The document is a lecture on the treatment of endometriosis-associated infertility according to 2022 ESHRE guidelines. It discusses various treatment options including medical treatment with hormonal therapies, surgery, assisted reproductive technologies (ART), and fertility preservation. Key recommendations include that ovarian suppression should not be used to improve fertility. Surgery and ART may be considered depending on the stage of endometriosis and patient factors. Extensive counseling is recommended when discussing fertility preservation options.
Invited Lecture delivered by Dr Sujoy Dasgupta in a CME, sponsored by Serum Institute of India Pvt Ltd in the Convocation Ceremony of Interns at Sagor Dutta Medical College
Invited Lecture delivered by Dr Sujoy Dasgupta in a CME, sponsored by Serum Institute of India Pvt Ltd in the Convocation Ceremony of Interns at Sagor Dutta Medical College
Invited Lecture delivered by Dr Sujoy Dasgupta in the Annual Conference of ISAR (Indian Society of Assisted Reproduction) held at Kolkata in November, 2019
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period.
This Presentation is made by Dr.Laxmi Shrikhande
Ovulation Stimulation Protocols for IUI - Dr Dhorepatil BharatiBharati Dhorepatil
What are important factors to be considered important
Ovarian reserve
Previous ovarian response
Basic hormone profile
Role of LH
Trigger
Luteal phase support
Pregnancy rate/cycle
ESHRE Guideline on Recurrent Pregnancy Loss (RPL)Sujoy Dasgupta
Dr Sujoy Dasgupta invited to deliver a lecture on "RPL- ESHRE Guideline" in the Annual Conference of RCOG (Royal College of Obstetricians and Gynaecologists) IRC (International Representative Committee) India East held on 20-21 May, 2023
Invited Lecture delivered by Dr Sujoy Dasgupta in the Annual Conference of ISAR (Indian Society of Assisted Reproduction) held at Kolkata in November, 2019
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period.
This Presentation is made by Dr.Laxmi Shrikhande
Ovulation Stimulation Protocols for IUI - Dr Dhorepatil BharatiBharati Dhorepatil
What are important factors to be considered important
Ovarian reserve
Previous ovarian response
Basic hormone profile
Role of LH
Trigger
Luteal phase support
Pregnancy rate/cycle
ESHRE Guideline on Recurrent Pregnancy Loss (RPL)Sujoy Dasgupta
Dr Sujoy Dasgupta invited to deliver a lecture on "RPL- ESHRE Guideline" in the Annual Conference of RCOG (Royal College of Obstetricians and Gynaecologists) IRC (International Representative Committee) India East held on 20-21 May, 2023
Ectopic pregnancy refers to the pregnancy occurring outside the uterine cavity, predominantly i.e. 90% of them in the fallopian tube. Ectopic pregnancy affects 11 in 1000 pregnancies and is a significant cause of morbidity and at times mortality in the first trimester of pregnancy. In a 20-year longitudinal study on ectopic pregnancy in a defined
population of women aged 15e39 years the rate of ectopic pregnancy per 1000 diagnosed conceptions increased
from 5.8 during 1960e4 to 11.1 during 1975e9. The mean annual incidence of ectopic pregnancy per 1000 women
increased from 0.6 to 1.2 during the same period. The numbers of ectopic pregnancies per 1000 diagnosed
conceptions increased with increasing age of the women and were 4.1 in the teenage group, 6.9 in women aged
20e29 years, and 12.9 in women aged 30e39.
