Skip to main content
UploadLanguage (EN)Support
BusinessMobileSocial MediaMarketingTechnologyArt & PhotosCareerDesignEducationPresentations & Public SpeakingGovernment & NonprofitHealthcareInternetLawLeadership & ManagementAutomotiveEngineeringSoftwareRecruiting & HRRetailSalesServicesScienceSmall Business & EntrepreneurshipFoodEnvironmentEconomy & FinanceData & AnalyticsInvestor RelationsSportsSpiritualNews & PoliticsTravelSelf ImprovementReal EstateEntertainment & HumorHealth & MedicineDevices & HardwareLifestyle
KS
Uploaded bykencha swathi
2,765 views

Antiarrythmic drugs

This document discusses antiarrhythmic drugs used to treat abnormal heart rhythms known as arrhythmias. It defines arrhythmias as problems with the heart's rhythm that can cause it to beat too fast (tachycardia) or too slow (bradycardia). Antiarrhythmic drugs are classified into four classes based on their mechanisms of action - Class I drugs block sodium channels, Class II drugs are beta-blockers, Class III drugs prolong the heart's repolarization phase, and Class IV drugs block calcium channels. Examples of specific antiarrhythmic drugs are provided for each class along with their uses and mechanisms of action in treating different types of arrhythmias.

Education◦
z ANTIARRYTHMIC DRUGS BY KENCHA SWATHI z
z ARRYTHMIAS  An arrythmia is a problem with the rhythm of the heart beat.  The heart can beat too fast or with an irregular rhythm  If heart beats too fast ,the condition is called as tachycardia  If heart beats too slow,then the condition is called as bradycardia
z SYMPTOMS  Fluttering chest sensation  Shortness of breath  Tiredness  Angina  Dizziness  Profuse sweating  Tachycardia &Bradycardia
z CAUSES OF ARRYTHMIAS  Pacemaker abnormality  Shift of the pacemaker from SA node to another place in the heart  Heart diseases like CHF,Cardiomyopathy,B.P,Myocardial infarction,valvular disease.  Drugs & alcohol intoxication  Electrolyte abnormality  Pneumonia  Hyperthyroidism
z CLASSIFICATION OF ANTIARRYTHMIC DRUGS  Class-I :Membrane depressant drugs Quinidine sulphate,Procainamide, Phenytoin,Disopyramide, Tocainide, Lidocaine  Class-II :β-Adrenergic blockers Sotalol  Class-III :Repolarisation prolongators Amiodarone,Mexiletine,Lorcainide  Class IV: Calcium channel blockers-Diltiazem,Verapamil
z QUINIDINE SULPHATE  Uses:To treat supraventricular and ventricular arrythmias To treat atrial and ventricular tachycardia To treat atrial flutter and atrial fibrillation
z PROCAINAMIDE HCl  Uses: To treat ventricular tachycardia and atrial arrythmias
z PHENYTOIN SODIUM  Uses:Anticonvulsant To treat arrythmias
z DISOPYRAMIDE PHOSPHATE  Uses: To treat arrythmias
z TOCAINIDE HCl  Uses:To prevent or to treat ventricular ectopy and tachycardia
z LIDOCAINE HCl  Uses:Local anaesthetic to treat arrythmias
z SOTALOL  Uses:β-Blocker To treat cardiac arrythmias
z AMIODARONE  Uses:To treat tachycardia To treat ventricular and supraventricular arrythmias.
z MEXILETINE HYDROCHLORIDE  Uses: Antiarrythmic agent
z LORCAINIDE HYDROCHLORIDE  Uses: Antiarrythmic drug
z  4 –Resting potential  O-open  1 –Inactive phase & 2-Plateau phase  3-Rapid repolarization & Next 4-Depolarisation
z MECHANISM OF ACTION OF DRUGS  Class-I Drugs: Class-I drugs are Na⁺ channel blockers.They increase threshold for excitability & decrease automaticity and prolongs action potential .Drug causes depression of contractility and decreases B.P.  Class-I Drugs prolongs PR,QRS and shortens repolarization.
z  Class-II drugs: β –adrenergic blockers competitively block catecholamine induced stimulation of cardiac β-receptors.  Drug depress phase 4 depolarization of pacemaker cells,⇩ Heart rate & ⇧ peripheral resistance.  These drugs prolongs action potential duration by ⇩ AV Conduction.  Then reduces myocardial oxygen demand.
z  Class-III drugs: These drugs prolong phase 3 repolarization without altering phase O.It prolongs action potential by blocking K⁺ channels & blocks inactivated Na⁺ channels & blocks Ca²⁺ channels,⇩ Conduction and also ⇩ ectopic automaticity.
z  Class IV drugs: These drugs inhibit the inward movement of calcium,⇩ contractility,automaticity and AV Conduction.
z z Fitness Progress Plan for a Healthy Lifestyle Healthy Lifestyle Diet Exercise Hydration Immune System Goals Mental Attitudes
z Thank You z