Update knowledge about Muntifocal IOL made by Asaduzzaman
Working as Associate Optometrist in Ispahani Islamia Eye Institute &Hospita, Dhaka 1215
Email:asad.optom92@yaho. com
The presentation I have made and uploaded provides you with an in-depth insight into the patterns the strabismus may take following anomalies of extraocular muscles, deformities of the orbital structures,innnervational disturbances.
The author does not assume responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.
No copyright infringement, or plagiarism intended.
Amrit Pokharel
The presentation I have made and uploaded provides you with an in-depth insight into the patterns the strabismus may take following anomalies of extraocular muscles, deformities of the orbital structures,innnervational disturbances.
The author does not assume responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.
No copyright infringement, or plagiarism intended.
Amrit Pokharel
Accommodative and multifocal intraocular lensesBijan Farpour
New generation premium lenses. Accommodative and multifocal intraocular lenses used for cataract surgery and presbyopic lens exchange in modern eye surgery.
La chirurgie de la presbytie n'est pas toujours possible avec le laser. Il faut alors envisager une chirurgie du cristallin claire avec des implants multi-focaux. Ceux-ci permettent de corriger la vision de loin et près de manière définitive.
The Right Contact - Up to date information regarding contact lenses, Hyrid lenses, Soft lenses, button materials, gas permable lens and contact lens care products.
The Right Contact - Up to date information regarding contact lenses, Hyrid lenses, Soft lenses, button materials, gas permable lens and contact lens care products.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Nutraceutical market, scope and growth: Herbal drug technology
Multifocal IOL
1. Optometry Care For
Multifocal IOL Implant
Presenter:
Md. Asaduzzaman
Jr.Optometrist
Moderator :
Mr. Riton Deb
Chief Optometrist
2. Multifocal and Accommodating
intraocular lenses are artificial
intraocular lenses (IOLs) that are
designed to provide focus of both
distance and near objects, in
contrast to monofocal intraocular
lenses which only have one focal
point and correct distance vision.
Multifocal IOLs
3. History of Multifocal IOLs
• Hoffer in 1982 was the first to hit upon the
idea of a multifocal IOL after observing a
patient who had 6/6 vision in spite of an IOL
that was decentred by more than 50% of the
pupillary area
• The credit goes to Dr. John Pierce in 1986 who
was to implant the bull’s eye style of the
multifocal IOL.
4. Types of MF IOLs
Refractive
Diffractive
Combination of both
6. Two Zone Lenses
• Central near vision segment
surrounded by distance vision
segment
• Central section 2mm in
diameter since pupil constricts
during near vision
• When pupil dilates during distance viewing peripheral
distance segment is exposed
• Disadvantage- in bright sunlight
• Poorly tolerated by pts enjoying outdoor sports
7. Annulus Type Or Bulls Eye Lens
• Central most portion –distance
vision
• Surrounded by near vision ring
• Surrounded by another distance
vision ring
• Marked pupillary constriction allows distance
vision,mild constriction allows distance and near
,all 3 segments exposed when pupil is dilated
• Excessive constriction during reading in bright light
blocks near ring –prevents clear near vision
8.
9.
10.
11. DIFFRACTIVE MFIOLS
• This IOL utilizes the principle of diffraction in
conjunction with refraction to create two foci.
• The basic refractive power is provided by the
anterior aspheric surface and the diffractive
power comes from the multiple grooves on its
posterior surface
15. AcrySof IQ ReSTOR Multifocal Toric
• Single solution for presbyopic patients who
also present with some astigmatism.
• In addition to its diffractive multifocality and
its toric correction, the lens is aspheric, uses a
single-piece design and has UV and blue-light
filters built in
• 0.5-3D of astigmatism
16. Pre-operative Considerations
• The Patient should have a strong desire to be spectacle
independent. This is the single most important
indication for multifocal lens surgery.
• Age- By and large, it would be better to operate
within the age group 35 to 75.
• Functional & Occupational Requirements -
patient have any hobbies like painting, playing
the piano, playing cards or billiards or is he just
the unusual avid reader?
• Patients often complain of the difficulty in
MULTI TASKING post IOL surgery with
monofocal lens implant.
17. Hypercritical & Demanding Patients
• This class of patients should be strictly avoided.
• One should prefer to operate on those patients
who trust their surgeon’s skills and capability
• It is better to avoid proving ourselves to a cynical
and suspecting patient who remains unhappy no
matter how best we perform.
18. Optometry Care for Multifocal
IOL Implantation
• Patient Selection- The right patient is to be
selected
• Accurate Biometry- IOL master strongly
recommended as optical biometry is
approximetely 10 times more exact. Use of
immersion biometry , would be better choice
than applanation biometry. Cross-checking by 2
technicians, clinical correlation with present or
past refractive error and comparison with fellow
eye is suggested
19. • Power Calculation- Maximize visual outcomes
by calculating for a post-operative refractive
spherical equivalent from Plano to <+0.25. Use
of newer formulae like SRK-T and Holladay are
helpful.
20. Disadvantages Of MFIOLs
• In bulls eye lenses amount of light transmitted for each of focal
length varies with pupil size
• In diffractive lenses image intensity is equal for distance and near
vision but even in ideal situation only one half of light entering
eye is in focus
• Even more light may be lost due to scattering
• Thus pts with MFIOL require brighter light to read well and
generally function less well in dim light
22. Reference
• Theory and practice of optics and
refraction, AK Khurana 3rd edition
• ATLAS ophthalmology pdf web portal
• Current and future IOL choices Where we
stand with MFIOLs, by Stefanie Petrou
Binder, MD
• Source: https://www.eyeworld.org/
• Picture Google and me