PD is commonly found disease these days, majorly causing dementia and loss of balance with tremors. Acanthopanax senticosus is widely used in research for the treatment of Parkinsons disease - PD across the world. Lets take a look at the research scope of the plant for Parkinsons.....

2. Presented by
Dr. Sudhakar Kokate
Director PPRC, India

3. O ! Almighty, grace us all researchers
with your blessings & inspiration to
find remedy for curing P.D.
This presentation is dedicated to all
P.D. sufferers.

4. PPRC/INDIA 01

5.  Nigral degenerative disorder
 Depressive behaviour
 Depletion of tyrosine hydroxylase
(TH) – positive neurons in the mid-
brain
PPRC/INDIA 02

15. Acanthopanax senticosus
Family: Alariaceae
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19. PPRC/INDIA 16

20.  Pole
 Catalepsy
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21. PPRC/INDIA 18

22.  Material: stem bark of
Acanthopanax senticosus Harms
(ASH)
 Ethanolic extract
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23. ASH caused a significant in DA
level in the striatum of rat brain &
that it resulted in protection against
dev. of P.D. caused by MPTP – 1-
methyl-4-phenyl-1,2,3,6-
tetrahydropyridine.
PPRC/INDIA 20

24. ASH has specific activity in the
nigrostriatal DAergic system which
plays important role in Motor
function & motivational aspects of
behaviour.
PPRC/INDIA 21

25. ASH has a specific effect in
suppressing the behavioural
features associated with P.D.
induced by MPTP.
PPRC/INDIA 22

26. ASH & its component sesamin helps in
protect DA cells from rotenone &
prevents P.D., rats exposed to the
agricultural chemical.
ASH may be useful for the critical
prevention of P.D. in hostile
environment. PPRC/INDIA 23

27. PPRC/INDIA 24

28. Gingko biloba /
Panax ginseng CA Meyer
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30. PPRC/INDIA 27

31.  Mechanism
 Search from other plants – new
natural compounds
 Methodology – new modified
 Want of other parameters
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