This document discusses flavonoids, which are secondary plant metabolites that provide color and protect plants. It defines flavonoids and describes their biosynthesis, distribution in plants, properties, classification, and various health benefits. Specifically, it summarizes different types of flavonoids like flavonols, flavanones, isoflavonoids, and anthocyanins and their sources. It also outlines several medicinal properties of flavonoids including their antioxidant, anti-inflammatory, anti-cancer, anti-bacterial, anti-ulcer, anti-atherosclerotic, and hepatoprotective effects.
Flavonoids classification, isolation and identificationMona Ismail
Flavonoids are groups of polyphenolic compounds which are found in fruits, flowers, seeds & vegetable.
(named from the Latin word flavus meaning yellow, their colour in nature)
Flavonoids classification, isolation and identificationMona Ismail
Flavonoids are groups of polyphenolic compounds which are found in fruits, flowers, seeds & vegetable.
(named from the Latin word flavus meaning yellow, their colour in nature)
Pharmacognosy
Final year B.Pharm
University of Mumbai
Phenylpropanoids are a diverse group of natural products composed of thousands of different compounds, synthesized from the primary metabolites, phenylalanine or tyrosine amino acids, through a series of enzymatic reactions. ... 4-Coumaryl Co-A serves as the common precursor to flavonoid and phenolic acids biosynthesis.
Introduction to saponin glycosides, Saponin glycosides, Properties of saponin glycosides, Types of saponin glycosides, chemical tests of saponin glycosides
Commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid.
It is an important biochemical metabolite in plants and microorganisms.
Its name comes from the Japanese flower shikimi the Japanese star anise, Illicium anisatum), from which it was first isolated in 1885 by Johan Fredrik Eykman.
The elucidation of its structure was made nearly 50 years later.
Shikimic acid is also the glycoside part of some hydrolysable tannins.
The shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
This pathway is not found in animals; therefore, phenylalanine and tryptophan represent essential amino acids that must be obtained from the animal's diet
Animals can synthesize tyrosine from phenylalanine, and therefore is not an essential amino acid except for individuals unable to hydroxylate phenylalanine to tyrosine).
Pharmacognosy
Final year B.Pharm
University of Mumbai
Phenylpropanoids are a diverse group of natural products composed of thousands of different compounds, synthesized from the primary metabolites, phenylalanine or tyrosine amino acids, through a series of enzymatic reactions. ... 4-Coumaryl Co-A serves as the common precursor to flavonoid and phenolic acids biosynthesis.
Introduction to saponin glycosides, Saponin glycosides, Properties of saponin glycosides, Types of saponin glycosides, chemical tests of saponin glycosides
Commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid.
It is an important biochemical metabolite in plants and microorganisms.
Its name comes from the Japanese flower shikimi the Japanese star anise, Illicium anisatum), from which it was first isolated in 1885 by Johan Fredrik Eykman.
The elucidation of its structure was made nearly 50 years later.
Shikimic acid is also the glycoside part of some hydrolysable tannins.
The shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
This pathway is not found in animals; therefore, phenylalanine and tryptophan represent essential amino acids that must be obtained from the animal's diet
Animals can synthesize tyrosine from phenylalanine, and therefore is not an essential amino acid except for individuals unable to hydroxylate phenylalanine to tyrosine).
Introduction, Isolation and Purification of Flavonoids
Introduction
Structure of flavonoid
Isolation and purification of flavonoid
Structure of Flavonoids
General extraction method of flavonoids
Fractional Crystallization
When
food containing, lignan precursors are
consumed they are converted to the enterolignans,
enterodiol and enterolactone by bacteria that
normally colonize the human intestine
Enterodiol
and enterolactone have weak estrogenic
activity but may also exert biological effects through
nonestrogenic mechanisms
Because
enterodiol and enterolactone can mimic
some of the effects of estrogens, their plant derived
lignan precursors are classified as phytoestrogens
Lignan
precursors that have been identified in the
human diet include pinoresinol, lariciresinol,
secoisolariciresinol, matairesinol and others
Flavonoids are the products of secondary metabolism of plants and, currently, over 4000 have been identified.
In fruits and vegetables, they are usually found in the form of glycosides and sometimes as acylglycosides, while acylated, methylated and sulfate molecules are less frequent and in lower concentrations.
They are water-soluble and accumulate in cell vacuoles.
