This document summarizes the evolution of hormonal contraceptives, including their mechanisms of action, modifications over time to dosage and delivery methods, and advantages and disadvantages. It describes the approval and characteristics of early oral contraceptives, followed by developments in injectables, patches, rings, IUDs and implants. Newer progestins were designed to reduce side effects while maintaining efficacy. Extended and low-dose regimens aim to improve tolerability. Emergency contraception effectively prevents pregnancy when used shortly after intercourse. Hormonal contraceptive use is associated with a small increased risk of breast cancer, though this risk decreases after stopping use.
Explain the wider meaning of family planning.
Give contraceptive counselling.
List the efficiency, contraindications and side effects of the various contraceptive methods.
List the important health benefits of contraception.
Advise a postpartum patient on the most appropriate method of contraception.
Contraception Successes: IUDs and ImplantsSummit Health
Although unintended pregnancy rates in the United States have been static (approximately 51%) for many years, long-acting reversible contraception such as intrauterine devices (IUDs) and contraceptive implants may be reliable alternatives to prevent unwanted pregnancies and further lower unintended pregnancy rates. Join us to learn more about how long-acting reversible contraception may help you!
Explain the wider meaning of family planning.
Give contraceptive counselling.
List the efficiency, contraindications and side effects of the various contraceptive methods.
List the important health benefits of contraception.
Advise a postpartum patient on the most appropriate method of contraception.
Contraception Successes: IUDs and ImplantsSummit Health
Although unintended pregnancy rates in the United States have been static (approximately 51%) for many years, long-acting reversible contraception such as intrauterine devices (IUDs) and contraceptive implants may be reliable alternatives to prevent unwanted pregnancies and further lower unintended pregnancy rates. Join us to learn more about how long-acting reversible contraception may help you!
These slides contain the information about Estrogen, its basic pharmacology, its synthesis in human body, Functions of estrogen, role in female puberty, Agonists of estrogen and antagonists of estrogen, also contain detail of the receptors associated with the estrogen functioning.
progestins pharmacology and different forms of it............................................................................................................................................................................................................................................
Caleva Process Solutions
http://www.caleva.com
Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection of slides will provide you with some very useful information on Extrusion Spheronization. This includes general information, the process of Extrusion Spheronization, Wet Massing and Pelletization!
For more information on Extrusion Spheronization, visit:
http://caleva.com/
the deliberate use of artificial methods or other techniques to prevent pregnancy as a consequence of sexual intercourse. The major forms of artificial contraception are barrier methods, of which the most common is the condom; the contraceptive pill, which contains synthetic sex hormones that prevent ovulation in the female; intrauterine devices, such as the coil, which prevent the fertilized ovum from implanting in the uterus; and male or female sterilization.
EMERGENCY CONTRACEPTION & RECENT ADVANCEMENT OF CONTRACEPTION.pptxTanuShekhawat6
EMERGENCY CONTRACEPTION & RECENT ADVANCEMENT IN CONTRACEPTION
Introduction
Emergency contraception (EC) is a method of contraception used as an emergency procedure before menstruation is missed, to prevent pregnancy following unprotected intercourse or expected failure of contraception.
Cont..
Emergency contraception is any method of contraception which is used after intercourse and before the potential time of implantation. This nomenclature, advocated by WHO lately and accepted by international Medical Advisory Panel and others recently.
Alternative terms: Postcoital contraception- still commonly used and 'morning after' contraception
Emergency contraception is not true contraception but rightly called interception. Interceptive - agents that do not interfere with fertilization but act on blastocyst before or soon after missing periods.
Emergency contraception is a backup plan. It cannot be used as an ongoing method of contraception because:
i) relatively high failure rates
ii) High incidence of irregular bleeding
INDIAN SCENARIO: NEED
India has the highest number of unsafe abortions in the world.
6,20,472 abortions reported in India in 2012, Two-third of them were unsafe
A woman dies every two hours due to unsafe abortion.
Widespread availability of EC can help reduce these abortions.
INDICATIONS
1. For aged couples who meet very infrequently.
2. Following single act of sexual exposure in young girls
3. When pregnancy is apprehended owing to rupture of condom, premature ejaculation in couples practising coitus interruptus etc.
4. In case of rape.
ADVANTAGES
Saves the couple from unwanted pregnancies
From unnecessary operative interferences for fear of pregnancy
From the agony of waiting for the next menstrual cycle.
