Lymphoma is cancer that begins in the lymph system. There are two main types: Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hodgkin's lymphoma is characterized by the presence of Reed Sternberg cells. Diagnosis involves lymph node biopsy and staging tests. Treatment depends on stage but may include chemotherapy, radiation, or stem cell transplant. Nursing focuses on managing pain, infection risk, nutrition, and activity tolerance.
An acute or chronic disease in humans and other warm-blooded animals characterized by an abnormal increase in the number of white blood cells in the tissues and often in the blood.
What is Lymphoma?
Malignant lymphoma is a term given to tumors of the lymphoid system and specifically of lymphocytes and their precursor cells
i.e.
Cancer of the lymphatic system.
Many lymphomas are known to be due to specific genetic mutations.
It is a malignant disease of a blood forming organs. The common feature of leukemia is an unregulated proliferation of white blood cells (WBCs) in the bone marrow.
Detailed Powerpoint Presentation on Wilms Tumour …. It includes definition with images, causes, sign and symptoms all treatment modalities with nursing responsibilities and recent research related to this...
oth Hodgkin's lymphoma and non-Hodgkin's lymphoma are lymphomas — a type of cancer that begins in a subset of white blood cells called lymphocytes. Lymphocytes are an integral part of your immune system, which protects you from germs.
An acute or chronic disease in humans and other warm-blooded animals characterized by an abnormal increase in the number of white blood cells in the tissues and often in the blood.
What is Lymphoma?
Malignant lymphoma is a term given to tumors of the lymphoid system and specifically of lymphocytes and their precursor cells
i.e.
Cancer of the lymphatic system.
Many lymphomas are known to be due to specific genetic mutations.
It is a malignant disease of a blood forming organs. The common feature of leukemia is an unregulated proliferation of white blood cells (WBCs) in the bone marrow.
Detailed Powerpoint Presentation on Wilms Tumour …. It includes definition with images, causes, sign and symptoms all treatment modalities with nursing responsibilities and recent research related to this...
oth Hodgkin's lymphoma and non-Hodgkin's lymphoma are lymphomas — a type of cancer that begins in a subset of white blood cells called lymphocytes. Lymphocytes are an integral part of your immune system, which protects you from germs.
Adcetris is approved for treating patients with relapsed/refractory Hodgkin lymphoma. It is also approved to treat patients with anaplastic large cell lymphoma. Adcetris comes in a single strength: 50 mg. It is available as a powder in a single-dose vial. The powder is mixed into a liquid solution, which is then administered by a healthcare provider as an intravenous (IV) infusion. Patients will likely have adcetris infusions each two/three weeks.
Adcetris 50 mg is an antibody-drug conjugate approved for the treatment of patients with relapsed/refractory Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL). The adcetris 50 mg selectively targets tumor cells expressing the CD30 antigen, a defining marker of HL (Hodgkin lymphoma) and Anaplastic Large Cell Lymphoma.
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)sunil kumar daha
Please find the power point onLymphoma . I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Successful, low cost lymphoma treatment india is a type of cancer that begins in immune system cells called lymphocytes- IndianMedGuru is the solution.
This is a lecture on Lymphoma, exploring the different types and subtypes of Lymphomas. It also discusses the epidemiology, stages, clinical features, diagnosis, treatment and prognosis.
This was presented to undergraduate medical students at University Teaching Hospital (UTH), department of Cancer Disease Hospital by Nghitukuhamba Tangi Elikana Kalipi (6th year medical student) at Cavendish University Zambia, School of Medicine.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. LYMPHOMA
❖ Lymphoma is the cancer of lymph node.
❖ Lymphoma is the type of cancer that begins in the
immune system cell called lymphocytes.
❖ There will be production of one or more abnormal
cells in one or more of the lymph nodes.
3. ETIOLOGY
Immune suppression
Infections
Epstein barr virus- EBV:- Burkitt lymphoma
H. pylori:- gastric lymphoma
**Symptoms often develop quickly, over just a few days or weeks. Burkitt
lymphoma usually causes lots of lymph nodes to enlarge in many
different parts of the body, and often involves your abdomen (tummy)
and bowel. Other organs like your spleen and liver may be affected.
The lymphoma may also be in the bone marrow and can spread to your
central nervous system (CNS; brain and spinal cord).
5. ➢ Abnormal lymphocytes collect in one or more
lymph nodes or in lymph tissues such as spleen,
tonsils & eventually they forms mass of cells
called tumors.
6. ETIOLOGY cont…
Previous cancer treatments: Chemotherapy
& radiotherapy treatment given for a previous
cancer can increase the risk of someone
developing lymphoma. This is thought to be due
to damage caused by these treatments to genes
(DNA) of lymphocytes.
Advanced age
Smoking
8. HODGKIN’S LYMPHOMA
▪ A neoplastic transformation of lymphocytes
particularly in lymph nodes.
Characterized by:-
1. Presence of Reed Sternberg cells on histology.
2. Spreading in an orderly fashion.
(e.g. Hodgkin's lymphoma that starts in cervical
lymph nodes, may spread first to the
supraclavicular nodes then to the axillary lymph
nodes.
9.