Phenyl propanoid pathway by kk sahu sirKAUSHAL SAHU
SYNOPSIS
INTRODUCTION
HISTORY
DEFINITION
PRIMARY VS SECONDARY PLANT METABOLISM
SECONDARY METABOLITES
PHENOLIC COMPOUND
PHENYLPROPANOID PATHWAY METABOLITES
PHENYLPROPANOID BIOSYNTHESIS
BIOCHEMICAL PATHWAYS TO PHENOLIC CLASSES
SOME IMPORTANT PRODUCTS OF PHENYLPROPANOID PATHWAY
LIGNANS AND LIGNINS
FLAVONOIDS
METABOLIC ENGINEERING OF PHENYLPROPANOID PRODUCTION
BIOTECHNOLOGICAL APPLICATIONS
CONCLUSION
REFERENCES
Flavonoids are phenolic naturally occurring plant material usually bound to sugar as glycosides.
Flavonoids are represented by C6 C3 C6
Carotenoids are organic pigments that are found in the chloroplasts and chloroplasts of plants and some other photosynthetic organisms, including some bacteria and some fungi. Carotenoids can be produced from fats and other basic organic metabolic building blocks by all these organisms.
In fact, many of the drugs available today contain active ingredients extracted from natural products. Since 1994, nearly half of all drugs were discovered using natural products. Furthermore, between 2005 and 2007, there were 13 new drugs based on natural products that entered the commercial market, including the following 5 new products: small molecule ixabepilone, retapamulin, trabectedin, and the peptides exenatide and ziconotide. Clearly, natural product drug discovery programs continue to play a significant role in the clinical development of new therapies in the biopharmaceutical industry.
This PPT include the description of flavonoids which is useful for pharmacognosy students. It include flavonoids description, classification and identification test.
When food containing, lignan precursors are consumed they are converted to the enterolignans, enterodiol and enterolactone, by bacteria that normally colonize the human intestine.
Enterodiol and enterolactone have weak estrogenic activity but may also exert biological effects through nonestrogenic mechanisms.
Because enterodiol and enterolactone can mimic some of the effects of estrogens, their plant-derived lignan precursors are classified as phytoestrogens.
Lignan precursors that have been identified in the human diet include pinoresinol, lariciresinol, secoisolariciresinol, matairesinol, and others
Flavonoids help regulate cellular activity and fight off free radicals that cause oxidative stress on your body. It has been reported that flavonoids are important for human health because of their antioxidant, antibacterial, antiviral, and anti‐inflammatory activities.
AN INTRODUCTION TOPLANT SECONDARY METABOLITES :ITS APPLICATIONSSupriya Sankranthi
This presentation is about different types of secondary metabolites produced by the plants and thier applications in different fields like medicine,drugs,cosmetics and perfumery,plant defense,role in ecological balance,textile industries.
Phytopharmaceuticals: Occurrence, isolation and characteristic features (chemical nature, uses in pharmacy, medicinal and health benefits) of Quercetin
WHO guidelines on herbal drug monitoringKaustav Dey
This presentation points out the various guidelines laid out by World health organization for safe & effective way of monitoring of Herbal Medicine in a pharmacovigilance setting
Solubility enhancement technique of BCS Class II drug by Solvent EvaporatiomKaustav Dey
I am very happy to share with you my B.Pharm Final semester Presentation. The topic of the presentation was “SOLUBILITY ENHANCEMENT TECHNIQUE OF BCS CLASS II DRUG BY SOLVENT EVAPORATION TECHNIQUE – FORMULATION & EVALUATION" which i have done under the esteemed guidance of Dr. Goutam Kumar Jena. It was a great experience to deliver this topic infront of the expert jury. I would also like thank all my teammates especially Agniv Masanta for his efforts. I hope everyone of you will like presentation and the research and efforts behind it.Thank you for giving your precious time. #research #science #thankyou #experience #share
Artificial intelligence in field of pharmacyKaustav Dey
AI is a program designed to produce outcome in a manner similar to human intelligence,logic and reasoning.This can be used in field of Pharmacy for betterment of humankind, to save lives,money and time
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. Contents
1. What are flavonoids ?
2. Distribution
3. Nomenclature
4. Properties
5. Classification
6. Different types of flavonoids
7. Medicinal & Health benefits
8. Extraction
9. Chemical Tests
3. Flavonoids
Secondary metabolite
Derived from word flavus meaning yellow color
Non - nitrogenous universal plant pigment
Discovered by Hungarian Biochemist Albert Szent-Gyorgi (1938)
Flavonoids are the largest groups (<20,000) of the naturally occurring phenols.
