Glaucoma describes conditions characterized by raised intraocular pressure, optic nerve damage, and visual field loss. It is one of the leading causes of blindness worldwide. Primary open-angle glaucoma is the most common type, where the anterior chamber angle remains open and there is no identifiable cause for optic nerve damage other than statistically elevated pressure. It is typically asymptomatic until late in the disease when significant vision has already been lost. Treatment aims to lower pressure sufficiently to stop further visual field loss and involves topical eye drops or surgery.
A presentation covering all aspects of Trachoma, one of the oldest infectious disease which is one of the leading causes of preventable blindness. Present day scenario and management.
A presentation covering all aspects of Trachoma, one of the oldest infectious disease which is one of the leading causes of preventable blindness. Present day scenario and management.
Ophthalmology Eye care Presentation, nasolacrimal duct obstruction, congenital nasolacrimal duct obstruction, acquired nasolacrimal duct obstruction, medical residency training presentation, ear nose and throat approach to nasolacrimal surgeries, federal medical centre lokoja, kogi state, Nigeria, ophthalmology surgery
This presentation gives a brief idea about angle of anterior chamber along with its structures and diagnostic methods to grade and visualize the structures.
Vitreous hemorrhage is the extravasation, or leakage, of blood into the areas in and around the vitreous humor of the eye.[1] The vitreous humor is the clear gel that fills the space between the lens and the retina of the eye. A variety of conditions can result in blood leaking into the vitreous humor, which can cause impaired vision, floaters, and photopsia.
It's an indepth presentation by Dr. Shah-Noor Hassan.
Ophthalmology Eye care Presentation, nasolacrimal duct obstruction, congenital nasolacrimal duct obstruction, acquired nasolacrimal duct obstruction, medical residency training presentation, ear nose and throat approach to nasolacrimal surgeries, federal medical centre lokoja, kogi state, Nigeria, ophthalmology surgery
This presentation gives a brief idea about angle of anterior chamber along with its structures and diagnostic methods to grade and visualize the structures.
Vitreous hemorrhage is the extravasation, or leakage, of blood into the areas in and around the vitreous humor of the eye.[1] The vitreous humor is the clear gel that fills the space between the lens and the retina of the eye. A variety of conditions can result in blood leaking into the vitreous humor, which can cause impaired vision, floaters, and photopsia.
It's an indepth presentation by Dr. Shah-Noor Hassan.
Glaucoma: the “silent thief of sight”
Glaucoma is a leading cause of preventable sight loss. Vision can often be preserved with early identification, good adherence to treatment and long-term monitoring.
you can get information about the glaucoma and its possible all types, its signs and symptoms, its pathogenesis, and its treatment (with medicines and with surgery).
you will know that how it affects the eye and causes the visual filed defects.
you will know that how it occurs in children and causes loss of vision.
Similar to ophthalomolgy.Glaucoma 1 lectures (dr. ali) (20)
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Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. Glaucoma
Introduction .
Glaucoma describes a number of ocular conditions characterized
by: -
1-Raised intraocular pressure (IOP).
2-Optic nerve head damage(cupping).
3-Corresponding loss of visual field (VF).
•IOP depends on the relationship between aqueous production
and outflow.
•The normal ocular tension is between 10-21mm.Hg. There is a
normal fluctuation in ocular tension of up to 3-5mm.Hg. during the
course of the day called diurnal variation.
•Glaucoma remains one of the principal causes of blindness
throughout the world
3.
4. Anatomy of the drainage angle
The anterior chamber(AC)
• is that space, containing aqueous humor, which is bounded in
front by the cornea and part of the sclera, and behind by the iris
and part of the ciliary body.
•Its normal depth in adults varies from 2.5-3.5mm.
•The angle of the anterior chamber.
•refers to that peripheral recess bounded posteriorly by the root of
the iris and the ciliary body and anteriorly by the corneo-scleral
junction or the limbus.
Among the deeper lamellae of the limbus,
•there is an annular channel, called the canal of Schlemm.
•The canal is separated from the aqueous in the anterior chamber
by the trabecular meshwork.
7. The trabecular meshwork is made up of
circumferentially disposed flattened collagenous
bands which criss-cross, leaving numerous
tortuous passages through which the aqueous
humor drains from the anterior chamber to the
canal of Schlemm.
The aqueous humor is a transparent colorless
fluid which fills the anterior and posterior
chambers of the eye. Its chief site of formation is
the processes of the ciliary body. The volume of
aqueous in the anterior chamber of the human
eye is 0.25 ml.
