This document summarizes various pathologies that can affect the eye and orbit. It discusses congenital anomalies, infections and inflammations, tumors, trauma, and miscellaneous conditions. For each condition, it provides a brief description and highlights relevant imaging findings on modalities such as CT, MRI, and plain films. Key features that help characterize many lesions include enhancement pattern, presence of calcification, and signal characteristics on different MRI sequences.
Overview of role of imaging in different intraconal and extraconal pathologies including infective,inflammatory and neoplastic pathologies.Also included is insight into anatomy,trauma,post operative imaging and certain miscellaneous disorders
Overview of role of imaging in different intraconal and extraconal pathologies including infective,inflammatory and neoplastic pathologies.Also included is insight into anatomy,trauma,post operative imaging and certain miscellaneous disorders
A radiological insight into various musculoskeletal complications in patients suffering from AIDS and how it'll affect the management of the patient. A must know for all Radiologists.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
22. Acute inflammation of optic nerve , commonly associated with multiple
sclerosis.
Edema and inflammatory cells infiltrate the nerve resulting in uniform
swelling and focal demyelination.
Imaging : MRI is the modality of choice with hyper intense signal of
T2WI due to fluid and edema. Fat Sat contrast enhanced T1WI will show
areas of demyelination. CT relatively insensitive.
Straightening and thickening
of right optic nerve.
23. Optic Neuritis. CE Fat Sat T1W axial
(B) MR images demonstrate subtle enlargement and enhancement of the left
optic nerve (curved arrow).
T 2 WI (C) demonstrates corresponding increased signal intensity (straight
arrow).
34. Benign yellow-white rare retinal tumor
Associated with Tuberous Sclerosis or
Neurofibromatosis
Early on it may look exactly like retinoblastoma
May involve retina or optic nerve
37. Benign cutaneous disorder
Affects eye and skin
Affects iris and ciliary body, choroid, retina
and optic nerve
May present as a solitary orbital mass
42. Choroidal osteoma
Benign tumor
Unilateral usually
Affects young white girls
Patients present with painless progressive
loss of vision
43.
44.
45.
46. Malignant uveal melanoma
More common in whites
May arise from pre-existing nevi
Metastasizes hematogeneously to liver
47.
48.
49.
50.
51.
52.
53.
54.
55. Orbital Pseudotumor
• The most common cause of orbital mass in adults.
• Acute form presents with pain, proptosis and
diminished ocular mobility, with histological changes
similar to vasculitis.
• Chronic form may mimic infection or lymphoma both
clinically and histologically. Unilateral presentation is
most common, but findings can be bilateral. All
compartments of the orbit may be affected.
56. • Imaging -- Heterogeneous poorly marginated
increased CT density and decreased T1 & T2
MRI signal intensity within the intraconal fat
surrounding a thickened sclera or enlarged optic
nerve, sometimes simulating a mass.
• The lacrimal gland may be enlarged.
Enhancement occurs following contrast infusion.
57. Fig A. Scleral pseudotumour. Marked thickening and irregularity of
the sclera of the right globe involves the adjacent retro-orbital fat.
Fig B. Diffuse pseudotumour. Axial MR T1WI showing a diffuse mass
in the right orbit due to pseudotumour.
58. Rhabdomyosarcoma
• Rhabdomyosarcoma is the most common primary
orbital malignancy in the pediatric age group. with
most patients presenting below 6 years of age.
• Patients present with rapidly progressive
exophthalmos that may mimic orbital infection.
Spread of the tumor esp. intracranially, portends
poor prognosis.
59. • Imaging : Both CT and MRI will typically show a
mass involving an extra ocular muscle. Lesions
are isodense on CT and isointense on T1WI
when compared to muscle.
• There may be associated bony destruction and
contiguous extra orbital spread. The tumor
involves the globe less often. Marked
enhancement throughout the mass is seen after
contrast administration.
60. Rhabdomyosarcoma. CECT image
(A) Orbits demonstrates right proptosis due to large, lobular, intraorbital
mass.
