Trauma is a leading cause of non-obstetric death in pregnancy and can complicate 6-7% of pregnancies. The most common causes of trauma during pregnancy are motor vehicle collisions, assaults, falls, and domestic violence. Managing trauma in pregnancy requires a multidisciplinary approach and care of both the mother and fetus. The priorities are resuscitation of the mother to also resuscitate the fetus, assessment of fetal well-being, and treatment of maternal injuries while minimizing risks to the fetus. Diagnostic imaging such as ultrasound and CT scans can be used judiciously as long as radiation exposure is minimized. Timely delivery via c-section may be needed if the mother or fetus are critically unstable.
Pregnant patients are admitted in ICU with a number of pregnancy related problems. Some of them are really life threatening. Identification and prompt action is the key to save lives.
Pregnant patients are admitted in ICU with a number of pregnancy related problems. Some of them are really life threatening. Identification and prompt action is the key to save lives.
Invited lecture by Dr Sujoy dasgupta in the Annual Conference of the "Academy of Clinical Embryologists" (ACE) held in October 2021 in "Hybrid mode" (Kolkata and Webinar)
SHARE Presentation: Having Children after Cancerbkling
Dr. Diana Chavkin, Reproductive Endocrinology and Infertility (REI) specialist at Genesis Fertility and Reproductive Medicine, made this presentation at SHARE about fertility preservation options before and after cancer treatment.
If you'd like to hear the audio, visit www.sharecancersupport.org/chavkin
The information in this presentation is not intended to be a substitute for professional medical advice, diagnosis or treatment. The presentation was given on May 15, 2014.
The loss of pregnancy at any stage - devastating experience, both patient and physician.
Recurrent miscarriage is defined as the occurrence of three or more consecutive spontaneous abortion before 20wks of gestation.
Ectopic, molar and biochemical pregnancies not included.
Placental abruption is premature separation of placenta from the uterus/ in other words separates before childbirth.
It occurs most commonly around 25 weeks of pregnancy characterized by vaginal bleeding, lower abdominal pain, and dangerously low blood pressure
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. • Trauma is not just something that happens to other
people. Trauma is a disease that could affect
anyone, but it is more importantly it is something
that we can all prevent.
3. • Complicates 6-7% of
pregnancies.
• Leading cause of non- obstetric
death.
• Maternal death is the common
cause of fetal death.
11. Predictors of Mortality
• Severity and type of trauma
• Gestational age
• Complications
• Internal injuries
• Severe hemorrhage
12. Keel et al reported the major killers in polytrauma
head injury (66%).
hemorrhagic shock (21%).
sepsis and multiorgan failure (13%)
coagulopathies (dilutional and
consumption).
13. ANATOMICAL & PHYSIOLOGICAL CHANGES
Plasma volume increases by 45-50% Reduce maternal resistance to
limited blood flow
Red cell mass Increases by 30% Dilutional anemia
Cardiac output Increases by 30-50% Relative maternal resistance to
limited blood loss
Uteroplacental blood flow 20-30% shunt Uterine injury may predispose
to increased blood loss,
increase vascularity
Uterine size Dramatic increase Change in position of
abdominal contents, supine
hypotension
Minute ventilation Increases by 25-30% Diminished Paco2
Diminished buffering capacity
Functional residual capacity decreased Predisposition to atelectasis
and hypoxemia
Gastric emptying delayed Predisposition to aspiration
15. BLUNT TRAUMA
• 2/3 cases of all trauma in pregnancy.
• CAUSES
- Motor vehicular collisions
- Assault
- Falls
• Especially in 2nd and 3rd trimester.
• PELVIC FRACTURES – engaged head
• Haemorrhage from dilated retroperitoneal
veins can cause massive hemorrhagic shock
and death
16. • MVA - Passenger
restraint system
decreases
maternal/fetal injury.
• Crosby & Costilee
- 33% maternal
mortality with no
restraints
- 5% using seat belts
17. Penetrating trauma
• Primarily -stabbing or gunshot wounds
• The gravid uterus in 2nd & 3rd trimester provides
protection to maternal internal organs.
