This document discusses the properties and health benefits of garlic. It notes that garlic is a bulbous plant used for seasoning and medicine. It provides a brief history of garlic use in ancient Greece, India, and China. The document outlines some of garlic's main bioactive compounds like allicin and discusses garlic's antimicrobial, antihypertensive, cardiovascular, and anticancer properties. It summarizes that garlic may help reduce blood pressure and the risk of diseases due to its antioxidant and anti-inflammatory effects.
This document discusses herb-drug interactions, noting that herbal-drug interactions are more common than drug-drug interactions. It provides examples of pharmacokinetic and pharmacodynamic interactions between certain herbs and drugs. St. John's Wort is shown to interact with many prescription drugs by inducing cytochrome P450 enzymes. Ginkgo biloba and green tea may prolong bleeding time when taken with anticoagulant or antiplatelet medications due to effects on platelet function. The document stresses the importance of patients disclosing herbal supplement use to physicians to avoid potential interactions.
This document summarizes the biological evaluation of plant-derived drug molecules digoxin and digitoxin. It discusses that biological evaluation is used when drugs cannot be fully evaluated by chemical and physical methods alone. The response of a test drug is compared to a standard preparation using living systems, and activity is measured in International Units. Digoxin and digitoxin are cardiac glycosides obtained from Digitalis plants that act as cardio-tonic agents, increasing heart muscle tone, excitability and contractility. Their isolation, biosynthesis, structure-activity relationships, and uses are described.
The importance of medicinal plants in the treatment of a variety of human ailments man has been dependent on the higher plants as a source of food and medicine.
Senna glycoside is a type of anthraquinone glycoside found in senna leaves. It consists mainly of dimeric anthracene glycosides called sennosides. Sennosides include sennoside A, B, C and D which contain rhein and/or emodin anthrones joined by C-C bonds. Their purgative effects are due to the anthracene aglycones which are released in the large intestine. Hydroxylation and the degree of oxidation impact activity. Glycosylation allows transport to the intestine. Senna preparations are used as laxatives and cathartics and work by stimulating intestinal peristalsis.
This document discusses herb-drug interactions, providing several examples. It notes that herbs are often taken with allopathic drugs with the belief they will provide benefits, but they can interact in ways that alter the kinetics and dynamics of both substances. Specifically, herbs may cause additive, synergistic, antagonistic or unidentified responses when taken with conventional drugs by changing absorption, distribution, metabolism, protein binding or excretion of the drugs. Several herbs are described that can interact through these pharmacokinetic or pharmacodynamic mechanisms, such as ginkgo decreasing alprazolam absorption or milk thistle upregulating liver enzymes. The document emphasizes the need to study herb-drug interactions due to lack of knowledge, quality control issues, and
Sonia Singh, an assistant professor at GLA University, gave a presentation on the pharmacognosy and phytochemistry of coriander. Coriander consists of the dried ripe fruits of Coriandrum sativum, which are cultivated in parts of Europe, Africa, and India. The fruit is yellowish-brown and spherical, containing volatile oils that are aromatic and spicy. Microscopic examination shows the fruit has a dorsal ridge and commissural surface, with epicarp cells containing calcium oxalate crystals. The chemical constituents include volatile oils like linalool, terpenes, and fatty acids. Therapeutically, coriander is used as a carminative, digestive aid, and
Rhubarb is a perennial herb that grows in temperate regions. Its roots have traditionally been used in Chinese medicine as a laxative and for other medicinal purposes. Rhubarb contains anthraquinone glycosides and tannins that are responsible for its pharmacological effects. While the roots are medicinal, the leaves contain toxic levels of oxalic acid and should not be consumed. Rhubarb is commonly used to treat constipation and digestive issues and has also shown anti-inflammatory properties.
This document discusses herb-drug interactions, noting that herbal-drug interactions are more common than drug-drug interactions. It provides examples of pharmacokinetic and pharmacodynamic interactions between certain herbs and drugs. St. John's Wort is shown to interact with many prescription drugs by inducing cytochrome P450 enzymes. Ginkgo biloba and green tea may prolong bleeding time when taken with anticoagulant or antiplatelet medications due to effects on platelet function. The document stresses the importance of patients disclosing herbal supplement use to physicians to avoid potential interactions.
This document summarizes the biological evaluation of plant-derived drug molecules digoxin and digitoxin. It discusses that biological evaluation is used when drugs cannot be fully evaluated by chemical and physical methods alone. The response of a test drug is compared to a standard preparation using living systems, and activity is measured in International Units. Digoxin and digitoxin are cardiac glycosides obtained from Digitalis plants that act as cardio-tonic agents, increasing heart muscle tone, excitability and contractility. Their isolation, biosynthesis, structure-activity relationships, and uses are described.
The importance of medicinal plants in the treatment of a variety of human ailments man has been dependent on the higher plants as a source of food and medicine.
Senna glycoside is a type of anthraquinone glycoside found in senna leaves. It consists mainly of dimeric anthracene glycosides called sennosides. Sennosides include sennoside A, B, C and D which contain rhein and/or emodin anthrones joined by C-C bonds. Their purgative effects are due to the anthracene aglycones which are released in the large intestine. Hydroxylation and the degree of oxidation impact activity. Glycosylation allows transport to the intestine. Senna preparations are used as laxatives and cathartics and work by stimulating intestinal peristalsis.
This document discusses herb-drug interactions, providing several examples. It notes that herbs are often taken with allopathic drugs with the belief they will provide benefits, but they can interact in ways that alter the kinetics and dynamics of both substances. Specifically, herbs may cause additive, synergistic, antagonistic or unidentified responses when taken with conventional drugs by changing absorption, distribution, metabolism, protein binding or excretion of the drugs. Several herbs are described that can interact through these pharmacokinetic or pharmacodynamic mechanisms, such as ginkgo decreasing alprazolam absorption or milk thistle upregulating liver enzymes. The document emphasizes the need to study herb-drug interactions due to lack of knowledge, quality control issues, and
Sonia Singh, an assistant professor at GLA University, gave a presentation on the pharmacognosy and phytochemistry of coriander. Coriander consists of the dried ripe fruits of Coriandrum sativum, which are cultivated in parts of Europe, Africa, and India. The fruit is yellowish-brown and spherical, containing volatile oils that are aromatic and spicy. Microscopic examination shows the fruit has a dorsal ridge and commissural surface, with epicarp cells containing calcium oxalate crystals. The chemical constituents include volatile oils like linalool, terpenes, and fatty acids. Therapeutically, coriander is used as a carminative, digestive aid, and
Rhubarb is a perennial herb that grows in temperate regions. Its roots have traditionally been used in Chinese medicine as a laxative and for other medicinal purposes. Rhubarb contains anthraquinone glycosides and tannins that are responsible for its pharmacological effects. While the roots are medicinal, the leaves contain toxic levels of oxalic acid and should not be consumed. Rhubarb is commonly used to treat constipation and digestive issues and has also shown anti-inflammatory properties.
