Tears are a complex mixture that helps lubricate and protect the eyes. When the eyes are not properly lubricated due to conditions like dry eye, excess tears may run down the cheeks as the eyes attempt to compensate for the lack of moisture. However, these tears are mostly water and do not have the same rich composition as normal tears, so they do not properly coat the eyes. Dry eye can be caused by problems with the tear film layers, decreased tear production due to various medical conditions or aging, eyelid issues that impair blinking, certain medications, and environmental factors like wind and computer use. Symptoms of dry eye include pain, light sensitivity, and blurred vision. Treatments include artificial tears, punctal plugs to
Dry Eye and Ocular surface diseases in diabetes mellitusDhwanit Khetwani
RELATION OF DIABETES WITH DRY EYE AND OTHER OCULAR SURFACE DISEASES, MADE FOR THE PURPOSE PROTOCOL PRESENTATION. MADE BY DR DHWANIT KHETWANI OPHTHALMOLOGY RESIDENT
Dry eye occurs when the eye does not produce
tears properly, or when the tears are not of the correct consistency and
evaporate too quickly.
In addition, inflammation of the surface of
the eye may occur along with dry eye. If left untreated, this condition can
lead to pain, ulcers, or scars on the cornea, and some loss of vision. However,
permanent loss of vision from dry eye is uncommon.
Dry eye can make it more difficult to perform
some activities, such as using a computer or reading for an extended period of
time, and it can decrease tolerance for dry environments, such as the air
inside an airplane.
Other names for dry eye include dry eye syndrome,
keratoconjunctivitis sicca (KCS), dysfunctional tear syndrome, lacrimal
keratoconjunctivitis, evaporative tear deficiency, aqueous tear deficiency, and
LASIK-induced neurotrophic epitheliopathy (LNE).
Dry Eye and Ocular surface diseases in diabetes mellitusDhwanit Khetwani
RELATION OF DIABETES WITH DRY EYE AND OTHER OCULAR SURFACE DISEASES, MADE FOR THE PURPOSE PROTOCOL PRESENTATION. MADE BY DR DHWANIT KHETWANI OPHTHALMOLOGY RESIDENT
Dry eye occurs when the eye does not produce
tears properly, or when the tears are not of the correct consistency and
evaporate too quickly.
In addition, inflammation of the surface of
the eye may occur along with dry eye. If left untreated, this condition can
lead to pain, ulcers, or scars on the cornea, and some loss of vision. However,
permanent loss of vision from dry eye is uncommon.
Dry eye can make it more difficult to perform
some activities, such as using a computer or reading for an extended period of
time, and it can decrease tolerance for dry environments, such as the air
inside an airplane.
Other names for dry eye include dry eye syndrome,
keratoconjunctivitis sicca (KCS), dysfunctional tear syndrome, lacrimal
keratoconjunctivitis, evaporative tear deficiency, aqueous tear deficiency, and
LASIK-induced neurotrophic epitheliopathy (LNE).
Dr. Lanin Chen Resident Dept. of Ophthalmology, D. Y. Patil Medical College, Dr. Nita Shanbhag Head of Dept. of Ophthalmology, D. Y. Patil Medical College Navi Mumbai.
In today's digital environment Dry Eyes and associated symptoms have become an epidemic. This presentation was recently delivered at a Pharmacy convention in Sydney Australia. It is applicable for anyone with dry eye problems.
Title: Making dry eyes wet
Author: Dr. Zia ul Mazhry
FRCS (Edin), FRCS (Glasgow), FCPS, CICOphth (UK)
PURPOSE: to review current management options to treat dry eyes especially evaluation of Genteal gel and Systane eye drops as novel new combinations.
clinical outcome. RESULTS: both the agents showed higher satisfaction and better clinical outcomes as compared to other available wetting agents. CONCLUSION: Genteal eye gel and Syatane eye drops are excellent recent additions to available options to treat dry eyes symptomatically. Genteal family appears to be better tolerated as compared to Systane E/D in our experience.
Dr. Zia ul Mazhry
FRCS (Edin), FRCS (Glasgow), FCPS, CICOphth (UK)
Consultant Eye Surgeon and Head of Eye Department
Wapda hospital complex
210 Feroz Pur Road Lahore
0300 440 1151
Eye allergy is 95% amongst allergy rhinitis and most neglected amongst allergy symptoms leading to severe keratoconjunctivitis, conus with complications
blepharitis is an eye disorder , this is divided into two types. one anterior blepharitis another is posterior blepharitis .this caused by other organisms like staphylococcus and dryness of the eyes, avoid touching of the eye .advice to take the medication as prescribed by the doctor.
