This document discusses controversies in aesthetic gynecology procedures. It begins by defining aesthetic gynecology as procedures that alter female genital appearance or structure for non-medical reasons. The document then outlines the increasing popularity of these procedures in recent years. It notes both opponents and proponents of these procedures and their differing views on issues like patient autonomy and lack of evidence. The document concludes by summarizing various medical organizations' ethical guidelines, which state that the safety and effectiveness of many aesthetic gynecology procedures have not been established and caution is warranted.
NEW USES OF LASER IN GYNECOLOGY
International Society for the Study of Vulvovaginal Disease (ISSVD)
International Continence Society (ICS)
2019 Guidelines
NEW USES OF LASER IN GYNECOLOGY
International Society for the Study of Vulvovaginal Disease (ISSVD)
International Continence Society (ICS)
2019 Guidelines
PANEL DISCUSSION ON ENDOMETRIOSIS RELATED INFERTILITY (EVIDENCE BASED)Lifecare Centre
PANEL DISCUSSION ON ENDOMETRIOSIS RELATED INFERTILITY (EVIDENCE BASED)
MODERATOR
DR SHARDA JAIN
DR JYOTI AGARWAL
DR ILA GUPTA
UMA RAI
RAJ BOKARIA
JYOTI AGARWAL
JYOTI BHASKER
RENU CHAWLA
DIPTI NABH
VANDANA GUPTA
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
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“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Invited Lecture delivered by Dr Sujoy Dasgupta in the Annual Conference of ISAR (Indian Society of Assisted Reproduction) held at Kolkata in November, 2019
Dr Sujoy Dasgupta moderated a Panel Discussion on "Difficult cases in IUI" in the Annual Conference of ISAR (Indian Society of Assisted Reproduction), Bengal held in December, 2022
PANEL DISCUSSION ON ENDOMETRIOSIS RELATED INFERTILITY (EVIDENCE BASED)Lifecare Centre
PANEL DISCUSSION ON ENDOMETRIOSIS RELATED INFERTILITY (EVIDENCE BASED)
MODERATOR
DR SHARDA JAIN
DR JYOTI AGARWAL
DR ILA GUPTA
UMA RAI
RAJ BOKARIA
JYOTI AGARWAL
JYOTI BHASKER
RENU CHAWLA
DIPTI NABH
VANDANA GUPTA
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Invited Lecture delivered by Dr Sujoy Dasgupta in the Annual Conference of ISAR (Indian Society of Assisted Reproduction) held at Kolkata in November, 2019
Dr Sujoy Dasgupta moderated a Panel Discussion on "Difficult cases in IUI" in the Annual Conference of ISAR (Indian Society of Assisted Reproduction), Bengal held in December, 2022
Fertility Management: Synergy between Endoscopists and Fertility SpecialistsSujoy Dasgupta
Dr Sujoy Dasgupta was invited to moderate a panel discussion on "Fertility Management: Synergy between Endoscopists and Fertility Specialists " in a CME by Torrent held on 27 May 2023.
Georgine Lamvu, MD, MPH prepared useful Practice Aids pertaining to the diagnosis and management of endometriosis and uterine fibroids for this CME activity titled "Current and Emerging Therapies for Endometriosis and Uterine Fibroids: What Do You Need to Know?" For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at https://bit.ly/3cH0J2A. CME credit will be available until August 2, 2021.
The Newer Concepts forReduced Surgery to preserve fertility in Endometrios...Lifecare Centre
The Newer Concepts forReduced Surgery to preserve fertility in Endometriosis
ENDOMETRIOSIS IS ENIGMA
DIAGNOSTIC DILEMMA
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RECURRENCE IS BIG PROBLEM
NO FINAL VERDICT ON CAUSE
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The exact prevalence of endometriosis is unknown, but estimates 10% in the general female population in India but up to 50% in infertile women
Uterus (womb) as an organ is pivotal not only to giving birth, but also to the overall well-being of women and their physical, emotional, and sexual health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
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Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
3. Aesthetic Gynecology: Aes G
Alteration of anatomy
vaginal or labial: for
Aesthetic reasons (artistic& visual) or
Treatment of normal changes that occur throughout
the life span.
Cosmetic procedures
Non medically indicated:
Change the structure& appearance of
healthy vulva or vagina.
ABOUBAKR ELNASHAR
4. FGM FGCS
1. Practice Condemned Requested
2. Conducted on Girls Adult women
3. Consent Against Mandatory
4. Objective False belief to
control female
sexuality
Improve their
appearance&
sexuality.
ABOUBAKR ELNASHAR
5. 2013:
In US:
Labiaplasty was reported to be the 4th most
common cosmetic surgical procedure, rising by
44%.
Following liposuction, breast augmentation, and rhinoplasty,
Australia:
3-fold increase in labiaplasties performed between
2003 and 2013
UK:
5-fold increase in these surgeries during the same period.