Neutraceuticals are food or food components that provide health benefits for preventing or treating disease. They can be classified based on their natural source, chemical constitution, or pharmacological effects. Common examples include probiotics, prebiotics, dietary fibers, antioxidants, phytochemicals, herbs, and minerals. Many neutraceuticals have anti-inflammatory, anticancer, or blood sugar regulating effects and are found in foods like flaxseeds, turmeric, soy, garlic, and ginger. Neutraceuticals are increasingly being incorporated into vitamin supplements and food products marketed for their health properties.
Herbal medicines have the potential to interact with conventional drugs when taken together through pharmacokinetic and pharmacodynamic mechanisms. An estimated 5-20% of people use herbal medicines which can interact in various ways like altering absorption, metabolism, or excretion of drugs. Some common herb-drug interactions involve garlic, ginger, black pepper, cinnamon, and green tea potentially impacting drugs like anticoagulants, antidiabetics, and antibiotics. Healthcare professionals have an important role in advising patients about monitoring herb-drug combinations and collecting data on suspected interactions to improve safety.
This document provides information on the herbal drug industry in India. It discusses the growth of the herbal medicine market globally and in India. It lists major herbal drug manufacturers and their popular products in India. It also outlines key government agencies and schemes that support research, development and promotion of medicinal plants and entrepreneurship in the herbal industry. Major herbal extracts and phytomedicines exported from India are highlighted.
Pharmacognosy OF LIQUORICE(Saponin Glycoside)ALOK SINGH
This document summarizes information about the plant liquorice (Glycyrrhiza glabra). It is grown in sub-Himalayan regions and parts of Europe. Microscopically, it exhibits cork layers, medullary rays, phloem fibers, xylem vessels and fibers, and parenchyma cells containing starch grains and calcium oxalate crystals. It contains saponin glycosides and glycyrrhetinic acid. Liquorice has demulcent, expectorant, and mineralocorticoid properties and is used in cough syrups, lozenges, and to mask bitter tastes in medicines. Its saponins aid absorption of some drugs. Adulterants include
WHO has established several guidelines for quality control and standardization of herbal medicines. This includes guidelines for crude plant materials, processed plant materials, and analytical procedures. Key aspects that must be standardized include authentication of plant identity and source, absence of contaminants, determination of marker compounds, and ensuring safety through tests for heavy metals, pesticides, and microbiological limits. Proper application of WHO guidelines can help ensure the quality, safety and efficacy of herbal medicines.
Macrolide antibiotics are a class of antibiotics that belong to the family of macrocyclic antibiotics. They contain a large macrocyclic lactone ring and generally consist of a central highly substituted lactone ring. There are three waves of macrolide development, starting with erythromycin, and progressing to newer derivatives with improved pharmacokinetics and ability to overcome bacterial resistance, such as azithromycin. Structure activity relationship studies showed that an amino sugar, lactone ring, and ketone group are important for antibacterial activity. Lead optimization efforts focused on modifications to increase acidic stability and effectiveness against resistant bacterial strains, such as through alkylation, ring expansion, or removal of the amino sugar to create ketol
This document outlines guidelines for good agricultural practices in cultivating medicinal plants according to WHO standards. It discusses selecting appropriate plant species and varieties, ensuring quality of propagation materials, optimizing cultivation conditions like climate, soil, irrigation and plant maintenance, proper harvest timing based on plant part and constituent quality, and ensuring trained personnel with knowledge of plant cultivation and hygiene practices are involved in the production process. The goal is to cultivate medicinal plants sustainably and produce high quality raw materials while conserving plant biodiversity and protecting the environment.
The branch of herbal medicine that describes the potentials and limitations of herbal drugs in the treatment of human diseases and should be practiced by physicians trained in herbalism.
Drug-Herb interactions (with reference to commonly used herbs)Punit Bhatt
The present presentation is about Drug-Herb interactions. The content was delivered at Dr Subhash Technical College for the Refresher course of Pharmacist. The content covers the commonly used herbs and its interactions with commonly used allopathic drugs.
This document provides information on various phytopharmaceuticals including their sources, constituents, pharmacology, therapeutic uses, and regulatory status. Some of the phytopharmaceuticals discussed include ephedra, ginger, garlic, kava kava, ginkgo biloba, valerian, chamomile, echinacea, ginseng, cranberry, acorus, comfrey, tomato, liquorice, senna, and cascara. For each one, key details about its botanical source, active constituents, pharmacological effects, recommended dosage, market preparations, and regulatory classification are summarized.
Ginseng is a perennial plant with fleshy roots belonging to the genus Panax. The two most common varieties are Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius). Ginseng grows wild in northeast Asia and North America. It has been used in traditional Chinese medicine to treat various conditions like erectile dysfunction, cardiovascular issues, cancer, and weight control. The active compounds in ginseng include ginsenosides, polysaccharides, and fatty acids. Common side effects of ginseng include insomnia, diarrhea, and skin rashes if taken in excessive amounts.
Alkaloidal amines ephedra, colchicum Pharmacognostic studyDivya Sree M S
This document provides information on the alkaloidal plants Ephedra and Colchicum. It describes their biological sources, geographical sources, cultivation methods, macroscopic and microscopic features, main chemical constituents including Ephedrine in Ephedra and Colchicine in Colchicum, chemical tests to identify the constituents, and traditional uses including as a bronchodilator and to treat gout respectively.
- Taxol is a potent anticancer compound obtained from the Pacific yew tree. It was first isolated in 1971 and has the generic name paclitaxel.
- Due to the tree's slow growth, industrial production of taxol involves extraction from tree bark or semi-synthesis from related compounds like 10-deacetylbaccatin III from European yew.
- Taxol is used to treat cancers like ovarian cancer, breast cancer, and lung cancer. It works by stabilizing microtubules to inhibit cancer cell growth. While initially challenging to source, taxol production is now sustainable through extraction and semi-synthesis.
The document discusses peppermint (Mentha pipertia), including its botanical information, parts used, chemical constituents like menthol and menthone, mechanisms of action as a calcium channel blocker, uses to treat nausea, headaches and reduce inflammation, potential side effects like heartburn and allergic reactions, contraindications during pregnancy and intestinal diseases, interactions with other drugs, and dosage recommendations of 3-6 grams as an infusion or 0.2 ml of peppermint oil per day in capsules.
Methods of Extraction, Pharmacognosy, types of extraction for herbal drugsDivya Sree M S
This document discusses various techniques for extracting medicinal compounds from plants and organisms. It defines extraction as separating medicinally active plant or animal tissues from inactive components using selective solvents. Several specific extraction methods are described, including maceration, digestion, decoction, percolation, Soxhlet extraction, ultrasound extraction, and supercritical fluid extraction. Each method has advantages and disadvantages related to efficiency, potential chemical changes during extraction, time requirements, and environmental impact.
Nutraceuticals- Inorganic mineral supplements and vitamin supplements NikitaSavita
This document discusses nutraceuticals, which are foods or food components that provide health benefits. It specifically focuses on inorganic mineral supplements and vitamin supplements. Minerals are inorganic elements found in rocks and soil that are essential for various body functions. Common mineral supplements include calcium, iron, magnesium, and zinc. Vitamins are organic compounds required in small amounts in the diet that the body cannot synthesize. There are 13 vitamins categorized as either fat-soluble or water-soluble. While vitamins and minerals can provide short-term benefits, supplements should not replace a healthy diet and long-term high-dose use may lead to toxicity for some vitamins and minerals.
