X-ray imaging is still one of the most important diagnostic methods used in medicine. It provides mainly morphological (anatomical) information - but may also provide some physiological (functional) information.
X- Ray physics- X-Ray Tube, Transformer, Generator and Rectifiers by kajalsra...DrKajalLimbad
X-Ray physics including x-ray tube, transformer, generator, and rectifiers. physics made an easy
Note: this ppt has many animations that may not be appreciated over here. Request original ppt at kajalsradiology@gmail.com
X- Ray physics- X-Ray Tube, Transformer, Generator and Rectifiers by kajalsra...DrKajalLimbad
X-Ray physics including x-ray tube, transformer, generator, and rectifiers. physics made an easy
Note: this ppt has many animations that may not be appreciated over here. Request original ppt at kajalsradiology@gmail.com
brief but informative knowledge about how CT works and what are its components ... easy to understand as well as presenting during lectures and in classes . share it
Quality Assurance Programme in Computed TomographyRamzee Small
Introduction to Computed Tomography
Basic description of the components of a CT System
Introduction to Quality Assurance
Quality Assurance and Quality Control Tests in Computed Tomography base on frequency
Objective of QA/QC Test
brief but informative knowledge about how CT works and what are its components ... easy to understand as well as presenting during lectures and in classes . share it
Quality Assurance Programme in Computed TomographyRamzee Small
Introduction to Computed Tomography
Basic description of the components of a CT System
Introduction to Quality Assurance
Quality Assurance and Quality Control Tests in Computed Tomography base on frequency
Objective of QA/QC Test
A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
3. X-Ray Imaging
X-ray imaging is still one of the most
important diagnostic methods used in
medicine. It provides mainly morphological
(anatomical) information - but may also
provide some physiological (functional)
information.
5. Basic x-ray physicsBasic x-ray physics
X-rays: a form of electromagnetic energyX-rays: a form of electromagnetic energy
Travel at the speed of lightTravel at the speed of light
Electromagnetic spectrumElectromagnetic spectrum
Gamma RaysGamma Rays X-raysX-rays
Visible lightVisible light Infrared lightInfrared light
MicrowavesMicrowaves RadarRadar
Radio wavesRadio waves
6. An X-ray machine is basically
like a camera. It uses X-
rays to expose the film, instead
of visible light.
X-rays are similar to light in
that they are electromagnetic
waves, but they are more
energetic so they can penetrate
many materials to varying
degrees. When the X-rays hit
the film, they expose it just as
light would. Various structures
such as bone, fat, muscle,
tumors and all other masses
absorb X-rays at different
levels
7. That X-ray light is very strong and is not visible to
human eyes
X-rays can penetrate objects opaque. X-rays are
commonly used to look at something we cannot see
directly.
X-rays or Roentgen rays are a form of electromagnetic
radiation
X-rays are commonly used in the diagnosis of medical
images
X-rays are a form of ionizing radiation and can be
dangerous.
8. Three things can happenThree things can happen
X-rays can:X-rays can:
PassPass all the wayall the way throughthrough the bodythe body
Be deflected orBe deflected or scatteredscattered
BeBe absorbedabsorbed
9. X-rays were discovered in 1895
when Wilhelm Conrad
Roentgen observed that a
screen coated with a barium
salt fluoresced when placed
near a cathode ray tube.
Roentgen concluded that a form
of penetrating radiation was
being emitted by the cathode
ray tube and called the
unknown rays, X-rays.
10. First ever X ray in historyFirst ever X ray in history
11. X-rays Passing Through TissueX-rays Passing Through Tissue
Depends on the energy of the x-ray and theDepends on the energy of the x-ray and the
atomic number of the tissueatomic number of the tissue
Higher energy x-ray - more likely to passHigher energy x-ray - more likely to pass
throughthrough
Higher atomic number - more likely to absorbHigher atomic number - more likely to absorb
the x-raythe x-ray
12. How do x-rays passing through theHow do x-rays passing through the
body create an image?body create an image?
