IHD also known as coronary artery diseases is a condition in which there is inadequate supply of blood and oxygen to a portion of myocardium. Imbalance between myocardial oxygen supply and demand causes Angina, MI, Hear failure, and Arrhythmia
2. ISCHEMIC HEART DISEASE
• Definition:
• Ischemic heart disease (IHD) is a condition in which there is inadequate supply of
blood and oxygen to a portion of myocardium. It tipically occurs when there is an
imbalance between myocardial oxygen supply and demand.
• It’s the most common, serious, chronic, life-theatening disease in the developed
countries.
• The most common cause is atherosclerotic disease of an epicardial coronary artery.
3. PATHOPHYSIOLOGY OF MYOCARDIAL ISCHEMIA
• Myocardial oxygen supply is decreased
• Narrowed coronary arteries (sclerosis, thrombus, spasmus, coronary embolism,
vasculitis)
• Hypotension
• Severe anemia
• Methemoglobinemia, increased carboxyhemoglobin
• Myocardial oxygen demand is increased
• Left ventricle hypertrophy
• Fever
• Hyperthyroidism
• Tachycardia
15. CLINICAL PICTURE OF IHD IS DIVIDED IN TO
TWO GROUPS:
1. Chronic ischemic heart diseases:
A: Stable angina .
B: Silent myocardial ischemia .
C: Variant or vasospastic angina.
2. Acute coronary syndrome ( ACS ):
a) Unstable angina
b) NSTEMI.
c) STEMI .
17. Silent myocardial ischemia ( no chest pain):
• In elderly patient.
• In diabetic patient.
• In female.
18. Variant or vasospastic angina:
• Vasospasm is present .
• Mostly at night .
• In the absent or present of stenosis.
• Clinical presentation:
- Chest pain .
• ECG:
- ST segment elevation or depression .
19.
20. SUMMARY OF THE CHARACTERISTICS OF
ANGINA PECTORIS
• Typical angina pectoris:
• Retrosternal chest pain (discomfort)
• Complaints occur after exertion or emotional stress
• The pain is relieved by rest and nitroglycerin
• Atypical angina pectoris: only two from three characteristics (especially in
women and diabetics, angina may be atypical in location and not strictly
related to provocing factors)
• Pseudoangina: Only one or no one out of three characteristics.
26. • Beta blocker :
- β₁ receptors( In the heart ).
- β₂ receptors (In bronchus and smooth muscles of vessels ).
- Beta blocker decreased sympathetic activity and reduced the oxygen
consumption of the heart.
27. • Calcium channel blocker (CCB) :
- It is used for variant angina or prenzmintal angina .
- Induce vasodilation in coronary and peripheral vessels .
• Nitroglycerine and nitrates( Isosorbide dinitrate and Isosorbide
mononitrate ):
- Dilate the vessels .
- Decreased preload and afterload .
- Antiplatelet effect .