PANEL DISCUSSION ON ENDOMETRIOSIS RELATED INFERTILITY (EVIDENCE BASED)Lifecare Centre
PANEL DISCUSSION ON ENDOMETRIOSIS RELATED INFERTILITY (EVIDENCE BASED)
MODERATOR
DR SHARDA JAIN
DR JYOTI AGARWAL
DR ILA GUPTA
UMA RAI
RAJ BOKARIA
JYOTI AGARWAL
JYOTI BHASKER
RENU CHAWLA
DIPTI NABH
VANDANA GUPTA
The Newer Concepts forReduced Surgery to preserve fertility in Endometrios...Lifecare Centre
The Newer Concepts forReduced Surgery to preserve fertility in Endometriosis
ENDOMETRIOSIS IS ENIGMA
DIAGNOSTIC DILEMMA
DEBILITATING DISEASE QOL
PROGRESSIVE DISEASE
RECURRENCE IS BIG PROBLEM
NO FINAL VERDICT ON CAUSE
NO PERMANENT CURE
The exact prevalence of endometriosis is unknown, but estimates 10% in the general female population in India but up to 50% in infertile women
Explore the intricacies of ovulation induction in intrauterine insemination (IUI) with Dr Laxmi Shrikhande's informative slide share presentation. From understanding the hormonal mechanisms to the latest techniques, this presentation offers insights into optimizing fertility through IUI. Whether you're a clinician seeking to enhance patient outcomes or an individual navigating fertility treatments, this resource provides valuable knowledge for your journey towards conception.
Adjuvant therapy, also known as adjunct therapy or add-on therapy, is therapy given in addition to the primary or initial therapy to maximize its effectiveness.
Add-ons have become ubiquitous with the process of assisted reproduction (ART) which is markedly more complex than it was at its inception.
The comparison of dinoprostone and vagiprost for induction of lobar in post t...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Phone Us ❤85270-49040❤ #ℂall #gIRLS In Surat By Surat @ℂall @Girls Hotel With...
Endometriosis associated infertility: ESHRE2022
1. 3/15/2022
ABOUBAKR ELNASHAR
You can get this lecture and 500 lecture from:
1.My scientific page on Face book: Aboubakr
Elnashar Lectures.
https://www.facebook.com/groups/2277448840913
51/
2.Slide share web site
3.elnashar53@hotmail.com
4.My clinic: Elthawra St. Mansura
TREATMENT OF
ENDOMETRIOSIS-ASSOCIATED INFERTILITY
ESHRE guidelines 2022
Prof. ABOUBAKR ELNASHAR
Benha university Hospital, Egypt
ABOUBAKRELNASHAR
ABOUBAKRELNASHAR
CONTENTS
I. DIAGNOSIS OF ENDOMETRIOSIS
II. TREATMENT OF ENDOMETRIOSIS-ASSOCIATED PAIN
III. TREATMENT OF ENDOMETRIOSIS-ASSOCIATED
INFERTILITY
IV. IMPACT OF ENDOMETRIOSIS ON PREGNANCY AND PREGNANCY OUTCOME
V. ENDOMETRIOSIS RECURRENCE
VI. ENDOMETRIOSIS AND ADOLESCENCE
VII. ENDOMETRIOSIS AND MENOPAUSE
VIII.EXTRAPELVIC ENDOMETRIOSIS
IX. ASYMPTOMATIC ENDOMETRIOSIS
X. PRIMARY PREVENTION OF ENDOMETRIOSIS
XI. ENDOMETRIOSIS AND CANCER
ABOUBAKRELNASHAR
Recommendations either ‘‘strong’’ or ‘‘weak” according to the GRADE
approach,
ABOUBAKRELNASHAR
DIAGNOSIS OF ENDOMETRIOSIS
Symptoms
Cyclical & non-cyclical:
Dysmenorrhea,
Deep dyspareunia ,
Infertility
Dysuria
Dyschezia
Painful rectal bleeding or
haematuria,
shoulder tip pain,
catamenial pneumothorax,
cyclical cough/haemoptysis/
chest pain, cyclical scar swelling
and pain, fatigue. GPP
ABOUBAKRELNASHAR
3/15/2022
Diary/questionnaire/app
No evidence that a symptom reduces the time to diagnosis or
leads to earlier diagnosis
Potential benefit in
completing the traditional history
pain
Other symptoms. GDG STATEMENT
Clinical examination, including vaginal examination
should be considered to identify
deep nodules or
endometriomas in patients with suspected endometriosis
Diagnostic accuracy is low.⊕Strong recommendation
ABOUBAKRELNASHAR
Investigation
Biomarkers: not to be used.⊕⊕⊕ Strong recommendation
1. Imaging (US or MRI):
Should be considered even if the clinical
examination is normal.⊕⊕ Strong recommendation
Negative finding does not exclude endometriosis,
particularly superficial peritoneal disease ⊕⊕Strong
recommendation
ABOUBAKRELNASHAR
Justification:
For endometrioma & DIE: TVS & MRI have a similar
or slightly better specificity & sensitivity than
laparoscopy
For superficial disease: imaging modalities have
inferior diagnostic value compared to laparoscopy
(Wykes, et al., 2004).