X-rays that pass through the body to the filmX-rays that pass through the body to the film
render the film dark (black)render the film dark (black)
X-rays that are totally blocked do not reach theX-rays that are totally blocked do not reach the
film and render the film light (white)film and render the film light (white)
Air = low atomic # = x-rays get through =Air = low atomic # = x-rays get through =
image is darkimage is dark
Metal = high atomic # = x-rays blocked =Metal = high atomic # = x-rays blocked =
image is light (white)image is light (white)
14. Different tissues in body absorbDifferent tissues in body absorb
X-rays at different extents:X-rays at different extents:
• Bone-Bone- high absorption (white)high absorption (white)
• Tissue-Tissue- somewhere in the middle absorptionsomewhere in the middle absorption
(grey)(grey)
• Air-Air- low absorption (black)low absorption (black)
15.
16. Main Parts of the X-ray DeviceMain Parts of the X-ray Device
X-ray tubeX-ray tube
Voltage-Current GeneratorVoltage-Current Generator::
- High Voltage TransformerHigh Voltage Transformer – supplies high voltage– supplies high voltage
(up to 150kV)(up to 150kV)
- RectifierRectifier -- producesproduces unidirectionalunidirectional tube electrontube electron
currentcurrent
17. Control panelControl panel – today most parameters of the– today most parameters of the
device (including voltage and current) aredevice (including voltage and current) are
controlled by means of a computer. It is locatedcontrolled by means of a computer. It is located
outside the examination room or behind a shieldoutside the examination room or behind a shield
made of glass containing lead (to protect themade of glass containing lead (to protect the
radiological assistantradiological assistant
18. MainMain mechanical partsmechanical parts: tube stand,: tube stand,
examination table, grid for removing scatteredexamination table, grid for removing scattered
photons (‘Bucky’),photons (‘Bucky’),
X-ray detectorX-ray detector: cassette with radiographic film: cassette with radiographic film
and adjacent fluorescent screens (and adjacent fluorescent screens (in radiographyin radiography))
19.
20. Passage of X-rays throughPassage of X-rays through
PatientPatient's Body's Body
X-rays emitted from a smallX-rays emitted from a small focal areafocal area of theof the
anode propagate in all directions. In the tubeanode propagate in all directions. In the tube
envelope, some low energy photons areenvelope, some low energy photons are
absorbed. Further absorption ofabsorbed. Further absorption of thesethese photonsphotons
occurs in theoccurs in the primary filterprimary filter, made of aluminium, made of aluminium
sheet.sheet. It absorbsIt absorbs low energy photons whichlow energy photons which
would be absorbed by surface tissues and do notwould be absorbed by surface tissues and do not
contribute to the image formation (unnecessarycontribute to the image formation (unnecessary
patient dose). X-ray beam is delimited bypatient dose). X-ray beam is delimited by
rectangularrectangular collimator platescollimator plates made of lead.made of lead.
21. The rays then pass through the body whereThe rays then pass through the body where
transmission or absorption ortransmission or absorption or scattering mayscattering may
occur. After that they pass through theoccur. After that they pass through the gridgrid,,
which is in front of the detector to removewhich is in front of the detector to remove
scattered photons as these would degrade thescattered photons as these would degrade the
image.image.
22. WavelengthWavelength
The wavelengthThe wavelength (( λλ )) of x-ray range 10of x-ray range 10
nanometers to 100 picometers (with frequencynanometers to 100 picometers (with frequency
10101616
Hz until 10Hz until 102020
HzHz).).
These X-rays have a shape similar to that ofThese X-rays have a shape similar to that of
ordinary light rays, infrared and radio waves;ordinary light rays, infrared and radio waves;
differing only in terms of wavelength otherdiffering only in terms of wavelength other
features.features.
24. Use of the Contrast AgentsUse of the Contrast Agents
The soft tissueThe soft tissuess only slightly differ in theironly slightly differ in their
attenuation. Therefore they cannot beattenuation. Therefore they cannot be
distinguished in a common radiograph.distinguished in a common radiograph.
That is the reason for the use ofThat is the reason for the use of
pharmaceuticals calledpharmaceuticals called contrast agentscontrast agents..
25. The attenuation of certain tissues can beThe attenuation of certain tissues can be
increased or lowered.increased or lowered. Positive contrastPositive contrast isis
achieved by substances having a high protonachieved by substances having a high proton
number as the probability of the photoelectricnumber as the probability of the photoelectric
effect is increased. A suspension of bariumeffect is increased. A suspension of barium
sulphate, “barium meal”, is used for imaging andsulphate, “barium meal”, is used for imaging and
functional examination of GIT. In examinationsfunctional examination of GIT. In examinations
of blood, biliary and urinary vessels etc.of blood, biliary and urinary vessels etc.
compounds with high content of iodine arecompounds with high content of iodine are
used.used.
