An intraocular lens (IOL) is an artificial lens implanted in the eye during cataract surgery or refractive lens exchange to replace the natural crystalline lens and correct vision. IOLs have evolved over generations from rigid PMMA lenses to modern foldable designs made of silicone, acrylic, or hydrogel materials. IOLs are either placed in the posterior chamber behind the iris or in the anterior chamber in front of the iris. Newer multifocal and accommodating IOL designs aim to provide both distance and near vision. Precise biometry is required to calculate the optimal IOL power to achieve the desired postoperative refraction. Potential complications include dislocation, opacification, deposits, and inflammation.
-IOL formula
1st generation formula : SRK, Binkhost
2nd generation formula : SRK II
3rd generation formula: Hoffer Q, Holladay 1, SRK/T
4th generation formula: Haigis, Holladay 2, Olsen
-The Hoffer Q, Holladay I, and SRK/T formula are all commonly used.
Aphakia and its causes. Correction of Aphakia. Advantages and disadvantages of different corrections. Surgeries and related signs and symptoms of aphakia. Complications related to Aphakia.
-IOL formula
1st generation formula : SRK, Binkhost
2nd generation formula : SRK II
3rd generation formula: Hoffer Q, Holladay 1, SRK/T
4th generation formula: Haigis, Holladay 2, Olsen
-The Hoffer Q, Holladay I, and SRK/T formula are all commonly used.
Aphakia and its causes. Correction of Aphakia. Advantages and disadvantages of different corrections. Surgeries and related signs and symptoms of aphakia. Complications related to Aphakia.
Synoptophore is an instrument for diagnosing imbalance of eye muscles and treating them by orthoptic methods. In this presentation the parts of the synoptophore and the different slides used in the instrument are discussed
SLIT LAMP AND ITS DIFFERENT ILLUMINATION TECHNIQUES.pptxAbhishek Kashyap
This presentation explains in detail about different illumination techniques and filters used in slit lamp examination and the procedure to perform slit lamp examination.
Biometry- Iol power and calculation final ppt.pptxKervi Mehta
Biometry- IOL power formulae and calculations
This presentation describes about different generations of IOL formulae and newer formulae. It also gives information how to calculate IOL power in special situations
Update knowledge about Muntifocal IOL made by Asaduzzaman
Working as Associate Optometrist in Ispahani Islamia Eye Institute &Hospita, Dhaka 1215
Email:asad.optom92@yaho. com
all about rabies
epidemiology of rabies,
pathogenesis of rabies,
clinical features of rabies,
treatment of rabies,
prevention of rabies,
rabies virus,
post exposure prophylaxis,
rabies in dogs
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. What is intraocular lens?
• An artificial lens implanted in the eyes
• Replaces the crystalline lens
• To correct the optical power of the eyes
following:-
Lens being
clouded by
cataract
Refractive surgery
3. Primary vs secondary implantation
• Primary implantation – use of IOLs during
surgery for cataract
• Secondary implantation – implantation of IOL
to correct aphakia in a previosly operated eye
4. Parts of an IOL
• OPTIC
Part of the lens that focuses
light on the retina.
• HAPTIC
Small filaments connected to
the optic that hold the lens in
place in the eye
HAPTEN
OPTIC
6. THE FIRST IOL!!
• PMMA made lens – 45 year
old female after performing
extracapsular cataract
extraction
• Disc shaped bi-convex design
• Site- posterior chamber
• First generation IOL
9. 4. Fourth generation IOLs
• Modern anterior chamber lens
• Flexible loops and multiple point fixation
• Advantages – more stable, better design, less
complications
• Disadvantages – anterior chamber is not the
physiological site for IOL
12. POSITIONING OF IOL
1. Posterior chamber
implantation
• Ciliary sulcus fixation
• In the bag fixation
• Scleral fixation
Eg:- modified C loop type
IOL
17. 3. Iris- fixated lens
• Fixed on the iris with
claws,loops or sutures
• Eg- Singh and Worst’s
iris claw lens
18. Different types of haptic angulation
relative to the plane of optic:-
For posterior chamber lens:-
• 100 anterior angulation to keep the optic
part away from the pupil.
For anterior chamber lens:-
• Posteriorly angulated lens to vault the
intraocular lens away from the pupil
19.
20. FOCUSSING ABILITY OF IOLs
1. Unifocal intraocular lens
• Lens with unifocal power
• Can have problem with near vision
23. Special function IOLs
TORIC IOLs
• Correct any associated
astigmatism
ASPHERIC IOLs
• Reduce spherical
aberration
24. ANIRIDIA IOLs
• Cover the defects of aniridia or
partial iris loss as in trauma
• Has a black diaphragm over the
optic
PIGGYBACK IOLs
• An IOL piggybacking onto an
existing IOL or simultaneous
implantation of 2 IOLs
25. BLUE LIGHT FILTERING IOLs
• Lenses are yellow colored to screen out UV
Light and blue spectrum
• Reduced risk of age related macular
degeneration
PHOTOCHROMATIC IOLs
• UV absorbing photo chromes
26. IMPLANTABLE MINIATURE
TELESCOPE
• Miniature implantable Galilean
telescope
• Implanted in posterior chamber
• Contains number of micro lenses
in the optic which gives a
magnification of about 3 at the
central visual field
• Used to treat macular
degeneration
27. TELESCOPIC IOLs
• New generation miniature
telescopes which uses 2 mirrors
instead of lens to provide
magnification with minimum
loss of peripheral vision
28. Phakic IOLs
• IOLs used to correct myopia with the eye’s
natural lens being untouched
• Implantable contact lenses
1. Angle supported lens
2. Iris – fixated lens
3. Sulcus supported lens
29. BIOMETRY
THEORETICAL FORMULAE
• Binkhorst formula
• Colenbrander’s formula
• Gull strand’s formula
• Hoffer’s formula
EMPERICAL FORMULAE
• Modified Sanders-Retzlaff-Kraff formula
• SRK II
• SRK III
• SRK T
• Haigis formula
30. Binkhorst formula
• E= [N/(L-C)] – NK/(N-KC)]
E
• Emmetropic IOL power
L
• Axial length of the eye
K
• Corneal dioptric power
C
N
• Psuedophakic length of anterior chamber
• Refractive index of aqueous and vitreous humor
32. Modified SRK Formula
• E=A - 2.5L - 0.9K
• Parameters used in the formula are
estimated by
• A-scan ultrasonographic sonometry and
keratometry
• Instrument - biometer
34. • Power ( I )required to produce Required post
operative refraction ( R ) ,
I = E – cr R
• cr – empirical constant
cr = 1 if E < 14
cr = 1.25 if E > 14
35. Complications of IOL implantation
• Mechanical damage to the IOL
• Dislocation
• Bullous keratopathy
• Posterior capsule rupture
• Anterior capsule opacification
• Posterior capsule opacification
• Calcium deposits within the optic of hydrophilic
intraocular lens
• Adherence
• UGH syndrome
• Sunset syndrome
37. “Lens of the future”-liquid injectable
IOLs
• A new IOL concept that combines an acrylic
IOL with a liquid, injectable IOL may someday
allow patients to retain accommodation.
• Following IOL implantation, liquid IOL is injected
and capsular bag is inflated fully and IOL kept in
place
• Mechanism- forward movement and thickening
of lens