Dedicated TVS in experienced hands (also MRI)
can replace laparoscopy
the gold standard for the diagnosis of
endometrioma & DIE in the pelvis
ABOUBAKRELNASHAR
2. Laparoscopy is considered for the diagnosis &TT in
1. Patients with negative imaging results
2. Empirical TT was unsuccessful or inappropriate GPP
Endometriotic lesions is confirmed by histology although
negative histology does not entirely rule out the disease GPP
Justification:
The benefits of laparoscopy need to be weighed up
against its risks (Bafort, et al., 2020, Byrne, et al., 2018b, Chapron, et
al., 1998).
Expensive, invasive& associated with morbidity mortality.
Direct, photographic& histological proof of lesions: an
important psychological factor for women
ABOUBAKRELNASHAR
2-step approach
Can be considered
endometriosis is suspected
imaging results are negative
not trying to conceive
TVS followed by empirical TT
oral contraceptive pill or progestogens(Kuznetsov, et
al., 2017).
If symptoms improve: endometriosis is presumed
the main underlying condition, although other
clinical causes can coexist.
ABOUBAKRELNASHAR
Women suspected of endometriosis
Diagnostic laparoscopy and
Imaging combined with empirical TT
Can be considered
No evidence of superiority of either approach:
Pros & cons should be discussed with the
patient. GDG STATEMENT
ABOUBAKRELNASHAR
2. 3/15/2022
TREATMENT OF ENDOMETRIOSIS-ASSOCIATED
INFERTILITY
LINES OF TREATMENT
I. IUI & OS
II. SURGERY
III. IVF
IV. FERTILITY PRESERVATION
Medical
Non medical
ABOUBAKRELNASHAR
Medical treatment
Ovarian suppression Should not be prescribed to
improve fertility ⊕⊕Strong recommendation
Justification:
Based on the results of the Cochrane review, suppression of ovarian
function (by means of danazol, GnRH agonists, progestogens, OCP)
to improve fertility is not effective and should not be offered for this
indication alone
Pentoxifylline, other anti-inflammatory drugs or
letrozole outside ovulation-induction: should not
prescribed to improve natural pregnancy rates
⊕Strong recommendation
ABOUBAKRELNASHAR
Justification
As endometriosis is associated with inflammation.
Pentoxifylline has anti‐inflammatory properties.
SR show no benefit of pentoxifylline, postoperative
aromatase inhibitor (letrozole), or postoperative
GnRH agonist (triptorelin) to improve pregnancy
rates in women with endometriosis.
ABOUBAKRELNASHAR
Non-medical management strategies for infertility
Nutrition, Chinese medicine,
Electrotherapy, acupuncture
Physiotherapy, exercise, and psychological
interventions
No clear evidence of benefit to increase the
chance of pregnancy.
No recommendation can be made to support
any to increase fertility.
The potential benefits and harms are unclear
GDG STATEMENT
ABOUBAKRELNASHAR
I. IUI with ovarian stimulation:
rASRM stage I/II, instead of expectant
management or IUI alone, as it increases PR
⊕Weak recommendation
could be considered in rASRM stage III/IV with
tubal patency Although the value is uncertain
⊕Weak recommendation
ABOUBAKRELNASHAR
II. SURGERY
Should be guided by
Presence or absence of pain symptoms
Patient age and preferences
History of previous surgery
Presence of other infertility factors
Ovarian reserve
Estimated Endometriosis Fertility Index (EFI)
GPP
Women should be counselled of their chances of
becoming pregnant after surgery.
