This document provides an overview of fluidized bed processing (FBP). It discusses the principle of fluidization, how FBP works, its components, and applications. FBP uses air to fluidize solid particles, allowing for high rates of heat and mass transfer. This makes it useful for granulation, drying, and coating processes. It has advantages like high drying rates and easy handling but also disadvantages like potential for product loss and requirement of skilled operators. FBP is widely used in pharmaceutical manufacturing for applications like granule drying, tablet coating, and functional powder coating.

1. 1
P. R. Pote Patil College of Pharmacy, Amravati
Fluidized Bed Processor
(FBP)
Prepared & Presented by :
Prof. Vedanshu R. Malviya
(M.pharm)

2. 2

3. INTRODUCTION
PRINCIPLE
APPLICATIONS OF FLUID BED PROCESSING
COMPONENTS
WORKING
ADVANTAGES
DISADVANTAGES
APPLICATION
REFERENCES
3

4. Fluidized bed processor (FBP) is well known and widely used
equipment in the pharmaceutical manufacturing .
The direct contact between particles and air is possible in fluid bed
system.
 It is used in granulation process for drying the material to get
desired moisture content in the granules required for perfect
compression of tablet formulation.
4

5. 5
 The principle involved in such techniques may be either by bottom spray
or top spray.
 These principles depend on the positioning of the spray gun in the
equipment.
 The top spray process helps in achieving the uniform granulation. The
bottom spray process uses a Wurster coating unit for the spray
(Leuenberger, 1990).

6. The main principle involved in fluidized bed dryer is
FLUIDIZATION
1. Hot air is passed at high speed through a perforated bottom of
the container containing granules
2. The granules are lifted from the bottom and suspended in the
stream of air this condition is called “fluidized state”.
6

7. Granulation & Drying
7

8. .
8
Powder coating (Functional Coating)

9. 9
 Inlet
 Exhaust
 Control Panel
 Bottom Plate
 Spray Nozzle
 Peristaltic Pump
 Finger bag
 Product Bowl

10. 10
:
1. Material to be dried is placed in the bowl type vessel.
2. Air is introduced from the top and heated at required temperature by
the heaters.
3. The air is filtered through the filter and then passes through the bed of
the material at the bottom.
4. The airflow is generated by the fans fitted at the top of the equipment.
5. The air flow rate and the operating temperature are adjusted by the
control panel.

11. 11
6. As the flow of air increases, the bed expands and particles of powder
start to rise up.
7. The regular contact with air causes the material to dry.
8. The air leaving the FBD passes through the filter to collect the fine
particles of the material.
9. Fluidized bed dryer has a high drying rate and the material is dried in a
very short time.
10. Material remains free-flowing and uniform. FBD bags have finger-like
shape to increase the volume of the drying bed that helps to increase the
drying rate and decrease the drying time.

12. 1. High rates of moisture removal.
2. Highly efficient in material drying.
3. Handling is easy.
4. Wide range of materials can be formulated.
12

13. 1. Product loss.
2. Sticky material is quite difficult.
3. High capital and maintenance cost.
4. Skilled person required
13

14. 1. Drying of the granules in the production of the tablet
2. Coating of the tablet
3. Agriculture , pharma, food & Dairy.
4. Polymer film coating
5. Drying moist
6. Top spray granulators
7. Formulation , development and production
14

15. 15
• Tapasya Engineering works Pvt
Ltd.
• Chitra Machineries Pvt Ltd.
• NU Pharma Engineers And
Consultant.
• Chamunda Pharma Machinery
Pvt. Ltd.

16. 16
1. Lachman L, Lieberman H.A, Kanig JL, Third edition “Granulation” , The Theory and practice of
industrial pharmacy,Verghese Publishing House, Bombay, 5859, 1991
2. Leuenberger H, Luy B, Struder J, New development in the control of a moist agglomeration and
pelletization process, STP Pharma Sci, 6, 1990, 303-309.
3. Ylirussi J, Rasanen E, Rantanen J, Mannermaa JP, The characterization of Fluidization Behavior Using a
Novel Multichamber Microscale Fluid Bed, J. Pharma Sci, 3, 2004, 780-791.
4. Gu L, Liew CV, Heng PW. Wet spheronization by rotary processing: a multistage single-pot process for
producing spheroids. Drug Dev Ind Pharm, 30, 2004, 111-123.
5. Ansel C, Allen LV, Popovich NG, Pharmaceutical dosage form and Drug delivery system, Edn 8, B.I
Publications, India, 193, 2005, 243.
6. Ravi Teja Pusapati*, T. Venkateswara Rao, Fluidized bed processing: A review, Indian Journal of
Research in Pharmacy and Biotechnology ISSN: 2321-5674(Print) ISSN: 2320 – 3471(Online)

17. 17