These are described as compounds with a C6-C3-C6 carbon skeleton (15 C-atoms)
Molecular formula – 2-phenyl chromen-4-one ; Phenyl benzopyran
4. Biosynthesis – Phenylpropanoid pathway
Starting material - 4-coumaroyl-CoA
Important enzymes needed for biosynthesis - Chalcone synthase,
flavanone 3-hydroxylase, dihydroflavonol 4-reductase, anthocyanidin
reductase.
Benefits - nutraceutical, pharmaceutical, medicinal and cosmetic
applications.
Therapeutic properties - anti-oxidative, anti-inflammatory, anti-
mutagenic and anti-carcinogenic properties coupled with their capacity
to modulate key cellular enzyme function.
5. Biochemical and antioxidant effects associated with various
diseases such as cancer, Alzheimer’s disease (AD), atherosclerosis, etc
Inhibitors for several enzymes, such as xanthine oxidase (XO) cyclo-
oxygenase (COX), lipoxygenase and phosphoinositide 3-kinase
Plant Benefits - used by vegetables for their growth and defense
against plaques.
Flavonoids protect plants from different biotic and abiotic stresses
and act as unique UV filters(10) , function as signal molecules,
allopathic compounds, phytoalexins, detoxifying agents and
antimicrobial defensive compounds
6. Distribution of Flavonoids
Absent in algae except member of Charophyceae (green algae)
Present in Fungi – Chloroflavonin and Dihydrochalkone (Aspergillus
candidus)
Present everywhere in higher plants
Found throughout the Gymnosperms and Angiosperms
Within plants they are present in every part of the plant.
○ Fruits – Berries, Grapes, Apple, Bell peppers, Citrus Fruits
○ Beans – Soyabeans , Legumes
○ Leaves – Tea, Gingko
○ Flowers
○ Roots & Rhizomes – Glycyrrhiza (Mulethi)
○ Stem & its modifications - Onion
7. Nomenclature
1. Systematic system
○ It is based on the chemical structure and IUPAC naming of the compound
○ Complex to use
○ Example- 2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one
2. Semi-systematic system
○ In this system, flavonoids are named in such a manner that it represent the
subgroup or the types of the flavonoid
○ Most common and more easy and simple to use
○ Example- Flavanone
8. 1. Trivial system
○ Largely on the basis of the name of the source from where they
are isolated
○ In this system ,the nomenclature is done in such a way that its
name indicates its structures
○ Flavonoids with suffix:
○ - 'nidin' indicates Anthacyanidin e.g., - Pelargonidin
○ - 'etin' indicates flavonol type e.g.-Quercetin
○ This method lacks consistency in naming and it was difficult to
adhere to this system
9. 4. Semi-trivial system
○ These names are obtained by modifying the trivial name of a
parent structure (e.g. Chrysin) with a systematic or semi
systematic modifier, e.g., to arrive at the name 8-Prenyl-chrysin.
○ Not used in mainstream due to problems like duplicacy and
ambiguity as the parent structure may have more than one
trivial name and severe difficulties in documentation
10. Properties of Flavonoids
Occur in both aglycone and glycosidic (O- and C-glycosides) form
Mostly are monomeric (e.g.- kaempferol) , but dimeric and oligo- or
polymeric structures (proanthocyanidins) are also known.
11. Properties of Flavonoids
Wide Solubility Pattern
Aglycones: Dichloromethane, Ethylacetate (medium polarity solvent)
Glycones: Methanol, Ethanol or Hydroalcoholics (more polar solvent)
Catechins: Water
12. Classification of Flavonoids
Flavonoids can be classified on the basis of :
○ Saturation of ring C
○ Position of ring B (most prevalent)
○ Molecular weight (least used)
14. Classification of Flavonoids – Saturation of Ring C
When ring C is unsaturated
○ Flavones
○ Flavonols
○ Isoflavones
○ Anthocyanidins
15. Classification of Flavonoids – Position of Ring B
Simple Flavonoids (Ring B attached to 2nd position of Ring C)
Iso-flavonoids (Ring B attached to 3rd position of Ring C)
Neo-flavonoids (Ring B attached to 4th position of Ring C)
16. Classification of Flavonoids – Position of Ring B
Simple Flavonoids
Also known as 2-Phenylbenzopyran
Flavans (flavan-3-ol; flavan-4-ol;
flavan-3,4-diol)
Flavanones
Flavanols (dihydro flavonol)
Flavones
Flavonols
17. Classification of Flavonoids – Position of Ring B
Isoflavonoids
Also known as 3-Phenyl
benzopyran
Isoflavan
Isoflavone
Isoflavanones
Isoflavanol
18. Classification of Flavonoids – Position of Ring B
Neoflavonoids
Also known as 4-Arylbenzopyran
4-ary; coumarins
3,4-dihydro-4-aryl coumarin
Neoflavene
Minor flavonoids
Chalcones
No heterocyclic ring but a open ring
system
Benzopyran nucleus is absent
Precursor for other flavonoids
19. Different Types of Flavonids
Anthocyanins (Pelargonidin, Delphinidin)
○ Found in Fruits, red wine, cereals, leafy & root vegetables.
