Wilms tumor (also called Wilms' tumor or nephroblastoma) is a type of childhood cancer that starts in the kidneys. It is the most common type of kidney cancer in children. About 9 of 10 kidney cancers in children are Wilms tumors.
Wilms tumor (also called Wilms' tumor or nephroblastoma) is a type of childhood cancer that starts in the kidneys. It is the most common type of kidney cancer in children. About 9 of 10 kidney cancers in children are Wilms tumors.
Detailed Powerpoint Presentation on Wilms Tumour …. It includes definition with images, causes, sign and symptoms all treatment modalities with nursing responsibilities and recent research related to this...
pediatric emergency its from important topics in pediatric and in this show we will discuss the most important things like shock and its types with special overview on hypovomlemic shock and its treatment and anaphylactic shock also with its treatment then transfered to other important one which is status asthmaticus and its treatment and then status epiliptucs and poisning
It is estimated that 1 3 rd of the world’s population is infected with Mycobacterium tuberculosis
Each year, about 9 million people develop TB, of whom about 1 5 million die
WHO has estimated that around 10 of global tuberculosis case load occurs in children( 0 14 years) of these childhood cases, 75 occur annually in 22 high burden countries that together account for 80 of the world’s estimated incident cases.
Human bodies are equipped with their own kind of immunity system to counteract the attack of different infectious viruses, bacteria and fungi.Know more by visiting www.plus100years.com
IMNCI (Integrated Management of Neonatal and Childhood Illness)Alam Nuzhathalam
An overview of IMNCI (Integrated Management of Neonatal and Childhood Illness). IMNCI - Introduction, Objectives, Components, Principles, Case Management Process - Assess, classify, identify and treat the sick child age up to 2 months and 2 months up to 5 years, F-IMNCI and C-IMNCI.
ACUTE FLACCID PARALYSIS
Kanishk Deep Sharma
definition
Sudden onset of weakness or paralysis over a period of 15 days in a patient aged less than 15 years age
Ddx
poliomyelitis
Non enveloped, positive stranded RNA virus
Genus ENTEROVIRUS
family PICORNAVIRIDAE
3 antigenically distinct serotypes:-1,2,3
pathogenesis
•Entry into mouth.
•Replication in pharynx, GI tract, Local Lymphatic.
•Hematologic spread to lymphatic and central nervous system.
•Viral spread along nerve fibers.
•Destruction of motor neurons
Immunity
Initially protected by maternal antibodies for first few weeks of life
Types
Asymptomatic
Abortive Polio
Non-paralytic
Paralytic
Spinal
Bulbar
Bulbospinal
Cf- asymptomatic
• Accounts for approximately 95% of cases
• Virus stays in intestinal tract and does not attack the nerves
• Virus is shed in the stool so infected individual is still able to infect others
Cf-abortive
•Does not lead to paralysis
•Mild symptoms seen such as sore throat, fever, n/v, diarrhea, constipation ( Minor illness)
•Most recover in <1><5><4days />95% immune after 3 doses
Immunity probably lifelong
Inactivated polio vaccine
Humoral immunity and to some extend pharyngeal immunity
Duration of immunity not known with certainty
Strategies for polio eradication
Global Polio Eradication Initiative launched in 1988
Polio cases have decreased by over 99%
1988 - >125 countries
In 2010 - 4 countries
The remaining countries are Afghanistan, India, Nigeria and Pakistan
Core strategies
High infant immunization coverage with four doses of oral poliovirus vaccine (OPV) in the first year of life
Supplementary doses of OPV to all children under five years of age during national immunization days
AFP surveillance among children under fifteen years of age
Targeted “mop-up” campaigns once wild poliovirus transmission is limited to a specific focal area.
Immunisation in india
Polio Vaccination under UIP
OPVº birth
OPV1 6 wks
OPV2 10 wks
OPV3 14 wks
OPV4 16-24 Months
Pulse Polio Immunization (PPI)
The supplementary immunization activities (SIAs) in India launched in 1995
Irrespective of the immunisation status
Usually Dec & Jan – Peak transmission
aim
Providing additional OPV doses to every child aged <5><15 years who have had the onset of flaccid paralysis within the preceding 60 days
All cases that are found are investigated immediately, with collection of two stool specimens before administration of OPV.
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood.
The Paediatric HIV Treatment Initiative (PHTI) to Speed Development and Avail...Medicines Patent Pool
At the AIDS2014 Conference in Melbourne, MPP Sandeep Juneja, Business Development Director at Medicines Patent Pool presented the Paediatric HIV Treatment Initiative (PHTI) and how it will speed the development and availability of needed formulations.
