Cytoskeleton - microtubules ,microfilaments and intermediate filamentsBIOTECH SIMPLIFIED
The cytoskeleton is a structure that helps cells maintain their shape and internal organization, and it also provides mechanical support that enables cells to carry out essential functions like division and movement. There is no single cytoskeletal component. Rather, several different components work together to form the cytoskeleton.
Nucleus: Structure and function
nuclear membrane
nuclear lamins
Nuclear pore complexe
nuclear matrix, composition and its role
cajal bodies
SFCs
nuclear speckles
PML bodies
Nucleolus
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
Cytoskeleton - microtubules ,microfilaments and intermediate filamentsBIOTECH SIMPLIFIED
The cytoskeleton is a structure that helps cells maintain their shape and internal organization, and it also provides mechanical support that enables cells to carry out essential functions like division and movement. There is no single cytoskeletal component. Rather, several different components work together to form the cytoskeleton.
Nucleus: Structure and function
nuclear membrane
nuclear lamins
Nuclear pore complexe
nuclear matrix, composition and its role
cajal bodies
SFCs
nuclear speckles
PML bodies
Nucleolus
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
The delivery of newly synthesized protein to their proper cellular destination, usually referred to as protein targeting or sorting.
The mode of protein transport depends chiefly on the location in the cell cytoplasm of the polysomes involved in protein synthesis.
There are two modes of protein sorting:-
1) Co - translational Transportation.
2) Post - translational Transportation.
Presentation include Nucleus and its components like nuclear envelope, nucleolus, chromatin fibers, ultra structure of nucleus and its general functions.
Nucleus” is a Latin word meaning Kernel
It is the “CONTROL CENTER” of the cell
Average diameter of nucleus is 6um, which occupies around 10% of cell volume
Nuclear Envelope
Nuclear Pores and complex
Nuclear lamina
Chromosomes & Chromatin
Nucleolus
Nucleoplasm
The delivery of newly synthesized protein to their proper cellular destination, usually referred to as protein targeting or sorting.
The mode of protein transport depends chiefly on the location in the cell cytoplasm of the polysomes involved in protein synthesis.
There are two modes of protein sorting:-
1) Co - translational Transportation.
2) Post - translational Transportation.
Presentation include Nucleus and its components like nuclear envelope, nucleolus, chromatin fibers, ultra structure of nucleus and its general functions.
Nucleus” is a Latin word meaning Kernel
It is the “CONTROL CENTER” of the cell
Average diameter of nucleus is 6um, which occupies around 10% of cell volume
Nuclear Envelope
Nuclear Pores and complex
Nuclear lamina
Chromosomes & Chromatin
Nucleolus
Nucleoplasm
The Top Skills That Can Get You Hired in 2017LinkedIn
We analyzed all the recruiting activity on LinkedIn this year and identified the Top Skills employers seek. Starting Oct 24, learn these skills and much more for free during the Week of Learning.
#AlwaysBeLearning https://learning.linkedin.com/week-of-learning
Cilia and Flagella are complex filamentous cytoplasmic structures protruding through a cell wall.
They are minute, especially differentiated appendices of the cell.
Flagella wriggle like eels. They generate waves that pass along their length, usually from base to tip at constant amplitude.
Thus the movement of water by a flagellum is parallel to its axis while a cilium moves water perpendicular to its axis and, hence, perpendicular to the surface of the cell. The axoneme is connected with the basal body which is an intracellular granule lying in the cell cortex and which originates from the centrioles.
Each axoneme is filled with ciliary matrix, in which are embedded two central singlet microtubules, each with the 13 protofilaments and nine outer pairs of microtubules, called doublets. This recurring motif is known as the 9 + 2 array.
It is a network of protein filaments in the cytoplasm of a cell
It provides structural framework to the cell.it also helps in the cell movement and movement of cytoplasmic components during several processes such as phagocytosis,endocytosis and exocytosis.
It consists of main three components microfilaments,microtubules and intermediate filament
Motor molecules also carry vesicles or organelles to various destinations along “monorails’ provided by the cytoskeleton.
Interactions of motor proteins and the cytoskeleton circulates materials within a cell via streaming.
Recently, evidence is accumulating that the cytoskeleton may transmit mechanical signals that re-arrange the nucleoli and other structures.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
4. •The range of techniques to understand the
cytosketeton include fluorescence microscopy,
digital video microscopy and electron
microscopy.
5. Microtubules
•Microtubules were first discovered by De
Roberties and Franchi (1953)
•In the axons of medullated nerve fibres and were
named neurotubules. Porter(1955)
•Term “Microtubules” was given by
Slautterback (1963)
6. •Microtubules are electron-microscopic structure.
•Found only in Eukaryotic cellular structures.
