2. z
ARRYTHMIAS
An arrythmia is a problem with the rhythm of the heart beat.
The heart can beat too fast or with an irregular rhythm
If heart beats too fast ,the condition is called as tachycardia
If heart beats too slow,then the condition is called as bradycardia
4. z
CAUSES OF ARRYTHMIAS
Pacemaker abnormality
Shift of the pacemaker from SA node to another place in the
heart
Heart diseases like CHF,Cardiomyopathy,B.P,Myocardial
infarction,valvular disease.
Drugs & alcohol intoxication
Electrolyte abnormality
Pneumonia
Hyperthyroidism
6. z
QUINIDINE SULPHATE
Uses:To treat supraventricular and ventricular arrythmias
To treat atrial and ventricular tachycardia
To treat atrial flutter and atrial fibrillation
17. z
MECHANISM OF ACTION OF DRUGS
Class-I Drugs: Class-I drugs are Na⁺ channel blockers.They
increase threshold for excitability & decrease automaticity and
prolongs action potential .Drug causes depression of
contractility and decreases B.P.
Class-I Drugs prolongs PR,QRS and shortens repolarization.
18. z
Class-II drugs: β –adrenergic blockers competitively block
catecholamine induced stimulation of cardiac β-receptors.
Drug depress phase 4 depolarization of pacemaker cells,⇩
Heart rate & ⇧ peripheral resistance.
These drugs prolongs action potential duration by ⇩ AV
Conduction.
Then reduces myocardial oxygen demand.
19. z
Class-III drugs: These drugs prolong phase 3 repolarization
without altering phase O.It prolongs action potential by blocking
K⁺ channels & blocks inactivated Na⁺ channels & blocks Ca²⁺
channels,⇩ Conduction and also ⇩ ectopic automaticity.
20. z
Class IV drugs: These drugs inhibit the inward movement of
calcium,⇩ contractility,automaticity and AV Conduction.
21. z
z
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