On the occasion of National Epilepsy Day 2014, Dr. Rama Krishnan gave a talk titled "Integrated Diagnostics – A Unique Epilepsy Approach" at the Epilepsy Knowledge Forum in Chennai organised by Neurokrish & Trimed and Sponsored Medall.
Epilepsy getting the most out of neuroimaging 2019Felice D'Arco
Lecture presented at the Great Ormond Street Hospital Paediatric Neuroradiology Masterclass 2019 on how to optimize MR imaging in epilepsy with most common epilepsy cases and differential diagnoses and use of multidisciplinary approach in lesion detection.
Epilepsy getting the most out of neuroimaging 2019Felice D'Arco
Lecture presented at the Great Ormond Street Hospital Paediatric Neuroradiology Masterclass 2019 on how to optimize MR imaging in epilepsy with most common epilepsy cases and differential diagnoses and use of multidisciplinary approach in lesion detection.
A Radiological Approach to CraniosynostosisFelice D'Arco
Presentation Summary: Normal Cranial Development (Anatomy and Genetic), Imaging Technique (how to do 3D CT, when to do MRI, why to do not do Plain Film), Imaging Patterns of Craniosynostosis, Associated Complications, Pitfalls.
A Radiological Approach to CraniosynostosisFelice D'Arco
Presentation Summary: Normal Cranial Development (Anatomy and Genetic), Imaging Technique (how to do 3D CT, when to do MRI, why to do not do Plain Film), Imaging Patterns of Craniosynostosis, Associated Complications, Pitfalls.
Hyperparathyroidism exists in three different forms: primary, secondary and tertiary. Primary hyperparathyroidism (pHPT) is the most frequent pathological condition of the parathyroid glands and one of the most frequent endocrine disorders overall. The most probable location of parathyroid gland is posterior to the thyroid gland. The parathyroid glands produce parathyroid hormone (PTH), which is important for maintaining calcium, phosphate and vitamin D homeostasis, and ultimately bone health.
Primary hyperparathyroidism is characterized by increased production and secretion of parathyroid hormone. This condition causes nephrocalcinosis, urolithiasis, osteoporosis, gastrointestinal disturbances, neuromuscular manifestation and neuropsychiatric disorders. Parathyroidectomy is the only curative treatment for pHPT. pHPT is typically caused by a solitary parathyroid adenoma (80%-90%), hyperplasia (10%) and less frequently parathyroid carcinoma (5%).
Secondary hyperparathyroidism develops as a consequent to a chronic hypocalcemic condition that can be caused by renal failure, gastroinstinal malabsorption, dietary rickets and ingestion of drugs. Secondary hyperparathyroidism is a frequent and serious complication in haemodialysis patients. Tertiary hyperparathyroidism is a condition where parathyroid hyperplasia, secondary to chronic hypocalcemia, becomes autonomous with development of hypercalcemia. Tertiary hyperparathyroidism is used to designate hyperparathyroidism that persists or develops after renal transplantation.
Localization of hyperfunctioning parathyroid tissue (adenomas or hyperplasia) in primary hyperparathyroidism is useful before surgery to help the surgeon localize the lesion, thus shortening the time of the procedure. Parathyroid glands can be imaged with multiple modalities, including scintigraphy, high-resolution ultrasonograhy, thin-section CT and MRI. Parathyroid scintigraphy may also be indicated for localization of hyperfunctioning parathyroid tissue in patients with persistent or
recurrent disease. For this situation scintigraphy is superior to any other radiological modalities, including MRI, CT scan, ultrasonography combined with needle aspiration and also some invasive techniques like arteriography, selective venography and mediastinoscopy.
Disorder of reversible subcortical vasogenic brain oedema in patients with acute neurological symptoms (eg, seizures, encephalopathy, headache, and visual disturbances) in the setting of renal failure, blood pressure fluctuations, cytotoxic drugs, autoimmune disorders, and pre-eclampsia or eclampsia.