ABOUBAKR ELNASHAR
6. CAUSES OF INCREASED DEMAND FOR AES G
1 Perception of ‘normal’ Vs ‘desirable’
والمرغوب طبيعي هو لما اﻻدراك
ABOUBAKR ELNASHAR
7. 4. Lack of anatomy education throughout life
5. In some countries:
Decreased cost & shame
Increased ease of access to Aes G
ABOUBAKR ELNASHAR
8. Comparing 2017 to 2016 data.
11% decrease in surgical procedures
Increase in laser/nonsurgical interventions
(American Society for Aesthetic Plastic Surgery, 2018)
This raised the question
Whether surgical procedures is a passing
trend? (Placik et al, 2019)
9. INDICATIONS: Why do women seek Aes G?
1. Aesthetic reasons
To reduce dissatisfaction associated with actual or
perceived abnormality of genital anatomy
2. Functional reasons:
To reduce
pain or interference with SI
discomfort when exercising or wearing tight clothing
To improve s. function or s. enhancement.
3. Psychological reasons: To address
embarrassment, poor self-esteem, anxiety
inhibition in relationships, or to be more 'normal'
ABOUBAKR ELNASHAR
10. PERFORMED BY
It is most commonly performed by:
1. Gynaecologists: 50%
2. Plastic surgeons: 30% (Placik et al, 2019)
3. GPs or non-specialist surgeons
(including dermatologists), with additional training in
cosmetic procedures
4. Urologists
ABOUBAKR ELNASHAR
11. PROCEDURES
I. Vulvoplasty: Augmentation or more frequently,
reduction of the external female genitalia
Labiaplasty: Augmentation or reduction of the labia
minora, or less commonly the labia majora
Hymenoplasty or ‘revirgination: Restoration of the
intact hymen
Clitoral hoodoplasty: Reduction of the clitoral hood
to expose the underlying clitoris
Vulvar lipoplasty: Removal of fat from mons pubis.
ABOUBAKR ELNASHAR
12. II. Vaginoplasty: Alteration of the internal female genitalia
Surgical vaginal tightening
Perineoplasty: Restoration of perineal length
Laser Vaginal Rejuvenation: vaginal tightening
using laser therapy
G-spot augmentation or amplifcation ('G-shot'®)
Autologous fat, collagen, or various filler injections
into a predetermined G-spot'
Orgasm Shot ('O-Shot’®): Patient’s own blood
products are injected into the clitoris & upper vaginal wall
ABOUBAKR ELNASHAR
13. Surgical:
Non-surgical
1. Energy-Based Procedures: use of
Lasers or
Radiofrequency (RF) energy
US
2. Injection
Botox
PRP
Filler
Autologs fat
Collagen ABOUBAKR ELNASHAR
16. Opponents Of Aes G
1. There is a wide range of normal genitalia:
surgery& rejuvenation procedures unnecessary
(Lloyd et al, 2005)
2. There are numerous marketing claims stating that
these procedures
enhance sexual satisfaction
treat both aesthetic& functional issues:
patients request surgery for the wrong
reasons (Braun, 2010)
ABOUBAKR ELNASHAR
17. 3. These procedures are lucrative
patients pay out of cost for these procedures,
raising concerns about direct patient cost& provider
conflict (Lglesia, 2012)
ABOUBAKR ELNASHAR
18. 4. A number of patients seeking Aes G are
at risk of body dysmorphic disorder
(Recurrent obsessive ideas that a particular aspect of
their appearance is severely faulty)
should be treated, rather than proceeding with
Aes G (Higgins, Wysong, 2018)
ABOUBAKR ELNASHAR
19. 5. The performance of some procedures can be
accepted in some instances
Others:
No medical justification or biological
acceptability.
Unethical (Pedro et al, 2018)
ABOUBAKR ELNASHAR
20. 6. Protrusion of the labia minora’
not a medical problem, but a cultural one.
Therefore, the solution should be
Cultural change
Female -centred strategies that support body-
positivity for women, rather than surgery (Nurka,
2019)
ABOUBAKR ELNASHAR
22. Proponents Of Aes G
1. We should maintain
Patient autonomy for a woman requesting
surgery
For reasons that she believes important to her,
even if severe anatomic pathology cannot be
exhibited (Cartwright, Cardozo, 2014)
الذاتي الحكم
ABOUBAKR ELNASHAR
23. 2. One of the most basic human rights is
right to self-choice & self-governance,
Free from
interference by others
limitations (including inadequate education or
inability to speak for themselves) to making an
autonomous choice (Cain et al, 2013)
الذاتي الحكم
ABOUBAKR ELNASHAR
24. 3. A patient's desire for
Symmetry
Lack of functional restriction
Improved sexual function& relationships
positive self-image
are reasonable concerns
it is difficult to argue with
what a patient believes as real or perceived
anatomical distortion.
ABOUBAKR ELNASHAR
25. 4. As long as there is
proper preoperative counseling&
patients have realistic expectations about
outcomes,
they should be free to decide for Aes G.
