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DRUGS USED IN CONGESTIVE
HEART FAILURE
BY
SWATHI KENCHA
ASSISTANT PROFESSOR
CONGESTIVE HEART FAILURE
• Congestive heart failure is defined as a chronic and progressive condition
where the heart muscle is unable to pump enough blood through the body
to meet the body need for blood and oxygen.
• It is a disorder in which the heart loses its ability to pump blood
efficiently.
• Congestive heart failure is an inefficiency of the heart to pump sufficient
amount of oxygenated blood to the organs to meet the metabolic demands
and to collect the blood from the organs.
• This leads to fluid retention and abnormality in left ventricles.
SYMPTOMS OF CONGESTIVE HEART FAILURE
• Fatigue
• Weakness
• Shortness of breath
• Fast heart rate
• Chestpain
• Heart palpitations(heartbeats that suddenly become noticeable)
• Swelling of legs and arms
• Swelling of abdomen
TREATMENT-SAVE YOUR HEART
• Check the cause of CHF
• Diet-Low salt and high calorie diet
• Digitalis-This drug will improve the cardiac contractility
• Diuretics-Reduces preload
• Dilators-Reduces afterload
Drugs used to treat CHF –Digoxin, Digitoxin, Nesiritide, Bosentan,
Tezosentan
DIGOXIN & DIGITOXIN
Uses:Digoxin &Digitoxin are used to treat heart failure and abnormal heart
rate(arrythmias).
It helps the heart to work better
(These drugs are obtained from the plant-Digitalis purpurea)
DIGITALIS TOXICITY
• Hypokalemia(Decreases K⁺)
• Dehydration
• Nausea
• Anorexia
• Diarrhoea
• Visual disturbances
• Arrythmias
• Malaise
NESIRITIDE
Uses:It is a recombinant form of the 32 amino acid peptide
To treat patients with heart failure and who are having dyspnea at
rest.
BOSENTAN & TEZOSENTAN
Uses:Tezosentan shows vasodilation in acute heart failure but not assist in
dyspnea.
Bosentan is used to treat pulmonary arterial hypertension(Blood flow
from heart to lungs)
MOA OF DIGOXIN & DIGITOXIN
Digitalis drugs are potent inhibitors of Na⁺/K⁺ ATPase.
This ion transport system moves sodium ions out of the cell and brings
potassium ions into the cell.
It is responsible for maintainance of resting membrane potential in most
excitable cardiac cells.
Digitalis shows positive ionotropic effect and negative chronotropic effect.
THANK YOU

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Drugs used in congestive

  • 1. DRUGS USED IN CONGESTIVE HEART FAILURE BY SWATHI KENCHA ASSISTANT PROFESSOR
  • 2. CONGESTIVE HEART FAILURE • Congestive heart failure is defined as a chronic and progressive condition where the heart muscle is unable to pump enough blood through the body to meet the body need for blood and oxygen. • It is a disorder in which the heart loses its ability to pump blood efficiently. • Congestive heart failure is an inefficiency of the heart to pump sufficient amount of oxygenated blood to the organs to meet the metabolic demands and to collect the blood from the organs. • This leads to fluid retention and abnormality in left ventricles.
  • 3. SYMPTOMS OF CONGESTIVE HEART FAILURE • Fatigue • Weakness • Shortness of breath • Fast heart rate • Chestpain • Heart palpitations(heartbeats that suddenly become noticeable) • Swelling of legs and arms • Swelling of abdomen
  • 4. TREATMENT-SAVE YOUR HEART • Check the cause of CHF • Diet-Low salt and high calorie diet • Digitalis-This drug will improve the cardiac contractility • Diuretics-Reduces preload • Dilators-Reduces afterload Drugs used to treat CHF –Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan
  • 5. DIGOXIN & DIGITOXIN Uses:Digoxin &Digitoxin are used to treat heart failure and abnormal heart rate(arrythmias). It helps the heart to work better (These drugs are obtained from the plant-Digitalis purpurea)
  • 6. DIGITALIS TOXICITY • Hypokalemia(Decreases K⁺) • Dehydration • Nausea • Anorexia • Diarrhoea • Visual disturbances • Arrythmias • Malaise
  • 7. NESIRITIDE Uses:It is a recombinant form of the 32 amino acid peptide To treat patients with heart failure and who are having dyspnea at rest.
  • 8. BOSENTAN & TEZOSENTAN Uses:Tezosentan shows vasodilation in acute heart failure but not assist in dyspnea. Bosentan is used to treat pulmonary arterial hypertension(Blood flow from heart to lungs)
  • 9. MOA OF DIGOXIN & DIGITOXIN Digitalis drugs are potent inhibitors of Na⁺/K⁺ ATPase. This ion transport system moves sodium ions out of the cell and brings potassium ions into the cell. It is responsible for maintainance of resting membrane potential in most excitable cardiac cells. Digitalis shows positive ionotropic effect and negative chronotropic effect.