The document describes a procedure to isolate mentha oil from mentha leaves using hydrodistillation with a Clavenger apparatus. It involves extracting the volatile oils from the leaves through distillation with water in the apparatus. Volatile oils are complex mixtures found in plants that are odorous and evaporate at room temperature. They are identified and standardized based on their volatile oil content and characteristics. The procedure aims to isolate mentha oil and identify menthol within it using thin layer chromatography.
This experiment aimed to determine the volume of citral present in a sample of lemongrass oil. Lemongrass oil contains at least 75% aldehyde, including citral, and is used in perfumes and flavorings. The procedure involved adding lemongrass oil to a sodium sulfite solution, heating to allow citral to react and form sodium citrate, then neutralizing and continuing to heat until the solution turned clear, indicating the reaction was complete. The separated oil volume would then indicate the original citral content in the sample. The report would state the exact citral volume determined from this experiment.
Herbal drugs can interact with pharmaceutical drugs in the body, altering their kinetic and dynamic properties. About 5-20% of people worldwide use herbal medicines. Herbal drugs can interact through pharmacokinetic or pharmacodynamic mechanisms. Evidence for interactions comes from animal studies, clinical trials, and case reports. Reasons for interactions include a lack of knowledge about combinations and the potent active ingredients in herbal supplements. Some herbs like garlic, ginger, green tea, and St. John's wort can interact with drugs like anticoagulants, antihypertensives, antidiabetics, and antidepressants. Pharmacists have an important role in advising about and monitoring for potential herb-drug interactions.
Red Reishi has more than 200 bio-active compounds and many of them can interfere with the growth, mobility, and invasiveness of cancer cells. Reishi, as the Japanese would call it is Gandoderma lucidum, and ancient medicinal remedy popular across Asia. Traditional healers have been using the herb for more than 4,000 years and found it to be beneficial in many health concerns.
Or other try to click here:
www.reishiscience.com.
If you need to order, text us at 09163224166 / 09276936715 / 09287144826 and/or email us at msaslarona@gmail.com and fraslarona@gmail.com. Thank you. God bless.
This document summarizes a study on the medicinal uses of 26 different vegetables from 12 families. It finds that vegetables can be used to treat various diseases as antibacterial, antiviral, antifungal, anti-inflammatory, and antitumor agents. The most commonly used vegetables for treating diseases are Allium sativum, Spinacia oleracea, and Daucus carota, while Cucumis melo, Ocimum gratissimum, and Telfairia occidentalis are used less often. Maintaining good health requires consuming around 280 grams of vegetables per day, with 40% being leafy vegetables, 30% being roots and tubers, and 30% being other vegetables.
Neutraceuticals are food or food components that provide health benefits for preventing or treating disease. They can be classified based on their natural source, chemical constitution, or pharmacological effects. Common examples include probiotics, prebiotics, dietary fibers, antioxidants, phytochemicals, herbs, and minerals. Many neutraceuticals have anti-inflammatory, anticancer, or blood sugar regulating effects and are found in foods like flaxseeds, turmeric, soy, garlic, and ginger. Neutraceuticals are increasingly being incorporated into vitamin supplements and food products marketed for their health properties.
Herbal medicines have the potential to interact with conventional drugs when taken together through pharmacokinetic and pharmacodynamic mechanisms. An estimated 5-20% of people use herbal medicines which can interact in various ways like altering absorption, metabolism, or excretion of drugs. Some common herb-drug interactions involve garlic, ginger, black pepper, cinnamon, and green tea potentially impacting drugs like anticoagulants, antidiabetics, and antibiotics. Healthcare professionals have an important role in advising patients about monitoring herb-drug combinations and collecting data on suspected interactions to improve safety.
This document provides information on the herbal drug industry in India. It discusses the growth of the herbal medicine market globally and in India. It lists major herbal drug manufacturers and their popular products in India. It also outlines key government agencies and schemes that support research, development and promotion of medicinal plants and entrepreneurship in the herbal industry. Major herbal extracts and phytomedicines exported from India are highlighted.
Pharmacognosy OF LIQUORICE(Saponin Glycoside)ALOK SINGH
This document summarizes information about the plant liquorice (Glycyrrhiza glabra). It is grown in sub-Himalayan regions and parts of Europe. Microscopically, it exhibits cork layers, medullary rays, phloem fibers, xylem vessels and fibers, and parenchyma cells containing starch grains and calcium oxalate crystals. It contains saponin glycosides and glycyrrhetinic acid. Liquorice has demulcent, expectorant, and mineralocorticoid properties and is used in cough syrups, lozenges, and to mask bitter tastes in medicines. Its saponins aid absorption of some drugs. Adulterants include
WHO has established several guidelines for quality control and standardization of herbal medicines. This includes guidelines for crude plant materials, processed plant materials, and analytical procedures. Key aspects that must be standardized include authentication of plant identity and source, absence of contaminants, determination of marker compounds, and ensuring safety through tests for heavy metals, pesticides, and microbiological limits. Proper application of WHO guidelines can help ensure the quality, safety and efficacy of herbal medicines.
Macrolide antibiotics are a class of antibiotics that belong to the family of macrocyclic antibiotics. They contain a large macrocyclic lactone ring and generally consist of a central highly substituted lactone ring. There are three waves of macrolide development, starting with erythromycin, and progressing to newer derivatives with improved pharmacokinetics and ability to overcome bacterial resistance, such as azithromycin. Structure activity relationship studies showed that an amino sugar, lactone ring, and ketone group are important for antibacterial activity. Lead optimization efforts focused on modifications to increase acidic stability and effectiveness against resistant bacterial strains, such as through alkylation, ring expansion, or removal of the amino sugar to create ketol
This document outlines guidelines for good agricultural practices in cultivating medicinal plants according to WHO standards. It discusses selecting appropriate plant species and varieties, ensuring quality of propagation materials, optimizing cultivation conditions like climate, soil, irrigation and plant maintenance, proper harvest timing based on plant part and constituent quality, and ensuring trained personnel with knowledge of plant cultivation and hygiene practices are involved in the production process. The goal is to cultivate medicinal plants sustainably and produce high quality raw materials while conserving plant biodiversity and protecting the environment.
The branch of herbal medicine that describes the potentials and limitations of herbal drugs in the treatment of human diseases and should be practiced by physicians trained in herbalism.
Drug-Herb interactions (with reference to commonly used herbs)Punit Bhatt
The present presentation is about Drug-Herb interactions. The content was delivered at Dr Subhash Technical College for the Refresher course of Pharmacist. The content covers the commonly used herbs and its interactions with commonly used allopathic drugs.
This document provides information on various phytopharmaceuticals including their sources, constituents, pharmacology, therapeutic uses, and regulatory status. Some of the phytopharmaceuticals discussed include ephedra, ginger, garlic, kava kava, ginkgo biloba, valerian, chamomile, echinacea, ginseng, cranberry, acorus, comfrey, tomato, liquorice, senna, and cascara. For each one, key details about its botanical source, active constituents, pharmacological effects, recommended dosage, market preparations, and regulatory classification are summarized.