Also called as:
Reversible posterior cerebral edema syndrome
Posterior leukoencephalopathy syndrome
Hyperperfusion encephalopathy
Brain capillary leak syndrome
PRES is caused by endothelial injury related to abrupt blood pressure changes or direct effects of cytokines on the endothelium, which leads to breakdown of the blood– brain barrier and subsequent brain edema.
PRES is generally reversible, both radio graphically and clinically, and has a favourable prognosis.
Cerebral blood flow can be regulated by four major mechanisms:
Myogenic,
Neurogenic,
Metabolic, or
Endothelial.
These mechanisms ensure that cerebral blood flow (CBF) is maintained within a relatively normal range. NO—nitric oxide, ET1—endothelin 1
Neuroimaging of Alzheimer’s disease and Healthy Aging
BY DR WASIM
UNDER THE GUIDANCE OF
DR R.K.SOLANKI
ANATOMICAL BRAIN IMAGING
CT – cerebral tomography
MRI – magnetic resonance imaging
FUNCTIONAL BRAIN IMAGING
SPECT – single photon emission computed tomography
PET – FDG – Positron emission tomography
BRAIN CHEMISTRY MEASUREMENT
MRS (spectroscopy – NAA/Cr: estimate neuronal volume)
BRAIN PATHOLOGY IMAGING
FDDNP – neurofibrillary pathology
Evolution of Neuroimaging in AD
Computed Tomography
MRI
Volumetric MRI
Functional MRI
FDG Glucose PET
Amyloid Imaging
FDG-PET in AD and MCI
TUBEROUS SCLEROSIS
Cutaneous Features
Neurological Features
Retinal Features
Systemic Features
NEUROFIBROMATOSIS
Cutaneous Features of Neurofibromatosis Type 1
Systemic Features of Neurofibromatosis Type 1
Neurological Features in Neurofibromatosis Type 1
Clinical Features of Neurofibromatosis Type 2
STURGE-WEBER SYNDROME
Cutaneous Features
Ocular Features
Neurological Features
Diagnostic Studies
Treatment
VON HIPPEL-LINDAU SYNDROME
Neurological Features
Ocular Features
Systemic Features
Molecular Genetics
Treatment
HEREDITARY HEMORRHAGIC TELANGIECTASIA
Neurological Features
Treatment
HYPOMELANOSIS OF ITO
Cutaneous Features
Neurological Features
Systemic Features
INCONTINENTIA PIGMENTI
Cutaneous Features
Neurological Features
Genetics
ATAXIA-TELANGIECTASIA
Cutaneous Features
Neurological Features
Immunodeficiency and Cancer Risk
Laboratory Diagnosis
EPIDERMAL NEVUS SYNDROME
Cutaneous Features
Neurological Features
Other Features
Neuroimaging
NEUROCUTANEOUS MELANOSIS
Cutaneous Features
Neurological Features
Laboratory Findings
Neuroimaging
EHLERS-DANLOS SYNDROME
Neurovascular Features
CEREBROTENDINOUS XANTHOMATOSIS
Neurological Features
Xanthomas
Other Clinical Features
Treatment
PROGRESSIVE FACIAL HEMIATROPHY
Clinical Features
KINKY HAIR SYNDROME (MENKES DISEASE)
Cutaneous Features
Other Clinical Features
Neurological Features
Neuroimaging
Genetic Studies
Diagnosis and Treatment
XERODERMA PIGMENTOSUM
Complementation Groups
Related Syndromes
Cutaneous and Ocular Features
Treatment
OTHER NEUROLOGICAL CONDITIONS WITH CUTANEOUS
MANIFESTATIONS
This talk was presented during "Symposium on Genetic Diseases From Mendelian to Malignancies" organized by SciGenom Research Foundation and Indian Institute of Technology – Madras and Sponsored by Medgenome.
