This document discusses fractures, including:
- Common causes are falls, car accidents, blows, repetitive forces, and pathology.
- Signs are swelling, tenderness, pain, numbness, bleeding, broken skin, and limited movement.
- Fractures are closed (hematoma internal) or open (hematoma communicates outside).
- Types include stress, birth, traumatic, and pathological. Principles of management include first aid, transport, assessment, resuscitation, x-rays, reduction, immobilization, physiotherapy, and rehabilitation.
- Healing occurs in inflammatory, reparative, and remodeling phases over weeks depending on factors like age, blood supply, and
Benign prostatic hyperplasia is an enlargement of the prostate gland resulting from an increase in the number of epithelial cells and stromal tissue and developing upward into the bladder and obstructing the outflow of urine.
Benign prostatic hyperplasia is an enlargement of the prostate gland resulting from an increase in the number of epithelial cells and stromal tissue and developing upward into the bladder and obstructing the outflow of urine.
The festival season has began. For some people the season has triggered painful memories of loss and grief. It becomes very important to understand PTSD and. Our awareness can help them in their healing process.
Ok, heres the story. I was teaching this otherwise sharp EMT-Basic class that bombed two respiratory emergency tests in a ROW!
So this is the remedial lecture I inflicted on them. I don\'t know if they passed because of this fine work, or just because they were afraid of another lecture fo they failed.
Hope its useful to you.
fracture is the breakdown in the continutity of the bone alignment this has many types as the fracure this topic include its definition , etiology, pathophysiology, clinical menisfestation, diagnosis and its treatment which can be used by nursing students for taking care of the patient suffering from fracture and for learning for their examination and knowledge purpose
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
3. Signs and Symptoms
Swelling or tenderness
pain
Numbness
Bleeding
Broken skin with bone protruding
Limitation or unwillingness to move a limb
4. Closed fracture: A closed fracture is one where the fracture hematoma does not
communicate with the outside
Open fracture: This is one where the fracture hematoma communicates with the
outside through an open wound.
1/ Traumatic
Fracture Types
Stress fracture :
It is a fracture occurring at a site in the bone subject to
repeated minor stresses over a period of time.
Birth fracture:
It is a fracture in the new born children
due to injury during delivery.
5. 2/ Pathological
It is a fracture occurring after a trivial violence in a bone weakened by some
pathological lesion. This lesion may be :
- Localized disorder
(e.g. secondary malignant deposit)
- Generalized disorder
(e.g. osteoporosis).
Fracture Types
6. Transverse Fracture
A fracture in which the # line is
perpendicular to the long axis of
the bone .
Oblique Fracture
A fracture in which the # line is at
oblique angle to the long axis of the
bone.
According to the Path of the # Line
Fracture Types
7. Spiral Fracture
A severe form of oblique fracture in
which the # plane rotates along the
long axis of the bone. These #s occur
secondary to rotational force.
Longitudinal Fracture
A fracture in which the # line runs
nearly parallel to the long axis of the
bone. A longitudinal fracture can be
considered a long oblique fracture.
According to the Path of the # Line
Fracture Types
8. Anatomical classification of fractures
Fractures
Comminuted # :
The bone is broken into than two
fragments.
Stellate fracture:
This # occurs in the flat bones of the
skull and in the patella, where the
fracture lines run in various directions
from one point.
9. Anatomical classification of fractures
Impacted fracture:
This # where a vertical force drives
the distal fragment of the fracture
into the proximal fragment.
Fracture Types
Depressed fracture:
This # occurs in the skull where a
segment of bone gets depressed
into the cranium.
10. Avulsion fracture:
This is one, where a chip of bone is avulsed by the sudden and unexpected
contraction of a powerful muscle from its point of insertion,
Examples
1. The supra spinatus muscle avulsing the
greater tuberosity of the humerus.
2. Avulsion fracture of the tibial tuberosity
Fracture Types
Anatomical classification of fractures
11. Fracture Types
Simple little or no bone displacement
Compound fracture ruptures the skin & bone protrudes
Green stick occurs mostly in children whose bones have not calcified or hardened
Transverse crack perpendicular to long axis of the bone - displacement may occur
Oblique diagonal crack across the long axis of the bone
Spiral diagonal crack involving a "twisting" of the bone about the longitudinal axis
Comminuted "crushing" fracture - more common in elderly
Impacted one end of bone is driven up into the other
Depressed broken bone is pressed inward (skull fracture)
Avulsion fragment of bone is pulled away by tendon
Summary
12.