(B) Image at lower level demonstrates invasion of right maxillary
sinus (asterisk) as well as extension through lateral orbital wall (arrow),
consistent with the aggressive nature of this tumor.
61. • Patients with abnormalities of the optic nerve and
its covering present with proptosis, visual loss and
papilloedema.
• Expansion of the tubular shaped optic nerve and
sheath is well demonstrated on CT and MRI.
• Imaging of the intracranial space is required
because the optic nerve and its coverings are
continuous with the brain and dura mater.
62. Occur in children
Are low grade astrocytomas.
Associated with NF-1
Imaging:- optic nerve may expand uniformly and diffusely. Plain
films will show asymmetric widening of the optic canal. Post
contrast show uniform enhancement.
Optic nerve glioma.
Enhanced coronal CT image
demonstrates homogeneous
enhancement of enlarged right
optic nerve.
63. Optic nerve glioma. Enhanced fat-saturated axial T1W image (A)
demonstrates mild enhancement and enlargement of intraorbital
and canalicular segments of left optic nerve.
Coronal image (B) confirms enlargement of nerve and surrounding perioptic
space.
64. • Meningiomas are dense fibrous tumors. Calcification is
common.
• Plain films may show widening of the optic canal, or
hyperostosis of the sphenoid wing.
• CT generally shows a dense, sharply defined tubular mass
surrounding and paralleling the course of the optic nerve, with
marked enhancement after contrast administration ('tram
track'). Kinking of the nerve may be seen.
• MRI will show a homogeneous mass of decreased T1 and T2
signal intensity, with strong enhancement, especially with the
use of fat suppression sequences.
• Coronal images are preferred, as the encased optic nerve will
be seen in relief against the densely enhanced tumor.
65. Fig A. Optic nerve Meningiomas. CT -- Enhancement of thickened right
optic nerve with elevation of optic disc (arrowhead).
Fig B. Axial T1-weighted post contrast fat-saturated image (B) demonstrates
peripheral enhancement of the thickened right optic nerve sheath.
Nonenhancing soft tissue within represents the encased optic nerve.
78. Thyroid ophthalmopathy.
Unenhanced axial (A) and coronal (B) CT images demonstrate massive
enlargement of the rectus muscles, including fusiform enlargement of the
lateral rectus with relative sparing of the distal muscle insertion.
79. Lymphoma. T1WI (A) demonstrates proptosis of right globe due to a large
intermediate signal intensity lesion that involves the lacrimal fossa and the
right lateral rectus muscle (arrow), with extension posteriorly in the
extraconal compartment.
Post contrast image (B) demonstrates homogeneous enhancement.
80. Cavernous Hemangioma. T1-weighted axial
(A) and sagittal (B) MR images demonstrate proptosis of right globe due
to well circumscribed, mid to high signal intensity intraconal mass.
81. Lymphangioma.
Axial T,-weighted (A) and T2 -weighted (B) MR images demonstrate mild right
proptosis due to complex, multi loculated, cystic, extra-axial lesion in the
superomedial aspect of the right orbit.
82. Encephalocele. Axial T1W MR image demonstrates marked
proptosis of right globe with stretching of attenuated right optic
nerve (arrowhead) due to herniation of dura and temporal lobe
through a large sphenoid defect in this patient with
neurofibromatosis.
83. Plexiform neurofibroma. T1WI(A) and T2WI (B) MR images show extensive
left temporal scalp lesion with extension to left orbit resulting in mild
proptosis. MR also demonstrates ectatic left optic nerve (arrow).
CT image at bone windows (C) demonstrates associated bony defect of left
lamdoid suture.
84. Metastases to the orbit may occur from systemic primaries,
particularly neuroblastoma and leukaemias in children, and breast, lung,
prostate and stomach cancer in adults. These lesions are poorly defined,
infiltrative and demonstrate marked contrast enhancement
on CT and MRI.
Prostatic Ca: Axial CT (A) shows small lytic lesion of left lateral orbital wall.
Soft-tissue windows (B) demonstrate contiguous extension of soft tissue into
lateral extraconal compartment (asterisk) with medial displacement of the
lateral rectus muscle.
