The hippocampus is located in the medial temporal lobe beneath the cortex and plays important roles in converting short-term to long-term memory, emotions, navigation, and spatial orientation. Studies have shown that severe stress in children can decrease hippocampal size by increasing stress hormones like cortisol. Long-term ecstasy use was also found to damage the hippocampus, with users' hippocampi being 10.5% smaller than average for alcoholics. Higher physical fitness in children has been correlated with larger hippocampal size likely due to increased growth of neurons and cell survival. Damage to the hippocampus can cause amnesia and difficulties learning and remembering, and may contribute to the development of Alzheimer's disease.