Aerosol are the products that depend on the power of a compressed or liquefied gas to expel the contents from the container. Aerosols are termed also pressurized package.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
A detailed study on every aspects of parenteral :- introduction, preformulation factors, essential requirements, vehicles and additives, isotonicity, production procedure, facilities, and controls, container and closure selection and finally the quality control evaluation of parenterals.
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
Pharmaceutical aerosols have been playing a crucial role in the health and wellbeing of millions of people throughout the world for many years. These products include pressurized metered dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, sublingual’s, skin sprays (coolants, anaesthetics, etc.) and dental sprays. The technology’s continual advancement, the ease of use, and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years.
Many of the tests required for the evaluation of MDIs are similar to those used for other dosage forms. These include description, identification, and assay of the active ingredient; microbial limits; moisture content; net weight, degradation products and impurities (if any); extractable; and any other tests deemed appropriate for the active ingredient.
Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.
a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
Pharmaceutical aerosols have been playing a crucial role in the health and wellbeing of millions of people throughout the world for many years. These products include pressurized metered dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, sublingual’s, skin sprays (coolants, anaesthetics, etc.) and dental sprays. The technology’s continual advancement, the ease of use, and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years.
Many of the tests required for the evaluation of MDIs are similar to those used for other dosage forms. These include description, identification, and assay of the active ingredient; microbial limits; moisture content; net weight, degradation products and impurities (if any); extractable; and any other tests deemed appropriate for the active ingredient.
Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.
a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.
Aeroso spray products (Pharmaceutical technology and genetical engineering)Silvia Shomba
well I don't like to make this type of presentation and i kinda felt super boring... It is described elaborately every single things... during presentation I felt lyk I was just reading not presenting anything... but it would be helpful for students like us to know this topic properly... and this presentation I made according to my course teachers' requirement.. so u guys can give it a shot and don't hesitate to tell me abt my lacking... thank u
Aerosol or Pressurized package is defined as ―A system that depends on the power of a compressed gas or liquefied gas to expel the contents from the container.
This presentation of aerosols tries to give some bit of infomartion about it which includes its introduction, history, advanatges and disadvantages along with quality testing and techniques. It includes some information about manufacturing and formaulation of aerosols that may help to know. It also having some key points about aerosols to remember.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
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Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
2. Aerosols
Aerosol are the products that depend on the power
of a compressed or liquefied gas to expel the
contents from the container. Aerosols are termed
also pressurized package.
Pharmaceutical aerosols:
Aerosol products containing therapeutically active
ingredients dissolved, suspended or emulsified in a
propellant or a mixture of solvent and propellant and
intended for topical administration, for administration into
one of the body cavities (ear, rectum and vagina) or
intended for administration orally or nasally as fine solid
particles or liquid mists through the pulmonary airways,
nasal passages or oral cavity.
4. PROPELLANTS
A propellant is a chemical with a vapor pressure
greater than atmospheric pressure at 40°C (105°F).
Function:
1) It is responsible for developing the vapor pressure
2)
3)
within the container
Expel the product when the valve is opened and in the
atomization or foam production of the product.
When the propellant is a liquefied gas or a mixture of
liquefied gases, it can also serve as the solvent or
vehicle for the product concentrate.
6. Propellants
Compressed Gas Propellants
Gases such as nitrogen, nitrous oxide, and carbon dioxide have been used
as aerosol propellants for products dispensed as fine mists, foams, or
semisolids. Compressed gas propellants only occupy the head space
above the liquid in the can. When the aerosol valve is opened the gas
'pushes' the liquid out of the can. The amount of gas in the headspace
remains the same but it has more space, and as a result the pressure will
drop during the life of the can.
Liquefied gas
Liquefied propellants are gases that exist as liquids under pressure.
Because the aerosol is under pressure the propellant exists mainly as a
liquid, but it will also be in the head space as a gas. As the product is used
up as the valve is opened, some of the liquid propellant turns to gas and
keeps the head space full of gas.
7.
8. Compressed gas propellants
Advantages
Low inhalation toxicity
High chemical stability
High purity
Inexpensive
No environmental problem
Disadvantages
Require use of a nonvolatile
co-solvent
Produce course droplet sprays
Pressure falls during use
9. Liquefied gas propellants
Hydrocarbons
It is mainly used for the preparation of topical preparation, chemically
stable, no hydrolysis, Inflammable , low toxicity.
They are lighter than water.
Chlorofluorocarbon (CFC) propellants
P-11, P-12, and P-114 are the CFCs of
choice for oral, nasal,
and inhalation aerosols.
Advantages
Low inhalation toxicity
High chemical stability
High purity
CFC-11 is a good solvent
10. Liquefied gas propellants
Hydrochlorofluorocarbons (HCFC) and Hydrofluorocarbons (HFC)
The hydrochlorofluorocarbons (HCFC) and hydrofluorocarbons (HFC) differ
from CFCs in that they may not contain chlorine and have one or more
hydrogen atoms. P-22, 142b, and 152a are used in topical pharmaceuticals.