Ginseng is a perennial plant with fleshy roots belonging to the genus Panax. The two most common varieties are Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius). Ginseng grows wild in northeast Asia and North America. It has been used in traditional Chinese medicine to treat various conditions like erectile dysfunction, cardiovascular issues, cancer, and weight control. The active compounds in ginseng include ginsenosides, polysaccharides, and fatty acids. Common side effects of ginseng include insomnia, diarrhea, and skin rashes if taken in excessive amounts.
Alkaloidal amines ephedra, colchicum Pharmacognostic studyDivya Sree M S
This document provides information on the alkaloidal plants Ephedra and Colchicum. It describes their biological sources, geographical sources, cultivation methods, macroscopic and microscopic features, main chemical constituents including Ephedrine in Ephedra and Colchicine in Colchicum, chemical tests to identify the constituents, and traditional uses including as a bronchodilator and to treat gout respectively.
- Taxol is a potent anticancer compound obtained from the Pacific yew tree. It was first isolated in 1971 and has the generic name paclitaxel.
- Due to the tree's slow growth, industrial production of taxol involves extraction from tree bark or semi-synthesis from related compounds like 10-deacetylbaccatin III from European yew.
- Taxol is used to treat cancers like ovarian cancer, breast cancer, and lung cancer. It works by stabilizing microtubules to inhibit cancer cell growth. While initially challenging to source, taxol production is now sustainable through extraction and semi-synthesis.
The document discusses peppermint (Mentha pipertia), including its botanical information, parts used, chemical constituents like menthol and menthone, mechanisms of action as a calcium channel blocker, uses to treat nausea, headaches and reduce inflammation, potential side effects like heartburn and allergic reactions, contraindications during pregnancy and intestinal diseases, interactions with other drugs, and dosage recommendations of 3-6 grams as an infusion or 0.2 ml of peppermint oil per day in capsules.
Methods of Extraction, Pharmacognosy, types of extraction for herbal drugsDivya Sree M S
This document discusses various techniques for extracting medicinal compounds from plants and organisms. It defines extraction as separating medicinally active plant or animal tissues from inactive components using selective solvents. Several specific extraction methods are described, including maceration, digestion, decoction, percolation, Soxhlet extraction, ultrasound extraction, and supercritical fluid extraction. Each method has advantages and disadvantages related to efficiency, potential chemical changes during extraction, time requirements, and environmental impact.
Nutraceuticals- Inorganic mineral supplements and vitamin supplements NikitaSavita
This document discusses nutraceuticals, which are foods or food components that provide health benefits. It specifically focuses on inorganic mineral supplements and vitamin supplements. Minerals are inorganic elements found in rocks and soil that are essential for various body functions. Common mineral supplements include calcium, iron, magnesium, and zinc. Vitamins are organic compounds required in small amounts in the diet that the body cannot synthesize. There are 13 vitamins categorized as either fat-soluble or water-soluble. While vitamins and minerals can provide short-term benefits, supplements should not replace a healthy diet and long-term high-dose use may lead to toxicity for some vitamins and minerals.
The document describes a procedure to isolate mentha oil from mentha leaves using hydrodistillation with a Clavenger apparatus. It involves extracting the volatile oils from the leaves through distillation with water in the apparatus. Volatile oils are complex mixtures found in plants that are odorous and evaporate at room temperature. They are identified and standardized based on their volatile oil content and characteristics. The procedure aims to isolate mentha oil and identify menthol within it using thin layer chromatography.
This experiment aimed to determine the volume of citral present in a sample of lemongrass oil. Lemongrass oil contains at least 75% aldehyde, including citral, and is used in perfumes and flavorings. The procedure involved adding lemongrass oil to a sodium sulfite solution, heating to allow citral to react and form sodium citrate, then neutralizing and continuing to heat until the solution turned clear, indicating the reaction was complete. The separated oil volume would then indicate the original citral content in the sample. The report would state the exact citral volume determined from this experiment.
Herbal drugs can interact with pharmaceutical drugs in the body, altering their kinetic and dynamic properties. About 5-20% of people worldwide use herbal medicines. Herbal drugs can interact through pharmacokinetic or pharmacodynamic mechanisms. Evidence for interactions comes from animal studies, clinical trials, and case reports. Reasons for interactions include a lack of knowledge about combinations and the potent active ingredients in herbal supplements. Some herbs like garlic, ginger, green tea, and St. John's wort can interact with drugs like anticoagulants, antihypertensives, antidiabetics, and antidepressants. Pharmacists have an important role in advising about and monitoring for potential herb-drug interactions.
Red Reishi has more than 200 bio-active compounds and many of them can interfere with the growth, mobility, and invasiveness of cancer cells. Reishi, as the Japanese would call it is Gandoderma lucidum, and ancient medicinal remedy popular across Asia. Traditional healers have been using the herb for more than 4,000 years and found it to be beneficial in many health concerns.
Or other try to click here:
www.reishiscience.com.
If you need to order, text us at 09163224166 / 09276936715 / 09287144826 and/or email us at msaslarona@gmail.com and fraslarona@gmail.com. Thank you. God bless.
This document summarizes a study on the medicinal uses of 26 different vegetables from 12 families. It finds that vegetables can be used to treat various diseases as antibacterial, antiviral, antifungal, anti-inflammatory, and antitumor agents. The most commonly used vegetables for treating diseases are Allium sativum, Spinacia oleracea, and Daucus carota, while Cucumis melo, Ocimum gratissimum, and Telfairia occidentalis are used less often. Maintaining good health requires consuming around 280 grams of vegetables per day, with 40% being leafy vegetables, 30% being roots and tubers, and 30% being other vegetables.
Ginger has been shown to reduce the severity and duration of chemotherapy-induced nausea in clinical trials. Additional research suggests ginger may help treat nausea from surgery, pregnancy, and motion sickness, though more research is still needed. Laboratory research also indicates ginger may inhibit the growth of some cancer cells and protect against Alzheimer's, but these effects have not been demonstrated in human clinical trials. Ginger should not be used by those with bleeding disorders or taking blood thinners, as it can inhibit clotting. More research is still needed to determine appropriate dosages and drug interactions when using ginger as an anti-nausea supplement.
ASTASHINE CAPSULES: AN EXCELLENT CHOICE FOR A CARDIOVASCULAR HEALTH ABSTRACTPUGOS Products Pvt Ltd
- Astaxanthin is a carotenoid with strong antioxidant and anti-inflammatory properties that can help prevent cardiovascular disease.
- Studies show astaxanthin from microalgae improves blood lipid and insulin resistance levels, reduces inflammation and oxidative stress, prevents fatty liver disease, and lowers blood pressure.
- The article reviews research demonstrating that astaxanthin supplementation has beneficial effects on metabolic health and reduces risks for conditions like atherosclerosis, hypertension, and hyperglycemia.
An excellent blend of fresh mint pineapple tasting supplement, providing several health maintenance and disease prevention ingredients based on scientific data available only from Richard Clement Nutrition.