• Maternal mortality lower than the non-pregnant
women – 3.9% vs 12.5%
• Awwad and colleagues, observed fetal death rates 70-
90%- direct injury to uterus and 38% for injuries
above uterus.
18. BURNS
• BURNS -6.8% to 7.8% of all pregnancies
• Fetal loss is 56% -if 15-25% of body surface area(BSA)
involved.
63% - If 25-50% BSA involved.
100%- If >50% BSA involved.
• Maternal and fetal deaths are often a result of
inadequate fluid resuscitation, prolonged hypotension,
shock, hypoxia, septicemia and hyponatremia.
• Potential for carbon monoxide poisoning
22. Primary Survey
Maternal assessment
„ Fetal age assessment & presence of life
If CPR unsuccessful consider Perimortem CS
Minimize effect of uterine compression on maternal
resuscitation
Fetal resuscitation
23. Maternal Resuscitation
The main principle guiding
therapy must be that
resuscitating the mother will
resuscitate the fetus.
25. CIRCULATION
• Position- 30 degrees to left.
• Volume resuscitation.
Crystalloid- 3:1 replacement
Blood transfusion
• Maternal B.P,H.R- not a reliable indicator of maternal and
fetal well being.
• Uterus not critical organ- after acute blood loss- uterine
blood flow decreased to maintain normal maternal B.P.
• When signs of shock appear- fetal compromise far advanced
32. IMAGING STUDIES
• Do not avoid or delay necessary exams due to
concerns about fetal radiation exposure.
• Fetal adverse effects are unlikely if radiation dose less than
5 rads or distance more than 10 cm.
• Relative risk of childhood cancer greatest before 8 weeks.
• Lesser than 1% of trauma patients are exposed to more
than 3 rads.
• Fetal effects of radiation depend upon gestational age at
the time of exposure.
33. • Ultrasound (US)
- simultaneous assessment of mother and fetus.
- Fluid or air collections in the abdomen
- ultrasound has a sensitivity of only 50% in detecting
abruption .
34. FAST (focused assessment with
sonography in trauma)
• Reduces the need for x-ray or CT scan.
• shortens the time to surgery.
• 96% of gravid trauma patients required no tests using
ionizing radiation
• sensitivity of 61% to 83% & specificity of 94% to 100%.
35. • CT scan
- Head and chest CT- 1 rads
- abdomen above uterus- 3 rads
- pelvic CT- 3 to 9 rads
• MRI – no documented fetal effects reported including
mutagenic.
36. DIAGNOSTIC PERITONEAL LAVAGE
• DPL is an invasive, rapid, and highly accurate test for
evaluating intraperitoneal haemorrhage or a ruptured
hollow viscus.
• Performed less frequently; replaced by FAST and helical
computed tomography (CT).
37. Anesthesia in OB trauma
• Maintain good anesthesia, oxygenation, normotension,
normothermia, normocarbia (PaCO2 = 30) and left uterine
displacement.
• Avoid ketamine > 2 mg /kg (uterine hypertonus).
• Monitor FHTs if practical. Loss of variability is normal, but
fetal tachy or bradycardia may mean hypoxia.
• Avoid benzodiazepines and N2O early in gestation
38. MOTHER STABLE, FETUS STABLE
• Once mother is stabilized, focus on fetus.
• Direct impact – not necessary for feto placental
pathology.
• No obvious abdominal trauma- still needs
monitoring.
• 4hr- CTG monitoring recommended.(Pearlman
et al.)
40. MOTHER UNSTABLE FETUS UNSTABLE
• Primary repair of maternal injuries- best course
• Even in fetal distress, as critically injured mother will not
withstand cesarean section.
• Early restoration of maternal physiology – best initial action
for fetus.
• If mother can withstand- cesarean section can be
performed
42. PERIMORTEM CS
• Maternal resuscitation as per ACLS guidelines.
• If no response- decision for perimortem cesarean section.
• No return of spontaneous circulation after resuscitation for
four minutes.
• Delivery within 5 min carries the best chance of fetal and
maternal survival.
43.
44. CONCLUSION
• Most diagnostic and therapeutic modalities relating to
trauma care should not be modified or avoided during
pregnancy.
• Co-management /multidisciplinary approach , function to
insure appropriate care of the trauma victim and her fetus.