These three propellants have a greater miscibility with water and therefore
are more useful as solvents. They are also slightly more flammable than the
other propellants.
Ether
Di Methyl Ether - This is an alternative liquefied propellant, and is more
common in personal care products, and some air fresheners. DME is
significantly higher in price than hydrocarbon propellants. Classified as a
flammable gas. It is a very strong and aggressive solvent. An advantage of
DME is its solubility in and compatibility with aqueous formulas.
Disadvantage of DME is that in aqueous formulas at levels at or above 19%,
the DME will attack the can lining thus requiring a corrosion inhibitor.
11. Formulation :
Contains two essential components:
Product concentrate : contains ingredients or mixture of active
ingredients and other such as solvents, antioxidants and
surfactants.
Propellant : Propellant May be single or blend of various
propellants
The type of the system
selected depends on many
factors such as
Physical, chemical and
pharmacological properties
of active ingredients
Site of application
12. Formulation
Depending on the type of aerosol system utilized, the pharmaceutical
aerosol may be dispensed as a fine mist, wet spray, quick-breaking
foam , stable foam, semisolid or solid.
Type of systems are
1. Solution system :
Consist of a solution of active ingredients in pure propellant or
a mixture of propellant and solvents.
Easy to formulate, provided that the ingredients are soluble in
the propellant
Aerosol solutions have been used
To make foot preparations
Local anesthetics
Spray on protective films
Anti-inflammatory preparations and
Aerosols for oral and nasal applications
13. 2. Suspension or Dispersion systems
Active ingredients are suspended or dispersed throughout the propellant or
propellant and solvent phase.
Anti-asthmatic drugs, steroids, and antibiotics are delivered as suspension
aerosols. When the valve is actuated, the suspension formulation is emitted
as an aerosol and the propellant rapidly vaporizes and leaves a fine
dispersion of the product concentrate.
There are some problem arise for suspension aerosols that are include
agglomeration, particle size growth, valve clogging, moisture content, and
particle size of the dispersed aerosolized particles.
To overcome these problems:
lubricants:
isopropyl myristate , oleic acid
Provide slippage between particles
Lubricate components parts of the valve
Surfactants: to disperse particles
14. 3.Water based system ( Emulsion, dispersion ):
Relatively large amounts of water can be used to replace all part or part of the
non aqueous solvents used in aerosol. These products are generally referred to
as water-based aerosols and depending on the formulation are emitted as a
spray or foam.
To produce a spray the formulation must consist of a dispersion of active
ingredients and the solvents in an emulsion system in which the propellants is
external phase.
In this way when the product is dispensed, the propellants vaporizes and
disperses the active ingredients into many particles. Since propellant and water
are not miscible a three phase forms (propellants phase, water phase and
vapor phase) are used. To increase the solubility of propellants in water, ethyl
alcohol can be added to the system. Ethanol has been used as a co solvent to
solubilize some of the propellant in the water.
15. 4. Foam system:
Foams are produced when the product concentrate is dispersed
throughout the propellant and the propellant is in the internal phase; i.e.,
the emulsion behaves like o/w emulsion.
Aqueous stable foams-The techniques used in preparing an aerosol
emulsion are the same as those used for non aerosol emulsions. This is
generally used for steroid antibiotics.
Non-aqueous stable foams-Various medicinal agents can be formulated by
this way.
Quick breaking foams-These type of system is specially applicable to
medication, which can be applied to limited or to large areas without the
use of mechanical force to dispense the active ingredients. Quick
breaking foams aerosol may be formulated by ethyl alcohol, surfactant,
water and hydrocarbon propellant.
Thermal foams - These are used when the warmness is required.
16. 5. Intranasal aerosol:
Drug delivery systems intended for the deposition of the
medication into the nasal passageways has long been used as a
most effective, means of administering drugs intended to produce
either a local action of systemic effect.
The Intranasal aerosol offers numerous disadvantage including the
delivery of a measured dose of drug , excellent depth of
penetration into the nasal passageways with minimal intervertent
penetration into lungs, reduce droplet of particle size , lower
dosage than a comparable system preparation maintenance of
sterility from dose to dose.
The modes of administering of intranasal preparations have been
limited to nasal drops, non-pressurized nasal sprays (mist),
inhalants, intranasal gel, creams, ointments.
17. Wherever the medicament is needed, there the
product can be delivered in the required form like
foam, spray etc.
It have rapid onset of action. It will act on targeted
area without any contamination.
In conclusion, aerosol dosage form is a dosage form
with an easy administration. It’s main advantage is it
requires lesser amount of active ingredients or
medicaments.