This document discusses the health benefits of tulsi (Ocimum sanctum), also known as holy basil. It provides information on tulsi's use in Ayurveda and Hinduism. The document then summarizes several studies that demonstrate tulsi's anti-diabetic, hypolipidemic, anti-inflammatory, and other health benefits. These studies show that consuming tulsi or its extracts can help reduce blood sugar, cholesterol, symptoms of diabetes, asthma, ulcers, and more. In conclusion, tulsi has many medicinal properties and can help prevent and treat various diseases.

1. Tulsi(Ocimum sanctum):
A Key To Various Health
Benefits.
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2. INTRODUCTION
• Tulsi (ocimum sanctum), also known as holy
basil is an aromatic plant in the family
Lamiaceae i.e. mints.
• Tulsi is cultivated for religious, medicine
purpose and for its essential oil.
• It is widely used as a herbal tea, in Ayurveda
and has a place within the Vaishnava
tradition of Hinduism, in which devotees
perform worship of Tulsi plant
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3. Tulsi, fresh leaves
Nutritional value per 100 g (3.5 oz)
Energy 94 kJ (22 kcal)
Carbohydrates 2.65 g
Dietary fiber 1.6 g
Fat 0.64 g
Protein 3.15 g
Vitamins Quantity
Vitamin A equiv.
beta-Carotene
264 μg
3142 μg
Thiamine (B1) 0.034 mg
Riboflavin (B2) 0.076 mg
Niacin (B3) 0.902 mg
Pantothenic
acid (B5)
0.209 mg
Vitamin B6 0.155 mg
Folate (B9) 68 μg
Choline 11.4 mg
Vitamin C 18.0 mg
Vitamin E 0.80 mg
Vitamin K 414.8 μg
Minerals Quantity
Calcium 177 mg
Copper 0.385 mg
Iron 3.17 mg
Magnesium 64 mg
Manganese 1.148 mg
Phosphorus 56 mg
Potassium 295 mg
Selenium 0.3 μg
Sodium 4 mg
Zinc 0.81 mg
Water 92.06 g
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4. • HEALTH BENEFITS OF TULSI:
• Anti-inflammatory
• Antioxidant
• Anti-diabetic
• Hypolipidemic
• Anti-asthamatic
• Anti-ulceric
• Immune-booster Bazila Surve.
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5. TULSI AS ANTI-DIABETIC DRUG.
Mechanism of Ocimum sanctum as anti-diabetic agent:
Ocimum
sanctum
sensitivity to
insulin receptor
Stimulate B-
cells
to release
insulin
Increase insulin
secretion
Decrease
glucose level
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6. • 30patients(5mg)Glibenclamide
• 30 patients (5mg+250mg)
Glibenclamide +
Ocimum sanctum
G (g/dl) G + O.S
(g/dl)
G(g/dl) G+ O.S
(g/dl)
FBG FBG PPBG PPBG
Day 1 174 171 247 254
Day 30 147 134 198 182
Day 90 114 103 152 143
Result: G + O.S group show more reduction in glucose levels.
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7. TYPE 2 DM
A,B,C
Handful of fresh leaves
Morning, afternoon,
night
5 weeks
Sr.
No
Treated
diabetes
mellitus
individual
0-Day
period
blood
sugar
level[m
g%]
7-Day
period
blood
sugar
level[m
g%]
14-Day
period
blood
sugar
level[m
g%]
21-Day
period
blood
sugar
level[m
g%]
28-Day
period
blood
sugar
level[m
g%]
35-Day
period
blood sugar
level[mg%]
1 A 250 240 225 200 160 110
2 B 200 195 185 165 130 80
3 C 230 220 205 180 140 90
Result: Tulsi decreases blood sugar level.
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8. Group 3-
mixture of
both leaf
powder
Group 2-
neem leaf
powder
Group 1-tulsi
leaf powder
(2gm)
2gm
powder
of each
90 Male NIDDDM,
3 mnths 3Group of
30 each
Group 1 Group 1 Group 2 Group 2 Group 3 Group3
Symptom Before After Before After Before After
Polydipsia 23 15 21 14 24 14
Polyuria 21 17 19 13 22 16
Polyphagia 19 15 17 11 15 9
Tiredness 15 13 11 9 16 12
Sweating 9 6 10 6 10 8
Result: More reduction in symptoms was seen in group3
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9. Feed was given
for 8 week
regularly in
morning
5 diabetic rat
Treated with saline
water.
0.1ml/100mgb.w
5 diabetic rat
Treated
with200mg/kgb.
wt of tulsi water
Group Plasma glucose
mg/dl
Plasma glucose mg/dl
At 0 week At 8 week
Diabetic+ saline 165 300
Diabetic+ Tulsi 172 112
Result: Tulsi as an anti-diabetic drug.
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10. • 20 hyperlipidemic & 20 hyperglycemic male patients.
• 3gm of powdered tulsi was given before & after
breakfast for 45 days.
Mg/dl (0 day) Mg/dl (45 day)
T. Cholesterol 163 148
Triglyceride 165 140
LDL 97 84
HDL 60 65
FBG 156 135
PPBG 199 150
Result: Decrease in TC, TG, LDL,FBG, PPBG & increase in HDL
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11. • 100 hyperlipidemic & hyperglycemic patients.
• one group of 50 served as control group
• Another group of 50 received Tulsi extract and served as study group.
Study group were asked to take 5ml of Tulsi extract with plain water in
morning and evening before food for three months regularly.
Parameters Control
group
(Before)
Study group
(After)
Control
group
(Before)
Study group
(After)
FBS(mg/dl) 203 202 209 155
TC(mg/dl) 257 256 244 209
TG(mg/dl) 176 175 176 138
HDL(mg/dl) 33 33 33 39
LDL(mg/dl) 169 167 174 142
VLDL(mg/dl) 35 33 35 27
Result: Decrease in FBS, TC, TG, LDL, VLDL & increase in HDL.