8.
9. Classification of glaucoma.
1-Angle configuration
a-open(POAG=primary open angle glaucoma).
b-Narrow/closed.(PACG=primary angle closure)
2-Onset a-acute(acute congestive glaucoma)red eye
differential diagnosis.
b-Chronic(primary open angle glaucoma)
3-Causes a-primary(POAG/PACG) or congenital/
developmental glaucoma.
c-acquired/secondary glaucoma(secondary open
angle and secondary close angle…)
Secondary to other ocular diseases.(neovascular glaucoma)
in CRVO or in diabetic eye disease(lens induced)I neglected
cataract.
13. PRIMARY OPEN-ANGLE GLAUCOMA(POAG).
Primary open-angle glaucoma (POAG) is characterized by the
1-development of glaucomatous optic neuropathy in an eye with
2-a normal-appearing mechanically opened anterior chamber angle
and
3- absence of other ocular or systemic disorders which may account
for the optic nerve damage.
4-Most cases of primary open-angle glaucoma are associated with
statistically elevated intraocular pressure.
Primary open-angle glaucoma is also called chronic open-angle
glaucoma or simple open-angle glaucoma.
POAG is the most common form of glaucoma.
It is typically a bilateral disease but may be asymmetric.
14. Risk factors: age(>40 y): positive family history; diabetes;
myopia.
Aetiology: Unknown. Theories suggest: functional inadequacy of
TM drainage; hypoperfusion of optic N. head; and weakness of
structural collagen in the angle and disc.
Symptoms: usually asymptomatic until late, when considerable
field loss has already occurred; not associated with pain,
discomfort or redness; new cases are usually identified by
screening.
Signs:
IOP: usually elevated, even sometimes double the normal value,
may be up to 40 mm hg.
Visual field (VF): up to 50% of ganglion cell axons entering the
disc may be lost before disc and field changes are evident.
Peripheral field is progressively lost, but central acuity is affected
late.
16. Pathophysiology:
Even today, much remains unknown about this disease.
•Elevated IOP almost certainly plays a significant role, but
the process is poorly understood.
• According to the mechanical theory of POAG,
chronically elevated IOP distorts the lamina cribrosa,
crimping the axons of retinal ganglion cells as they pass
through the lamina cribrosa and eventually killing the
cells.
•The vascular theory suggests that with elevated IOP,
reduced blood flow to the optic nerve starves the cells of
oxygen and nutrients
17. Clinical Testing and Examination Techniques in
Glaucoma
1/TONOMETRY(intraocular pressure measurement-IOP)
•Indentation Tonometry
The Schiotz tonometer is the primary indentation tonometer used to measure
intraocular pressure.
• Applanation Tonometry
Applanation Tonometry uses a variable amount of force to produce a fixed amount
of flattening of the corneal surface. Applanation Tonometry is based on the
Imbert-Fick principle, which states that the external force (F) exerted to a sphere,
equals the pressure inside this sphere (P) times the area (A) which is flattened or
"applanated" by the external force.
2/GONIOSCOPY.
is an examination technique used to visualize the structures of the anterior
chamber angle. Mastering the various techniques of Gonioscopy is crucial in the
evaluation of the Pathophysiology of aqueous humor outflow obstruction and the
diagnosis of the various glaucomas.
3/FUNDOSCOPY.
Disc: damage usually begins as an upper or lower temporal notch, giving rise to a
nasal arcuate scotoma,then progressive cupping can occur with progressive field
loss
20. Management Aims.
Progressive disc cupping and field loss in POAG progress at a
variable rate, leading in the most severe cases to profound field
constriction and ultimately blindness.
The aim of management is to lower IOP sufficiently to arrest
progressive VF loss.
1/Medical treatment: topical beta-blocker (Timolol,
carteolol,betaxolol) /prostaglandin
derivatives(latanoprost)/adrenergic agonist(brimonidine)/topical
carbonic Anhydrase blockers(dorsolamide)and
parasympathomimetics (pilocarpine).
2/Surgical treatment:
Trabeculectomy provides a definitive and permanent reduction of
IOP to within safe limits in the majority of cases.
21.
22. References .
1-Parson’s disease of the
eye 2003.
2-Lecture notes on
ophthalmology, Bruce
James, Chris Chew, ninth
edition, Blackwell
scientific 2003
3-Atlas of ocular pathology,
ocular trauma, on CD.
2-Clinical ophthalmology
Kanski J 2007
3-ophthalmology.a short
textbook.Gerhard.k.Lang.T
hieme publications.2000.