Emotions enable us to react to situations – for example, anger or fear will set your heart racing, and feeling happy will make you smile. One of the key areas of your brain that deals with showing, recognising and controlling the body's reactions to emotions is known as the limbic system. Learn more about it in this presentation.
Most people with dementia undergo behavioral changes during the course of the disease. They may become anxious or repeat the same question or activity over and over. The unpredictability of these changes can be stressful for caregivers. As the disease progresses, your loved one's behavior may seem inappropriate, childlike or impulsive. Anticipating behavioral changes and understanding the causes can help you deal with them more effectively.
1. To understand the circumstances and consequences of terminal illness and death.
2. To understand grief in the context of impending death- both in the aware patient, the caregiver and loved ones
3. To explore the understanding of death across cultures
4. To develop relevant skills in dealing with death in clinical situations, with specific reference to dementia
On the occasion of National Epilepsy Day 2014, Dr. ES Krishnamoorthy introduced basic concepts of Epilepsy at the Epilepsy Knowledge Forum in Chennai organised by Neurokrish & Trimed and Sponsored Medall.
On the occasion of National Epilepsy Day 2014, Dr. V Natarajan gave a talk titled "New Trends in Epilepsy Management" at the Epilepsy Knowledge Forum in Chennai organised by Neurokrish & Trimed and Sponsored Medall.
The medial temporal epilepsy syndrome should logically include neurobehavioral features: memory problems/complaints as well as the inter ictal behavioral syndrome of Gastaut-Geschwind & Blumer
There may be differential roles for different key structures in engendering neurobehavioral symptoms
Recent studies both community and hospital based have shown that there is a significant burden of psychiatric disorder in epilepsy, with as many as 50% of all subjects studied being affected.
The available epidemiological data suggests that psychiatric disorders are over-represented in epilepsy, the evidence for psychosis in particular being rather compelling
“Epilepsy and mental disorder are two states of illness of the very closest relationship; they represent identical pathological conditions in two different areas of the nervous system”
In this lecture:
1. AED’s: Looking Beyond Epilepsy- Their Relevance & Utility in Neuropsychiatry
2. Parodoxical relationships: seizures, behavior and AEDs
3. What relevance do these findings hold for epilepsy
More from Neurokrish - the neuropsychiatry centre (11)
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Integrated Diagnostics – A Unique Epilepsy Approach
1. MMEEDDAALLLL
Integrated Diagnostics – A Unique Epilepsy Approach
DDrr.. RRaammaa KKrriisshhnnaann
Consultant Radiologist
Medall Health Care Private Limited
Chennai
2. MMEEDDAALLLL
Next 20 minutes…
Basic introduction to epilepsy and the burden of disease
in society and the need for investigations.
Imaging modalities - MRI
Clinico-radiologic images.
Integrated Neuro diagnostics.
3. MMEEDDAALLLL
Seizure & Epilepsy
Seizure - Definite event of altered
cerebral function due to excessive
and abnormal electrical discharge
from brain cells.
Greek word - epilepsia “taking hold
of or seizing”
Chronic neurologic disorder
Spontaneous recurrent seizures
First seizure ever 4% of population
Epilepsy 1% of population
Uncontrollable epi 0.4% of population
80% has epileptogenic focus
on dedicated MRI
Imaging can be normal
Fever, drugs, dehydration & sleep deprivation
5. MMEEDDAALLLL
50 million sufferers in the world today, 85% of
whom live in the developing countries
2.4 million new cases each year
50% cases begin in childhood/adolescents
70-80% of people with epilepsy could lead
normal lives if properly diagnosed and treated
6. MMEEDDAALLLL
Impact to society
Physical hazards due to
unpredictability of seizures
Social exclusion because of
negative attitudes of others
towards epilepsy
20-30 % of people with
epilepsy and physically able
to work are unemployed
7. MMEEDDAALLLL
How is epilepsy
treated?