85. These are congenital lesions that result from sequestration of primitive
ectoderm in the region of the orbit, usually presenting during childhood as a
discrete mass, located near the lacrimal fossa or nasal bone and are
homogeneous in appearance. The presence of fat is clearly seen on CT and
MRI. They do not enhance.
Lacrimal gland dermoid.
Coronal T 1WI demonstrate a well-
circumscribed lesion located in the
upper outer quadrant of left orbit.
High signal intensity is consistent with
fat.
A, Axial CT scan shows a microphthalmic left eye associated with a small calcification. B, Axial CT scan in another patient shows bilateral microphthalmia with marked calcifications.
Phthisis bulbi: Axial CT scan shows a dense right eye with irregular calcification. This child with acquired immune deficiency syndrome developed cytomegalovirus chorioretinitis, resulting in a disorganized eye with associated dystrophic calcification.
Typical coloboma of the optic disc. Axial CT scan shows a large posterior global defect (arrow) with optic disc excavation on the right side. The defect appears to be surrounded by an enhancing, deformed sclera and seems to have a direct connection with the vitreous body.
Colobomatous cyst. A, Axial CT scan shows bilateral microphthalmia and a large cyst (C) separated from the right globe by a band of enhancement (arrows), which is related to abnormal gliotic tissue. B, Anatomic section of an enucleated right eye. Note the small eye, large colobomatous defect, abnormal white tissues, gliotic tissues (G), and large cyst (C). Note the lens (L) and the optic nerve. C, Histologic section of an eye shows a large retinochoroidal coloboma (arrow), gliotic tissue (G ), cyst (C ), and lens (L).
Colobomatous cyst. Axial CT scan shows microphthalmic eyes with large cysts (arrows).
Posterior hyaloid detachment and retinal detachment in a patient
Sag T1 – white arrows is chronic subretinal hemorrhage and black arrows is posterior hyaloid detachment.
Sagittal T1-weighted MR image shows two semilunar regions; the posterior region (white arrows) is caused by chronic subretinal hemorrhage, and the anterior region (black arrows) is caused by posterior hyaloid detachment. Surgery confirmed
these findings.
Retinal detachment.
A - White arrows is retinal detachment
B – Black arrows – hyperintense areas - subretinal exudate
Total retinal detachment.
Axial T2-weighted MR image shows a detached retina (arrows) with the characteristic V-shaped configuration with the apex at the optic disc. Hypointensity of the left globe is caused by injection of silicone oil into the vitreous, which also has escaped into the subretinal space. The arrowhead points to residual subretinal fluid not replaced by silicone oil.
Retinal detachment. T1-weighted coronal MR image shows the characteristic appearance of retinal folds (arrows) and a hyperintense subretinal exudate (E ).
Serous choroidal detachment. Axial CT scan shows two prominent linear images (solid arrows) in the right eye. Because of the anchoring effect of posterior ciliary arteries and nerves, detached leaves of choroid usually do not appear to converge at the disc, unlike retinal leaves in retinal detachment.
The suprachoroidal space (S) is isodense with vitreous, indicating serous choroidal detachment. The enlarged right globe results from known congenital glaucoma.
Note the postsurgical changes in the left eye and the scleral-encircling silicone band (curved arrow).
A, Endophthalmitis and choroidal abscess. Enhanced axial CT scan shows marked thickening and enhancement of the right globe. Note the focal nodular enhancement (arrow) compatible with choroidal abscess.
B, Scleritis: Enhanced axial CT scan shows marked thickening with enhancement of the right globe.
C, Endophthalmitis: Enhanced sagittal T1-weighted MR image shows marked irregular thickening of the entire uveal tract associated with distortion of vitreous cavity.
Optic papilledema. Axial CT scan shows bulging of the left optic disc in this patient with bilateral papilledema. There was bilateral optic disc enhancement on enhanced T1-weighted MR images.
Posterior scleritis. Enhanced axial CT scan shows thickening with enhancement of the posterior scleral-uveal coat (arrow- heads).
