This document summarizes pharmacotherapy options for common ENT conditions. It discusses various drug classes used to treat conditions like otitis externa, otitis media, allergic rhinitis, sinusitis, and cough. These include decongestants, antihistamines, mast cell stabilizers, corticosteroids, antifungals, antibiotics, antitussives, analgesics, and ceruminolytics. Specific drug examples are provided for each class. Administration techniques are described for nasal drops and sprays. Side effects and interactions are outlined for several drug classes.
Stase Kepaniteraan Departemen Ilmu Penyakit Saraf (Neurologi)
Universitas Kristen Indonesia
Hanya untuk referensi bukan untuk dicopy paste
Hak cipta penulis langsung
Stase Kepaniteraan Departemen Ilmu Penyakit Saraf (Neurologi)
Universitas Kristen Indonesia
Hanya untuk referensi bukan untuk dicopy paste
Hak cipta penulis langsung
Allergic Rhinitis ppt.
by Vishnuvardhan Thotakura [vishnutv9@gmail.com]
3yr MBBS
i have put BASICS to know all ABOUT ALLERGIC RHINITIS in this ppt. and hope you understand it!
ref: ENT books - Dhingra, Hazarika , pics and video from the internet.
Intranasal drug delivery system - Introduction, Nasal enzymes and nasal ph, cross sectional view of nose, factors affecting nasal absorption, general formulations of intranasal drugs, Intranasal dosage forms, nasal sprays, spray pump devices, nasal aerosols, compressed air nebulizers, nasal powder, nasal gels, applications of intranasal drug delivery system, delivery of intranasal vaccines, intranasal anaesthesia, Evaluation of intranasal formulation, ussing chamber, Advantages and disadvantages of intranasal drug delivery system
As the public by rhinitis - if the nasal allergic content for allergen for affect by nasal mucosa
Can affect for seriously if nasal decongestant and antihistamine .Nasal corticosteroid ...
Ever hear the term "bronchial asthma" and wonder what it means? When people talk about bronchial asthma, they are really talking about asthma, a chronic inflammatory disease of the airways that causes periodic "attacks" of coughing, wheezing, shortness of breath, and chest tightness.
According to the CDC, more than 25 million Americans, including 6.8 million children under age 18, suffer with asthma today.
Allergies are strongly linked to asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Most interestingly, a recent analysis of people with asthma showed that those who had both allergies and asthma were much more likely to have nighttime awakening due to asthma, miss work because of asthma, and require more powerful medications to control their symptoms.
Asthma is associated with mast cells, eosinophils, and T lymphocytes. Mast cells are the allergy-causing cells that release chemicals like histamine. Histamine is the substance that causes nasal stuffiness and dripping in a cold or hay fever, constriction of airways in asthma, and itchy areas in a skin allergy. Eosinophils are a type of white blood cell associated with allergic disease. T lymphocytes are also white blood cells associated with allergy and inflammation.
These cells, along with other inflammatory cells, are involved in the development of airway inflammation in asthma that contributes to the airway hyperresponsiveness, airflow limitation, respiratory symptoms, and chronic disease. In certain individuals, the inflammation results in the feelings of chest tightness and breathlessness that's felt often at night (nocturnal asthma) or in the early morning hours. Others only feel symptoms when they exercise (called exercise-induced asthma). Because of the inflammation, the airway hyperresponsiveness occurs as a result of specific triggers.
At the end of the lecture, students should be able to:
▶ Classify Antihistamines
Define mechanism of action and uses of Antihistamines
Enlisting the adverse effects of Antihistamines.
Describe the Pharmacology of Expectorants and Mucolytics
Explain the mechanism of action ,clinical uses and toxicity of cough suppressants
▶ Histamine is a chemical messenger mostly generated
in mast cell that mediates a wide range of cellular responses, Including;
-Allergic and inflammatory reactions,
-Gastric acid secretion
- Neurotransmission in parts of the brain
▶ Histamine has no clinical application but antihistamines have important therapeutic applications.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
5. Nasal Decongestant:
Nasal decongestants are vasoconstrictive
drugs extremely useful as
nonprescription medication. Both oral
and topical dosage forms are often
chosen as therapy in the common cold.
6. Mechanism of action:
Nasal decongestants belong to the
pharmacological class of
sympathomimetic amines. Decongestant
stimulates alpha-adrenergic agonist, by
constriction of blood vessels, reducing
its supply to the nose, decrease the
amount of blood in sinusoid vessels and
decrease mucosal edema.
7. Types of nasal decongestant:
• Internally or systemic decongestant:
(e.g. pseudoephedrine,
phenylpropanolamine (PPA) and
phenylephrine).
• Topical decongestant: drops or sprays
(e.g. xylometazoline, phenylephrine,
oxymetazoline, naphazoline).
• Inhaler: (1-desoxyephedrine and
propylhexedrine).