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12. • These all study on diabetes proved tulsi as an
anti-diabetic & hypolipidemic drug.
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13. • Study on Anti-tuberculosis effect of Tulsi in
macrophage cell culture.
• Anti-tb effect was because of different oil
present in tulsi & mostly because of eugenol.
Concentration 50ml 75ml 100ml
Colony count 20 11 0
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14. Tulsi as an disinfectant.
100mg
of tulsi
leaf
extract
1 litre of
tapwater &
river water
each
Treated
for 16 hrs
5 ml of
water
sample
removed
at every
hour
Estimation of
microorganis
m by plate
count
method
Microbial
population
decreased
from 22000
cells to 16000
cells
Tulsi as an
disinfectant
.
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15. Effect of Tulsi on air travel health
problems.
• Air travel health problem- noise-stress, jet-
lag( Rapid Time Zone Change Syndrome),
psychological stress, nausea, discomfort, etc.
• Fresh leaves of tulsi yield some phenolic
compounds (antioxidants), apigenin,
rosameric acid, eugenol which have
pharmacological effects.
• Tulsi consumption in the form of tea before,
after or during travel help to prevent or
remove the ill-effects of air travel on human
body system. Bazila Surve.
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16. Tulsi as anti-asthamatic drug.
• 50 asthamatic patients - Period- 3 weeks
• 1 week salbutamol sulphate capsule- 1 week washout period- 1
week ocimum sanctum.
• FEV1(Forced expiratory volume)( amount of air exhale by person
in 1 second)
• OS (Tulsi) contains constituents such as methyleugenol, saponins
and ursolic acid is responsible for the anti-asthamatic activity.
DAY0(OS) DAY 0 (SS) DAY 4(OS) DAY 4(SS) DAY7(OS) DAY 7(SS)
2.1 2.2 2.3 2.5 2.4 2.6
1.4 1.4 1.5 1.6 1.6 1.7
2 1.9 2 2.2 2 2.3
2.1 2.1 2.3 2.4 2.3 2.5
1.9 2 2 2 2.1 2
2.4 2.5 2.5 2.7 2.6 2.7
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17. Tulsi as immunomodulatory
• 22 people-2 groups-300mg capsules of ethanolic extracts of leaves of Tulsi-
empty stomach- 4 week
• significant increase in the levels of IFN-γ, IL-4 were observed after 4 weeks
in the Tulsi extract intervention group in contrast to the placebo group.
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18. Anti-Ulceric activity of Tulsi.
To reduce the recurrence of mouth ulcers in 40 night shift workers by
daily consumption of 5tbsp of fresh yogurt, 5 leaves of Holy basil
swallowed in the morning daily for 3 weeks.
Tulsi is abundant in vitamin C, vitamin A, phytonutrients and essential
oils making it an excellent anti-oxidant against free radicals. Its anti-
bacterial properties make it an effective oral disinfectant that destroy
up to 99% of mouth commensal organisms and relieve the symptoms
of ulcer. Tulsi has anti-ulcerogenic and ulcer-healing properties.
After 3 week
No ulcer 29
Recurrence of ulcer 11
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19. • 30 ulcer rat- 5 groups of 6 animals each.
• Group I served as control in which distilled water (10 ml/kg).
• Group II, III & IV received ocimum sanctum leaf extract in doses of 50
mg/kg, 100 mg/kg & 200 mg/kg respectively. Group V was given ranitidine
(10 mg/ kg) served as standard for comparison. All the drugs are given
orally once daily for 7 days.
• Result show that the grp which were fed with 200mg of tulsi show similar
activity as that of rantidine & ulcer were reduced in that group.
• The mechanism is that tulsi act on neural pathways controlling acid
secretion thereby strengthening the physiological capabilities to decrease
stress and hence reduce ulcers.
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20. CONCLUSION:
• Holy Basil or Tulsi or Ocimum Sanctum is a treasure of various
health benefits.
• Including them in our diet will help us to cure or prevent various
disease.
• It has anti-diabetic, hypolipidemic, antioxidant, anti-tuberculosis,
anti-asthamatic, immunomodulatory & anti-ulceric properties &
thus serve as a key to various health benefits.
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21. Bibliography
1Diverse Role of Ocimum Sanctum: A Magic Remedy of Nature.
Harsimran Singh, Mishu Sharma, Jagdeep Kaur, Pms Bedi, M.U. Khan
Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab, India
Received 21/06/2013 Available online 30/06/2013
2. EVALUATION OF THE ANTIDIABETIC EFFECT OF OCIMUM SANCTUM IN TYPE 2
DIABETIC PATIENTS.
G. SOMASUNDARAM, K. MANIMEKALAI, KARTIK J. SALWE AND J. PANDIAMUNIAN
Department of Pharmacology, Mahatma Gandhi Medical College & Research
Institute,
Pillaiyarkuppam, Puducherry 607402.
Vol 2/Issue 3/Jul-Sept 2012
3. Leaves of Ocimum Sanctum [LOS]: A Potent Anti-diabetic Herbal Medicine.
ISSN 2278 – 0211 (Online)
Dr. Srinivasa Prasadacharyulu Ch.
Reader, Department of Biochemistry
S.K.P. Govt. Degree College, Guntakal, Andhra Pradesh, India.
April, 2014 Vol 3 Issue 4