10. Reed Sternberg cells: They are mature
B-cells that have become malignant,
usually large & carry more than 1
nucleus.
11. ETIOLOGY
1. Certain viruses:
➢ Epstein-Barr virus (EBV)
2. Weak immune system :
➢ Inherited condition
➢ Certain drugs used after organ transplant
3. Age: Hodgkin’s lymphoma is most common among teens
and adults aged 15 to 20 years and adults aged 55 years
and older.
4. Family history
12. SIGN & SYMPTOMS
Enlarged, painful, Rubbery, non-erythematous,
lymph nodes are the hallmark of the disease.
Other symptoms:-
Night sweats
Frequent weight loss (‘B’ SYMPTOMS)
Fever
Pruritis (itchy skin)
13. Cervical, supraclavicular & axillary
lymphadenopathy are the most common initial
signs.
Hepatospleenomegaly
Extralymphatic sites may get involved such as
liver, bone marrow, lungs & CNS but,
extralymphatic involvement is more common with
Non Hodgkin’s lymphoma.
Pleural & pericardial effusion
14. STAGES OF HODGKIN’S & NON-
HODGKIN’S LYMPHOMA
STAGE I Involvement of a single lymph node or a single
extra lymphatic organ or site
STAGE II Involvement of >2 lymph node regions or
lymphatic structures on the same side (upper or
lower) of diaphragm
STAGE III Involvement of lymph nodes on both (upper or
lower) sides of diaphragm which may include
extra lymphatic organ or tissue
STAGE IV Diffuse or disseminated involvement of >1 extra
lymphatic organ or tissue
15.
16. DIAGNOSTIC EVALUATION
An excisional lymph node biopsy is the essential first step in
diagnosis. A biopsy is the only sure way to diagnose Hodgkin
lymphoma.
The biopsy can be:
❖ Excisional biopsy (the whole lesion is removed & tested)
❖ Incisional biopsy(a piece of tissue is taken from a lesion
& tested)
❖ After that the most important step is to determine the
extent of the disease because the stage will determine
the nature of the therapy, that is, radiation vs.
chemotherapy
17. ➢ Chest x-ray : X-ray pictures may show swollen lymph nodes
or other signs of disease in the chest .
➢ CT: Chest, abdomen and pelvis ( CT is sensitive enough to
detect any abnormal nodes)
➢ MRI
➢ PET scan
➢ LP(lumbar puncture) for CSF cytology if any CNS signs
➢ A bone marrow biopsy is used when ‘B’ symptoms are
present
18. TREATMENT
➢ Therapy is entirely based on the stage.
➢ Localized disease ( stage I and II ) is managed with
radiation.
➢ All patients with evidence of ‘’B’’ symptoms as well as
stage III and IV are managed with chemotherapy.
➢ The most effective combination chemotherapeutic regimen
for Hodgkin lymphoma is
A : Adriamycin
B: Bleomycin
V: Vinblastin
D: Dacarbazine.
19. ABVD is superior to
M: Meclorethamine
O: Oncovin
P: Prednisolone and Procarbazine because ,
ABVD has fewer side effects such as:
▪ Permanent sterility
▪ Secondary cancer formation
▪ Aplastic anemia
▪ Peripheral neuropathy
20. NON HODGKIN’S LYMPHOMA
(NHL)
The neoplastic transformation of either B or T cell.
NHL causes the accumulation of neoplastic cells
in the lymph nodes as well as more often diffusely
in extralymphatic organs and the bloodstream.
Absent reed-Sternberg cells.
21. RISK FACTORS
Infections:
➢ Epstein-Barr virus (EBV): Linked to Burkitt
lymphoma.
➢ Helicobacter pylori: Associated with gastric
lymphoma
Age:
Most people with non-Hodgkin lymphoma are older
than 60
22. CLINICAL PRESENTATION
Clinical presentation is the same as Hodgkin
lymphoma.
The difference is that Hodgkin is localized to
cervical and supraclavicular nodes 80%-90% of
the time.
Whereas NHL is localized 10-20% of the time.
CNS involvement is more common with NHL.
HIV positive patients often have CNS involvement
24. GRADES
NHL divided into Low or high grade
A high grade lymphoma has cells which look quite
different from normal cells.
They tend to grow fast (aggressive) usually look
follicular, potentially curable, Wider dissemination
at presentation.
25.
26. Low grade lymphomas have cells which look much
like normal cells and multiply slowly, usually look
diffuse, Incurable.
27. TREATMENT
Same principles of treating Hodgkin Lymphoma.
The initial chemotherapeutic regimen is CHOP
(Cyclophosmamide, Hydroxy-adriamycine,
Oncovin and Prednisolone).
CNS lymphoma is often treated with radiation in
addition to CHOP.
Relapses can be controlled with BM (Bone
marrow) transplantation.
29. NURSING DIAGNOSIS
Acute pain related to metastasis of tumor as
evidenced by facial expression & pain scoring.
Hyperthermia related to secondary infections as
evidenced by body temperature measurement.
Imbalanced nutrition less than body requirement
related to anorexia as evidenced by rejection to
consume food.
30. Activity intolerance related to weakness as
evidenced by patient’s verbalization.
Risk for infection related to
immunodeficiency.