8. Systemic nasal decongestant:
Mechanism of action:
Potent direct acting alpha-adrenergic
stimulator with weak beta-Adrenergic
activity, causes vasoconstriction of the
arterioles of the nasal mucosa and
conjunctive, activates the dilator muscle
of the pupil to causes contraction, and
produce systemic arterial
vasoconstriction.
9. Side effect of systemic decongestant:
• CNS effect: Nervousness, restlessness,
headach and insomnia.
• CV effect: increase blood pressure and
increase heart rate.
• Urinary sphincter constriction
12. 1- sprays:
Its advantages:
• Have fast onset of action.
• Cover large surface area.
• Simple to use.
• Inexpensive.
Its disadvantage:
• Imprecise dosage
• Tendency for tip the bottle to become
clogged.
13. 2- drops:
It preferred for small children.
Its disadvantage:
– High risk of contamination.
– Limited coverage into nasal mucosa.
– Easy passage into larynx.
15. Side effect of topical decongestant:
• Local irritation.
• Rebound congestion
16. Example of topical decongestant:
Ephedrine HCL, Xylometazoline HCL,
Oxymetazoline HCL, Ipratropium bromide
(antimuscarinic).
17. Antihistamin
General Mechanism of Action of Antihistamines
• Blocks action of histamine at receptor
• Competes with histamine for binding
• Displaces histamine from receptor
• Most beneficial when given early
19. Toxic Reactions & Side Effects of H1 Blockers
1. CNS depression (mainly in first generation agents).
2. Allergic reactions (topical application).
3. Appetite loss, nausea and vomiting, constipation or
diarrhea.
4. Insomnia, tremors, nervousness, irritability,
tachycardia, dry mouth, blurred vision, urinary
retention, constipation (1st generation).
5. CNS stimulation with hallucinations, motor
disturbances (tremors and convulsions), and death.
6. Secreted in breast milk and can cross the placenta.
20. Drug Interactions of H1 Blockers
• Antihistamines that produce sedation can
potentiate CNS depressants (e.g., barbiturates,
opiates, general anesthetics, and alcohol)
• Antihistamines that possess anticholinergic
actions can produce manifestations of
excessive blockade if given with anticholinergic
drugs (e.g., dry mouth, constipation, or blurred
vision)
21. Second Generation Antihistamines
• Generally do not cause the sedation
• Do not cross the blood-brain barrier as readily
as First Generation compounds
• Lipophobicity
• Large molecular size
23. Corticosteroid
• Act by inhibiting the body's immune
response. They decrease inflammation
and edema of the mucous membranes.
Have no decongestant or antihistamine
effect. Not used to treat the common
cold.
24. Example of Corticosteroid Drugs
• Beclomethasone for nasal
• Mometasone for nasal
• Dexamethasone for ear
25. Antiyeast
• Yeasts, which are one-celled organisms that
are closely related to fungi, grow easily in the
warm, moist, dark environment of the mouth.
This is especially true in patients whose
immune systems are compromised by disease.
Candida albicans yeast infections of the mouth
are also known as oral candidiasis (thrush) or
monilia.
27. Antitusive
• Decrease coughing by suppressing the cough
center in brain or anesthetizing stretch
receptors in respiratory tract. Main purpose is
to control dry, nonproductive coughs. Not
prescribed to treat a productive cough.
30. Obat tetes telinga
Dibuat dalam bentuk sediaan khusus untuk
telinga dgn pembawa yang mudah menyebar
ke dalam liang telinga.
Obat telinga tidak boleh digunakan untuk
jangka panjang karena bisa menimbulkan
ototoksik dan superinfeksi.
Bila infeksi disebabkan oleh jamur/virus tidak
boleh menggunakan obat telinga yang
mengandung antibiotika karena bisa
menimbulkan superinfeksi.
Supplement
40. Penggunaan Tetes Hidung
• 1. Blow the nose.
• 2. Sit down and tilt head backward strongly or lie
down with a pillow under the shoulders; keep head
straight.
• 3. Insert the dropper one centimeter into the
nostril.
• 4. Apply the amount of drops prescribed.
41. • 5. Immediately afterward tilt head forward strongly
(head between knees).
• 6. Sit up after a few seconds, the drops will then
drip into the pharynx.
• 7. Repeat the procedure for the other nostril, if
necessary.
• 8. Rinse the dropper with boiled water.
42. Penggunaan Nasal Spray
• 1. Blow the nose.
• 2. Sit with the head slightly tilted forward.
• 3. Shake the spray.
• 4. Insert the tip in one nostril.
• 5. Close the other nostril and mouth.
• 6. Spray by squeezing the vial (flask, container) and
sniff slowly
43. • 7. Remove the tip from the nose and bend the
head forward strongly (head between the knees).
• 8. Sit up after a few seconds; the spray will drip
down the pharynx.
• 9. Breathe through the mouth.
• 10. Repeat the procedure for the other nostril, if
necessary.
• 11. Rinse the tip with boiled water