ABOUBAKRELNASHAR
3/15/2022
ABOUBAKRELNASHAR
Operative laparoscopy
For rASRM stage I/II could be offered {improves the
rate of ongoing pregnancy} ⊕⊕Weak recommendation
For endometrioma-associated infertility May be
considered {may increase their chance of natural
pregnancy}, although no data from comparative
studies exist ⊕ Weak recommendation
For deep endometriosis: No convincing evidence
exists that it improves fertility
May represent TT option in symptomatic patients
wishing to conceive ⊕Weak recommendation
ABOUBAKRELNASHAR
Postoperative hormone suppression
Should not be prescribed with the sole purpose to
enhance future pregnancy rates ⊕⊕Strong
recommendation
may be offered for women who cannot attempt to
or decide not to conceive immediately after surgery
{does not negatively impact their fertility and
improves the immediate outcome of surgery for
pain} ⊕⊕ Weak recommendation
ABOUBAKRELNASHAR
III. ART
Can be performed especially if
1. Tubal function is compromised
2. Male factor infertility
3. Low EFI and/or
4. Other treatments have failed ⊕⊕ Weak recommendation
To identify patients that may benefit from ART after surgery
EFI should be used as it is validated,
reproducible and cost-effective.
Other fertility investigations such as their
partner’s sperm analysis GDG STATEMENT
ABOUBAKRELNASHAR
Surgery prior ART
rASRM stage I/II endometriosis: Not recommended as the
potential benefits are unclear ⊕⊕Strong recommendation
Endometrioma
Not recommended {no benefit& surgery is likely to have
a negative impact on ovarian reserve}. ⊕⊕Strong
recommendation
can be considered to improve endometriosis-associated
pain or accessibility of follicles GPP
Deep endometriosis: should be guided mainly by pain
symptoms& patient preference as its effectiveness on
reproductive outcome is uncertain due to lack of RCT
⊕Strong recommendation
ABOUBAKRELNASHAR
Protocol
Both GnRHan & agonist can be offered based on
patients’& physicians’ preferences as no difference
in PR or LBR ⊕ Weak recommendation
The extended GnRHa is not recommended, as the
benefit is uncertain ⊕Strong recommendation
Insufficient evidence to recommend prolonged
administration of COC/progestogens as a pre-TT to
ART to increase LPR ⊕ Weak recommendation
The data are very limited and do not allow to draw any conclusion.
This does not preclude use of OCP for planning purposes.
ABOUBAKRELNASHAR
3. 3/15/2022
Oocyte retrieval
In women with endometrioma, clinicians may use
antibiotic prophylaxis
Although the risk of ovarian abscess formation
following follicle aspiration is low GPP
Recurrence rates are not increased compared to
those women not undergoing ART ⊕⊕⊕ Weak
recommendation
ABOUBAKRELNASHAR
IV. Fertility Preservation (FP): oocyte cryopreservation
In case of extensive ovarian endometriosis,
clinicians should discuss the pros & cons of FP
The true benefit of FP is unknown ⊕ Strong recommendation
FP may increase future chances of pregnancy of some
women
FP is expensive& ±some clinical risks.
Still many questions remain unanswered
Cost effectiveness
Criteria to select those women.
Strong recommendation for counselling& information
provision.
ABOUBAKRELNASHAR
ABOUBAKRELNASHAR ABOUBAKR ELNASHAR
You can get this lecture and 500 lecture from:
1.My scientific page on Face book: Aboubakr
Elnashar Lectures.
https://www.facebook.com/groups/2277448840913
51/
2.Slide share web site
3.elnashar53@hotmail.com
4.My clinic: Elthawra St. Mansura