Granulomatous uveitis.
A, Axial T2WI shows hypointense lesions (arrows).
B, Axial enhanced, T1WI shows marked enhancement of the entire uveal tract (arrow).
C, Unenhanced axial T1-WI shows nodular thickening of the posterior aspect of the right globe (arrow) and thickening of the anterior segment (arrowheads) of the right globe.
D, Enhanced axial fat-suppressed, T1WI shows nodular enhancement of the posterior aspect of the right globe (arrowhead and open arrow) related to granulomatous involvement of the choroids.
Granulomatous uveitis.
E, Enhanced sagittal T1WI shows granuloma at the optic disc (white arrowhead) as well as involvement of the optic nerve (black arrowhead ). F, Enhanced axial fat-suppressed, T1WI shows enhancement of the markedly thickened uveal tract (arrowheads).
Retinoblastoma. A, Leukokoric left eye (whitish papillary reflex). B, Axial CT scan shows a large calcified intraocular mass (M). Note the noncalcified component (arrowhead). C, Axial T1WI shows a relatively hyperintense infiltrative mass (arrows). D, Axial T2WI shows a hypointense infiltrative mass (M). Note the extension along the temporal aspect of the globe (arrows).
Retinoblastoma with optic nerve involvement. A, Enhanced, fat-suppressed, axial T1-weighted MR image shows marked enhancement of a retinoblastoma (R) with extension into the optic nerve (arrow). B, Photomicrograph of an enucleated eye showing the tumor (T) as well as extension into the optic nerve head (arrow). (Courtesy of D. Ainbinder, MD, Tacoma, WA.)
Tetralateral retinoblastoma. A, Axial T2-weighted MR image shows bilateral retinoblastoma (arrows). B, Enhanced axial T1-weighted MR image shows a markedly enhancing suprasellar mass (m). Note the subarachnoid spread of the tumor, seen as leptomeningeal enhancement along the sylvian fissures (arrows). C, Enhanced axial T1-weighted MR image shows marked enhancement of a pinealoblastoma (arrow). D, Enhanced sagittal T1-weighted MR image obtained a few months later shows diffuse distal spinal cord (C ) and subarachnoid metastases (arrows).
ROP. A, Axial CT scan shows increased density of the globes and left microphthalmos. B, Axial PW MR image shows hyperintensity of both globes, presumably caused by subretinal hemorrhage. Note the retrolental abnormal tissues (arrows) and detached retina (curved arrow). C, Axial T2-weighted MR image shows hyperintensity of the globes and abnormal retrolental soft tissues (arrows). Note the detached retina (curved arrow) and the layered acute hemorrhage in the right subretinal space (arrowhead ).
Coats’ disease. A, Axial CT scan shows generalized increased density of the left globe caused by bullous retinal detachment. The leaves of the detached retina are faintly seen, as shown by the arrows. B, Axial PW MR image shows hyperintensity of the left globe caused by subretinal lipoproteinaceous effusion. Note the leaves of the detached retina (arrows). C, Axial T2-weighted MR image shows the detached retina (arrows).
Astrocytic hamartoma. Axial CT scan shows a mass (arrow) in the posterior aspect of the right eye.
Juvenile xanthogranuloma. Precontrast axial T1-weighted (500/23, TR/TE) (A) and postcontrast T1-weighted (533/23, TR/TE) (B) MR images show an infiltrative enhancing mass involving the left eye (arrow). (Courtesy of A. Hidayat, MD, Washington, DC.)
Optic nerve head drusen. Axial CT scan shows increased density at the optic disc (arrow).
Choroidal osteoma. Axial CT scan shows a peripapillary calcified mass (arrows) compatible with choroidal osteoma.
Malignant melanoma of the choroid. Axial CT scan shows a mushroom-shaped mass with increased density in the temporal quadrant of the left globe (arrowheads).
Malignant melanoma of the choroid. A, Axial CT scan shows a mass (arrow). B, Axial PW MR image (top) and T2-weighted MR image (bottom) show a mass (arrow) and exudative retinal detachment (arrowheads). Retinal detachment is distinguished better on MR imaging than on CT.
