Disease of the nasal septum can cause nasal obstruction, excessive nasal discharge, epistaxis, headache and sinusitis. The diseases could be deviated nasal septum, septal haematoma, septal abscess and septal perforation. All these complaints are treatable.
Disease of the nasal septum can cause nasal obstruction, excessive nasal discharge, epistaxis, headache and sinusitis. The diseases could be deviated nasal septum, septal haematoma, septal abscess and septal perforation. All these complaints are treatable.
The Nose and nasal cavity, anatomy, and clinical diseases of nasal cavity and...HamzehKYacoub
Nasal cavity is the most superior part of the respiratory system.
Blood supply of nose and Cavernous Sinus.
Epistaxis causes and locations.
Allergic Rhinitis and Non-allergic rhinitis with eosinophilia (NARES).
Ostiomeatal complex (OMC)
Sinusitis.
Nasal polyps.
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all about rabies
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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6. NASAL SEPTAL DISEASES
Deviated Fracture of
nasal nasal
septum septum
Septal Septal
haemato abcess
ma
Septal Nasal
perforation synechia
7. 1.FRACTURES OF NASAL SEPTUM
Aetiopathogenesis
• Trauma
• Fate of septum - buckling
vertical or horizontal fracture
crushed into pieces
• Septal injuries with mucosal tear profuse epistaxis
• Septal injuries without mucosal tear septal hematoma
• Types- 1.Jarjaway fracture
2.Chevallet fracture
8.
9. Treatment
• Early recognition and treatment of septal injuries is
essential.
• Haematoma is drained
• Dislocated or fractured septal fragments should be
repositioned and supported between mucoperichondrial
flaps with mattress sutures and nasal packing
12. 1. TRAUMA
• A lateral blow on the nose may cause displacement of
septal cartilage from the vomerine groove and maxillary
crest
• A crushing blow from the front may cause buckling ,
twisting ,fractures and crushing of nasal septum
• Trauma during delivery
13. 2 . DEVELOPMENTAL ERRORS
• Nasal septum is formed by the tectoseptal process which
descends to meet the two halves of developing palate in
the midline
• During primary and secondary dentition further
developments takes place in palate
• Unequal growth between palate and base of skull may
cause buckling of nasal septum
• In mouth breathers-high arched palate and DNS
• In cleft palate,cleft lip,dental abnormalities
14.
15. 3. RACIAL FACTORS
Caucasians are more affected than negroes
4. HEREDITARY FACTORS
Members of same family may have deviated
septum
16.
17. Sites of DNS
• Cartilagenous/bony/both
• Anterior/posterior
• High/low
22. Effects of DNS
1. Compensatory hypertrophy of turbinates of opposite
side
2. External deformity
3. Impairment of drainage to sinus
4. Secondary atrophic rhinits
23. Clinical features
1 . NASAL OBSTRUCTION
• Sites
1. Vestibular
2. At the nasal valve
3. Attic
4. Turbinal
5. Choanal
• Bilateral/unilateral obstruction
24. COTTLE TEST
• Used in nasal obstruction due to abnormality of nasal
valve
• In this test ,cheek is drawn laterally while patient
breathes quietly.If the nasal airway improves on test
side,the test is positive and indicates abnormality of
vestibular component of nasal valve
27. TREATMENT
• Minor degrees of septal deviation require no treatment
• If produces mechanical nasal obstruction or other
symptoms, an operation is indicated
28. 1.SUBMUCOUS RESECTION OPERATION
• Generally done in adults under local anaesthesia
• Elevating the mucoperichondrial and mucoperiosteal
flaps on either side of the septal framework by a single
incision made on one side of the septum
• Removing the deflected parts of bony and cartilaginous
septum
• Repositioning the flaps
29.
30. 2.SEPTOPLASTY
• Conservative surgery
• Only most deviated parts are removed
• Rest of the septal framework is corrected and
repositioned by plastic means.
• Mucoperichondrial or mucoperiosteal flap is generally
raised only in one side of the septum retaining the
attachment and blood supply of the other
31.
32. SEPTAL HAEMATOMA
Definition
• Collection of blood under the perichondrium or
periosteum of nasal septum
Aetiology
1. nasal trauma
2. septal surgery
3. bleeding disorders
33. Clinical features
• Bilateral nasal obstruction and mouth breathing
• Frontal headache
• Sense of pressure over nasal bridge
• Smooth rounded swelling of the septum in both nasal fossae
• Soft and fluctuant mass felt
34.
35. Treatment
• Small haematoma- Aspiration with a wide bore sterile
needle
• Large haematoma-Incised and drained by a small
anteroposterior incision parallel to the nasal floor
• Nose is packed on both sides to prevent reaccumulation
• Antibiotics
36. Complications
• Permanently thickened septum
• Septal abscess with necrosis of cartilage and depression
of nasal dorsum
37. SEPTAL ABSCESS
Aetiology
• Secondary infection from septal haematoma
• Furuncle of the nose or upper lip
• Acute infection such as typhoid or measles
38.
39. Clinical features
• Severe bilateral nasal obstruction with pain and
tenderness over the bridge of nose
• fever with chills and frontal headache
• Skin over the nose -- red and swollen
• smooth bilateral swelling of nasal septum
• Fluctuation elicited
• Septal mucosa -- congested
• Submandibular lymph nodes -- enlarged and tender
40.
41. Treatment
• Early drainage
• Incision made in the most dependent parts of the abscess
• A piece of septal mucosa is excised
• Pus and necrosed pieces of cartilages are removed by suction
• Incision reopened daily for 2-3 days
• Systemic antibiotics
42. Complications
• Depression of the cartilaginous dorsum in the supratip area
• Septal perforation
• Meningitis and cavernous sinus thrombosis
43. PERFORATION OF NASAL SEPTUM
Aetiology
1. Traumatic perforation
• Injury to mucosal flaps during SMR
• cauterization of septum with chemicals
• galvanocautery for epistaxis
• Habitual nose- picking
44. 2 . Pathologic perforations
• Septal abscess
• Nasal myiasis
• Rhinolith or neglected foreign body
• Chronic granulomatous conditions like Lupus,
tuberculosis, leprosy, syphilis
• Wegener’s granuloma
45. 3 . Drugs and chemicals
• Prolonged use of steroids in nasal allergy
• Cocaine addicts
• Workers in certain occupations. Eg .chromium
plating,dichromate or soda ash manufacture
or those exposed to arsenic or its compounds
4.Idiopathic
46.
47. Clinical features
• Small anterior perforation cause whistling
sound during inspiration or expiration
• Large perforations develop crusts which
obstruct the nose or cause epistaxis when
removed
48.
49. Treatment
• Based on cause and size of perforation
• Small perforation--closed by plastic flaps
• Larger perforations
treatment aim -- to keep the nose--crust free
By alkaline nasal douches and application of a
bland ointment
• A thin silastic button can be worn
50. NASAL SYNECHIA
Aetiology
• Adhesions between septum and lateral wall
• Adhesions between middle turbinate and lateral wall
• Following nasal surgery and nasal packing
Clinical features
• Nasal obstruction
• Sinusitis and headache
51.
52. Treatment
• Excision and release of adhesion
• Dental wax plates/sialistic sheets between 2 surfaces
Prevention
• Proper perioperative cleaning
• Lubrication of nasal pack before insertion
• Use of septal splints following surgery
Editor's Notes
1-using diathermy.bipolarcautery,laser2-for 1 wk-prevent further adhesions