of chromosomes, and is the most frequently observed type of cytogenetic abnormality.
Mendelian inheritance has its physical basis in the behavior of chromosomes during sexual life cycles.
Morgan traced a gene to a specific chromosome.
Sex-linked genes have unique patterns of inheritance.
Alterations of chromosome numbers or structure cause some genetic disorders.
Linked genes tend to be inherited together because they are located on the same chromosome.
Independent assortment of chromosomes and crossing over produce genetic variation (recombinants)
Geneticists can use recombination data to map a chromosomes genetic loci.
Chromosomal basis for sex is dependent upon the organism.
Breaking down Biology into simpler bits is the most effective way to learn hence this presentation aims to simplify the concept of 'Linked Inheritance' which makes understanding Inheritance better.
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Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
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Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
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Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
2. Simple Dominant Heredity
This type of heredity is what Mendel
observed.
It only takes one dominant allele for an
organism to show a dominant trait.
For example, the genotypes RR and Rr would
show the same phenotype of ROUND seeds.
3. Simple dominant traits
Tongue rolling
Hapsburg lip (protruding lower lip)
Free earlobes
Hitchhiker’s thumb
Almond shaped eyes
Thick lips
Presence of hair on middle knuckles.
4. Incomplete dominance
Phenotype of the heterozygote is
intermediate between those of 2
homozygotes.
Example: Homozygous red flower (RR) is
crossed with a homozygous white-flowered
plant (R’R’), all the offspring will have pink
flowers.
Neither allele of the pair is completely
dominant.
6. Why does this happen?
R allele codes for an enzyme that produces red
pigment
R’ allele codes for a defective enzyme that makes no
pigment
If the genotype is RR’ it only makes half the pigment
thus causing the phenotype to be pink.
7. Codominance occurs when both alleles for a gene are
expressed in a heterozygous offspring.
In Codominance, neither allele is dominant or recessive, nor
do the phenotypes appear to blend. Both alleles of a gene are
active and influence the phenotype.
Codominant genes are written as capital letters with a
different letter for each phenotype.
Cows demonstrate codominance in regards to hair
color.
R and W
RR = Red
WW = White
RW = Roan (both red and white)
8. Example: White Cow (WW) x Red Bull (RR)
Results:
Genotype: RW
Phenotype: Roan
R R
W
W
RW RW
RW RW
* Pay attention to the ‘ it does not matter if it is on the 1st
or 2nd
letter
9.
10. Codominance in humans
Sickle cell anemia
Most common in Americans whose families
originated from Africa
1 in 12 African Americans is heterozygous
for the disorder.
An individual who is homozygous for the
sickle-cell allele, the oxygen-carrying
protein (hemoglobin) differs by one amino
acid from normal hemoglobin.
11. Sickle-cell anemia
The defective hemoglobin forms crystal-like
structures that change the shape of red blood cells.
They are shaped like a sickle (half moon)
This shape causes slow blood flow, blocked small
vessels and tissue damage
12. Polygenic inheritance
Traits such as skin color and height vary over
a wide range.
These wide ranges occur because these
traits are governed by many different genes.
Polygenic inheritance is the inheritance
pattern of a trait that is controlled by 2 or
more genes.
13.
14. Multiple phenotypes from
multiple alleles
Traits controlled by more than two alleles in a
population have multiple alleles
Blood type is an example of a single gene that has multiple alleles in humans.
Alleles for blood type:
IA
IB
i
16. Sex determination
Humans have 23 pairs of chromosomes.
22 of these pairs are autosomal (matching
homologous chromosomes)
Homologous autosomes look exactly alike.
The 23rd
pair differs in males and females.
These are sex chromosomes.
17.
18.
19. Sex-linked inheritance
Traits controlled by genes located on sex chromosomes
are called sex-linked.
Alleles for sex-linked traits are written as subscripts of
the X or Y chromosome.
X and Y chromosomes are not homologous, therefore
the Y chromosome has no corresponding allele on the X
chromosome and no subscript is used.
Any allele on the x chromosome of a male will not be
masked by a corresponding allele on the Y chromosome!
20. Sex linked traits in humans
Sex linked traits are inherited on the sex chromosomes
Most are located on the X chromosome
Males pass an X chromosome to their daughters and a Y
chromosome to their sons
Females pass an X to both
If a son receives an X chromosome with a recessive
allele from his mother, he will express the trait because
there is no chance of inheriting a dominant allele from
his father to mask the trait (X and Y are not homologous)
23. Each male child whose mother is a carrier for
a defect has a 50% chance of inheriting the
defect
Each female child whose mother is a carrier
for a defect has a 50% chance of becoming a
carrier
24. Red-green color blindness
Color blindness is caused by the inheritance of
either of 2 recessive alleles at 2 gene sites on
the X chromosome that affect the red and green
receptors in the cells of eyes
Hemophilia
Inability to clot blood
X-linked disorder; affects 1 in every 10,000
males
Only affects 1 in 100 million females
25. Males inherit the allele on the X chromosome
from carrier mothers
A single recessive allele will cause the disorder
in males
Females need 2 recessive alleles to inherit
hemophilia
Queen Victoria’s family is the most well-known
study for hemophilia
26. Sex-Influenced Traits
The presence of male or female sex
hormones influences the expression of
certain human traits.
Estrogen
Testosterone
With this type of trait, males and females
have different phenotypes even when they
have the same genotype.
These genes are located on autosomes.
27. Example: Pattern Baldness
B = dominant, hair loss
B’ = normal, no hair loss
BB male = hair loss
BB female = hair loss
BB’ male = hair loss
BB’ female = NO hair loss
The differences in gene expression are due to
higher levels of testosterone in men.