This document discusses occupational radiation safety in radiotherapy. It outlines potential radiation hazards from teletherapy equipment like telecobalt units and linear accelerators, as well as brachytherapy sources. Case studies of accidents are presented to illustrate hazards that can occur from equipment malfunctions, improper safety procedures, and lack of regulatory oversight. The document recommends strict adherence to safety guidelines and regulatory standards to minimize risks and ensure occupational exposures are kept as low as reasonably achievable. Regular equipment maintenance, staff training, and quality assurance are emphasized.
Radiation emergencies and preparedness in radiotherapyDeepjyoti saha
In a Radiotherapy Department where cancer patients are being treated with high energy photons,gamma rays,electrons; all the radiation workers should be alert regarding radiation accidents & how to face the situation.
Particle beam – proton,neutron & heavy ion therapyAswathi c p
particle therapy is advanced external beam therapy used to treat cancer , which uses beams of protons or other charged particles such as helium, carbon or other ions instead of photons. charged particles have different depth-dose distributions compared to photons. They deposit most of their energy in the last final millimeters of their trajectory (when their speed slows). This results in a sharp and localized peak of dose, known as the Bragg peak.
Radiation emergencies and preparedness in radiotherapyDeepjyoti saha
In a Radiotherapy Department where cancer patients are being treated with high energy photons,gamma rays,electrons; all the radiation workers should be alert regarding radiation accidents & how to face the situation.
Particle beam – proton,neutron & heavy ion therapyAswathi c p
particle therapy is advanced external beam therapy used to treat cancer , which uses beams of protons or other charged particles such as helium, carbon or other ions instead of photons. charged particles have different depth-dose distributions compared to photons. They deposit most of their energy in the last final millimeters of their trajectory (when their speed slows). This results in a sharp and localized peak of dose, known as the Bragg peak.
Quality Assurance in Radiotherapy. Web-based quality assurance; using medical web instrument to facilitate the education, collaboration and peer review, providing an environment in which clinical investigators can receive, share and analyse treatment planning digital data.
TISSUE PHANTOM RATIO - THE PHOTON BEAM QUALITY INDEXVictor Ekpo
TPR(20,10) is the recommended photon beam quality index by IAEA TRS-398 for megavoltage clinical photons generated by linear accelerators. This presentation goes through the basics of Tissue Phantom Ratio (TPR).
LDR and HDR Brachytherapy: A Primer for non radiation oncologistsSantam Chakraborty
A small presentation I made for a 30 minutes class comparing and contrasting LDR and HDR brachytherapy. Good for a person with non radiation oncology background to grasp the basics.
In 2000 IAEA published another International Code of Practice.
“Absorbed Dose Determination in External Beam Radiotherapy” (Technical Report Series No. 398)
Recommending procedures to obtain the absorbed dose in water from measurements made with an ionisation chamber in external beam radiotherapy (EBRT).
Quality Assurance in Radiotherapy. Web-based quality assurance; using medical web instrument to facilitate the education, collaboration and peer review, providing an environment in which clinical investigators can receive, share and analyse treatment planning digital data.
TISSUE PHANTOM RATIO - THE PHOTON BEAM QUALITY INDEXVictor Ekpo
TPR(20,10) is the recommended photon beam quality index by IAEA TRS-398 for megavoltage clinical photons generated by linear accelerators. This presentation goes through the basics of Tissue Phantom Ratio (TPR).
LDR and HDR Brachytherapy: A Primer for non radiation oncologistsSantam Chakraborty
A small presentation I made for a 30 minutes class comparing and contrasting LDR and HDR brachytherapy. Good for a person with non radiation oncology background to grasp the basics.
In 2000 IAEA published another International Code of Practice.
“Absorbed Dose Determination in External Beam Radiotherapy” (Technical Report Series No. 398)
Recommending procedures to obtain the absorbed dose in water from measurements made with an ionisation chamber in external beam radiotherapy (EBRT).
