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Eugenol
This document summarizes research on the potential use of eugenol as a new anti-depressant. Eugenol is a natural compound found in some plants and spices that has demonstrated various biological activities, including anti-microbial and anti-inflammatory effects. It is currently used as a food flavoring and preservative, and in dentistry. The document discusses depression as a common psychiatric disorder, current drug treatments for depression, and opportunities to study eugenol's mechanism of action and potential therapeutic effects on depression, based on its biological profile.
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Eugenol
- 1. Research Account on New Anti-depressant EUGENOL ….R& D for better tomorrow
- 2. Presented by Dr. SudhakarKokate Director PPRC, India
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- 6. Ф Natural compoundfrom plants esp. from spices and medi-herbs Ф Biological activities: Anti-convulsive, anti-microbial, anti-inflammatory, anti-oxidative PPRC/INDIA 04
- 7. Ф Used fora natural food flavour and as a preservative Ф In dentistry used in root canal-filling materials as an analgesic & as an anti- septic PPRC/INDIA 05
- 8. Ф Used asa pesticide Ф Effective against wide spectrum microbes in vitro: E. coli, H. pylori Ф Anti-oxidant activity Ф Effective on CNS PPRC/INDIA 06
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- 11. Ф Common psycho-disorder ФStat : 20 % at any generation PPRC/INDIA 09
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- 14. Ф Some reports– it is inherited disorder but many other don’t agree Ф Serious societal problem PPRC/INDIA 12
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- 16. Ф Monoamines likenoradrenalin, dopamine, serotonin work as stimulating neurotransmitters in the brain PPRC/INDIA 14
- 17. Ф The amountof monoamines deplete in the pre-synaptic neurons is decreased & also in synaptic spaces Ф Thus neurotransmission is diminished Ф Life activity is decreased - depression PPRC/INDIA 15
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- 19. Ф Decrease inappetite Ф Low activity Ф Hesitate to meet Ф Don’t feel like working Ф No interest in societal activity PPRC/INDIA 17
- 20. Present drugs fordepression PPRC/INDIA 18
- 21. Ф Imipramine Ф Monoamineoxidase inhibitors Ф Modified tricyclic acids / tetracyclic acids PPRC/INDIA 19
- 22. Ф Selective serotoninreceptor inhibitors Ф Serotonin – noradrenalin receptor inhibitors PPRC/INDIA 20
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- 24. Ф Hippocampus isreduced in patients Ф It is restored as the patient recovers Ф Drugs promote regeneration / degeneration PPRC/INDIA 22
- 25. Ф Brain-derived neurotrophicfactor (BDNF) plays important role Ф Increase BDNF in the hippocampus decrease causes depression PPRC/INDIA 23
- 26. Ф Disruption ofneurogenesis completely abolished with drug Ф Inducer of neurodegenerative in depression is not clear Ф Glucocorticoid cause depression in animals PPRC/INDIA 24
- 27. Choice of othersto treat PPRC/INDIA 25
- 28. Ф Herbal medicines ФElectroconvulsive theory Ф Sleep deprivation method PPRC/INDIA 26
- 29. Ф Psychological approach ФYoga & meditation approach Ф Religious method PPRC/INDIA 27
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- 31. Ф Clinical tests ФMisc. approach methods Ф Mechanism Ф Study of Eugenol in Alzheimer’s & Parkinson’s diseases PPRC/INDIA 29
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