bladder pain syndrome is highly prevalent. it is a diagnosis of exclusion. the biggest hurdle in management is diagnosis. more often than not patients suffering with BPS move from pillar to post, from a clinician to another, often getting urethral dilatations, receiving NSAIDS and even antipsychotics (having been labelled as 'psychiatric' patient).
once diagnosis is made, treatment is multipronged and based on phenotype - the concept is called UPOINT. interstitial cystitis is a small but significant minority (moreover ulcerative type) of BPS.
Gabapentin, amitriptyline and pentosan polysulfate are cornerstone pharmacotherapeutic agents for IC/BPS
Approah to a child / adult presenting with acute scrotum - testicular pain.
The acute scrotum – definition and causes with differential diagnosis
Management of the acute scrotum
Testicular torsion
Torsion of a testicular or epididymal appendage
Epididymitis or epididymo-orchitis
Idiopathic scrotal oedema
Fat necrosis of the scrotum
Case Discussion
bladder pain syndrome is highly prevalent. it is a diagnosis of exclusion. the biggest hurdle in management is diagnosis. more often than not patients suffering with BPS move from pillar to post, from a clinician to another, often getting urethral dilatations, receiving NSAIDS and even antipsychotics (having been labelled as 'psychiatric' patient).
once diagnosis is made, treatment is multipronged and based on phenotype - the concept is called UPOINT. interstitial cystitis is a small but significant minority (moreover ulcerative type) of BPS.
Gabapentin, amitriptyline and pentosan polysulfate are cornerstone pharmacotherapeutic agents for IC/BPS
Approah to a child / adult presenting with acute scrotum - testicular pain.
The acute scrotum – definition and causes with differential diagnosis
Management of the acute scrotum
Testicular torsion
Torsion of a testicular or epididymal appendage
Epididymitis or epididymo-orchitis
Idiopathic scrotal oedema
Fat necrosis of the scrotum
Case Discussion
This slide introduces the latest status of the SIGVerse project talked in the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) 2016.
International journal of Construction Engineering and Planning
is primarily devoted to scientific articles and comprehensive reviews that are focused on the quality control, risk assessment, resource management in the field of construction engineering and planning. Journal also focuses on the production planning, critical path method that can create an impact on the ongoing research.
Pancreatitis -a detailed study ( medical information )martinshaji
Pancreatitis is the Inflammation of the pancreatic parenchyma. Acute condition of diffuse pancreatic inflammation & auto digestion, presents with abdominal pain, and is usually associated with raised pancreatic enzyme levels in the blood &urine. this is a detailed study pancreatitis describing factors such as definition , epidemiology , etiology , pathophysiology , treatment , prevention , imaging techniques , diagnosis , lab investigations , images , drugs , control etc
please comment
thank u
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Surgical Site Infections, pathophysiology, and prevention.pptx
Non traumatic emergencies
1.
2. Define common urological emergencies
that may face non urologists.
How to diagnose these emergencies
Initial management of these problems
for non urologists
3. 1 Loin pain
2 Retention of urine
3 Testicular pain
4 Hematuria
5 Problems with the penis
6 Problems with catheters
4. Acute renal colic is the most
excruciatingly painful event a person can
endure .
Non traumatic
emergency
5. Does not always present with classic history
Classically presents with loin pain radiating
around abdomen, as stone moves down
ureter
May get testicular/labial pain +/- strangury if
stone impacts at VUJ
6. - Reflects the somatic
sensory distribution
of the spinal level of
renal innervations
- (T1o-T12).
- Most probable
hypothesis:
Afferents from the
skin & viscera
converge on the
same neuron in the
spinal cord and
share the same
ascending neuron .
9. Limitations
Significant
obstruction may be
associated with little
dilatation of
collecting system.
Relatively poor in
visualizing the ureter.
Difficult to detect
stones < 5mm in size
Operator and
equipment
dependent
10. 95% sensitivity
98% specificity
Performed in 5 min.
Identifies radiolucent
stones .
Identifies other causes
of flank pain.
stone
11. Treat the symptoms –analgesia
Blood cultures if pyrexial
Consider antibiotics
quinolone if not vomiting
gentamicin if vomiting
12. Persistent pain .
Ureteral obstruction from a stone in a
solitary or transplanted kidney .
Ureteral obstruction from a stone in
presence of UTI, fever, sepsis or
pyonephrosis.
