Toxoplasma Gondii.
Toxoplasmosis - Congenital Toxoplasmosis
The transition between tachyzoites and bradyzoites.
T.gondii as an Epigenator.
Immune Response Pathway.
Behavior Changer by T.gondii infection.
Toxoplasma Gondii.
Toxoplasmosis - Congenital Toxoplasmosis
The transition between tachyzoites and bradyzoites.
T.gondii as an Epigenator.
Immune Response Pathway.
Behavior Changer by T.gondii infection.
paragonimiasis is a intracellular food born disease mainly cause by paragonimus westermani (lung fluk) . it is mainly found in middle Asia, central Africa and Latin America. The first intermediate host fresh water snail and second is human.
Helminthology is such an important topic not only in India but worldwide. Here is an introduction to the medically important parasites causing diseases to man.
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
paragonimiasis is a intracellular food born disease mainly cause by paragonimus westermani (lung fluk) . it is mainly found in middle Asia, central Africa and Latin America. The first intermediate host fresh water snail and second is human.
Helminthology is such an important topic not only in India but worldwide. Here is an introduction to the medically important parasites causing diseases to man.
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
Parasitology:
The Liver Flukes
Parasites: Fasciola species
Fasciola hepatica and Fasciola gigantica
Morphology Adult & Ova
Diagnostic Features
Diagnosis
Mode of Transmission
Disease Produced
Pathology and Symptomology
Incubation period
Life cycle
laboratory diagnosis
treatment
Prevention and control
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Introduction to class Trematoda and Fasciola hepatica
1. University of Duhok
College of Health Sciences
Dep. of Medical Laboratories
Parasitology Theory
3rd stage
Lecture 11
Lecturer: Dr. Shameeran S. Ismael
BVM & S, M.Sc Medical Microbiology(Parasitology),
PhD Molecular Parasitology
3. Introduction to Trematodes
• Flattened dorsoventrally, leaf like un-segmented
worms
• Body cavity is absent
• Hermophrodites, except Shistosoma species
(sexes are separated)
• Most flukes have two suckers for attaching to the
host, one close to the mouth (dorsal sucker) and on
the ventral side (ventral sucker).
4. • Digestive system is simple, the
oral opening leading to a
pharynx, oesophagus & pair of
branched intestinal caeca
which end blindly.
• Excretory system includes:
flame cells, capillaries,
collecting tubules and an
excretory bladder
5. • The body is covered with tegument, which may
partially or completely covered with spines, tubercles
or smooth
• All member are oviparous.
• Infective stage is usually a encysted metacercria,
except for Schistosoma species is cercaria
• Have indirect life cycle
• Intermediate host is snail
6. Trematode Reproduction
Male reproductive system:
• Usually have two testes (number may vary)
• Vas efferent leaves each testis and forms the
vas deferens.
• The vas deferens gives rise to a seminal vesicle
which stores sperm
• the muscular cirrus pouch stores the male
copulatory organ called the cirrus.
7. Female reproductive system
• Usually a single rounded ovary but in some
species may be lobulated or branched.
• A short oviduct leads from the ovary and has a
sphincter called the ovicapt which regulates the
passage of ova.
• Vitellaria or vitelline glands are important
because they contribute yolk to the eggs.
• Where the oviduct and the vitelline duct join
there is a expansion which forms the ootype.
8. • Mehlis glands surround the ootype and in
combination with the ootype and vitelline glands
forms the oogenotop or egg forming apparatus.
• Beyond this, the duct expands to form the uterus
and on to the genital pore.
9. Trematode stages:
• Egg
• Miracidium
• Sporocyst (mother and daughter)
• Redia (redia1 and redia2)
• Cercaria
• Metacercaria and
• Adult
12. Fasciola hepatica (Distomum hepaticum),
also known as the common liver fluke, is a parasitic
flatworm of the class Trematoda, phylum
Platyhelminthes that infects the livers of various
mammals, including humans. The disease caused by
the fluke is called fascioliasis (also known as
fasciolosis).