13. Other Terms used in describing fracture
Greenstick
is the fracture in the young bone of children where the break is incomplete,
leaving one cortex intact .
Plastic - Bowing fracture in children without disruption of cortex.
Distraction Is a separation of fragments that have been pulled apart.
Greenstick #
Distraction #
14. 1.Position - changed or unchanged
Terms used in fracture follow-up
.2. Healing -central or peripheral
bony bridging
15. Delayed union - the healing process
is slower than normal.
Non-union - the healing stopped
before union occurred.
Malunion - the fracture healed
in unacceptable position.
Terms used in fracture follow-up
17. Principles of Management:
Aims : (A)- safe life (B)-save the limb (C)-save the
function
1. Efficient First Aid: This relieves the pain and prevents complications.
2. Safe transport: This help to minimize complications in injures to the spine,
fracture of the lower limbs, ribs etc (all fractures should be immobilized
immediately ) .
3. Assessment of condition of the patients for shock & other injuries.
4. Assessment of local condition of the injured limb regarding complications like
vascular injury, nerve involvement and injury to neighboring joints .
5. Resuscitation. If needed
6. Radiography of the part
X-ray before plaster AP & LAT( to determine site and degree of
displacement)
Post Reduction films ( wet plaster) for insurance of good alignment
Follow up films to assess healing
Films Before removal of plaster to confirm complete healing
7. Reduction of the fracture(correction of
displacement of fragments and done by :
closed Manipulation
open reduction
18. 8. Immobilization of the fragments.
External fixation
Cast (plaster)
Internal fixation
Screws
Plates
intramedullary nails and rod
wires & pins
Principles of Management:
19. 9.9. Early physiotherapyEarly physiotherapy :: for the preservation of function of the limbfor the preservation of function of the limb
(local complication such as ischemia ,nerve damage ,joint stiffness(local complication such as ischemia ,nerve damage ,joint stiffness
,infection ..etc may endanger the function of the limb.,infection ..etc may endanger the function of the limb.
10.10. RehabilitationRehabilitation : After union of the fracture to restore full: After union of the fracture to restore full
muscle power and joint movements and to make the patient fit formuscle power and joint movements and to make the patient fit for
his original job.his original job.
NOTE:NOTE:
Fractures are treated by reduction (realignment) &immediate
immobilization
In most cases, simple fractures heal completely in
approximately 6 - 8 weeks
Compound # better to deal with it within6hrs of injury to avoid
infection
The accurate diagnosis of the fracture (site ,lines and
displacement ) is made from X- ray examination.
Tow projections is required AP or PA +lateral or oblique
Tow joints above and below the site of the # should be included
in the radiographs
Tow limbs radiographs for comparison of value in children.
20. FRACTURE HEALING
Fracture healing is considered as a series of phases which occur in
sequence as follows:
(I) Inflammatory Phase.
(A)Stage or hematoma formation.
(B)Stage of granulation tissue. (more fibrin to
the hematoma and increase blood flow
(II) Reparative Phase.
(A) Stage of fibro cartilaginous callus.
(B) Stage of bony callus (woven bone become
calcified)).
(III) Remodeling Phase.
Excess material inside bone shaft is
replaced by more compact bone
21. Factors Affecting Bone Healing
Enhancing
Youth
Early Immobilization of
fracture fragments
Bone fragments contact
Adequate blood supply
Proper Nutrition
Adequate hormones
Growth hormone
Thyroxin
Calcitonin
Inhibiting
Age (e.g. Average # Femur Healing
Time)
Infant: 4 weeks
Teenager: 12 to 16 weeks
Extensive local soft tissue trauma
Bone loss due to the severity of the
fracture
Inadequate immobilization (motion
at the fracture site)
Infection
Avascular Necrosis
22. Fracture - ComplicationsFracture - Complications
At time of injury (Immediate)
◦ Haemorrhage
◦ Damage to important internal structures (brain ,heart..)
◦ Skin loss ,Shock ,Nerve damage
Later Complications
Local General
Tissue necrosis Deep Vein Thrombosis,
Local wound Infection Pulmonary embolism
Loss of alignment Osteoarthritis
Delayed and malunion
Joint stiffness
23. What is Dislocation?
Joints Dislocation
Is the total displacement of the articular end of a bone from the joint cavity.
Subluxation : Is an incomplete displacement.
Reduction : Is the restoration of the normal alignment of the bones.
Classification:
Dislocations are classified
as follows:
A. Congenital
B. Traumatic
C. Pathological
D. Paralytic