1) The document discusses osteoporosis, including the challenges it presents, its prevalence, risk factors, diagnosis, complications, management principles, and treatment goals. 2) Key points include that osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue, leading to fragility and increased risk of fractures. It affects millions worldwide, with over 50% of women and 20% of men experiencing fractures due to osteoporosis in their lifetimes. 3) Diagnosis involves bone mineral density tests to measure bone density and predict fracture risk. Treatment aims to prevent further bone loss and fractures, relieve pain and deformities, and improve quality of life.

1. WelcomeBICC|27th July, 2010

2. Osteoporosis: Challenges, When & How to TreatDRAFT Aclasta Brand BookOsteoporosis: Challenges to meet Prof. Muhammad ShahiduzzamanProf & Head, Department of Orthopaedics and TraumatologyDhaka Medical College Hospital

3. ObjectivesBone and its component

4. Bone Homeostasis

5. Bone remodeling

6. Definition and classification of osteoporosis

7. Prevalence

8. Risk Factors and presentation

9. Diagnosis

10. Consequences

11. Management principle

12. Treatment goalOsteoporosis: Challenges to meet| BICC | 27th July, 2010

13. Bone and its componentOrganic Component:

14. protein collagen & specialized cells called osteoclasts, osteoblasts, and osteocytes

15. Inorganic component:

16. Mainly as calcium phosphate, in the form of HydroxyapatiteOsteoporosis: Challenges to meet| BICC | 27th July, 2010

17. Bone HomeostasisBone Homeostasis:

18. the situation when the body requires and achieves an equal amount of bone resorption and bone formation

19. the amount of bone eroded by osteoclasts is equal to the amount of bone produced by osteoblasts, thereby producing a stable net mass of bone in the bodyHomeostasisOsteoporosis: Challenges to meet| BICC | 27th July, 2010

20. Bone RemodelingThe combined processes of breaking down bone and building new bone are called Bone Remodeling.

21. It is the body’s way of maintaining bone homeostasis.

22. 5 Stages:

23. Initiation,

24. Resorption,

25. Reversal,

26. Bone formation and

27. Completion of remodeling. Osteoporosis: Challenges to meet| BICC | 27th July, 2010

28. Remodeling: ActivationOsteoclast precursor cells are attracted to a bone site and penetrate the bone lining cells. These osteoclast precursor cells then form activated osteoclasts that align themselves in direct contact with mineralized bone matrix. Osteoporosis: Challenges to meet| BICC | 27th July, 2010

29. Remodeling: ResorptionThe osteoclasts erode a cavity by removing mineral and organic components from the bone. The osteoclasts eventually die. This completes the resorption phase. Osteoporosis: Challenges to meet| BICC | 27th July, 2010

30. Remodeling: RevarsalCells of unknown origin prepare the bone surface for new bone formation by smoothing the surface of the cavity and depositing a thin layer of a cement-like substance. Osteoporosis: Challenges to meet| BICC | 27th July, 2010