22. 4. Effect of supplementation of tulsi (ocimum sanctum) and neem (azadirachtaindica) leaf
powder on diabetic symptoms, anthropometric parameters and blood pressure of non
insulin dependent male diabetics.
Anita Kochhar, Neha Sharma & Rajbir Sachdeva
Published online: 02 Oct 2017
5. Effect of Tulasi (Ocimum Sanctum) on Diabetes mellitus.
D.T. Khogare
Govt. Rajaram College, Kolhapur
Vol. 1, Issue II / March 2011, pp. 189-191
6. Effect of Ocimum Sanctum (Tulsi) Powder on Hyperlipidemic and Hyperglycemic Male
Patients.
Dr. Bhavana Chauhan
Volume – 1 | Issue – 5
IJTSRD | Available Online @ www.ijtsrd.com
7. Effect of Tulsi (Ocimum sanctum Linn) on clinical and biochemical parameters of
metabolic syndrome.
D.K.Devra, K.C.Mathur, R.P. Agrawal, Indra bhadu, Shekhar goyal, Vivek agarwal,
Department of physiology, S.P.Medical College, Bikaner diabetes care & research centre,
S.P. Medical College, Bikaner. Vol. 12/1 (2012) 63-67
8. Effect of Ocimum sanctum Leaf Powder on Blood Lipoproteins, Glycated Proteins and
Total Amino Acids in Patients with Non-insulin-dependent Diabetes Mellitus.
V. RAI MSC, U. V. MANI MSC PHD FICN AND U. M. IYER MSC PHD
Pages 113-118 | Published online: 13 Jul 2009

23. 9. Anti Tuberculosis effect of ocimum sanctum extracts in vitro and microphage
culture.
Taghi Naserpour Farivar, Amir Hossein Mohaghedi Fard, Mohammed Naderi
May – June 2006
Journal of Medical Sciences.
10. Effect of Tulsi (Ocimum sanctum) as a Disinfectant for Water Treatment
Pavithra Sundaramurthi, Saranya Dhandapani, Sankar Ponnusamy, Murugesan
Subbaiyan
[accessed Sep 02 2018] VOL -1 (1), JAN 2012
11. Tulsi: A potential protector against air travel health problem.
Narendra singh, Marilena Gilca
Received 22 December 2006 Accepted 30 April 2007
Natural Product Radiance Vol 7(1)
12. Bronchodilator activity of Ocimum sanctum Linn. (tulsi) in mild and moderate
asthmatic patients in comparison with salbutamol: a single-blind cross-over study.
Vinaya M, Kudagi B. L, Mohammed Ameeruddin Kamdod, Mallikarjuna Swamy
International Journal of Basic & Clinical Pharmacology
Received: 03 February 2017
Accepted: 14 February 2017

24. 13. Double-blinded randomized controlled trial for immunomodulatory
effects of Tulsi
(Ocimum sanctum Linn.) leaf extract on healthy volunteers.
Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, Mehta
, Mahapatra SC
Jul 14;136(3):452-6. doi: 10.1016/j.jep.2011.05.012. Epub 2011 May 17.
14. Consumption of Yogurt, Aloe-vera pulp and Holy Basil leaves to
reduce the recurrence of aphthous mouth ulcers in night shift workers.
Dr. Prashant Devidas Khuje and Dr Sandeep M Hulke
Received: 16-02-2017 Accepted: 17-03-2017
International Journal of Applied Research 2017; 3(4): 807-809
15. EVALUATION OF ANTIULCEROGENIC ACTIVITY OF OCIMUM
SANCTUM LINN IN STRESS
INDUCED ULCER IN RATS
Ayesha Vaseem, Naseeruddin Nadeem, Mazher Ali, Khuteja Afshan,
Mujtaba T Rumana.
INTERNATIONAL JOURNAL OF PHYTOTHERAPY RESEARCH
Volume 4 Issue 4, 2014

25. THANK YOU.