Tobacco Smoke is Radioactive (But Don't Tell Anybody)Charlie Gosh
Tobacco smoke is radioactive, but it wasn't always so. Using a cheap fertilizer that improves the taste is the culprit.
Second-hand smoke is radioactive, too.
Next time you wonder why smokers have so many health problems, remember that their bodies are radioactive, and they'll remain radioactive for thousands of years.
This seminar is presented as a part of weekly journal club and seminar regularly conducted at Apollo hospital,Kolkata Department of Radiation oncology.
It has been concluded that the management of radiation accidents is a very challenging process and that nuclear medicine physicians have to be well organized in.
Guidelines on Radiation Safety in DentistryChow Peng Yue
Radiation is an integral part of many diagnostic and therapeutic procedures in healthcare, and dentistry is no exception. In the field of dentistry, X-rays play a crucial role in aiding dentists in the diagnosis and treatment of various oral health conditions. While these diagnostic tools offer valuable insights, it is essential to prioritize the safety of both patients and dental healthcare professionals when utilizing ionizing radiation.
Radiation safety in dentistry encompasses a set of practices, guidelines, and precautions designed to minimize the potential risks associated with exposure to ionizing radiation. Dental professionals must strike a delicate balance between obtaining necessary diagnostic information and ensuring the well-being of patients by minimizing radiation exposure.
The primary goal of radiation safety in dentistry is to achieve optimal diagnostic results while keeping radiation exposure as low as reasonably achievable (ALARA). This principle emphasizes the importance of utilizing the lowest possible radiation dose without compromising diagnostic efficacy. Dental practitioners must be well-versed in radiation safety protocols, equipment calibration, and proper shielding techniques to achieve this delicate balance.
Occupational exposure to radiation in a nuclear power plant, medicalsJanne Anttila
I gave a lecture on health evaluations of radiation workers in a nuclear power plant for Mehiläinen Work Life Services on 8.6.17. The hope is to support colleagues taking care of our contract workers. Many contractors come from outside Finland. I’m also interested in connecting to colleagues and health professionals working in occupational health in the nuclear power sector. For that and as a language exercise why I translated the set of slides in English. Some of the slides are from official presentations and part modified from material produced by Timo Kontio, who is the group leader of radiation protection here at Fortum Loviisa NPP.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
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AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Occupational radiation safety in Radiotherapy, Timothy Peace S
1. OCCUPATIONAL RADIATION SAFETY IN
RADIOTHERAPY
DEPARTMENT OF RADIOTHERAPY
CHRISTIAN MEDICAL COLLEGE, VELLORE
Timothy Peace S
2. PRESENTATION OUTLINE
• INTRODUCTION
• POTENTIAL AREAS OF RADIATION HAZARDS IN RT
• TELETHERAPY
– TELECOBALT
– MEDICAL LINEAR ACCELERATOR
• BRACHYTHERAPY
• GENERAL RADIATION SAFETY MEASURES
• RECOMMENDATIONS
3. INTRODUCTION
• Radiation therapy aims to
– Destroy the cancer
– using gamma rays, high-energy x-rays
electrons, protons and heavy ions
– generated from radioisotopes, medical
linear accelerators and synchrotrons
• Double-edged sword
– The cancer destroying radiation can also
destroy normal cells
– Deterministic effects
• Gastrointestinal syndrome, CNS
syndrome, cataract, pneumonitis, sterility,
erythema, alopecia, cataract
– Stochastic effects
• Radiation carcinogenesis and genetic
effects
4. POTENTIAL AREAS OF RADIATION HAZARDS IN RT
• Teletherapy