Long term pharmacotherapy -
Drugs
Neurosurgery – when removal
of epileptogenic focus is
possible without unacceptable
neurologic deficit
Uncontrollable epi 0.4% of population
80% has epileptogenic focus
on dedicated MRI
Lesion resection can lead to seizure freedom in many patients
8. MMEEDDAALLLL
Role of neuroimaging
To identify underlying structural abnormalities
that require specific treatment
Determine functional areas
To aid in formulating a syndromic or etiologic
diagnosis
10. MMEEDDAALLLL
CT
Emergency settings
(status epilepticus )
Calcification-Sturge
-Weber
Useful as a screening
tool
SOL and granulomas
11. MMEEDDAALLLL
CT – PITFALLS
Sensitivity not more than 30%
Poor resolution in the temporal fossa – not helpful
in the diagnosis of MTS
Fails to detect abnormalities upto 50% of patients
12. MMEEDDAALLLL
ILAE RECOMMENDATIONS
CT can be the diagnostic
imaging of choice in
patients with epilepsy if
MRI is not available
Patients who have
intractable seizures
should have an MRI
study even if CT is
normal
13. MMEEDDAALLLL
MRI
Imaging procedure of choice
Identifies and localizes structural
abnormalities like MTS
Surgical planning
Covers both anatomic and
physiologic aspects
Post-operative imaging
14. MMEEDDAALLLL
Epilepsy Protocol MRI
(Medall)
1.5 T magnet
Axial, coronal and sagittal
T1 and T2 weighted images
FLAIR
Oblique coronal perpendicular to the long axis of hippocampus
3D Isotropic T1 sequence
Susceptibility weighted imaging
Spectroscopy if needed
Contrast if needed
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PATHOLOGIC SUBSTRATES
Hippocampal sclerosis
Malformations of cortical
development
Neoplasms
Vascular malformations
Gliosis & miscellaneous
abnormalities
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Hippocampal sclerosis
Complex partial seizures –
MC cause in adults
Most common entity in pts
undergoing surgery
H/o complicated childhood
febrile seizures, complicated
delivery and developmental
process
Surgical removal of visible MRI changes associated with
unilateral mesial temporal sclerosis leads to seizure freedom in
up to 80% of cases.
24. MMEEDDAALLLL
a b n o r m a l n e u r o n a l
p r o l i f e r a t i o n
a b n o r m a l n e u r o n a l
m i g r a t i o n
a b n o r m a l n e u r o n a l
o r g a n i z a t i o n
d e v e l o p m e n t a l
a b n o r m a l i t i e s
25. MMEEDDAALLLL
Focal cortical dysplasia
Cortical or subcortical
hyperintensities
Blurred interface between
grey and white matter
Transmantle sign
31. MMEEDDAALLLL
Functional MRI (fMRI)
Demonstrates alterations in blood oxygenation
Before cranial surgery to map with high accuracy functional areas
such as language, motor, and visual cortices
Speech paradigm
Astrocytoma
32. MMEEDDAALLLL
Nuclear medicine imaging in epilepsy
Perfusion changes, metabolic
changes and neurotransmission
abnormalities.
Ictal spect and Inter-ictal PET.
PET lateralizion and localization in
cases of non-lesional epilepsy, in
cases of multiple lesions visible on
MRI and can guide intracranial
electrode placement.
Ictal
Inter-ictal
34. MMEEDDAALLLL
Lab tests
Metabolic and genetic
abnormalities may manifest
as seizures without any
structural abnormality.
MRI = Normal in early
infection.
CBC and the blood chemistry
panel.
35. MMEEDDAALLLL
Complete
blood count
Infections
Allergies
Other abnormalities that may affect
the choice of appropriate
anticonvulsant drugs
Help monitor the possible drug-induced
side effects in the future.
38. MMEEDDAALLLL
to conclude…
MRI is excellent tool for imaging and for surgical
planning.
Integrated neurodiagnostic approach is the most
efficient method for evaluating patients with
epilepsy.