Detailed Powerpoint Presentation on Wilms Tumour …. It includes definition with images, causes, sign and symptoms all treatment modalities with nursing responsibilities and recent research related to this...
pediatric emergency its from important topics in pediatric and in this show we will discuss the most important things like shock and its types with special overview on hypovomlemic shock and its treatment and anaphylactic shock also with its treatment then transfered to other important one which is status asthmaticus and its treatment and then status epiliptucs and poisning
It is estimated that 1 3 rd of the world’s population is infected with Mycobacterium tuberculosis
Each year, about 9 million people develop TB, of whom about 1 5 million die
WHO has estimated that around 10 of global tuberculosis case load occurs in children( 0 14 years) of these childhood cases, 75 occur annually in 22 high burden countries that together account for 80 of the world’s estimated incident cases.
Human bodies are equipped with their own kind of immunity system to counteract the attack of different infectious viruses, bacteria and fungi.Know more by visiting www.plus100years.com
IMNCI (Integrated Management of Neonatal and Childhood Illness)Alam Nuzhathalam
An overview of IMNCI (Integrated Management of Neonatal and Childhood Illness). IMNCI - Introduction, Objectives, Components, Principles, Case Management Process - Assess, classify, identify and treat the sick child age up to 2 months and 2 months up to 5 years, F-IMNCI and C-IMNCI.
ACUTE FLACCID PARALYSIS
Kanishk Deep Sharma
definition
Sudden onset of weakness or paralysis over a period of 15 days in a patient aged less than 15 years age
Ddx
poliomyelitis
Non enveloped, positive stranded RNA virus
Genus ENTEROVIRUS
family PICORNAVIRIDAE
3 antigenically distinct serotypes:-1,2,3
pathogenesis
•Entry into mouth.
•Replication in pharynx, GI tract, Local Lymphatic.
•Hematologic spread to lymphatic and central nervous system.
•Viral spread along nerve fibers.
•Destruction of motor neurons
Immunity
Initially protected by maternal antibodies for first few weeks of life
Types
Asymptomatic
Abortive Polio
Non-paralytic
Paralytic
Spinal
Bulbar
Bulbospinal
Cf- asymptomatic
• Accounts for approximately 95% of cases
• Virus stays in intestinal tract and does not attack the nerves
• Virus is shed in the stool so infected individual is still able to infect others
Cf-abortive
•Does not lead to paralysis
•Mild symptoms seen such as sore throat, fever, n/v, diarrhea, constipation ( Minor illness)
•Most recover in <1><5><4days />95% immune after 3 doses
Immunity probably lifelong
Inactivated polio vaccine
Humoral immunity and to some extend pharyngeal immunity
Duration of immunity not known with certainty
Strategies for polio eradication
Global Polio Eradication Initiative launched in 1988
Polio cases have decreased by over 99%
1988 - >125 countries
In 2010 - 4 countries
The remaining countries are Afghanistan, India, Nigeria and Pakistan
Core strategies
High infant immunization coverage with four doses of oral poliovirus vaccine (OPV) in the first year of life
Supplementary doses of OPV to all children under five years of age during national immunization days
AFP surveillance among children under fifteen years of age
Targeted “mop-up” campaigns once wild poliovirus transmission is limited to a specific focal area.
Immunisation in india
Polio Vaccination under UIP
OPVº birth
OPV1 6 wks
OPV2 10 wks
OPV3 14 wks
OPV4 16-24 Months
Pulse Polio Immunization (PPI)
The supplementary immunization activities (SIAs) in India launched in 1995
Irrespective of the immunisation status
Usually Dec & Jan – Peak transmission
aim
Providing additional OPV doses to every child aged <5><15 years who have had the onset of flaccid paralysis within the preceding 60 days
All cases that are found are investigated immediately, with collection of two stool specimens before administration of OPV.
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood.
The Paediatric HIV Treatment Initiative (PHTI) to Speed Development and Avail...Medicines Patent Pool
At the AIDS2014 Conference in Melbourne, MPP Sandeep Juneja, Business Development Director at Medicines Patent Pool presented the Paediatric HIV Treatment Initiative (PHTI) and how it will speed the development and availability of needed formulations.
CD4 counts give you and your doctor a good idea of how much damage HIV has done to your immune system. But you also need to know how fast that damage is happening. Viral load tests, which tell the doctor how much HIV is in your blood, are a very important clue to how quickly HIV is doing harm.
