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Gastric Proton pump inhibitors

The document discusses proton pump inhibitors (PPIs) which inhibit gastric acid secretion by blocking the hydrogen-potassium ATPase pump in the stomach. PPIs are converted to sulfoxide derivatives that covalently bind to cysteine residues on the pump, preventing it from pumping protons into the stomach lumen. Common PPIs mentioned are omeprazole, pantoprazole, rabeprazole, and lansoprazole. Each drug is used to treat various acid-related gastrointestinal conditions such as heartburn, GERD, and ulcers. The mechanism of action involves the covalent inhibition of the proton pump through binding of activated PPIs to the pump.

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PROTON PUMP INHIBITORS BY KENCHA SWATHI ASSISTANT PROFESSOR BANGALORE Swathi Pharma Jnan
GASTRIC PROTON PUMP INHIBITORS • Acid secretion in the parietal cells leads to pumping of protons into the lumen of stomach by the membrane H+,K+ - ATPase pump. • Inhibition of proton pump leads to blockade of gastric acid secretion. • Proton pump inhibitors converted to sulfoxide derivatives which are highly potent • These drugs inhibits proton pump via covalent interaction with sulfhydryl groups with cysteine residues of the H+ -K+ ATPase pump. Eg: Omeprazole, Pantoprazole,Rabeprazole, Lansoprazole Swathi Pharma Jnan
OMEPRAZOLE Uses: To treat heart burn,GERD,duodenal ulcer,Erosive esophagitis & Gastric ulcer Swathi Pharma Jnan
PANTOPRAZOLE Uses: To treat Erosive esophagitis, Zollinger- Elison syndrome. Swathi Pharma Jnan
RABEPRAZOLE Uses: To treat duodenal ulcer To treat Gastro esophageal Reflux disorder. To treat H.Pylori infection Swathi Pharma Jnan
LANSOPRAZOLE Uses: To treat gastric & duodenal ulcer To treat gastritis associated with NSAIDS. To treat Zollinger- Elison syndrome & duodenal ulcer with H.Pylori infection. Swathi Pharma Jnan
MECHANISM OF ACTION • Proton pump inhibitors converted to sulfoxide derivatives which are highly potent • These drugs inhibits proton pump via covalent interaction with sulfhydryl groups with cysteine residues of the H+ -K+ ATPase pump. Swathi Pharma Jnan
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