Relative indication:
Co morbid conditions (e.g. diabetes ,
dehydration, renal failure, or any immuno
compromised state)
13. Size of Stone
< 4mm
4-6 mm
> 6mm
Management
Conservative: 90% pass
spontaneously
50% pass
spontaneously – trial
of passage
Intervention likely, only
10% pass
spontaneously
14. Stone on KUB - No stone on KUB
Pyrexia - No pyrexia
Hematuria - No hematuria
Raised creatinine - Normal creatinine
21. Do it immediately
Urethral catheter 12/14F
Record the residual
Two attempts then call for help
16F SPC if urethra impassable
22. Obstruction develops slowly, the bladder
is distended (stretched) very gradually
over weeks/months, so pain is not a
feature .
Presentation:
› Urinary dribbling
› Overflow incontinence
› Palpable lower suprapubic mass
Non traumatic
emergency
23. Usually associated with
› Reduced renal function.
› Upper tract dilatation
R/x is directed to renal support.
Bladder drainage under slow rate to
avoid sudden decompression>
hematuria.
Late R/x of cause.
28. Can occur at any age
Most common in adolescents
Occasionally seen in neonates
In infants & neonates the symptoms and
signs are imprecise
Prompt action required to avoid
irreversible testicular ischemia
31. Color Doppler ultrasound:
› Assessment of anatomy and determining the
presence or absence of blood flow.
› Sensitivity: 88.9% specificity of 98.8%
› Operator dependent.
32. If you have time Scrotal ultrasound scan
If you don’t have time explore the
scrotum
You only have 6 hours
36. Presentation:
Indolent process.
Scrotal swelling, erythema, and pain.
Dysuria and fever is more common
P/E :
› localized epididymal tenderness, a swollen and tender
epididymis, or a massively swollen hemiscrotum with
absence of landmarks.
› Cremasteric reflex should be present
Urine:
› pyuria, bacteriuria, or a positive urine culture(Gram-
negative bacteria) .
Non traumatic
emergency
37. Management:
› Bed rest for 1 to 3 days then relative
restriction .
› Scrotal elevation
› Parenteral antibiotic therapy
› Urethral instrumentation should be avoided
38.
39. Definition :
presence of blood in the urine.
The passage of blood in the urine is
always alarming and investigation is
warranted.
Non traumatic
emergency
40. Hematuria.
Hemoglobinuria, myoglobinuia.
Anthrocyanin in beets and blackberries.
Chronic lead and mercury poisoning.
Phenolphthalein (in bowel evacuants).
Phenothiazines (compazine).
Rifampicin.
42. Microscopic examination :
Urine dipsticks test :
-Urine dipsticks test for hem
(i.e. they test for presence of
hemoglobin & myoglobin in
urine ).
- Hem catalyses the oxidation
of orthotolidine by organic
peroxidase producing a blue
coloured compound.
-Dipsticks are capable of
detecting the presence of
hemoglobin from 1 or 2 RBCs.
43. False positive results :
Myoglobinuria,
Bacterial peroxidases,
Povidine & hypochlorite.
• False negative results (rare):
Reducing agents ( e.g. ascorbic acid which
prevents oxidation of orthotolidine).
44. Age and sex.
Smoking.
History of schistomiasis in endemic areas.
Occupational exposure to carcinogens.
Drugs e.g. NSAID, Cyclophosphamides.
Pain, fever, dysuria, frequency.
History of recent throat pain suggests post
infectious g.n.
Information about exercise, menstruation, recent
catheterization or passage of calculi.
45. Diagnoses
Urothelial cancer
UTI/STI
Stone disease
Decision
Pain on voiding?
Are there clots?
Are they voiding?
Clinical/DRE
Temperature
Urinalysis
MSU/cytology
Bloods/PSA
IVU/UTUSS
Cystoscopy
46. Physiologic phimosis Pathologic phimosis Pathological
phimosis showing a
thickened indurated
phimotic band.
Non traumatic
emergency
47. Paraphimosis. Venous
return from the glans is impaired
and the prepuce is
edematous and engorged distal to
the phimotic ring
Sustained gentle
pressure is required
in order to reduce
the edematous
foreskin over the
glans
48. The term “Priapism” is derived from
Priapus, the Greek god of fertility.
An erection lasting longer than 4 h that is
not associated with sexual stimulation
Non traumatic
emergency
49. Venous, low flow.
Cessation of arterial
inflow serves to create
an acidotic and
hypoxic condition in
the penis.
Increased
intracorporeal
pressure similar to the
compartment
syndrome.
Arterial , high flow
Unregulated arterial
inflow
Ischemic Non ischemic
50. Idiopathic 50%.
Intracavernosal inj.
Antidepressant
Antipsychotics,
chlorpromazine,
phenothiazine.