Core disciplines in agriculture-nutrition-health research: NutritionILRI
Presented by Jody Harris, Paula Dominguez and Dominic Rowland at the Agriculture, Nutrition and Health (ANH) Academy Week, Addis Ababa, Ethiopia, 20-24 June 2016.
Clinical Cases from Resource Limited Settings: Suzinne Pak-GorsteinUWGlobalHealth
Participants will be able to: recognize importance and identify resources for learning about a country and local 'disease' profile; local/regional guidelines and algorithms appropriate for the specific clinical setting; how to address limitations in clinical resources for diagnosis and management of clinical cases; and understanding health care service structure and personnel/staffing structure.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. INTRODUCTION.
40 million people are estimated to be living with
HIV/AIDS.
3 millions are children.
Epidemiology in recent times are the highest between
individuals 15-24 years of age.
95% of the people that have HIV live in the developing
world.
3. MOTHER TO INFANT
TRANSMISSION.
35% of infants born to HIV+ will contract HIV without
interventions.
15-20% occur during pregnancy.
50% occur during labor/ delivery.
33% occur during breastfeeding.
4. BREASTFEEDING.
•Infants can contract HIV through breastfeeding.
•In developing countries, formula is not often available or
is not financially possible, as a result it would be an
inevitable option.
•If the formula is available, then concerns are directed at
the cleanliness of the water supply or sterilization of
bottles.
5. DIAGNOSIS.
•An infant < 18 months of age is considered HIV-infected
if they are sero+ or were born to an HIV infected mother
and has +results on two separate HIV tests.
•An infant can be excluded by the disappearance of anti-
HIV antibody by 18 months of age – seroreversion.
6. CONDITIONS ASSOCIATED
WITH HIV.
Malnutrition.
Impaired nutritional absorption.
Increased nutritional
requirements.
Reduced food intake.
Lactose intolerance.
Dehydration.
HIV-induced diarrhea.
Failure to thrive.
Alterations in function of GI
tract.
Increased use of body fat
stores.
Oral lesions and HIV-specific
gingivitis.
Developmental delays.
Micronutrient deficiencies.
Depletion of vitamin and
mineral stores.
Neurological problems.
Abnormal swallowing
mechanisms.
Impaired brain growth.
Seizures/ Strokes.
Opportunistic infections.
Cryptosporidiosis.
Tuberculosis.
Normal infections are
potentially fatal.
7. OTHER PROBLEMS.
•Categorized as an ‘AIDS’ family – stigma.
•Psychological burden.
•Socioeconomic status.
•Access to medication.
10. MANAGEMENT.
•Estimate energy needs using a Metabolic Cart, RDA
tables or Bentler & Stannish formula.
200kcal/kg & 4g/kg.
•Aggressive treatment of opportunistic infections.
•Tolerable anti-HIV regimen including a combination of 3
different medications.
2 reverse transcriptase inhibitors (zidovudine + tenofovir) + 1
protease inhibitor (indinavir) – weight gain, improved mental
functioning.
11. MANAGEMENT.
•Consult with doctor before immunizations/ booster
shots.
•Evaluate feeding skills to see if tube feeding is necessary
or TPN is required.
•Diarrhoea.
Lactaid milk & yogurt.
Soy milk.
Soluble forms of fibre – oatmeal, rice.
Replace fluid loss with electrolyte solutions such as Pedialyte.
12. PROGNOSIS.
•Although HIV is usually deadly in children. The
development of anti-retroviral is promising.
•The nutritional status of the child and the diligence in
which viral replication is controlled is also important.
•Aggressive treatment of opportunistic infections are
important.
•Control of hematologic disturbances such as anaemia,
thrombocytopenia and neutropenia are also important.
•Natural progression of vertically acquired HIV infection
appears to have a trimodal distribution.
15% have rapidly progressive disease. The remainder has either a
chronic progressive course or an infection pattern.
Mean survival is 10 years.
13. PROGNOSTIC FACTORS.
•Advanced maternal
disease.
•High maternal viral load.
•Low maternal CD4+ count.
•Prematurity.
•In utero transmission.
•High viral load in the first
2 months of life.
•Lack of neutralizing
antibodies.
•Presence of p24 antigen.
•AIDS-defining illnesses.
(Pneumocystic carinii)
•Early cytomegalovirus
(CMV) infection.
•Early neurologic disease.
•Failure to thrive.
•Early-onset diarrhea.