Prevents adolescent pregnancies
Helps to reduce unsafe abortion
COMBINED ETHINYL ESTRADIOL AND LEVONORGESTREL (YUZPE METHOD)
Yuzpe method (Canadian Prof. Albert Yuzpe) consists of the oral administration of 2 doses of 0.1mg(100 µg) ethinyl estradiol (EE) and 0.5mg(500 µg) levonorgestrel 12 hours apart.
Failure rate- 0-2%
Ovral tablets (each containing 50 µg ethinyl estradiol and 250 µg levonorgestrel) are most commonly used to provide these doses.
Others- Noral, Ovidon
PROGESTIN-ONLY (LEVONORGESTREL)
In India- EC pill, Pill 72, unwanted
LNG-ONLY PILLS
2 doses of 0.75mg LNG pill to be taken orally 12 hours apart within 72hours of intercourse. OR Single dose of 1.5mg LNG pill to be taken within 72 hours of intercourse.
Trials have shown that a high proportion of pregnancies were averted even up to 5days (120hours). WHO recommends levonorgestrel for emergency contraceptive pill use.
Failure rate- 0-1%
Cont.
Side Effects:-
1. Nausea- in 50% using Yuzpe regimen & 20% for Levonorgestrel.
2. Vomiting - in 20% Yuzpe regimen & 5% using LNG-only pills.
If vomiting occurs within 2 hours of taking the pills - the dose should be repeated. In cases of severe vomiting - administer pills vaginally.
3. Irregular uterine bleedi
A brief overview on sorafenib which is used for treatment of Hepatocellular Carcinoma,Renal Cell Carcinoma and Differentiated Thyroid Carcinoma including some indications, side effects, overdose, contraindications and using during pregnancy.
Drugs proposed under the philippine rh lawJenniferStLucy
Many contraceptive drugs have abortifacient (anti-implantation) effects that they are not telling. What has a bad effect on one aspect of the body (prevention of ovulation) will be expected to have other negative effects as well, but this survey is just surprising.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. • The first hormonal contraceptive
Enovid TM
150 ug mestranol and
9.85 mg norethynodrel,
was approved (FDA) in 1960.
• Mechanisms of action:
1. Inhibition of ovulation
2. Modification of the endometrium, thus preventing implantation.
ABOUBAKR ELNASHAR
3. Modifications:
1.Decrease in the dose of estrogen and progestin
2.New progestins to decrease androgenic side
effects.
3. Alternative delivery systems in an effort to
improve tolerability, compliance, and
convenience:
Transdermal,
Subdermal
Injectable
Intrauterine
Vaginal.
ABOUBAKR ELNASHAR
8. 2. COMBINED
Approved by FDA in 2000.
•Cyclofem: 25 mg of DMPA and 5 mg of estradiol
cypionate
•Mesygyna: 50 mg NET-EN and 5 mg estradiol
valerate
•Administered by deep IM every month.
•The contraceptive efficacy is similar to (DMPA) and
OCs, an estimated failure rate of 0–0.1 per 100
woman-years.
•The most common side effect:
irregular bleeding during the first three months.
Over the longer term, however, most women (83%)
have regular menses
ABOUBAKR ELNASHAR
10. Advantages:
1. Return to normal ovulatory cycles is rapid (63 to 112 days
after the final injection)
2. less bleeding
3. Side-effects: similar to OCs.
The product has been removed from the market
ABOUBAKR ELNASHAR
12. The transdermal combined
estrogen/progestin patch
(Ortho EvraTM/EvraTM)
•Approved by the FDA in 2002.
•The patch is 20 cm2 (4X5 cm) and delivers 20 ug/d
of EE and 150 ug/d of noregestromin (a biologically
active metabolite of norgestimate)
•Dose:
one patch weekly for three consecutive weeks,
followed by a patch-free week.
ABOUBAKR ELNASHAR
13. •The patch may be applied to the buttock,
abdomen, upper outer arm, or upper torso
excluding the breasts. Mean serum concentrations
of hormone are not affected by heat, humidity,
exercise, or cold-water immersion
•The observed contraceptive failure was 0.7 per
100woman-years, but was higher in women with
body weight 90 kg
Side effect: similar to OCs
ABOUBAKR ELNASHAR
16. A combined estrogen/progestin vaginal ring
(CVR) (NuvaRing)
•Approved by the FDA in 2001.
•Consists of a flexible ring made of ethylene vinyl
acetate copolymer with an outer ring diameter of 54
mm and a cross-sectional diameter of 4 mm.