ABOUBAKR ELNASHAR
26. 5. The initial controversies over Aes G have almost
settled down
Evidence suggesting that a number of procedures are
Safe
Effective
Capable of treating to a considerable extent the
conditions associated with life vulvo-vaginal
changes.
Delivering What Women Want (Magon, Alinsod;
2018)
ABOUBAKR ELNASHAR
27. ABOUBAKR ELNASHAR
6. Overall patient satisfaction rates: high(Goodman, 2008)
Complications: 4% to 18% of women (Alter, 2008,
Goodman, 2010)
28. ETHICAL GUDELINES
Evidence based
1. RCOG, 2013
2. SOGC, 2013
3. RANZCOG: Royal Australian& New Zealand College of
Obstetricians and Gynaecologists, 2011, 2015
4. FIGO: 2015
5. ACOG: 2007, 2013, 2017
6. ISSVD: International Society for the Study of Vulvovaginal
Disease, 2018
7. ISSVD & ICS, 2019
8. ACOG, 2020
ALL state that
they cannot clearly support such surgery ethically.
(Goldstein, Jutrzonka, 2016)
ABOUBAKR ELNASHAR
29. All (Goldstein, Jutrzonka, 2016)
1.There is a need to exercise caution in providing
Aes G. The message is clear: there is inadequate
evidence to support the beneficial claims of Aes G.
2.The need for informed consent & lack of clear
evidence on which to base such consent.
3.The procedures are not medically indicated& are
not part of the training of gynecologists or plastic
surgeons during residency.
ABOUBAKR ELNASHAR
30. 4. Conflict of interest and the veracity of web-based advertising.
5. Terms commonly used to advertise these procedures
are
poorly understood
marketing terms only
Non-medical terms:
Vaginal rejuvenation
Clitoral resurfacing
G-spot enhancement
ABOUBAKR ELNASHAR
31. RCOG Ethics Committee, 2013
1. Counseling
1. Normal variations of vulva
2. Body image distress
3. Risks
4. Lack of reliable evidence of postive effects
2. Written records of physical & mental health reasons for the procedure
3. Advertising should not mislead people on
what is deemed to be normal or
what is possible with surgey
4.FGCS should not be undertaken within the NHS
unless it is medically indicated
ABOUBAKR ELNASHAR
32. ACOG, 2017
Minimal adequate long-term studies addressing
satisfaction, safety, and complication rates
Use of fractional laser is not FDA approved for
gynecologic uses including vulvovaginal
atrophy or rejuvenation.
ABOUBAKR ELNASHAR
33. ABOUBAKR ELNASHAR
II. FDA 2018:
Not approved any energy-based device for vag cosmetic
improvement or TT of symptoms associated with the GMS.
Neither the safety nor effectiveness of these devices for
treatment
Warns against use of laser-type devices as their use
may result in serious adverse events
Vaginal burns
Scarring
Dyspareunia
Recurring/chronic pain
34. III. The International Society for the Study of Vulvovaginal
Disease, 2018
• We strongly recommend against
G-spot augmentation
Hymenoplasty
Vulvar& perianal bleaching/whitening
Any FGCS with the intention of enhancing sexual
function
{lack of evidence to demonstrate benefit in the literature}.
• Robust evidence to support the use of laser or
radiofrequency to treat vaginal atrophy or “vaginal laxity” is
lacking ABOUBAKR ELNASHAR
35. ABOUBAKR ELNASHAR
The International Society for the Study of
Vulvovaginal Disease (ISSVD) and
International Continence Society (ICS) , 2019
Based on the available scientific evidence, with no
supporting long term follow-up data:
use of LASER should, at present, not be
recommended for TT of
Vaginal atrophy
Vulvodynia, or
Lichen sclerosus.
36. The data for the role of LASER for
Stress urinary incontinence&
Vaginal laxity are inadequate to draw any
conclusions or safe practice
recommendations.
37. ABOUBAKR ELNASHAR
ACOG 2020
Lack of
Published studies
Standardized nomenclature
Outcomes: risks & benefits.
Counseling:
Effectiveness: lack of high-quality data that support
Potential complications: pain, bleeding, infection,
scarring, adhesions, altered sensation, dyspareunia, and
need for reoperation.
38. ABOUBAKR ELNASHAR
Gynecologists should have sufficient training to recognize
women with
Sexual dysfunction
Psychiatric conditions:
depression, anxiety
body dysmorphic disorder.
referral for evaluation before surgery.
Gynecologist: inform patients about outcomes
Substantial risk
Safety & effectiveness have not been established.
39. ABOUBAKR ELNASHAR
NICE 2021.
The evidence on TV laser therapy for SUI or
urogenital atrophy does not show any short-
term safety concerns.
Evidence on long-term safety & efficacy is
inadequate in quality and quantity.
Therefore, this procedure should only be used
in the context of research.
40. You can get this lecture and 480 lectures from:
1.My scientific page on Face book: Aboubakr
Elnashar Lectures.
https://www.facebook.com/groups/2277448840913
51/
2.Slide share web site
3.elnashar53@hotmail.com
4.My clinic: Elthwara St. Mansura