Manufactured in the USA in a GMP plant
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Anti-Diabetic Activity of Some Medicinal Plants IIJSRJournal
Diabetes mellitus is generally a chronic disease which is a main reason for deaths in whole world. It is not easy to control the delayed complication of diabetes even with progress in the medical management of the syndrome. The disease is spreading day by day. The main trait element of diabetes is hyperglycemia, which reflects the drop in the use of glucose due to a poor reaction to insulin discharge. There are many plants are used to cure diabetes because of the antidiabetic action. Hypoglycemic and anti-hyperglycemic actions have been saved with abundant plants, a lot of which are worn as an established herbal treatment of diabetes. A huge number of substances are obtained from plants that suggest antidiabetic potential, while others may affect hypoglycemia as a bad result due to their toxicity, mainly their hepatotoxicity. This review shows the importance of plants and the action of some plants to act against diabetes that is used as a natural medicine for this disease.
This document describes a study that developed a herbal cocktail to prevent stroke and cerebrovascular diseases. The study investigated the effects of a high fat diet on rats and the impact of treating the rats with extracts from four herbs: Artemisia Judaica, Panax ginseng, Salvia officinalis, and Polygonum multiflorum, both individually and combined in a cocktail. The herbal cocktail significantly lowered lipid levels, oxidative stress markers, and inflammatory mediators in the blood and liver compared to a high fat diet alone. The results suggest that the herbal cocktail has anti-hyperlipidemic and antioxidant effects and may help prevent obesity-related health problems like stroke.
This document discusses preserving homeostasis in patients with COVID-19 by modulating the renin-angiotensin system (RAS). It describes how SARS-CoV-2 infection can dysregulate RAS, leading to overactivation of angiotensin II and oxidative stress. The use of angiotensin receptor blockers like losartan is proposed to counteract this and inhibit virus replication by distorting the binding of the virus to ACE2 receptors. Studies in cell cultures found losartan treatment before and after infection reduced viral replication. Maintaining RAS homeostasis is proposed as a promising therapeutic strategy for COVID-19 given the dysregulatory impacts of viral infections.
The document discusses several spices and their potential health benefits. It provides information on the phytochemicals contained in various spices like turmeric, garlic, ginger, chili peppers, and their anti-inflammatory, antioxidant, and anticancer properties based on in vitro, animal, and human studies. However, more research is still needed to better understand the biological effects of individual spices and their potential roles in cancer prevention and treatment.
This document discusses how flavonols may help reduce the risk of coronary heart disease and atherosclerosis. Specifically, it summarizes that flavonols like quercetin and kaempferol found in foods like onions and tea can help prevent low-density lipoprotein oxidation and reduce expression of adhesion molecules involved in plaque formation. However, more research is needed on the cardiovascular protective effects of bioavailable flavonol metabolites, as most studies so far have used pure flavonol forms. Incorporating a variety of fruits and vegetables high in flavonols into one's diet may help gain their potential heart health benefits.
Even though there is plethora of scientific literature available
regarding the role of gut microbiome in hypertension, but till date,
there is neither clarity nor established guidelines and consensus
regarding strain-specificity for hypertension in any of the existing
national and international guidelines like European Society of
Hypertension (ESH), International Society of Hypertension
(ISH) etc. Innovative microbiome-based or targeted medication
related research, which have the potential to revolutionize the
treatment of hypertension are highly recommended in future
because effects of probiotics can be specific to certain probiotic
species and strains. Recommendations for their use in the clinical
practice or in research studies need to be compulsorily species and
strain specific and interpretation of data from studies involving
mixture of probiotic supplements can be misleading in terms of
beneficial effects, efficacy and safety and should be cautious
Red Reishi has more than 200 bio-active compounds and many of them can interfere with the growth, mobility, and invasiveness of cancer cells. Reishi, as the Japanese would call it is Gandoderma lucidum, and ancient medicinal remedy popular across Asia. Traditional healers have been using the herb for more than 4,000 years and found it to be beneficial in many health concerns.
Wheatgrass has powerful anti-oxidants, phytochemicals and other nutrients that help cleanse the blood, neutralize toxins and eliminate excess fats, free radicals and heavy metals from our system. It is also rich in fiber which helps clear our toxins and garbage in the digestive tract.
So Easy is a safe and effective regimen designed to efficiently remove mucoid plaque and get rid of the stagnating fecal matter.
By completely staying away from your usual meals and religiously following the 3 day Colon Cleansing Program - you allow your intestinal system to rest, thus restoring the normal operation of your gastro-intestinal tract.
This study examined the effects of combined inhibition of the Src family kinases (SFK) and insulin-like growth factor 1 receptor (IGF-1R) pathways in prostate cancer (PCa) cells and in mouse models. Dual inhibition of these pathways more potently inhibited PCa tumor growth in vitro and in vivo compared to inhibiting either pathway alone. The combination treatment more completely inhibited Akt phosphorylation and downstream survival pathways in the cancer cells. This suggests that targeting both the SFK and IGF-1R pathways may be a promising therapeutic strategy for PCa by blocking independent and cooperative processes important for tumor growth and survival.
Crimson Publishers: Dietary Supplements as a Possible Trigger of Autoimmune H...CrimsonGastroenterology
Introduction: Autoimmune hepatitis (AIH) etiology remains unknown, but in genetically predisposed individuals, diverse agents may trigger the disease. Herbal and drug induced AIH have been reported in recent years probable due to the increase in self-medication. More studies are necessary to define if drugs and herbal/dietary supplements unmask and induce AIH or drug-induced hepatitis with autoimmune features.
Purpose: We report an autoimmune hepatitis case possibly induced by herbal/dietary supplements intake.
Case-report: A 55-year-old female presented with a 15-day course of jaundice and increased aminotransferases. Immunologic panel showed antinuclear antibody titer of 1:320 and serum immunoglobulin G (IgG) level approximately 2 times the upper limit of normal. She reported regular daily ingestion of Herbalife® products for 6 months which were discontinued when symptoms began. Laboratory tests worsened despite the fact that patient had stopped supplements usage, and a liver biopsy was performed. Histology was suggestive of both AIH and drug induced liver disease. The patient fulfilled criteria for probable AIH based on the revised criteria for diagnosing autoimmune hepatitis, and improved with prednisolone and azathioprine therapy, with progressive laboratory improvement and symptoms remission.
Discussion: Herbal/dietary supplements induced AIH has been previously reported, but the causality is not yet well established. Worsening of aminotransferases despite supplement suspension, histological findings and favorable response with corticosteroid treatment, supported the hypothesis of AIH induced by the used supplement. This case report aims to demonstrate the possible causality between herbal/dietary supplements and liver injury, including autoimmune hepatitis.
This document summarizes a seminar presentation on the role of garlic in managing high cholesterol. It discusses how elevated cholesterol can lead to atherosclerosis and how garlic may help lower cholesterol levels. The presentation covers an overview of garlic's composition and chemistry. It describes allicin, garlic's main bioactive compound, and its role in cholesterol reduction. The presentation also reviews garlic's potential health benefits, including antioxidant, anti-thrombotic, anti-aging, and anti-cancer effects. It concludes that garlic can significantly help manage high cholesterol based on literature reviews.