– Telecobalt treatment unit (1.25 MeV, gamma photons)
– Medical linear accelerator (6 & 15 MV high energy x-ray photons),
electrons ranging from 4-21 MeV and neutrons arising from linear accelerators
delivering more than 10 MV x-ray photons)
• Brachytherapy
– Pre-loaded system
– Manual after-loading system (only low dose rate brachytherapy)
– Remote after-loading system (also high dose rate brachytherapy)
• Simulator
– Diagnostic x-ray-based simulator unit
5. * The whole body dose limit is 20 mSv a year when averaged
over 5 years with a maximum of 30 mSv in any one year (AERB)
Source: International Commission on Radiological Protection 26
Tissue or Organ Radiation Worker Member of Public
Whole of body 20* mSv /yr 1 mSv /yr
Lens of eye 150 mSv /yr 15 mSv /yr
Skin 500 mSv/yr 50 mSv /yr
Hands and feet 500 mSv /yr 50 mSv /yr
Pregnancy once
declared
2 mSv to lower
trunk
(1 mSv to foetus)
Foetus is
considered to be
member of public
ANNUAL DOSE LIMITS
6. TELETHERAPY TELECOBALT UNIT
• Potential Hazard 1: Source stuck
during treatment
– Emergency situation when the
Cobalt-60 source gets stuck in
between the “off” and “on” position
– Potential Occupational Exposure:
The radiographer has to enter the
treatment room to push the source
back
• Steps for minimizing exposure:
• Ask the patient (via intercom) to come out
– If not possible, enter from maze wall side (TLD badge
must be worn)
– Rotate gantry to side opposite to maze wall
– Insert “T-rod” and push it till the source reaches “safe”
position
7. TELETHERAPY TELECOBALT UNIT
Potential Hazard 2: Telecobalt Source transfer
– Replacement of Co-60 source
• Removal of old source
• Insertion of new source
– Occupational exposure during transfer
• Steps for minimizing exposure:
– Plan the procedure, minimize time and limit personnel
– Wear TLD badge and pocket dosimeter
– Monitor dose level using survey meter
Aligned with the machine head, “T-rod “used to exchange the source drawers
8. TELETHERAPY TELECOBALT UNIT
Potential Hazard 3: Dismantling without Decommissioning
– The telecobalt unit is dismantled or scrapped without
decommissioning the unit (AERB-approved procedure for
removal and disposal of source)
Case Study: Goiânia, Brazil
• 1985: Private radiotherapy clinic
closed down
• 1375 Ci – Cs -137 teletherapy
machine abandoned
• 1987: teletherapy head stolen
• Unit dismantled, source capsule
ruptured causing major
contamination
• 249 people contaminated
• 0.1 - 6.2 Gy (6200 mSv)
• Permissible limit: 1 mSv for public
• 4 people died
9. CASE STUDY: SAMUT PRAKARN,THAILAND
• October 1999: 3 disused teletherapy
sources stored by a private company
at unsecured parking lot
• Jan/Feb 2000: unauthorized removal
of one unit - dismantled for scrap
• 425 Ci - cobalt-60 source unshielded
• 10 people highly exposed
• 3 of whom died
Steps for avoiding this radiation disaster:
• Proper decommissioning procedure
• Proper removal of source
• Survey, contamination check & documentation
• Disposal of source
• Each step approved by regulatory body
10. TELETHERAPY – MEDICAL LINEAR ACCELERATOR
• The linear accelerator does not consist of a radioactive
source and hence poses a lesser radiation hazard
• It generates high energy electrons (4-21 MeV) and x-rays
(6-15MV)
• Potential hazard: Personnel entering the room when the
radiation is „on‟ can potentially receive lifetime dose in a
single exposure
• Case study: St Teresa’s Hospital (STH), Hong Kong
– Two physicists performed quality assurance check on a medical
linac
– discovered the accidental presence of a female ward assistant
– through the room's CCTV
– As for the affected female staff received 70 Sv (very low)
11. TELETHERAPY –LINEAR ACCELERATOR
• Case study: Industrial Accelerator
– 15 MV food irradiation facility in Hanoi.
– An individual entered the irradiation room without the operators‟
knowledge
– unwittingly exposed his hands to the x-ray beam.
