Hodgkin's lymphoma, also known as Hodgkin's disease, is a type of cancer that originates from white blood cells called lymphocytes. It is characterized by the abnormal growth of Reed-Sternberg cells in the lymph nodes and spreads through the lymphatic system. Common symptoms include painless swelling of lymph nodes in the neck, armpits or groin, fever, night sweats, and weight loss. Hodgkin's lymphoma is diagnosed through lymph node biopsy and imaging tests. Treatment involves chemotherapy, radiation therapy, or a combination of both depending on the stage and characteristics of the disease.
What is Lymphoma?
Malignant lymphoma is a term given to tumors of the lymphoid system and specifically of lymphocytes and their precursor cells
i.e.
Cancer of the lymphatic system.
Many lymphomas are known to be due to specific genetic mutations.
What is Lymphoma?
Malignant lymphoma is a term given to tumors of the lymphoid system and specifically of lymphocytes and their precursor cells
i.e.
Cancer of the lymphatic system.
Many lymphomas are known to be due to specific genetic mutations.
oth Hodgkin's lymphoma and non-Hodgkin's lymphoma are lymphomas — a type of cancer that begins in a subset of white blood cells called lymphocytes. Lymphocytes are an integral part of your immune system, which protects you from germs.
Adcetris 50 mg is an antibody-drug conjugate approved for the treatment of patients with relapsed/refractory Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL). The adcetris 50 mg selectively targets tumor cells expressing the CD30 antigen, a defining marker of HL (Hodgkin lymphoma) and Anaplastic Large Cell Lymphoma.
Adcetris is approved for treating patients with relapsed/refractory Hodgkin lymphoma. It is also approved to treat patients with anaplastic large cell lymphoma. Adcetris comes in a single strength: 50 mg. It is available as a powder in a single-dose vial. The powder is mixed into a liquid solution, which is then administered by a healthcare provider as an intravenous (IV) infusion. Patients will likely have adcetris infusions each two/three weeks.
This is a lecture on Lymphoma, exploring the different types and subtypes of Lymphomas. It also discusses the epidemiology, stages, clinical features, diagnosis, treatment and prognosis.
This was presented to undergraduate medical students at University Teaching Hospital (UTH), department of Cancer Disease Hospital by Nghitukuhamba Tangi Elikana Kalipi (6th year medical student) at Cavendish University Zambia, School of Medicine.
Lymphoma is the cancer of immune cells or infection-fighting cells of the immune system known as lymphocytes. These cells are present in the lymph nodes, bone marrow, spleen, thymus, and other parts of the body.
For more information: www.cancertame.com
Email Id: support@cancertame.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. Def:
is a chronic ( in rare case acute) disease ,the growth of the
tumor cells take place mainly in the lymphatic node.
Hodgkin's disease, is a type of lymphoma, which is a type of
cancer originating from white blood cells called
lymphocytes.
3. History:
It was named after Dr. Thomas Hodgkin, who
first described abnormalities in the lymph system in
1832.
Dorothy Reed and Carl Stenberg first
described the malignant cells of Hodgkin’s lymphoma
called Reed Stenberg cells.
1798-1866
4. Sign and symptoms:(Clinical features)
Night Sweats
Unexplained weight loss
Lymph nodes: the most common symptom of Hodgkin's is the
painless enlargement of one or more lymph nodes. The nodes
may also feel rubbery and swollen when examined
Splenomegaly: enlargement of the spleen occurs in about 30%
of people with Hodgkin's lymphoma
Hepatomegaly: enlargement of the liver
5. 1. Painless Lymphadenopathy –
involving superficial lymph nodes of cervical and (Dsupraclavicular
nodes)
• The lymph nodes are swollen and have a rubbery feeling
2. Systemic Symptoms
a) Fevers, Night Sweats and Weight Loss
b) Pruritus
c) Pel-Ebstein Fever
e) cough and dyspnoea.
3. Pain
a) Alcohol – induced pain
b) Abdominal Pain
c) Bone Pain
d) Neurogenic Pain
e) Back Pain
f) chest pain
6. Famous People With Hodgkin's Disease:
• Paul Allen- Investor and co-founder of Microsoft
Corporation.
• Charles Lindbergh- The first pilot to make a transatlantic
flight.
• Jackie Kennedy- Former First Lady
• Gene Wilder- Actor
7. Causes:
The exact cause of Hodgkin's lymphoma is unknown
Hodgkin's lymphoma commonly begins in lymph nodes
located in the upper part of your body.
Some lymph nodes are in areas more readily noticed, such as
in your neck, above your collarbone, under your arms or in
your groin area.
Enlarged lymph nodes in the chest cavity also are common.
Eventually, Hodgkin's lymphoma may spread outside your
lymph nodes to virtually any part of your body.
