The document discusses various classifications and biological underpinnings of depression and antidepressant medications. It describes two main types of depression - episodic/reactive depression brought on by life events and endogenous depression with no clear precipitating cause. Various antidepressant drug classes are also outlined, including tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs). The document suggests that depression may be related to imbalances in neurotransmitters like norepinephrine and serotonin in the brain.
Introduction to Pharmacology of Anti-depressants
Classification, Ideal characteristics, Mechanism of action, Pharmacokinetic profile, Indications, Adverse effects, Drug interactions, Contra indications, Current trends, Conclusion
Presented by
G. Sai Swetha
Department of Pharmacology
They are specific 5-HT and various degrees NE reuptake inhibition.
Venlafaxine, at lower doses (75–100 mg/day) acts as SSRI. As the dose increases it inhibit NE reuptake (& 2ry ↓ DA reuptake in prefrontal cortex, which lacks DAT→ ↑ DA).
Mechanism of Action
300-3000 fold selectivity to block 5-HT >NE reuptake.
Receptors: M, α & H (little blockade)
Uses:
Depression (1st line of treatment of MDD )
Anxiety disorders (GAD, OCD, Panic, …..)
Eating Disorders e.g. Bulimia nervosa, Anorexia Nervosa
Introduction to Pharmacology of Anti-depressants
Classification, Ideal characteristics, Mechanism of action, Pharmacokinetic profile, Indications, Adverse effects, Drug interactions, Contra indications, Current trends, Conclusion
Presented by
G. Sai Swetha
Department of Pharmacology
They are specific 5-HT and various degrees NE reuptake inhibition.
Venlafaxine, at lower doses (75–100 mg/day) acts as SSRI. As the dose increases it inhibit NE reuptake (& 2ry ↓ DA reuptake in prefrontal cortex, which lacks DAT→ ↑ DA).
Mechanism of Action
300-3000 fold selectivity to block 5-HT >NE reuptake.
Receptors: M, α & H (little blockade)
Uses:
Depression (1st line of treatment of MDD )
Anxiety disorders (GAD, OCD, Panic, …..)
Eating Disorders e.g. Bulimia nervosa, Anorexia Nervosa
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An overview of atypical anti depressantsBrajesh Lahri
This powerpoint presentation deals with the pharmacology and psychiatric uses of atypical anti-depressants. TCAs and SSRIs are considered as typical anti-depressants, while other classes include SNRI, RIMAs and atypical antidepressants. In this presentation, i have briefly given an overview of atypical anti-depressants as well as of SNRIs and RIMAs.
Serotonin is major neurotransmitter and affects the physiology of our body. Serotonin antagonists are used in various pathological conditions of body. This is a small presentation showing feature of serotonin.
Major depression and mania are two extremes of affective disorders which refer to a pathological change in mood state
Major depressions characterized by symptoms like sad mood, loss of interest and pleasure, low energy, worthlessness, guilt, psychomotor retardation or agitation, change in appetite and/or sleep, melancholia, suicidal thoughts, etc
3. The mood change may have a psychotic basis with delusional thinking or occur in isolation and induce anxiety. On the other hand, pathological anxiety may lead to depression.
57. XVI. Anti-Manic Drugs PIP PIP 2 G IP 3 IP 2 IP 1 Inositol PI X Li + PLC DAG Ca 2+ www.freelivedoctor.com
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Editor's Notes
High correlation particularly among kin Reserpine, a drug used in the treatment o hypertension and schizophrenia can cause depression because it depletes the vesicular storage of amine neurotransmitters (NE, 5-HT, DA). Depression could be relieved by isoniazid, a drug used in the treatment of tuberculosis. TCAs, MAOIs, SSRIs, and all the new drugs. ECT causes a massive release of NTs and is a very effective antidepressant.