•But absent in mature mammalian erythrocytes,slim moulds
and prokaryotes
•Microtubules (MTs) are largest element of the cytoskeleton.
•Cytoplasmic microtubules:- 1) maintain axons; 2) maintain
shape; 3) orient cellulose microfibrils (in plants); 4) mitotic
and meiotic spindles for chromosome movements; and 5)
vesicle movement.
•Axonemal microtubules:- highly organized, stable
microtubules in specific movement associated subcellular
structures (cilia, flagella and attachment basal bodies). The
central shaft (axoneme) consists of a highly ordered bundle of
axonemal MTs (see sperm tail axoneme).
7. Microtubule Structure
Microtubule Structure:- is made up
of heterodimers of alpha-tubulin and
beta-tubulin (form an alpha-beta-
heterodimer).
•An a,b-tubulin heterodimer is the
basic structural unit of microtubules.
•The heterodimer does not come
apart, once formed.
ab
GTP GTP
tubulin
heterodimer
8. •The alpha-tubulin and beta-tubulin molecules are 4-5
nm in diamater and 55 kDa, have almost identical
shapes but only share 40% amino acid sequence
identity.
•A microtubule is a hollow cylinder of 13
protofilaments around a lumen with an outer
diameter (25 nm), inner diameter (15 nm) and dimer
width (8 nm).
•Singlet microtubules are 13 protofilaments;
doublets are 13 plus 10 (or 11)
[in cilica or flagella] and
•Triplets are 13 plus 10 (or 11)
plus 10 (or 11)
•[in basal bodies or centrioles].
9. •A microtubule is a hollow cylinder,
about 24 nm in diameter.
•Along the microtubule axis, tubulin
heterodimers join end-to-end to form
protofilaments, with alternating a & b
subunits.
•Staggered assembly of 13 protofilaments
yields a helical arrangement of tubulin
heterodimers in the cylinder wall.
seam
microtubule3-starthelix
b-GDP
a-GTP
b-GTP
a-GTP
+
Note :-Electron microscopy of microtubules
decorated with motor protein heads indicate a "3-
start helix.“
Each turn of the helix spans 3 tubulin monomers
(e.g., a, b, a).
10. •Microtubules form by addition of tubulin dimers at the ends.
New microtubules form nucleation centres (oligomers) and
grow by addition of subunits on either end: elongation.
Critical concentration is when disassemby and assemby is
exactly balanaced: treadmilling.
The plus end: rapidly growing end; the minus end: the slower
growing end.
•Microtubule-organizing centre (MTOC)
•serves as a site for initiation and
as an anchor.
•A centrosome (animals cells) has two
centrioles surrounded by pericentriolar
material.
•The microtubule polarity can vary with cell function.
•Microtubule-associated proteins (MAPs) act as stabilizing
and bundling proteins.
Centrioles at right angles,
as in the centrosome.
cartwheel structure
at one end
12. •Microfilaments (MFs) are smallest element of the
cytoskeleton.
•Thread-like protein fibers
•Found only in the cytoplasm of all eukaryotic cells
•This are present in microvilli, muscle fibres. In muscle
fibres these are called myofilaments
•They are 3-7nm in Diameter
•This are long, narrow, cylindrical,
contractile & proteinous structure
•These are absent in prokaryotes
13.
14.
15. Functions
1) As cytoskeleton:- 1) Actin filaments are interlinked by
actin-binding proteins like Fimbrin & Villin while these are
linked to the micrevillin membrane by another actin-binding
protein calmodulin
2) The arrangements of proteins make the microfilaments
make a rigid structure which provide mechanical support to
maintain the form of microvilli
2)Movement of cell membrane:- MF act as a cell
muscles & help in the cell membrane movement which also
help in endocytosis through the cell membrane
16. 3)In movement & locomotion :- Microfilaments of the
myofibers of the muscles fibres help in movement &
locomotion during Actomyosin complexes.
These are formed bw the heads of thick myosin and actin
sites of thin actin filaments in the presence of energy released
during hydrolysis of ATP by myosin & ATPase enzyme in
presence of calcium ion released form yhe depolarized
sarcoplasmic recticulam
The head of myosin filaments undergo swivelling(rotaion)
which pull the actin filament inward which inward over the
myosin filament. This is called sliding-filament theory
17.
18. Difference BW
Microtubules
• These are non-contractile
• A microtubule contain 13
protofilaments
• They are hallow tubules
• Microtubules are formed of
a&btubulin proteins.
• The diameter of
microtubule is 25 nm
Microfilaments
• These are contractile.
• These do not posses
longitudnal sub-units.
• Microfilaments are solid
structures.
• Microfilaments are mainly
made up of actin.
• The diameter of a
miocrofilaments is 5-6 nm.
•