A key step in Hodgkin's lymphoma involves the
development of abnormal B cells.
9. Classic:
1.Nodular Sclerosis:
Most common type diagnosed.
About 70% of adolescents
Lacunar cells are seen
40% of younger patients
CD 15 and 30 positive
EBV negative
Only subtype without a male predominance
Seen in younger pts with stage I – II disease
10. 2. Lymphocyte-Rich:
This was introduced by the World
Health Organization classification in
1999.
RS cells CD15+, CD30+; 40% EBV+
Uncommon
M > F
Tends to be seen in older adults
This is an uncommon form of classical HL
11. 3. Mixed Cellularity:
Constitutes about 20%
More common in young children
CD 15,30 EBV positive
Presents in advanced stages
Tendency to involve spleen , bone marrow
More than 50% present as stage III or IV disease
Biphasic incidence, peaking in young adults and again in adults
older than 55
12. 4. Lymphocyte depleted:
Constitutes <5%
RS cells CD15+, CD30+; most EBV+
Worst prognosis of all subtypes
Present as febrile illness with
pancytopenia, hepatomegaly,
and no peripheral lymphadenopathy
Older males , rare in children
Advanced stage , Stage IV
HIV infection
13. Non-Classic:
Lymphocyte predominant Hodgkins lymphoma
<5% of Hodgkins lymphoma
Mainly involves cervical ,
axillary or mediastinal
“L&H” cells or Popcorn
cells are seen
Positive for CD20,45
Negative for CD15,30.EBV
14. Ann Arbor Staging Classification for
Hodgkin Disease:
Stage I:
Involvement of a single lymph node (1) or of a single
extra lymphatic site or organ(1f)
Stage II:
Involvement of two or more lymph node regions
on the same side of the diaphragm(II)
or localised involvement of an extra lymphatic
Site or organ and one or more lymph node regions
on the same side of the diaphragm (IIf)
15. Stage III:
Involvement of lymph node regions on both sides of
the diaphragm (III) which may be accompanied by the
involvement of spleen (IIIS) or by localized involvement of
an extra lymphatic site or organ ( IIIf) or both ( IIIsf)
Stage IV:
Diffuse or disseminated involvement of one or more
extra lymphatic organs or tissues with or without associated
lymph node involvement. involvement of liver or bone
marrow
16. Epidemiology:
Most frequently (Bimodal)occur in age group 15 to 35 and >50
years
More common in males except Nodular Sclerosis which is more
common in females
Increase incidence in HIV infections.
Bimodal incidence
Early peak middle to late 20s Second peak after 50 yearr
Immunodeficiency
17. Sex (Male : Female)
4: 1 for 3-7 yr
3: 1 for 7-9 yr
1-3: 1 for > 10 yr
100 folds risk for unaffected monozygotic twin of affected
twin
Associated with specific HLA antigen
Infectious agents
Human herpes virus 6
CMV
Epstein – Barr virus
19. Complication:
Renal amyloidosis followed by contracted kidney and uremia
Intoxication
Septic complication
Cardiovascular disease
Second malignancy, such as leukemia, non-Hodgkin's lymphoma
and tumors in the lungs, breasts or gastrointestinal system
Vascular disease, including stroke
Thyroid dysfunction
Sterility
24. TREATMENT:
Treatment depends on :
Stage of the disease
Age at diagnosis
Presence / absence of B symptoms
Presence of hilar lymphadenopathy
Presence of bulky nodal disease
Current Treatment Regimen:
Combined chemotherapy with or without low
dose involved field radiation therapy.
26. Radiotherapy:
Radiation therapy is the most effective single thrapeutic
agent for treating Hodgkin lymphoma.
The main objective of radiation in Hodgkin lymphoma is
to treat involved and contiguous field.
Radiotherapy can be given by
1. 2D planning
2. 3D planning
3. IFRT
Involved field radiotherapy is the most commonly used
technique at present. It targets a smaller area rather than a
classical extended field.
27. Conclusion:
Radiation therapy is the most effective single therapeutic
agent for treating Hodgkins lymphoma
The management of Hodgkins lymphoma has evolved from
extended field radiation to a combined modality of chemo
radiation or chemo alone.
Interest is in achieving the best therapeutic ratio by
minimizing late toxicity while maintaining effectiveness.
With improvement in diagnostic modality and PET
scanning and improved treatment policy the results in
future will be encouraging
28. IFRT
Involved field radiotherapy.
IFRT is the most commonly used technique at present
Targets a smaller area rather than a classical extended field.
IFRT(ASTRO 2002)DEFINITION
IFRT encompasses region and not an individual lymph node.
Initially involved Pre chemo sites and volume are treated
Exception to above rule is for transverse diameter of
mediastinum and paraaortic lymphnodes for which reduced post
chemo volume is treated.