Malignant uveal melanoma. A, Macroscopic section showing a mushroom-shaped melanoma (curved arrows) and a detached retina (open arrows). B, Sagittal PW MR image of another patient shows a hyperintense mass (arrows) and retinal detachment (arrow- head)
Malignant uveal melanoma. C, Sagittal T2-weighted MR image shows a mushroom-shaped hypointense melanoma (arrows). The subretinal effusion remains hyperintense.
Uveal metastasis. Axial precontrast (top) and postcon- trast (bottom) T1-weighted MR images show bilateral choroidal metastases (arrows).
Mets are usually from the breast or lung and spread is hematogeneous via short posterior ciliary arteries
Choroidal lymphoma. Axial postcontrast T1-weighted MR image shows an irregular, infiltrative, moderately enhancing mass (arrows) involving the left globe. The appearance cannot be differentiated from that of uveal metastasis.
Melanocytoma of the optic disc. Axial T1-weighted (A) and T2-weighted (B) MR images showing a melanocytoma (arrows). C, Axial T2-weighted MR image in another patient shows a melanocytoma (arrow). (Courtesy of M.F. Mafee, MD, FACR, Chicago.)
Choroidal metastasis. A, Axial PW MR image shows a hyperintense lesion (arrows) consistent with an ophthalmoscopic finding of choroidal metastasis. Note the irregularity of the lesion’s surface. B, The lesion remained slightly hyperintense in this axial T2-weighted MR image.
Leiomyoma of the ciliary body. A, Axial PW MR image shows a large, hyperintense mass (arrow). B, Axial T2-weighted MR image shows that the lesion remains hyperintense (arrow). Note the extension into the anterior chamber (arrowhead).
Medulloepithelioma. Axial CT scan shows a hyperdense mass (arrow).
Ocular rupture. Axial CT scan shows deformity of the left eye with uveoscleral infolding due to ocular hypotony related to a
rupture.
Ocular trauma and choroidal hematoma. Axial CT scan shows a hyperdense left choroidal hematoma. This can be confused with a choroidal melanoma.
Choroidal hematoma following ocular surgery. Axial CT scan shows multiple choroidal hematomas of various sizes involving the left eye.
Perforation and collapse of the globe. posterior aspect of the globe, Axial CT scans show infolding (arrowheads) of the posterior aspect of the globe, and the lens (arrow) is partially displaced.
A, Axial CT scan shows the intraocular lens (arrow) on the right side. Left globe has lost tone and has partially collapsed, with infolding of the posterior sclera.
B, Sagittal reconstruction shows the displacement of the lens (arrowhead) into the posterior aspect of the vitreous compartment.
Acute perforation of the globe on the right side. Phthisis bulbi and calcified lens on the left side. Axial CT scans at narrow (A) and wide (B) window settings. There is inward buckling of the sclera of the right globe after acute trauma. There is calcification along the wall of the globe on the left, with a calcified lens (arrow) from a previous insult.
Perforation of the cornea. Axial CT scan shows perforation of the cornea with hypotony of the aqueous chamber. The fluid space between the cornea and the lens on the right side (arrowhead) is diminished compared to the left. A normal aqueous chamber is seen on the left side (arrow).
Axial CT. Acute perforation of the lens capsule. The abnormal lens (arrowhead) has low density due to the influx of fluid diluting the normally high protein of the lens. Compare with the opposite side.
Dislocated lens, right eye; scleral buckle, left eye. MR imaging. A, Axial T1-weighted image shows the dislocated lens (arrow) posteriorly positioned in the right globe. B, Axial T1-weighted axial image. On the left side, the low-signal areas (arrowheads) on the medial and lateral aspect of the globe represent the scleral buckle. C, Axial T2-weighted image shows the dislocated lens on the right and the scleral buckle (low signal) on the left.
Scleral buckle in retinal detachment. A to D, Axial CT images showing the linear radial density encircling the globe (arrows). Note that if followed on all images, the radiodensity makes a complete ring around the globe.