SHER-E-KASHMIRUNIVERSITY OF AGRICULTURAL SCIENCES ANDTECHNOLOGY, KASHMIR.pptxcdrecordsection
This case study evaluated the hepatoprotective effects of formulations containing extracts of Berberis aristata, Solanum nigrum, and Aloe vera (Formulation A), and a decoction of Phyllanthus fraternus (Formulation B), on patients receiving antitubercular treatment. Patients taking the formulations showed no significant increases in liver enzymes, while the control group showed significant increases. The formulations helped prevent antitubercular treatment-induced hepatotoxicity and allowed patients to complete their treatment courses.
This document reviews medicinal plants with anticancer activity. It discusses several plants traditionally used in Indian Ayurvedic medicine to treat cancer, including Allium sativum (garlic), Annona muricata, Bidens pilosa, Cannabis sativa, Daphne mezereum, Gossypium hirsutum, Andrographis paniculata, Salvia miltiorrhiza, Cynodon dactylon, Drosera indica, Salacia fruticosa, and Vitex pinnata. For each plant, one or two active compounds believed to have anticancer properties are described. The document concludes that medicinal plants have played an important
Zinper softgel caps: a natural nutrient helps to ease occasional nausea & pro...SriramNagarajan16
Chemotherapy –induced nausea and vomiting (CINV), also known by the term emesis, is one of the most
common and dreaded side effects following cancer treatment, and can strongly impact the quality of day –today living of cancer patients. Many Chemotherapeutic agents are associated with significant nausea and
vomiting which represent a challenge to effective therapy. The active ingredients present in Zinper softgels are
terpenes and oleoresin. The major identified components from terpenes are gingerol and shogaols. Zinper
softgels has staring potential as anti-tumor, anti-oxidant, anti inflammatory, anti-microbial, anti-emetic effect,
Anti-angiogenesis, anti-nausea and an effective adjuvant treatment for chemotherapy-induced nausea and
vomiting. The effectiveness of Zinper softgels in preventing or suppressing cancer growth has been examined in
a variety of cancer types, including lymphoma, hepatoma, colorectal cancer, breast cancer, skin cancer, liver
cancer, and bladder cancer. This article reviews the current available scientific literature regarding the effect of
Zinper softgels as A Natural Nutrient to Promote Healthy GI peristalsis in cancer patients.
Pregnant women need good nutrition to support fetal development and reduce health risks. A balanced diet provides enough protein, iron, calcium, vitamins and minerals. Increased needs include folic acid to prevent birth defects, and iron and calcium due to the baby's growth. Common issues like nausea and constipation can be managed through dietary changes. Exercise also benefits pregnancy by reducing discomforts, though risky activities should be avoided.
The document describes a study that developed a herbal mixture to study its effects on insulin resistance in diabetes patients. The mixture contained amla powder, clove powder, hing powder, and cinnamon. It was administered to an experimental group for 3 months, while a control group received no treatment. Results showed the mixture was accepted by patients. For males in the experimental group, there were significant decreases in fasting blood glucose, HbA1c, and BMI compared to the control group. However, females did not see significant changes. The herbal mixture thus had some beneficial effects on diabetic male patients.
Severely malnourished children are at greater risk of developing pneumonia for three main reasons:
1) They have deficient immune responses that make it harder to fight infections like bacteria and viruses that cause pneumonia.
2) When infections reach the lungs, the lack of a strong immune response allows bacteria to easily spread through the fluid-filled air spaces.
3) Several studies have found that the lack of nutrients like leptin due to severe malnutrition increases the risk of death from pneumonia through respiratory failure and shock.
This document discusses the relationship between yoga and cardiovascular disease. It begins with an introduction to cardiovascular disease, describing the main types and common causes like hypertension, obesity, stress, and diabetes. It then outlines how regular yoga practice, including various asanas, pranayama techniques, meditation, and an sattvic diet, can help treat and prevent cardiovascular disease by reducing risk factors. Specifically, it explores how yoga helps lower blood pressure and stress levels, manage weight, and improve heart health. The document concludes by discussing cardiac yoga, a style focused on cardiovascular benefits.
This study aims to examine the prevalence of anemia among stunted children aged 4-10 years and its impact on physical fitness. It will assess the nutritional status of 60 boy and girl samples through anthropometric measurements and 24-hour dietary recalls, analyze hemoglobin levels, and evaluate the effect on physical fitness using a 1-mile run test on 30 stunted children. Results and conclusions will then be drawn from statistical analysis of the collected data.
The study aimed to assess and compare the nutritional status, body composition, physical activity levels, and injury rates between karate students and non-karate students aged 13-17 years. It found that karate students generally had lower socioeconomic status and were underweight, while non-karate students had higher socioeconomic status and were overweight. Both groups had inadequate nutrient intakes compared to RDA values, but karate students' intake was more deficient due to their financial constraints. Significant correlations were also found between physical activity and BMI for both groups, as well as between fat intake and BMI for boys and protein intake and BMI for girls. The study highlights the vulnerability of karate students to nutritional deficiencies and injuries due to vigorous
This study assessed the nutritional status and knowledge of 60 post-operative coronary artery bypass grafting (CABG) patients in India. The results showed that most patients had a poor nutritional status, as over 60% were overweight or obese. Many patients had medical histories of diabetes and hypertension. The dietary surveys found that over 65% of patients consumed below the recommended daily calorie intake, with low protein and fiber intake. Patients' diets relied on readily available and inexpensive foods like refined wheat products, with high fat and low fruit and vegetable consumption. The study concluded that patients lacked nutritional knowledge and consumed an unbalanced diet, suggesting the need for pre-surgical nutrition education and status assessments.
The document discusses intermittent fasting, which involves consciously skipping meals or restricting eating to specific time windows. It describes several intermittent fasting protocols, such as 16/8 where eating is restricted to an 8-hour window daily. The document then discusses the history of intermittent fasting and how modern lifestyles differ from when our genes evolved. Intermittent fasting is said to help regulate metabolism, increase resistance to stress, convert white fat to brown fat, improve brain function, protect against diseases, and reduce cardiovascular disease risk factors.
Brown rice has several health benefits over white rice. It is higher in nutrients like magnesium, fiber, and antioxidants. Studies show brown rice may help reduce risk of cardiovascular disease, obesity, and diabetes. The antioxidants and fibers in brown rice help lower blood glucose and cholesterol levels. Brown rice also acts as an antioxidant, helping reduce oxidative stress and potentially preventing cancer cell growth. Further research is still needed on the bioavailability of brown rice's beneficial components in humans.
This document discusses the health benefits of tulsi (Ocimum sanctum), also known as holy basil. It provides information on tulsi's use in Ayurveda and Hinduism. The document then summarizes several studies that demonstrate tulsi's anti-diabetic, hypolipidemic, anti-inflammatory, and other health benefits. These studies show that consuming tulsi or its extracts can help reduce blood sugar, cholesterol, symptoms of diabetes, asthma, ulcers, and more. In conclusion, tulsi has many medicinal properties and can help prevent and treat various diseases.