– The individual received doses
• 10 - 25,000 mSv to the left hand
• 20 - 50,000 mSv to the right hand.
– Within one month one hand had to be amputated as well as the
fingers on the other hand.
• Simple steps that could have avoided these unnecessary
exposures
– Console to face treatment room door
– Door interlock
– “Last man out” switch
– Check CCTV before starting exposure
Limit for hand: 500 mSv
12. BRACHYTHERAPY
• Method of treatment in which the
sealed radioactive sources are
used to deliver high radiation at
short distance
• Pre-loading or “Hot” loading
– Radioactive sources loaded in the
applicators which are then inserted
into the patient
– High occupational dose to
personnel
– Dr Cyril Jayachandran developed
a remote-controlled trolley to
transfer the source to the „radium
theater‟
– Now an obsolete technique
– Replaced by manual and remote
afterloading systems
13. BRACHYTHERAPY - MANUAL AFTERLOADING
• Case study from another country:
Mishandling of source ribbons
– Patient scheduled for endobronchial
implant
• Ir 192 seeds: Activity- 2516 MBq.
– Staff mistakenly gave the attending
physician the inactive end of source
ribbon who inserted it into patient.
– Staff, assumed pieces of ribbon
contained no radioactive material,
coiled them and held them in her
hands.
– Dose to the staff‟s hand
• ~2.7 Gy (~2700 mSv – Allowed
500 mSv),
14. HDR BRACHYTHERAPY
• Case study from another country: Malfunction
of high dose rate equipment
– Patient was to be treated with a HDR
containing 159 GBq of Ir192
– The source wire had been broken and the
source had remained in the patient.
– Personnel disregarded the alarm from an area
radiation monitor because the unit console
indicated 'safe'.
– The source remained in the patient for
almost four days and the patient received
16,000 Gy at 1cm (Prescription: 18 Gy)
– The patient died shortly after removal of the
source
– The loss of the source resulted in radiation
exposure to 94 individuals
• Persons at the cancer clinic and the
nursing home,
• Ambulance staff and workers at the waste
disposal company
15. GENERAL RADIATION SAFETY MEASURES
• Area Monitor
– Gamma zone monitor for telecobalt
and brachytherapy installations
• Personnel Monitoring
– TLD, pocket dosimeters
– OSLD
• Audio-visual system
• Door interlocks
16. GENERAL RADIATION SAFETY MEASURES
• “Last man out” switch
– First in India (2005)
• Emergency Buttons
• Radiation warning symbols
18. DISCUSSION
• History shows that accidents rarely occur due to a single
equipment failure or a single human error. In most accident
cases there was a combination of elements such as:
– a) no prior safety assessment
– b) poor education and lack of training, especially when faced
with an unusual situation,
– c) management pressure (real or perceived) to continue work
even when safety systems were inoperable or deficient,
– d) poor maintenance programme or none at all, leading to a
reduction in layers of safety, and non-investigated false
alarms leading to persons ignoring warning systems.
19. RECOMMENDATIONS
• Each radiation professional in RT must cooperate with the Radiation
Safety Officer to ensure
– Effective organisation of all radiotherapy practice
– Education, training and awareness
– Communication
– Follow-up of equipment faults
– Frequent Quality assurance
– General radiation safety measures (Area and personnel monitoring,
routine survey, audio-visual system, safety interlocks and warning symbols)
– AERB guidelines must be followed for installation, commissioning and
decommissioning of radiotherapy equipment
– AERB approved procedure for procurement, replacement and
disposal of sources
– This will enable each radiation worker to handle radiation in a safe
environment and limit the occupational exposure to “As Low as
Reasonably Achievable - ALARA”
20. ACKNOWLEDGEMENTS
• Dr I Rabi Raja Singh, Radiation Safety Officer, CMC, Vellore
• Mr Jose Solomon Raj, Medical Physics Intern
• Mr Mohamathu Rafic, Lecturer in Medical Physics