Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue, leading to fragile bones and increased risk of fractures. It is defined by the World Health Organization as a bone mineral density score of -2.5 or below. Those at highest risk include older adults, especially post-menopausal women, and those with low calcium/vitamin D intake or other risk factors such as smoking. Symptoms may include back pain or loss of height from vertebral fractures. Treatment focuses on calcium and vitamin D supplementation, as well as bisphosphonate medications to decrease bone resorption and reduce fracture risk. Prevention emphasizes building strong bones through diet, exercise and lifestyle habits during childhood and adolescence.
Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
Osteoarthritis is a chronic degenerative disorder of synovial joints in which there is progressive softening and erosion/disintegration of the articular cartilage. In the presentation, I will deal in detail about the condition in every dimension with the most recent evidence.
Osteoarthritis is a chronic degenerative disorder of synovial joints in which there is progressive softening and erosion/disintegration of the articular cartilage. In the presentation, I will deal in detail about the condition in every dimension with the most recent evidence.
Osteoporosis is a chronic, progressive skeletal disease characterized by low bone mass, microarchitecture deterioration of bone tissue, bone fragility, and a consequent increase in fracture risk.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
For info log on to www.healthlibrary.com. Osteoporosis of Bones By Dr. Prakash Khalap
OSTEOPOROSIS which is more in Elderly, Osteoporosis is Common in both females and males after 60 yrs. Fractures, reduction in height, Backache, vague Pain of body are common symptoms which many elderly suffers unknowingly.
Know everything about Osteoporosis- prevention and management.
Did You Know?
The incidence of hip fracture is 1 woman to 1 man in India
Know more such facts and useful information on prevention of Osteoporosis.
For medical students, especially for early clinical exposure , it will help preclinical medical students. It gives details of about seven case reports in carbohydrate metabolism. MBBS students can use the information for theory exam also.
For medical students , it will help. Especially for preclinical students, as early clinical exposure, it will be very useful. Even for theory exam, it will help.
Extra cellular matrix is recently being explored in connection with cancer , metastases and autoimmune disorders. It is prepared for the benefit of both UG and PG medical and dental students.
Various neurotransmitters, mechanism of action and their physiological functions are explained and is useful for ug and pg students of medicine, neurology, psychiatry branches.
Porphyrias are difficult to diagnose . Here it is comprehensively explained to aid making diagnosis of porphyrias easier for the benefit of medical students and practitioners.
Renal function tests are very useful for effective clinical evaluation of renal failure for effective management. So it is useful for medical and allied professional students and clinical practitioners.
Test for pancreatic and intestinal functions are very important for clinical evaluation gastro intestinal disorders . So it will e useful for medical and allied professional students and practitioners.
Liver function tests and interpretation is a very important topic for students of medical and allied fields. It is essential for efficient practice of clinical and laboratory medicine.
Students of medical and allied subjects must be exposed to the concept of monoclonal antibodies for the efficient practice of clinical and laboratory medicine.
Concepts of acid base balance and its disorders are very important for practice of medicine.It is for the benefit of medical and students of allied fields.
Coronary heart disease due to atherosclerotic process is the major cause of death.Lipids have been implicated for enhanced atherosclerosis. The major lipids involved are triacy glycerol and cholesterol which are transported in the plasma by lipoproteins. So a better understanding of lipid transport and its abnormalities is essential for medical and health professional students.
Water and electrolyte balance is clinically very important topic . It will be very useful for both UG and PG medical students. Efforts are made to explain basic concepts clearly.
It gives basic things regarding urinalysis and will be very useful for medical students, house surgeons, laboratory technicians and postgraduates in medicine.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
2. Defining Osteoporosis
“Progressive systemic skeletal disease
characterized by low bone mass and
microarchitectural deterioration of bone
tissue, leading to enhanced bone fragility
and a consequent increase in fracture risk”
True Definition: bone with lower density
and higher fracture risk
WHO: utilizes Bone Mineral Density as
definition (T score <-2.5); surrogate marker
3. Who Gets Osteoporosis?
Age
Estrogen deficiency
Testosterone deficiency
Family history/genetics
Female sex
Low calcium/vitamin D intake
Poor exercise
Smoking
Alcohol
4. Who gets osteoporosis?
Low body weight/anorexia
Hyperthyroidism
Hyperparathyroidism
Prednisone use
Liver and renal disease (think about vit d
synthesis)
Low sun exposure
Medications (antiepileptics, heparin)
Malignancies (metastatic disease; multiple
myeloma can present as osteopenia!)