•The vaginal ring releases 120 ug of etonogestrel (a
biologically active metabolite of desogestrel) and 15
ug of EE per day.
•Dose: three weeks continuously followed by a one-
week ring-free period to allow for regular menstrual
bleeding.
ABOUBAKR ELNASHAR
19. •Advantage:
CVR is not fitted. It is inserted and removed
by the user and may or may not be removed
for coitus.
•Side effects:
headache (6.6%),
leukorrhea (5.3%), and
vaginitis (5.0%).
•The failure rate:
0.65 per 100 woman-years (95% CI, 0.24–
1.41).
ABOUBAKR ELNASHAR
21. A levonorgestrel (LNG)-releasing intrauterine device
(IUD) (Mirena)
•Approved by the FDA in 2000.
The first progesterone-releasing IUD (Progestasert)
was approved by the FDA in 1976 but was removed
voluntarily from the market in 2001.
•T-shaped with a steroid reservoir containing 52 mg
of levonorgestrel mixed with polydimethylsiloxane,
which controls the release rate of hormone.
•Remains in place for five years.
ABOUBAKR ELNASHAR
23. • Advantages:
1.Failure rate between 0 and 0.2 per 100 woman-
years
2.Ectopic pregnancy rate is 0.02 per 100 woman
years
3.Menstrual bleeding is decreased by 75%
{progestin-induced decidualization and suppression
of the endometrium}
20% to 50% of users become amenorrheic within the
first two years after insertion
4. Following removal, there is rapid return to normal
fecundability
ABOUBAKR ELNASHAR
26. 1. Norplant
•Approved by the FDA in 1990 and withdrawn
from the market in 2002 due to complications
associated with removal.
•This device contained 216 mg of
levonorgestrel in six implantable rods to be
removed after five years.
ABOUBAKR ELNASHAR
28. 2. Norplant II (Jadelle)
•Approved by the FDA.
•Contains two rods 4 cm in length with total
dose of 150 mg of levonorgestrel for a three-
year duration.
•Failure rate: 0.8 to 1.0 per 100 woman-years
ABOUBAKR ELNASHAR
30. 3. Implanon
•Consists of a single non-biodegradable rod
measuring 40 mm in length & 2 mm in
diameter & releases 40 ug etonorgestrel/d
(desogestrel metabolite having less
androgenic activity than levonorgestrel).
The carrier polymer, ethylene vinyl acetate, is
more stable than the silastic material used in
Norplant.
It should be removed 3 y after insertion
ABOUBAKR ELNASHAR
33. Among newer implant delivery systems
currently under development, biodegradable
progestin implants in the form of rods and
pellets have the advantage that the implant
does not need to be
ABOUBAKR ELNASHAR
35. EVOLUTION OF ORAL CONTRACEPTIVES
•Oral contraceptive agents have been
modified over time to limit estrogen and
progestin dosage and decrease side effects.
•Progestin combinations with low dose
estrogens (30–35 ug EE) are effective with
limited side effects.
Lower dose estrogens (20ug EE) and newer
progestins have subsequently been
introduced.
ABOUBAKR ELNASHAR
36. 1. Newer Progestins
•The original progestins used in hormonal
contraceptives were all derived from ethisterone (an
orally active testosterone derivative). Removal of the
carbon at C-19 position confers progestational
activity, with some residual androgenic
activity (19). These progestins are referred to as 19-
nortestosterones and include
norethindrone,
norethynodrel,
norethindrone acetate,
ethynodiol diacetate,
levonorgestrel,
and norethindrone enanthate.
ABOUBAKR ELNASHAR
37. •The newer progestins include
norgestimate,
desogestrel,and
gestodene
These progestins were designed to minimize
androgenic side effects (acne, hirsutism, nausea,
and lipid changes) while increasing progestational
effects. Norgestimate has the greatest
progestational effect, and levonorgestrel is the most
androgenic
•The newest progestin, drospirenone, is an
analogue
of the aldosterone antagonist spironolactone and
exhibits both progestational and antiandrogenic
activity ABOUBAKR ELNASHAR
39. 2. Low dose OCs with 20 ug EE
•Reported pregnancy rates ranging between 0.07–
2.1 pregnancies per 100 woman-years of treatment
•When compared with a 35 ug OC, the 20 ug OC
has comparable cycle control and reduced
symptoms of bloating and breast tenderness
ABOUBAKR ELNASHAR
41. 3. Extended OC Therapy
Idea: to delay or prevent menses has been
evaluated.