This document summarizes a study assessing the impact of lifestyle interventions on men and women aged 24-50 with prediabetes in Mumbai, India. The study involved 35 participants who received nutritional education and were encouraged to increase physical activity and make healthier diet choices. Biochemical parameters, eating habits, and physical activity levels were measured before and after the 2-month intervention. The results showed reductions in fasting blood sugar, post-lunch blood sugar, consumption of fried and junk foods, and sweetened products. Physical activity levels increased. The nutritional education and lifestyle changes had a positive impact on the health of prediabetic participants.
1) The study examined the effect of calcium status on 80 hypertensive patients aged 35-70 years.
2) Biochemical parameters and dietary intake were analyzed and found that serum calcium levels and dietary calcium intake were significantly lower in grade 1 hypertensive patients compared to normotensive patients.
3) Anthropometric measurements like age, hip circumference, and energy intake were positively associated with hypertension, while serum calcium and dietary calcium were inversely associated with hypertension.
This document discusses a study on metabolic syndrome among young adults in Mumbai, India. The study aims to identify risk factors for metabolic syndrome such as family history, lifestyle habits, nutrition status and dietary patterns. Anthropometric measurements were taken for 200 participants aged 18-24 years old from various areas in Mumbai. Questionnaires assessed physical activity, lifestyle and dietary intake. Results found higher prevalence of obesity in participants with a family history of diseases. Obese participants consumed more non-vegetarian diets and were less physically active. Significant factors for metabolic syndrome risk among young adults in Mumbai were identified.
The study aimed to determine the prevalence of obesity among young girls aged 18-22 years in the Dawoodi Bohra community in central Mumbai. A sample of 405 girls was assessed using anthropometric measurements, dietary recalls, and questionnaires. The results found a 5% prevalence of obesity and 15% prevalence of overweight individuals. Obese and overweight subjects had higher calorie and fat intake compared to recommendations. Neck circumference of 33.35cm or more accurately predicted obesity with high sensitivity and specificity. Overall, dietary patterns needed improvement and more physical activity was recommended to manage weight.
The study aimed to determine the impact of an 8-week nutrition education program on the knowledge, attitudes, practices, and lifestyle habits of 150 orphan girls aged 10-15 in Mumbai, India. Baseline assessments found the girls' diets to be deficient in some nutrients compared to recommendations. After the program, the girls' nutrition knowledge and attitudes increased significantly, though their practices did not fully change due to relying on institution-provided meals. Overall, the study suggests nutrition education can improve orphan girls' health literacy but that organized feeding and hygienic living conditions also need to be addressed for optimal nutrition status.
The document discusses a study that assessed the nutritional status and feeding practices of toddlers aged 12-24 months in Mumbai, India. 90 mothers participated in interviews about their child's feeding patterns, diet, and anthropometric measurements. Key findings included that working mothers were less likely to breastfeed, families with higher incomes preferred readymade foods, and toddlers' weight and height increased with age appropriately. The type of food fed did not significantly impact the toddlers' current nutritional status.
- Dietary fiber is classified as soluble or insoluble and comes from plant foods. Bananas are a good source of soluble fiber that can promote fullness.
- Childhood obesity has increased globally and contributes to health issues. The study aimed to evaluate if banana fiber intake affected weight loss in overweight Indian children aged 4-13 years.
- Over 3 months, anthropometric measures declined more for children supplemented with bananas compared to controls, indicating banana fiber aided weight loss. Banana fiber intake was associated with reduced food cravings and feeling full.
This study evaluated the effects of consuming a mixture of cinnamon, clove, and bay leaf powder on blood glucose levels in 100 type 2 diabetes patients aged 30-70. The experimental group (n=33) consumed 6g per day for 6 weeks, while the control group (n=31) did not. Fasting blood sugar significantly decreased in the experimental group compared to controls. Both fasting and post-prandial blood sugars also significantly decreased within the experimental group pre- and post-intervention. Protein intake increased and fat intake decreased significantly in the experimental group as well. The study concluded the herbal mixture can help control blood glucose levels in type 2 diabetes patients.
This study aimed to evaluate the effect of a nutrition and lifestyle education program on the nutritional status of 150 elderly adults (ages 50-95 years) living in two old age homes in Mumbai, India. The study assessed nutritional status, nutrient intake, nutrition knowledge, and happiness levels before and after the 2-month education program. The results showed slight improvements in BMI, fruit and vegetable intake, physical activity, and nutrition knowledge after the intervention. However, no significant differences were found in energy, protein, fat, or carbohydrate intake between BMI groups before and after the program. The study concluded the education program had a positive impact on behaviors and eating habits of the elderly participants.
The document summarizes a study on the effect of physical activity on clinical manifestations of dysmenorrhea in young women. The study involved 80 dysmenorrheic young women divided into experimental and control groups. The experimental group performed yoga exercises for 8 weeks while the control did not. Results showed a reduction in pain intensity and medicine use in the experimental group, though changes in weight, BMI and waist circumference were minor. Limitations included a short study duration and small sample size. Recommendations included a longer study period and larger sample size.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
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2. INTRODUCTION.
Bulbous plant.
Height- 1.2 m
Family- allium
Botanical name- allium sativum
Uses- in seasoning, flavouring food.
also as a medicine.
23.Leyla Bayan,1 Peir Hossain Koulivand,1 and Ali Gorji1,2,*. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed. 2014 Jan-Feb
Prapti Gandhi. Dr.BMN college of home science
3. History of garlic
During olympics in Greece, atheletes used garlic to
improve stamina
Ancient Indian and Chinese medicine- respiration,
digestion, leprosy, parasitic infestation.
Used by Sumerians and Egyptians.
23.Leyla Bayan,1 Peir Hossain Koulivand,1 and Ali Gorji1,2,*. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed.
2014 Jan-Feb
Prapti Gandhi. Dr.BMN college of home science
4. Nutritional value
Prapti Gandhi. Dr.BMN college of home science
https://depositphotos.com/118637586/stock-illustration-nutritional-value-of-garlic.html
5. Bio-active components of garlic
Garlic consist of several sulfurous phytochemical compounds.
Allin- sulfurous compound.24
allinase
Allin Allicin
(when fresh raw
garlic is crushed)
Prapti Gandhi. Dr.BMN college of home science
. Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM. The Health Benefits of Garlic: Nature’s Best Medicine. Published on December 13,
2016
6. Allin
Diallyl disulside Diallyl trisulfide Diallyl tetrasulfide
Allicin
Prapti Gandhi. Dr.BMN college of home science
Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM. The Health Benefits of Garlic: Nature’s Best Medicine. Published on December 13,
2016
8. Anti- Microbial properties.
Allicin and Aged Garlic Extract -
Anti-oxidant properties
Practically vapour form more preferable
anti-inflammatory effects
gamma delta-T cells and Nk cells
1.Daynea Wallock-Richards et al. Garlic Revisited: Antimicrobial Activity of Allicin-Containing Garlic Extracts against Burkholderia cepacia Complex. December 1,
2014
2.Jana Reiter et al. Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains,
as a Vapor. Molecules. 2017 Oct 12
3.Fozieh Jahani Moghadam et al. Antibacterial Activity of Garlic (Allium sativum L.) on Multi-Drug Resistant Helicobacter pylori Isolated From Gastric Biopsies. Int
J Enteric Pathog. 2014
4.Mahmoud Zardast et al. Assessment of antibacterial effect of garlic in patients infected with Helicobacter pylori using urease breath test. Avicenna J Phytomed.