Proanthocyanidins & Luecoanthocyanidins
Flavones (Luteolin, Apigenin)
○ Found in aromatic herbs like parsley, celery, garlic, green peppers, chamomile tea
and some cereals such as millet and wheat.
Flavonols (Kaempferol, Quercetin, Rutin)
○ Found in Onions , broccoli, blueberries, red wine and tea.
20. Different Types of Flavonids
Flavanones & Flavanonols (Hesperidin, Naringenin)
○ Found in tomatoes, oranges, lemons, mandarins, mint.
Bi-flavonoids (Theasinensin A, Amentoflavone)
Iso-Flavonoids (Gentisin, Diadezin)
○ Found in leguminous plants, soya.
Neo-Flavonoids (Dalbergichromene)
Chalcones (Carthamin) & Aurones (Sulefretin)
○ Found in apples, pears, apricots, red wine, green tea, chocolate.
Rotenoids (Rotenone)
Pterocarpans (Pisatin)
21.
22.
23. Flavonols
Flavonols are flavonoids with a ketone group.
They are building blocks of proanthocyanins.
Flavonols occur abundantly in a variety of fruits and vegetables.
The most studied flavonols are kaempferol, quercetin, myricetin.
Onions, kale, lettuce, tomatoes, apples, grapes tea, red wine and berries
are rich sources of flavonols.
Intake of flavonols is found to be associated with a wide range of health
benefits which includes antioxidant potential and reduced risk of
vascular disease.
24. Flavanones
Flavanones are another important class which is generally present in
all citrus fruits such as oranges, lemons and grapes.
Hesperitin, naringenin and eriodictyol are examples of this class of
flavonoids.
Flavonones are associated with a number of health benefits because
of their free radical scavenging properties.
These compounds are responsible for the bitter taste of the juice
and peel of citrus fruits.
25. Isoflavonoids
Isoflavonoids are a large and very distinctive subgroup of flavonoids.
Isoflavonoids enjoy only a limited distribution in the plant kingdom
and are predominantly found in soyabeans and other leguminous
plants.
Some isoflavonoids have also been reported to be present in
microbes to play an important role as precursors for the
development of phytoalexins during plant microbe interactions .
Isoflavonoids exhibit tremendous potential to fight a number of
diseases.
26. Neoflavonoids
Neoflavonoids are a class of polyphenolic compounds.
While flavonoids have a 2-phenylchromen-4-one backbone,
neoflavonoids have a 4-phenylchromen backbone with no hydroxyl
group substitution at position 2.
The first neoflavone isolated from natural sources in 1951 was
calophyllolide from Calophyllum inophyllum seeds.
It is also found in the bark and timber of the Sri Lankan endemic plant
Mesua thwaitesii .
27. Flavanols, flavan-3-ols or catechins
Flavanols, also called dihydroflavonols or catechins, are the 3-hydroxy
derivatives of flavanones.
They are a highly diversified and multisubstituted subgroup.
Flavanols are also referred to flavan-3-ols as the hydroxyl group is always
bound to position 3 of the C ring.
Unlike many flavonoids, there is no double bond between positions 2 and 3.
Flavanols are found abundantly in bananas, apples, blueberries, peaches and
pears
28. Anthocyanins
Anthocyanins are pigments responsible for colours in plants,
flowers and fruits.
Cyanidin, delphinidin, malvidin, pelargonidin and peonidin are the
most commonly studied anthocyanins .
They occur predominantly in the outer cell layers of various fruits
such as cranberries, black currants, red grapes, merlot grapes,
raspberries, strawberries, blueberries, bilberries and blackberries.
Stability coupled with health benefits of these compounds facilitate
them to be used in the food industry in a variety of applications .
29. Chalcones
Chalcones are a subclass of flavonoids.
They are characterised by the absence of ‘ring C’ of the basic
flavonoid skeleton structure.
Hence, they can also be referred to as open-chain flavonoids.
Major examples of chalcones include phloridzin, arbutin, phloretin
and chalconaringenin.
Chalcones occur in significant amounts in tomatoes, pears,
strawberries, bearberries and certain wheat products.
32. Flavonoids as antioxidants
The best described and most useful property of almost every group of
flavonoids is their capacity to act as antioxidants.
