This document discusses fluidized bed dryers (FBDs) used in pharmaceutical manufacturing. It provides information on: 1) The principle of fluidization where hot air is passed through granules in a container, lifting and suspending them in a "fluidized state" for drying. 2) The construction of FBDs using stainless steel with a detachable bowl, fan, filters and air inlets/outlets. 3) The working where granules are placed in the dryer and hot air flows through them to achieve drying before the air exits.

1. Fluidized Bed Dryer
(FBD)
AMAN VYAWAHARE
4th yr. BPHARM
(P.R.POTE.PATIL COLLAGE OF PHARMACYAMRAVAT)
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2. Contents
• INTRODUCTION
• PRINCIPLE
• CONSTRUCTION
• WORKING
• TYPES OF FBD
• ADVANTAGES
• DISADVANTAGES
• APPLICATION
• VALIDATION 2

3. Introduction :
• Fluidized bed dryer (FBD) is well known and widely used equipment in the
pharmaceutical manufacturing .
• The direct contact between particles and air is possible in fluid bed system
• It is used in granulation process for drying the material to get desired moisture
content in the granules required for perfect compression of tablet formulation.
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4. Principle
• The main principle involved in fluidized bed dryer is
FLUIDIZATION
• Hot air is passed at high speed through a perforated bottom of the container
containing granules
• The granules are lifted from the bottom and suspended in the stream of air this
condition is called “fluidized state”.
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5. CONSTRUCTION:
• Made up of stainless steel
• Detachable bowl
• Fan
• Fresh air inlet, heat exchanger
• Bag filter
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WORKING:
Granules are placed
Hot air flows through the bottom
Granules rise and the fall back
Condition: fluidized state

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Air leaves
Drying is achieved
Time for drying

8. TYPES:
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1. Batch type fluidized
bed dryer

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2. Continuous fluid bed
dryer

10. ADVANTAGES:
• High rates of moisture removal
• Low capital and maintenance cost
• Highly efficient in material drying
• Handling is easy
• Wide range
• No hot spot on the product
• Suitable for both
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11. DIS-ADVANTAGES:
• Poor fluidization and low flexibility
• Not the best choice of equipment
• Entertainment of fine particles
• Product loss
• Sticky material is quite difficult
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12. Application:
• Drying of the granules in the production of the tablet
• Coating of the tablet
• Agriculture , pharma, food ,dairy
• Polymer film coating
• Drying moist (DCPA)
• Top spray granulators
• Formulation , development and production
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13. VALIDATION protocol:
• A Validation Protocol is an approved document which outlines the program to be
employed, the tests that will be made and the acceptance criteria for those tests.
• Validation Phases:
DQ- Design Qualification
IQ- Installation Qualification
OQ-Operational Qualification
PQ- Performance Qualification
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14. DESIGNQUALIFICATION
In fluidized bed dryer the design of the instrument should be:
• occupy the small place.
• Based on our requirement we can go for horizontal or vertical.
• kept in mind while doing the design.
• Every fluid bed dryer must have explosion relief device .
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15. INSTALLATIONQUALIFICATION:
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• Verifying the approved purchase order
model number, serial number
• Ensure all documentation is received
• Check the manufacturer and supplier.
• Check for any physical damage.
• Confirm location and installation
• Dust free area and moisture free air
should be provided.
• Installation shall be conducted per
instructions provided in the manual.

16. OPERATIONAL QUALIFICATION:
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• Verify alarm control.
• Operate the equipment at
low, medium, and high
speed
• Verify that all switches
and push buttons are
functioning properly.
• procedures
• training program
• electrical fittings

17. PERFORMANCE QUALIFICATION:
• Run the trial batch during the:
• 1. Size
• 2. Shape
• 3.Surface of the material which we kept for drying.
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18. MAKERS OF FBD:
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• Tapasya Engineering
works Pvt Ltd.
• Chitra Machineries
Pvt Ltd.
• NU Pharma
Engineers And
Consultant.
• Chamunda Pharma
Machinery Pvt. Ltd.

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