You have probably researched how to say goodbye to dark circles and eye bags, and you would do almost anything to get rid of them. But, unfortunately, even after you have tried tons of expensive treatments, they just come back!
Dark circles under the eyes may look purple, blue, or dark brown — and you may be wondering if this calls for a serious health problem. The answer is no, but many patients feel that dark circles under the eye area make them look tired, older, and unhealthy.
DRY EYE BY INDRAJIT BISWAS
DRY EYE BY RAIN HEALTH CARE
what is a dry eye?
causes of dry eye
sign symptoms
causes of dry eye,
management of dry eye,
sign and symptoms of dry eye,
what is a dry eye?
At A Plus Optometry, we have a specialised dry eye clinic in Melbourne where we discuss information on the causes and treatment for dry eyes. With a highly qualified team, our Dry Eye Centre will help you prevent and manage dry eyes. Call us on 0388130505 or for more detail visit our site.
People frequently think dark circles are due to tiredness and an absence of sleep. Even though this can be one reason, there are other explanations for dark under eye circles, for instance allergies or the natural aging process.
Dark circles under the eyes might look purple or blue to dark brown or black, depending on skin colour. In some cases, dark circles under the eyes can indicate a need for lifestyle changes, such as improvements to sleep habits or diet. But life today is too busy to do something additional, that’s why London Aesthetics presents you the Best Dark Circle Treatment in town.
Explanation on Eye problems and reviews by Vipin Buckshey at Visual Aids CentreVipin Buckshey
Optometrist Vipin Buckshey is explaining about the common eye problems at Visual Aids Centre. Visual Aids Centre is providing the best iLasik surgery in India.Read reviews about Visual Aids Centre and Vipin Buckshey in this slide.
1. Identify the difference between vertigo, disequilibrium,, near-syncope, and Undifferentiated dizziness.
2. Identify helpful tests to distinguish peripheral from central vertigo.
3. Understand how to treat different kinds of vertigo
Hair diseases are disorders primarily associated with the follicles of the hair. Many hair diseases can be associated with distinct underlying disorders. Hair disease may refer to excessive shedding or baldness (or both). Balding can be localized or diffuse, scarring or non-scarring.
Communication is the act of conveying meanings from one entity or group to another through the use of mutually understood signs and semiotic rules
The ability to communicate effectively is an essential skill in today's world. Communication is a dynamic process.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. • Tears are a complex mixture of water, fatty
oils, and mucus.
• This mixture helps make the surface of
your eyes smooth and clear, and it helps
protect your eyes from infection.
4. Sometimes, a person with a dry eye will have excess tears
running down the cheeks, which may seem confusing.
This happens when the eye isn't getting enough lubrication.
The eye sends a distress signal through the nervous
system for more lubrication. In response, the eye is flooded
with tears to try to compensate for the underlying dryness.
However, these tears are mostly water and do not have the
lubricating qualities or the rich composition of normal tears.
They will wash debris away, but they will not coat the eye
surface properly.
5.
6.
7. 1- Poor tear quality
The tear film has three basic layers: oil, water and mucus.
Problems or imbalance with any of these layers can cause dry
eyes symptoms.
2- Decreased tear production as in
•People older than 50 .
•Postmenopausal woman .
•Have a medical condition that reduces your tear production
such as diabetes, rheumatoid arthritis, lupus, scleroderma,
thyroid disorders and vitamin A deficiency.
•Have had laser eye surgery ( LASIK ).
•Have tear gland damage as from inflammation or radiation
8. 3- Eyelid problems
Blinking spreads a continuous thin film of tears across the
surface of your eyes.
If you have an eyelid problem that makes it difficult to
blink, tears may not be spread across your eye
adequately or your tears may evaporate too quickly,
causing dry eyes.
Eyelid problems can include an out-turning of the lids or
an in-turning of the lids .
9. 4- Medications that cause dry eyes
•Some drugs used to treat high blood pressure (BETA
blockers )
•Antihistamines and decongestants
•Hormone replacement therapy
•Certain antidepressants
•Isotretinoin-type drugs for treatment of acne
10. 5- Additional causes
•Wind
•Dry air
•Tasks that require enough concentration that you blink
less often, such as working at a computer, driving or
reading
11.
12. When tears do not adequately lubricate the eye, a
person may experience:
• Pain
• Light sensitivity
• gritty sensation
• feeling of a foreign body or sand in the eye
• Itching
•Eye fatigue
• Redness
• Blurring of vision
13.
14.
15. • Artificial tear drops and ointments
• Temporary punctal occlusion
• Non-dissolving punctal plugs and punctal
• occlusion by cautery (application of heat to tear
exit duct).
• There is growing evidence that increasing the
oral intake of fish oil and omega-3 via diet or
supplement is very helpful to those suffering with
dry eye.