13. Fasciola hepatica
Kingdome: Animalia
Phylum: Platyhelminthes
Class: Trematoda
Order: Echinostomadia
Super family: Fasciolidea
Family: Fasciolidae
Genus: Fasciola
Species: Fasciola hepatica
Common name: Liver fluke or hepatic fluke
Final host: human
14. Intermediate host: Snails of genus Lymnaea
Site of infection: Bile duct- gall bladder & sometimes in
the peritoneal cavity
Life cycle: Indirect
Infective stage: Encysted metacercaria
Rout of infection: By ingestion of contaminated grasses
or drinking of water with encysted metacercaria
Disease: Fascioliasis
15. Adult liver flukes have a flat body, an oval shape, and
large up to 30 mm long and 15 mm wide. Pink-grayish
to dark red color.
The anterior end is conical in shape & with two clear
shoulders and the posterior end is some time rounded.
Liver flukes have two suckers (Dorsal and ventral
suckers)
Morphology
16. The body surface is covered with numerous spines
(spiny tegument).
The most characteristic features is the extensive
branching of intestine, testis & vitellain gland
17.
18.
19. Eggs:
• Oval in shape & large
• Yellowish in color
• Operculated
• Un-embryonated eggs
21. Life Cycle
Fasciola hepatica has an indirect life
cycle with snails as intermediate hosts, typically from
the genus Lymnaea.
Adult flukes lay eggs in the bile ducts of their hosts.
These eggs reach the gall bladder and are passed with
feces
22. Out side the host, eggs hatch and miracidium release
in 7 to 15 days. These larvae can survive for weeks off
a host provided there is enough humidity. They die
quickly in a dry environment. Miracidia can swim and
penetrate actively into the snails where they remain for
4 to 8 weeks and develop successively
to sporocysts, rediae and cercariae, the usual larval
stages of most fluke species.
23. Mature cercariae leave the snail, attach to the
vegetation, lose their tail and become
encysted (metacercariae), which are infective for the
final host. Such cysts can survive for months in the
vegetation.
After ingestion of metacercaria, excystation occur
young immature flukes release and within a few hours
they cross the intestinal wall and get into the peritoneal
cavity where they migrate towards the liver, which they
reach in about 3 weeks.
24. To reach the bile duct they have to cross the hepatic
tissue, a particularly harmful process for the host that
lasts 6 to 8 weeks. Once in the bile ducts they complete
their development to adult flukes and start producing
eggs.
25.
26. In GIT there is a little damage is caused by juveniles
penetrating the intestinal wall and juveniles migrating
through the liver tissues and crossing the wall of
the bile ducts cause the major harm. This process
destroys the tissues and causes bleeding. The spines in
the surface of the flukes irritate the tissues that
become inflamed. All this leads to cell death
and fibrosis. Affected livers increase in size and
become fragile. Some flukes can become encapsulated
in the liver tissues and build cysts as large as walnuts.
The bile ducts are also damaged: they become
thickened and can be calcified and even obstructed.
Pathogenesis
27. 1.Acute disease
Acute type occurs 2-6 wks after ingestion of large No.
of metacercaria (over 2000)
Sudden death due to massive invasion of liver by
young fluke with acute hepatic insufficient and
hemorrhage in peritoneal cavity
28. 2.Sub-acute disease occurs 6-10 wks after ingestion of 500-
1500 metacercaria, Cause cholengitis
3.Chronic or latent phase, it’s occurs 4-5 months after the
ingestion of moderate No. (200-500) of metacercaria
Develop slowly due to mature liver fluke in bile duct which
cause cholongitis, bilary obstruction, destruction of hepatic
tissue, fibrosis and hemorrhagic anemia
29. Clinical signs
Pallor of mucus membrane
Rapid loss of weight
Abdominal pain
Ascites
Dyspnoeic
30. Diagnosis
•History (Present of snail in area)
•Clinical signs, based on emaciation, diarrhea, bottle jaw,
sudden death
•Laboratory diagnosis, by fecal examination for detection
of characteristic eggs (oval in shape, yellowish and
operculated)
31. •Wash Aquatic Vegetables in 6% Vinegar for 5-10
minutes
•Control of the snail vectors
• Health education.
• People must be aware of how infection might
occur.
Control