2016 Sep-Oct
5.Nantz MP et al. Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a
randomized, double-blind, placebo-controlled nutrition intervention. Clin Nutr. 2012 Jun
Prapti Gandhi. Dr.BMN college of home science
9. Mechanism
Bacteria- GSH or cysteine residues
GSH or cysteine acted upon by free
thiols present in allicin
By sulfhydryl modifying activity
inhibits action of bacteria.
Prapti Gandhi. Dr.BMN college of home science
10. Anti-Hypertensive properties
Allicin present in garlic-
Reduces hypertension with no side effects.
Allicin reduces SBP by 10%
Allicor is more effective than kwai
500 mg capsules- twice in a day showed better effect SBP.
6.Marjan Mahdavi-Roshan et al. Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial
Study. Iran Red Crescent Med J. 2016 Nov
7. Ried K etal. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. Eur J Clin Nutr. 2013 Jan
8.Sobenin IA et al. Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension.
Hypertens Res. 2009 Jun
9.Kshitij Bhardwaj, Manish Kumar Verma, Narsingh Verma, Shipra Bhardwaj, Saumya Mishra. Effect of long term supplementation of active garlic allicin
in reducing blood pressure in hypertensive subjects. Vol 2, No 3 (2015) Bhardwaj.
10.Chuan Hsiao Han et al. Antihypertensive activities of processed garlic on spontaneously hypertensive rats and hypertensive humans. Journal Botanical
Studies
Prapti Gandhi. Dr.BMN college of home science
11. Mechanism
11
Mediation of
intracellular
nitric oxide
Mediation of
intracellular
hydrogen
sulphide
Obstruction
of
angiotensin-
II production
11.Karin Ried and Peter Fakler. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014
Prapti Gandhi. Dr.BMN college of home science
12. AGE increases thiol
antioxidants-
increases NO
eNOS
(synthesis
requires L-
arginine and
BH4 cofactor)
By
guanylyl
cyclase
dependent
pathway
Increase in
dilation of
blood vessels.
Hydrogen sulphide
mediates through
sulfhydration of ATP-
sensitive potassium
channels
Voltage sensitive
channel opens
Vascular relaxation
of smooth
muscles
AGE inhibits
angiotensin-II enzyme
Suppresses
angiotensin-II
production
Leads to
vasodilation and
reduces
hypertension
Prapti Gandhi. Dr.BMN college of home science
13. Garlic in CVD
Supplements- AGE capsule(250 gm), vit B12(100 micro gm), l-arginine(100mg), folic
acid(300micro gm), vit B6(12.5 mg) for 1 year
Prevents atherosclerosis
total cholestrol, homocysteine, LDL-C, IgG and IgM were decreased. HDL-C, Lp(a)
levels increased in controlled group
wEAT and homocysteine levels in AGE+S group
bEAT/wEAT, TR=vascular function
Mechanism
AGE+S inhibits damage of NO synthesis. Arginine increases NO bioavailability, thus prevents
vascular stiffness.
12.Isaacsohn JL et al. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch Intern Med. 1998 Jun 8
13.Matthew J.BudoffM.D et al. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Preventive Medicine, Volume 39, Issue 5,
November 2004
14.Budoff MJ etal. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med. 2009 Aug-Sep
15.Seo DY et al. Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women. Nutr Res Pract. 2012 Jun
16.Ahmadi N et al. Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis. Int J
Cardiol. 2013 Oct 3
Prapti Gandhi. Dr.BMN college of home science
14. Anti-
cancer
properties
In ovarian
cancer
In Saos-2
osteosarcoma
Breast cancerLiver cancer
Pancreatic
cancer
Anti-cancer properties
18.Xu Y1, et al S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1.
19.Wen-Peng Xie et al. Treatment of Saos-2 osteosarcoma cells with diallyl trisulfide is associated with an increase in calreticulin expression. Exp Ther Med. 2018 Jun;
20.Malki A et al. Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells. Cancer Biol Ther. 2009 Nov;8
21.Wu CC et al. Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. Food Chem Toxicol. 2004 Dec
22.Hong-Bing Ma et al. Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells. World J Gastroenterol. 2014 Jan 7
Prapti Gandhi. Dr.BMN college of home science
15. Type of cancer Bio-active compound of
garlic
Result
Ovarian cancer S-allyl cysteine SAC arrest G1/S phase of A2780 cell
Decreases level of DNA methylation, DNMT1
DNMT1- process of DNA methylation
DNA methylation- causes cancer development
Osteosarcoma cells Diallyl trisulfide (DAT) DATS- calreticulin(CRT) expression osteosarcoma cells.
CRT supplies macrophages to tumor cells to attack, produces killer lymphocytes,
decrease blood supply to tumor tissue
Breast cancer Diallyl trisulfide (DAT) apoptosis in MCF-7 cell lines.
Increases expression levels of FAS and cyclin D1(apoptotic cells)
Decreases expression of Akt and Bcl-2 (cancer cell lines).
Liver cancer Diallyl sulfide(DAS), diallyl
disulfide(DADS), diallyl
trisulfide(DATS)
DATS-more effective in inhibiting cells.
DATS reduces cyclin dependent kinase-Cdk7 protein levels in J5 and increases
cyclin B1 level.
Modulation potency- DATS>DADS>DAS
Reason- sulfuric atom numbers in structure of this allyl sulfides
Pancreatic cancer Diallyl trisulfide(DAT) expression of FAS, p21, p53 and cyclin B1 (apoptotic causing cells)
expression of Akt, MDM2 and Bcl-2(causes inhibition of apoptosis)
DATS - capan-2 cells apoptosis than in H6C7 cells
Prapti Gandhi. Dr.BMN college of home science
16. CONCLUSION
Garlic have shown many positive effects on various diseases like
microbial infection, hypertension, CVD, cancer.
Allicin plays a chief role in reducing blood pressure, as anti-
microbial.
It has anti-oxidant and anti-inflammatory properties due to
presence of phytochemicals, flavonoids- inhibits infection.
Garlic also lowers risk of atherosclerosis
It is anti-thrombogenic, anti-oxidant, vasodilator, lowers LDL-C,
TG levels, lowers cholestrol
Prapti Gandhi. Dr.BMN college of home science
17. Studies about CVD still needs more research because different forms
and constituents used gives variation in results. Dose and amount,
process for lowering calcification has to be clearly described.
DATS shows anti-cancer properties by cell cycle arrest, inhibiting cancer
cell growth, apoptosis in various cancer cells like of ovarian, pancreatic,
liver, breast cancer etc.
Positive results are found but investigation for proper mechanism of
apoptotic nature has to be described.
People who are sensitive to sulfur can have flatulance, bloating, burning
sensation.
Thus garlic can be said to be a super food due to multi-functional
properties. Consuming 2 garlic a day is recommended.
Prapti Gandhi. Dr.BMN college of home science
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Prapti Gandhi. Dr.BMN college of home science