Osmosis and diffusion play key roles in the kidneys by facilitating the movement of substances like water, nutrients, and waste products. Through osmosis, water and nutrients are transferred from blood in the kidneys into urine for excretion or delivery to cells. Diffusion allows for the movement of toxins, drugs, and other harmful substances out of the blood and into urine. If osmosis and diffusion failed, the kidneys would be unable to filter wastes and regulate water levels, leading to a buildup of toxins in the blood and improper fluid balance in the body.