•A RCT compared a traditional 28-day cycle to an
extended 49-day cycle of a 30 ug EE/300 ug
norgestrel monophasic birth control regimen
The extended regimen resulted in
Fewer bleeding days
No increase in mean spotting or abnormal bleeding
episodes.
No significant differences in other reported side
effects (headaches, weight gain, cramping, or
breast tenderness).
•Similar results have been obtained with extended
use of OCs containing 20 ug of EE
ABOUBAKR ELNASHAR
42. 4. EMERGENCY CONTRACEPTION
• Effective when used within 72 hours of
unprotected intercourse regardless of stage in
menstrual cycle
• Types:
1.Combined estrogen/progestin regimen
2.Progestin-only treatment regimen
• Dose: two doses, the second administered 12
hours after the first.
ABOUBAKR ELNASHAR
43. • Mechanism of action: inhibition or delay of
ovulation and neither appears to interrupt or
disrupt an already established pregnancy.
Types: (FDA-approved)
1.PrevenTM (pill containing 50 ug of EE and
0.25 mg of levonorgestrel; two pills taken 12
hours apart)
2.Plan B (pill containing 0.75 mg of
levonorgestrel; one pill taken 12 hours
apart).
ABOUBAKR ELNASHAR
46. 3. Progestin-only regimen being significantly
more effective {pregnancies prevented in the
progestin-only and combined regimens was
85% and 57%, respectively}(RR 0.36; 95%
CI, 0.18–0.70).
4. Emergency contraceptive is still less
effective in pregnancy prevention than
consistent use of other contraceptive
methods.
ABOUBAKR ELNASHAR
47. Side effects:
1. Nausea and vomiting are the predominant
side effects (42% and 16% of patients using
the combined regimen, respectively though
these symptoms are significantly less with the
progestin only regimen)
2. Ectopic pregnancy can occur following
emergency contraception, but the risk does not
appear to be increased
ABOUBAKR ELNASHAR
48. Contraindications:
No except pregnancy, although no studies
have investigated outcomes in women with
contraindications to combined
OC
The progestin-only regimen may be a better
choice for women with a personal or a family
history of thrombosis.
ABOUBAKR ELNASHAR
49. Antiprogestins
Mifepristone in a single dose of 600 mg,
100mg, 50 mg, or 10 mg is equally effective
in the prevention of pregnancy and has been
shown to be more effective than the
combined OC regimen with fewer side effects
ABOUBAKR ELNASHAR
50. HORMONAL CONTRACEPTION AND CANCER
RISK
1. Breast Cancer
Breast cancer risk associated with OC use has been
evaluated in a pooled analysis from 54 studies
involving 53,297 women with breast cancer and
over100,000 controls
A small increase in the relative risk of localized
breast cancer associated with current OC use (RR
1.24; 95% CI, 1.15–1.33) and also with OC use
within one to four years (RR 1.16; 95% CI,1.08–
1.23), compared to controls. This risk declines
shortly after stopping use and disappears within 10
years.
ABOUBAKR ELNASHAR
51. .
By age 50, there is no difference in risk of breast
cancer in ever users of OC and controls. Breast
cancers diagnosed in OC users were significantly
less advanced than those in never users (for
spread of disease beyond the breast, RR 0.88;
95% CI, 0.81–0.95).
Overall, there is no evidence of any increase in
lifetime risk of breast cancer among OC users.
Breast cancer risk associated with use of OC in
perimenopausal women has not been evaluated.
ABOUBAKR ELNASHAR
52. 2. Endometrial Cancer
Oral contraceptive use is associated with a lower risk
of endometrial cancer. A meta-analysis found that the
incidence would be reduced by 56%, 67%, and 72%
with use of
combined OCs for four, eight, and 12 years. The
lowered risk of disease persists after stopping OC
use and by 20 years is almost 50% below that in
women who have never used OCs
When taken for more than 12 months, combined
OCs confer equal protection against the three major
histological subtypes of endometrial cancer:
adenocarcinoma, adenosquamous carcinoma, and
adenoacanthoma
ABOUBAKR ELNASHAR
53. Whereas earlier studies evaluated the effect
of high dose OC preparations, a Swedish
case–control study indicates that lower dose
(30–35 g) OC formulations provide
comparable protection
DMPA has been shown to decrease the risk of
endometrial cancer by 80%, with protective
effects lasting for at least eight years after
cessation of treatment
ABOUBAKR ELNASHAR
54. 3. Ovarian Cancer
The risk of ovarian cancer declines with increasing
duration of OC use. The incidence is 41%, 54%,
and 61% lower with use for four years, eight years,
and 12 years, respectively
The protective effects of OCs become apparent
after as little as three to six months of use and
continue for up to 20 years after discontinuation
{The protective effect most likely derives from the
progestin component of the combined OC}
Risk for the four main histologic subtypes of
epithelial ovarian cancer (serous,
endometrioid,mucinous, and clear cell) is reduced to
the same degree.
