Semecarpus anacardium L., known as the 'marking nut tree,' is recognized in Ayurveda for its medicinal properties, including anti-cancer effects. The plant exhibits a variety of bioactivities such as anti-inflammatory, anti-microbial, and immunomodulatory effects, with promising results against cancer types like esophagus and liver cancer. Various preparations of this plant are reported to show encouraging anti-tumor activities and the ability to regulate key enzymes involved in cancer progression.

1. Potent Anti-cancer plant
Semecarpus anacardium L.

2. Presented by
Dr. Sudhakar Kokate
Director PPRC, India

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6. Normal cell Cancer cells

7. Semecarpus anacardium L.
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9. Description

10.  Well-known in Ayurveda & Siddha
medicine
 Popularly known as “Marking Nut tree”
 Family: Anacardiaceae
 Medium sized to large tree
 Ht: 15-25 m, grey bark
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11.  Leaves: simple, alternate, obovate
oblong, rounded at the apex
 Flowers: greenish white
 Fruits: ovoid / oblong drupes, 2.5 cm
long
 Nut: 1” x 0.75” x 0.33” Avg. wt: 3.5 gm
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12. Chemicalconstituents

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17. Bio-activity

18. 1. Anti-inflammatory
2. Anti-arthritic
3. Contraceptive agent
4. Hypoglycaemic
5. Lipoxygenase inhibitory
6. Hypo-lipidemic
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19. 7. Hypo-cholesterolemic
8. Anti-microbial
9. Anti-stress
10.Spasmogenic effect
11.Immunomodulatory
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20. Anti-tumour-activity

21.  A variety of “Marking Nut”
preparations used in clinical practice
 Encouraging results reported for
oesophagus, liver, urinary bladder,
cancer and leukaemia
 The flavonoids present in nut have the
ability to prevent various cancers
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22.  It showed differential action in ascites
tumour in the rats
 Extract revealed anti-carcinogenic
activity against AFB1 mediated
hepatocellular carcinoma
 Nut milk extract also showed anti-
tumour activity
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23.  Anti-peroxidative capacity of the nut
extract
 Act as an anti-neoplastic agent
 Regulating the key enzymes
 Significant role in mitochondrial energy
production
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24. Diseasecure

25. 1. Dyspepsia
2. Nervous debility
3. Acute rheumatism
4. Asthma
5. Cough
6. Swelling
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26. 7. Piles
8. Helmintic infections
9. Gout
10.Vision improvement
11.Leucoderma
12.Syphilis
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27. 13.Gonorrhoea
14.Wound healing
15.Diabetes
16.Urinary diseases
17.Leprosy
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28. Thank you!!