The flavones and catechins seem to be the most powerful flavonoids
for protecting the body against reactive oxygen species (ROS).
Flavonoids can prevent injury caused by free radicals in various ways.
One way is the direct scavenging of free radicals.
Flavonoids are oxidized by radicals, resulting in a more stable, less-
reactive radical.
33. Anti atherosclerotic effects
Atherosclerosis is a condition that results from the gradual build-up of
fatty substances, including cholesterol, on the walls of the arteries.
This build-up, called plaque, reduces the blood flow to the heart, brain
and other tissues and can progress to cause a heart attack or stroke.
An elevated plasma low density lipoprotein (LDL) concentration is a
primary risk factor for the development of atherosclerosis and
coronary artery disease.
Flavonoids seems to suppress LDL oxidation and inflammatory
progression in the artery wall.
34. Anti platelet aggregation effects
Platelet adhesion and subsequent aggregation contributes to both the
development of atherosclerosis and acute platelet thrombus
formation, followed by embolization of constricted arteries.
The main anti aggregatory effect of flavonoids is thought to be by
inhibition of thromboxane A2 formation.
In vitro studies showed that flavonoids bind to platelet membranes
and may therefore have an accumulative effect over time.
35. Anti Ulcer effect
A peptic ulcer is an ulcer of an area of the gastrointestinal tract that is
usually acidic and thus extremely painful.
Majority of peptic ulcers are associated with helicobacter pylori, a
bacterium that lives in the acidic environment of the stomach.
Quercetin seems to play a very important role in the prevention and
treatment of peptic ulcer.
It acts by promoting mucus secretion, thereby serves as gastroprotective
agent, also quercetin has been shown to inhibit the growth of
helicobacter pylori bacterium in in-vitro studies
36. Hepatoprotective Activity
Several flavonoids such as catechin, apigenin, quercetin, naringenin,
rutin, and venoruton are reported for their hepatoprotective activities.
Silymarin , a flavonolignan, has been reported to stimulate enzymatic
activity of DNA-dependent RNA polymerase 1 and subsequent
biosynthesis of RNA and protein, resulting in DNA biosynthesis and cell
proliferation leading to liver regeneration only in damaged livers
Several clinical investigations have shown the efficacy and safety of
flavonoids in the treatment of digestive complaints, such as sensation
of fullness, loss of appetite, nausea, and abdominal pain.
37. Anti-bacterial activity
Flavonoids are known to be synthesized by plants in response to
microbial infection; thus it should not be surprising that they have
been found in vitro to be effective antimicrobial substances against a
wide array of microorganisms.
Flavonoid rich plant extracts from different species have been
reported to possess antibacterial activity.
Several flavonoids including apigenin, galangin, flavone and flavonol
glycosides, isoflavones, flavanones, and chalcones have been shown
to possess potent antibacterial activity
38. Anti-inflammatory Activity
Inflammation is a normal biological process in response to tissue
injury, microbial pathogen infection, and chemical irritation.
A number of flavonoids such as hesperidin, apigenin, luteolin, and
quercetin are reported to possess anti-inflammatory and analgesic
effects. Flavonoids may affect specifically the function of enzyme
systems critically involved in the generation of inflammatory
processes, especially tyrosine and serine-threonine protein
kinases.
39. Anti-cancer Activity
Dietary factors play an important role in the prevention of cancers.
Fruits and vegetables having flavonoids have been reported as
cancer chemo preventive agents.
Consumption of onions and/or apples, two major sources of the
flavonol quercetin, is inversely associated with the incidence of
cancer of the prostate, lung, stomach, and breast.
40. Anti-cancer Activity
Major molecular mechanisms of action of flavonoids are given as
follows:
(1) down regulation of mutant p53 protein,
(2) cell cycle arrest,
(3) tyrosine kinase inhibition,
(4) inhibition of heat shock proteins,
(5) estrogen receptor binding capacity,
(6) inhibition of expression of Ras proteins
43. Chemical Tests
Name of Test Procedure Inference
Shinoda Test
To the alcoholic extract add Mg
turnings and conc. HCl
Orange to red color
indicates presence of
flavonoids
Zinc Test
To the alcoholic extract add Zn
turnings and conc. HCl
Deep red color
indicates presence of
dihydro-flavonoids
Ammonia Test
Dip a strip of filter paper in
alcoholic extract of the plant
and expose it to ammonia
vapors
Yellow color of paper
strip indicates
flavonoids
Vanillin HCl
Test
Vanillin-HCl solution is added to
alcoholic extract of plant
Pink color indicates
flavonoids
44. References
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