Hemiplegia s/p CVA/ immobility
5. Back pain, which can be severe if fractured or collapsed
vertebra
Loss of height over time, with an accompanying stooped
posture
Fracture of the vertebrae, wrists, hips or other bones
8. WHO, Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis, 1998.
T-Score
World Health Organization (WHO)
Osteoporosis Guidelines
1.4
1.3
1.2
1.1
1.0
0.9
0.8
0.7
0.6
0.5
0.4
0.3
20 30 40 50 60 70 80
Age
BMD
Mean
–2 SD
Consider preventive intervention
Consider therapeutic interventio
Mean Lumbar Spine BMD:
Decades 3 to 9 of a Woman’s Life
Bone Mineral Density Values
9. Osteoporosis
PATHOGENESIS
1. Peak bone mass : about 20 years old
- genetic, hormone, nutrition, life style
2. Rate of bone loss : after age 30-45, bone resorption
(osteoclast)> formation (osteoblast) and become
exaggerated after menopause
(50 years old)
3. Bone remodeling : keep balance at 20-30 years old,
after that become negative balance
9
11. Osteoporosis
Type 1 Type 2 Type 3
Postmenopausal Senile secondary
Age 55 -70 years 70-90 years all
Sex(F/M) 6:1 2 :1 1:1
Fx site vertebrae vertebrae vertebrae
distal forearm hip hip
distal forearm
The threshold for Fx is reduced for osteoporotic
bone
11
12. Risk factor for osteoporosis fracture
Potentially modifiable
1. Cigarette smoking
2. Low body weight ( < 58 kg.)
3. Estrogen deficiency : early menopause
(<45 years)
4. Low calcium intake, high salt and protein diet
5. Alcoholism
6. Inadequate physical activity
7. Poor health
12
13. Lab Investigations
CBC
ESR
Serum calcium (8.6 – 10.4 mg/dl)
Serum phosphorus (3.00 – 4.5 mg/dl) Children 4-6 mg/dl
Serum alkaline phosphatase (44 – 147 Iu/lit.) Children 1.5 -
2.5 times more
Liver function tests
Renal function tests
T3,T4, TSH
Para thyroid hormones
Vitamin D 25 (25 – 80 ng/ml)
Protein electrophoresis (M band)
Anti endomysial antibody (Coeliac disease)
14. Osteoporosis Treatment: Calcium and
Vitamin D
Fewer than half adults take recommended
amounts
Higher risk: malabsorption, renal disease, liver
disease
Calcium and vit D supplementation shown to
decrease risk of hip fracture in older adults
1000 mg/day standard; 1500 mg/day in
postmenopausal women/osteoporosis
Vitamin D (25 and 1,25): 400 IU day at least;
Frail older patients with limited sun exposure may need
up to 800 IU/day
15. Osteoporosis Treatment: Calcitonin
Likely not as effective as
bisphosphonates
200 IU nasally/day (alternating nares)
Decrease pain with acute vertebral
compression fracture
16. Osteoporosis Treatment: Bisphosphonates
Decrease bone resorption
Multiple studies demonstrate decrease in hip and
vertebral fractures
Alendronate, risodronate
IV: pamidronate, zolendronate (usually used for
hypercalcemia of malignancy, malignancy related
fractures, and multiple myeloma related
osteopenia)
Ibandronate (boniva): once/month
Those at highest risk of fracture (pre-existing
vertebral fractures) had greatest benefit with
treatment
19. 98% of a woman’s skeletal mass is acquired by age 20
Optimal strategies for building strong bones occurs during childhood and
adolescence
A study of disease management in
a rural healthcare population
demonstrated that a preventive
program was able to reduce hip
fractures and save money.
1. A balanced diet rich in calcium and
vitamin D
2. Weight-bearing and resistance-
training exercises
3. A healthy lifestyle with no smoking
or excessive alcohol intake
4. Talking to one’s healthcare
professional about bone health
5. Bone density testing and
medication when appropriate
Five Steps Toward Prevention