26. Hollow inner body organs can beHollow inner body organs can be
visualised byvisualised by negative contrastnegative contrast. Air or. Air or
better CObetter CO22 can be used. The cavities arecan be used. The cavities are
filled by gas, inflated, so that they can befilled by gas, inflated, so that they can be
visualised as structures of very lowvisualised as structures of very low
attenuation (pleural space, peritoneum,attenuation (pleural space, peritoneum,
brain chambers).brain chambers).
27. Positive and Negative ContrastPositive and Negative Contrast
Contrast image of the
appendix – diverticulosis –
combination with negative
contrast
29. Why is a lead shield/apron placed on youWhy is a lead shield/apron placed on you
when you get an x ray?when you get an x ray?
X-rays emit radiation which cause mutationsX-rays emit radiation which cause mutations
to healthy cells. X-rays are only harmful ifto healthy cells. X-rays are only harmful if
you are exposed to them for a really LONGyou are exposed to them for a really LONG
time. X-rays you get at the doctors are okaytime. X-rays you get at the doctors are okay
because you don’t get them everyday. X raysbecause you don’t get them everyday. X rays
are more beneficial than they are harmfulare more beneficial than they are harmful
because they can detect problems that canbecause they can detect problems that can
be detrimental to your health.be detrimental to your health.
31. Can be obtained by changing the relativeCan be obtained by changing the relative
orientation of the body and the direction of theorientation of the body and the direction of the
X-ray beamX-ray beam
32. The PA (postero-anterior) viewThe PA (postero-anterior) view
It is the mostIt is the most frequently requiredfrequently required radiologicalradiological
examination. Comparison of current film withexamination. Comparison of current film with
old films is valuableold films is valuable
33. Position:Position: Patient facing thePatient facing the
film, chin up with the shouldersfilm, chin up with the shoulders
rotated forwards to displacedrotated forwards to displaced
the scapulae from the lungs.the scapulae from the lungs.
Exposure is made on fullExposure is made on full
inspirationinspiration
34. AP viewAP view
The X ray beam enters through anterior aspectThe X ray beam enters through anterior aspect
and exits through the posterior aspectand exits through the posterior aspect
35. Lateral view:Lateral view:
The pt stands with bothThe pt stands with both
arms raised and the left sidearms raised and the left side
of the chest pressed againstof the chest pressed against
a flat surfacea flat surface
36. Lateral decubitus positionLateral decubitus position
It is helpful to assess the volume of pleuralIt is helpful to assess the volume of pleural
effusion and demonstrate whether a pleuraleffusion and demonstrate whether a pleural
effusion is mobile or noteffusion is mobile or not
Lateral decubitus position film showing mobile
pleural effusion (arrows
37. CTCT
ScannerScanner Computed tomography or CT scan
works on the same principles as fixed
plate x rays, only with a CT scan, an x ray
tube rotates around the individual, taking
hundreds of images that are then compiled
by a computer to produce a two-
dimensional cross section of the body.
Although many images are taken to
produce a CT scan, the total dose of
radiation the individual is exposed to is
low.
38. Optimal ViewingOptimal Viewing
Dedicated light sourceDedicated light source
Darkened environment (like a movie theater)Darkened environment (like a movie theater)
Limit distractionLimit distraction
40. Medical ImagingMedical Imaging
Primary purpose is to identify pathologicPrimary purpose is to identify pathologic
conditions.conditions.
Requires recognition of normal anatomy.Requires recognition of normal anatomy.
41. Summary:Summary: How do x-rays create an image ofHow do x-rays create an image of
internal body structures?internal body structures?
X-rays pass through the body to varying degreesX-rays pass through the body to varying degrees
Higher atomic number structures block x-raysHigher atomic number structures block x-rays
better, example bone.better, example bone.
Lower atomic number structures allow x-rays toLower atomic number structures allow x-rays to
pass through, example: air in the lungs.pass through, example: air in the lungs.