ABOUBAKR ELNASHAR
55. Ovarian cancer risk associated with OCs
containing the newer progestins, biphasic and
triphasic pills, or lower dose OCs (20 ug EE)
has not yet been clearly defined but appears
similar.
ABOUBAKR ELNASHAR
56. Oral contraceptives may also have protective benefits
for women at risk for hereditary ovarian cancer
Continuous use for 10 years in women with a family
history of ovarian cancer may reduce the risk of
epithelial ovarian cancer to a level less than or equal
to that observed in women with no family history of
the disease
A case–control study involving 207 women with
hereditary ovarian cancer (with BRCA1 and BRCA2
genetic mutations) and 161 of their sisters as controls
found significant protection against ovarian cancer
with any past use of OCs compared with never use
(RR 0.5; 95% CI, 0.3–0.8) Greatest protection was
noted with six or more years of use (RR 0.3; 95% CI,
0.1–0.7). ABOUBAKR ELNASHAR
57. 4. Cervical Cancer
The use of OCs has been associated with an
increased risk of CIN and cervical cancer
However, since the human papillomavirus (HPV)
has been implicated as the main causative agent in
cervical cancer, OC use most likely acts as a co-
factor in the development of this disease.
Hormonal contraception for fewer than five years
did not increase the risk of cervical cancer (OR
0.73; 95%CI, 0.52–1.03). However, risk increased
with use of hormonal contraception for five to nine
years (OR 2.82; 95%CI, 1.46–5.42) and was
greatest with use for 10 years or longer (OR 4.03;
95% CI, 2.09–8.02).
ABOUBAKR ELNASHAR
58. The proposed mechanism for this association
is a hormonal effect on the cervix, a
hypothesis that is supported by the increased
risk of cervical cancer associated with
increased parity and HPV and the correlation
between higher estradiol receptor
concentrations induced by OCs and the risk
of low-grade CIN
ABOUBAKR ELNASHAR
59. 5. Colorectal Cancer
There is growing epidemiologic evidence that OCs
may protect women from developing colorectal
cancer.
In a metaanalysis, the overall estimated relative risk
of colon cancer in OC users was 0.82 (95% CI,
0.74–0.92). The protection was stronger for women
who had used OCs within the previous
10 years (RR 0.46; 95% CI, 0.30–0.71)
ABOUBAKR ELNASHAR
60. MEDICAL RISKS OF HORMONAL
CONTRACEPTION
1. Bone Density
1.DMPA:
{lower ovarian estrogen production resulting from
suppression of gonadotropin secretion}.
decrease in bone density in the spine and distal
radius in women currently using DMPA
ABOUBAKR ELNASHAR
61. Although bone loss correlates with duration of
treatment and becomes significant after 15
years of use, other studies indicate the effect
is reversible after discontinuation of treatment
and therefore may not pose any longer term
risk
ABOUBAKR ELNASHAR
62. 2. The levonorgestrel-containing
contraceptive implant:
a significant increase in lumbar spine bone
density over 12 months.
Studies of forearm bone density in adults
have yielded conflicting results, with both
increases and decreases reported.
The levonorgestrel implant should not
decrease bone density as much as DMPA
{estrogen levels are not as consistently
suppressed, and 19-norprogestogens have a
beneficial effect on bone }
ABOUBAKR ELNASHAR
63. 3. OCs:
in postmenopausal women who have
previously used OCs have revealed improved
bone density that correlates with years of use
Reduced fracture risks that correlate with the
use of high-dose formulations and use after
the age of 40 have also been demonstrated
in postmenopausal women
Short-term studies in current users have
demonstrated a small gain in bone density or
no significant change
ABOUBAKR ELNASHAR
64. 2. Myocardial Infarction
low dose OCs increases the risk of myocardial
infarction by two-fold among users even after
controlling for cardiovascular risk factors (including
smoking, hypertension, hypercholesterolemia,
diabetes, and obesity).
The myocardial infarction risk in OC users is
increased by smoking, an effect that is more
noticeable among women over age 35 years.