Antihypertensives ;
hydralazine, prazozine
High fat content of TPN
Cocaine and alcohol
Direct trauma to penis,
perineum or pelvis
arterial rupture and
increased arterial
inflow.
Ischemic Non ischemic
51. Sickle cell anemia.
Leukemia.
Neurologic :
lumber spinal stenosis,
cerebrovascular disease,
seizure disorders.
Neoplasm: Ca bladder, Ca
prostate, metastatic renal
cell carcinoma
infiltrate and obstruct
venous drainage. (This type
of priapism is usually
treated with chemotherapy
or radiotherapy).
Trauma to penis, perineum
or pelvis
arterial rupture and
increased intracorporeal
arterial inflow.
Ischemic Non ischemic
T
52. Aspiration of corporeal blood
For ABG
Dark venous blood
PH <7.25
PO2 <30 mmHg
PCO2 > 60 mm Hg
CBC for leukemia
Sickle C test
Doppler U/S
No cavernous arterial flow
Bright arterial blood
PH >7.3
PO2 >50 mm Hg
PCO2 < 40 mm Hg
Ruptured cavernosal artery
with unregulated blood flow
pooling.
Laboratory testing
Ischemic
Non ischemic
53. History:
Duration and quality of erection .
Pain or no pain.
Medication and recreational drugs
Sickle cell anemia or hypercoagulable state.
Physical examination :
- Rigid painful erection with a softer glans with
ischemic priapism
- Semirigid painless penis often with non ischemic
priapism
- Signs of genital or perineal trauma
- Signs of lymphadenopathy
54. Penile nerve block : Inject lidocaine 1% at the
base of the penis at the 3 o’clock and 9 o’clock
positions.
Insert an 18-gauge or 20-gauge butterfly needle into
one of the corpora cavernosa (2 o’clock or 10 o’clock
positions). Attach to a large syringe.
Aspiration : Aspirate 50 mL (it may be necessary
to milk the penis). Dark blood is aspirated initially.
If this does not lead to detumescence, then another 50
mL is aspirated from the contralateral corpus. Then
apply manual pressure to the penis for few minutes.
55. Irrigation: If failure, then another 50 mL should
be aspirated from the corpora and irrigate
with 30–40 mL warm, sterile heparinised
saline solution (5000 U/L) and then aspirate
another 30–40 mL.
Infusion: If failure, apply a tourniquet to the base of
the penis. Inject 200 μg of Phenylephrine (a1 agonist,
vasoconstrictor),50-100 μg Ephedrine, 20-80 μg Nor
adrenaline or 10-20 μg Adrenaline into the corpora.
Need to measure blood pressure, pulse rate every 5
minutes and to have electrocardiogram monitoring.
56. Wait for 5–10 minutes; if this
fails, then repeat the
injection with another 200 μg
of phenylephrine. If this fails,
then consider another 500 μg
of phenylephrine.
If phenylephrine is not
available, then adrenaline 10–
20 μg every 5 minutes could
be used
If failure, Surgery : Distal
shunt, if fails : Proximal
shunt
57. 1 Aspiration for diagnosis. Do not use
sympathomimetics
2 Observation
3 Embolization
4 Surgery, aided by intraoperative Doppler
ultrasound
58.
59. Blocked catheter
Change the catheter don’t wash it out
Send a CSU
? Start antibiotics
Admit if pyrexial
Non traumatic
emergency
60. Urine bypassing the catheter
Wash the bladder out
Start anticholinergic drugs
Non traumatic
emergency
Editor's Notes
Fowler’s syndrome (impaired relaxation of external sphincter occurring in premenopausal women, often in association with polycystic ovaries
Haematuria leading to clot retention
Drugs: anticholinergics, sympathomimetic agents such as ephedrine in nasal decongestants
Pain (adrenergic stimulation of the bladder neck)
postoperative retention;
sacral (S2–S4) nerve compression or damage—so-called cauda equina compression (due to prolapsed L2–L3 disc or L3–L4 intervertebral disc, trauma to the vertebrae, benign or metastatic tumours)
radical pelvic surgery damaging the parasympathetic plexus (radical hysterectomy, abdominoperineal resection);
pelvic fracture rupturing the urethra (more likely in men than women);
neurotropic viruses involving the sensory dorsal root ganglia of S2–S4 (herpes simplex or zoster);
multiple sclerosis
transverse myelitis
diabetic cystopathy
Damage to dorsal columns of spinal cord causing loss of bladder sensation (tabes dorsalis, pernicious anaemia).