This document defines atherosclerosis and its causes and risk factors. It discusses how atherosclerosis is initiated by inflammation in artery walls in response to LDL particles. As LDL particles accumulate in arteries, they can become oxidized, attracting macrophages. If macrophages cannot process the oxidized LDL, foam cells form, which can rupture and further narrow arteries. Risk factors include older age, male sex, diabetes, high LDL and low HDL cholesterol levels, smoking, and genetic factors. Diagnosis involves medical tests, and treatment includes medications, surgery, lifestyle changes, and managing underlying conditions like high blood pressure and cholesterol.