Oral contraceptives should therefore be used with
caution in women over age 35 who smoke.
ABOUBAKR ELNASHAR
65. 3. Ischemic Stroke
The risk of ischemic stroke was 2.2-fold
higher (95% CI, 1.9–2.7) with current use of
OCs containing 50 ug ethinyl estradiol,
compared to non-users.
Risk is not related to the progestin
component of OCs
ABOUBAKR ELNASHAR
66. Among women with a history of migraines, the
relative risk of ischemic stroke is not significantly
increased for those using OCs containing 50 ug
ethinyl estradiol, compared to non-users. The risk of
ischemic stroke associated with OCs is not
significantly different in women with simple migraine
(no aura) compared to those with classic migraine
(with aura).
The risk of stroke in women with migraines who use
OCs is increased significantly by smoking
. Oral contraceptives should not be used in patients
with visual changes or focal neurologic deficits
associated with migraine headache (i.e., weakness,
speech deficits).
ABOUBAKR ELNASHAR
67. 4. Hemorrhagic Stroke
OC-associated risk of hemorrhagic stroke for
users under 35 years of age was not
increased compared to non-users (RR 1.0,
95% CI, 0.7–1.5).
For OC users ages 35 and older, the OC-
associated risk of hemorrhagic stroke was
2.2-fold higher compared with non-users
(95% CI, 1.5–3.3).
ABOUBAKR ELNASHAR
68. 5. Venous Thromboembolism
Oral contraceptive use is associated with a three-fold
higher risk of VTE. The risk appears to be
proportional to the estrogen dose VTE risk
associated with newer progestins yielded an absolute
excess risk of 1.5 events per 10,000 woman-years for
women using formulations containing desogestrel or
gestodene
The risk remained significantly elevated for short-
term and long-term users and for users of differing
ages but is far less than that associated with
pregnancy.
Although the risk of VTE is statistically significant, it is
still a rare event and would translate to one to two
cases per 10,000 women years of use
The FDA has suggested no change in prescribingABOUBAKR ELNASHAR
69. The risk of VTE associated with prothrombotic
conditions is further increased with OC use.
The most common of these is the Factor V Leiden
mutation which results in resistance to activated
protein C. The risk of VTE in women who are
heterozygous for the mutation is seven-fold higher
than in non-carriers. In women who are
heterozygous carriers and use OCs, the risk is 35-
fold higher (95% CI, 7.8– 154).
The prevalence of the Factor V Leiden mutation is
5% in Caucasians but extremely low in Asian and
African populations
ABOUBAKR ELNASHAR
70. A genetic defect in prothrombin is also associated
with increased risk of VTE and increases the risk of
VTE in users of OCs. Other known factors involved
in the development of VTE include protein C, protein
S, and antithrombin III deficiencies
The presence of more than one of these mutations
increases the risk of VTE significantly.
Oral contraceptives should not be used in individuals
who carry these mutations. At this time, screening for
these mutations prior to initiating OC use is
recommended only for women having a personal or
family history of thrombosis
ABOUBAKR ELNASHAR
71. CONCLUSIONS
. Hormonal contraception is a safe and
effective form of reversible contraception.
. New transdermal, injectable, vaginal, and
implantable delivery methods appear to have
safety and efficacy comparable to that of OCs.
. Modifications of OCs, including
progressively lower doses of estrogens and
the development of newer progestins, have
maintained contraceptive efficacy while
reducing the incidence of side effects.
ABOUBAKR ELNASHAR
72. .
Emergency contraception using either
combined estrogen/progestin or progestin-
only regimens is effective in reducing the risk
of pregnancy.
The progestin-only regimen may be more
effective with fewer side effects.
ABOUBAKR ELNASHAR
73. .
There is a reduced incidence of endometrial
and ovarian cancers in past and current users
of OCs.
There is a potential for increased risk of
cervical cancer with longer durations of OC
use.
There is no increase in lifetime risk of breast
cancer associated with OC use, although
prevalence is modestly increased in the first
five years of use.
ABOUBAKR ELNASHAR
74. The risk of stroke & myocardial infarction in
reproductive aged women is low, but is
increased in OC users over age 35 who
smoke.
. The risk of VTE is increased in OC users and
higher in those heterozygous for mutations
resulting in prothrombotic conditions.
Screening for thrombophilias prior to initiating
therapy with OCs is recommended only for
women having a personal or a family history of
thrombosis.
ABOUBAKR ELNASHAR