Recent advancements in modern x ray tubeSantosh Ojha
All the advancements in X-ray tubes till date are done to increase the Tube heat storage capacity thus increasing the lifetime of x -ray tubes. This slide explains about these recent advancements in x-ray tubes.
Recent advancements in modern x ray tubeSantosh Ojha
All the advancements in X-ray tubes till date are done to increase the Tube heat storage capacity thus increasing the lifetime of x -ray tubes. This slide explains about these recent advancements in x-ray tubes.
Solar energy can be directly converted into electrical energy.
Energy conversion devices which are used to convert sunlight into electricity by the use of photovoltaic effect are called solar cell.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Contents
• Brief introduction to Generators and Transformers
• Rectification
• Rectifiers
• Types of Rectifiers
• Summary
3. Generators
• An x-ray generator is the device that supplies electric power to the
x-ray tube.
• The tube requires electrical energy for two purposes:
1. to boil electrons from the filament and
2. to accelerate these electrons from the cathode to the anode.
4. • The mechanism of an x-ray generator is usually continued in two
separate compartments
1. a control panel or console and
2. a transformer assembly
5.
6. Transformers
• Transformers are used to change the potential difference of the
incoming electric energy to the appropriate level.
7. • A transformer consists of two wire coils wrapped around a closed
core.
• The circuit containing the first coil (which is connected to the
available electric energy source) is called the primary circuit.
• The circuit containing the second coil (from which comes the
modified electric energy) is called the secondary circuit.
9. Transformers in x-ray circuit
• The transformer assembly , is a grounded metal box filled with oil.
• It contains
1. a low-voltage transformer for the filament circuit and
2. a high-voltage transformer and a group of rectifiers for the high-
voltage circuit.
• Autotransformer
10.
11. Rectification
• Rectification is the process of changing alternating current into
direct current.
• The high-voltage transformer provides an alternating voltage for the
x-ray tube.
12. • When the cathode is negative with respect to the anode, electrons
flow at high speed from the cathode to the anode and x rays are
produced.
• During the next half of the electrical cycle the target (anode) of the
x-ray tube is negative and the filament positive, so electrons, if they
are available, would flow away from the target toward the filament.
14. • It would be highly undesirable to have electrons moving from the
target to the filament for two reasons:
1. such electrons would not produce useful x rays, and
2. such electrons would further heat the filament and reduce its
lifetime.
15. Rectifier
• A rectifier is a device that allows an electrical current to flow in one
direction but does not allow current to flow in the other direction.
• Rectifiers are incorporated into the x-ray circuit in series with the x-
ray tube.
16.
17. Types
1. Vacuum tube rectifiers :
2. Solid-state rectifiers : Solid-state rectifiers are smaller, more
reliable, and have a longer life.
Selenium was the first material used for solid-state rectifiers. Today
most x-ray generators use silicon rectifiers.
18. • A single silicon rectifier (called a cell) will resist a reverse voltage of
about 1000 V, which is 10 to 20 times higher than a selenium
rectifier.
• Silicon rectifiers can withstand a temperature of up to 392° C,
considerably higher than selenium at 266° C.
• A silicon rectifier is made up of a number of cells, or individual
diodes, connected together to form a cylindrical stack that might
have dimensions of 20 to 30 cm long by 20 mm diameter. Such a
rectifier can operate up to 150 kVp and 1000 mA.
21. Semiconductor
• The heart of a solid-state rectifier is a semiconductor, which is
usually a piece of crystalline silicon.
• Silicon contains four valence electrons.
• The valence electrons must lose or gain energy to move from one
energy level to another.
• Electrons in the conduction band (which corresponds to unfilled
energy levels) are relatively free from atomic bonding and may
move freely through the semiconductor material.
22. • If there is no forbidden region at
normal temperature and pressure,
the material is called a conductor.
• If, the forbidden region is in the
order of an electron volt, the
material is called a semiconductor.
• If the forbidden gap is of the order
of 10 eV the material is an insulator.
23. • At absolute zero temperature, the semiconductor behaves as an
insulator.
• At room temperature, some of the electrons are thermally raised to
the conduction band and are available to support a current.
• So the word "semiconductor" describes material that at low
temperatures acts like an insulator, but at normal room
temperature acts like a conductor.
24. N-type Semiconductor
• Silicon contains four valence electrons. If a material with five
valence electrons is added as an impurity to the silicon crystal, the
added atoms will take the place of some silicon atoms throughout
the crystal.
• This unbound electron can move about in the crystal much easier
than one of the bound electrons.
• The impurity is called a donor since it donates an extra electron .
The crystal resulting from the addition of the donor is called N-type,
with N derived from the negative charge of the surplus electron.
• Arsenic and Antimony
26. P-type Semiconductor
• If an impurity with only three valence electrons is added to silicon,
the impurity atom will have only three electrons to share with four
surrounding silicon atoms.
• One silicon atom now has an electron that is looking for another
electron with which to form a covalent bond.
• The absence of this electron is called a "hole." Since the hole is a
positive particle, as compared to the negative electron, the material
is called a P-type semiconductor.
• Indium, Gallium, and Aluminium
28. P-N Junctions
• P-N junction can be formed only by a complex process in which the
P and N materials are diffused into a single crystal.
• When the junction is formed, electrons diffuse across the junction
• When electrons leave the N-type material, the junction area is left
with a net positive charge. Similarly, the P-type material acquires a
negative charge. This creates what is called a "depletion layer."
• The depletion layer has a junction potential that is opposite in sign
to the designation of the materials (i.e., the junction potential is
positive on the side of the N-type and negative on the side of the P-
type material).
29. • The device formed by a P-N junction is called a diode. Solid-state
rectifiers are diodes.
• If a voltage is applied to a diode, current will flow or not flow
depending on the polarity.
• If the polarity of the applied voltage is opposite that of the junction,
electrons will flow from the N-type material across the junction
barrier to the P-type material and current will flow.
30.
31. Forward bias
• The negative pole of a battery is connected to the N-type material
and the positive pole to the P-type. This is called forward bias.
32. Reverse bias
• If the polarity of the applied voltage were reversed, with the
negative pole of a battery being connected to the P-type material,
the junction potential would be augmented and no current would
flow. This is called reverse bias.
33. Types of rectifiers
1. Single phase
Half-wave rectifier
Full-wave rectifier
Bridge-wave rectifier
2. Three phase
Six pulse, six-rectifier
Six pulse, twelve-rectifier
Twelve-pulse rectifier
34.
35. Half-wave rectifier
• Electrons flow through the x-ray tube from the cathode to the
anode.
• When the voltage reverses during the inverse half of the alternating
cycle, the rectifier stops current flow.
• When rectifiers are used in this manner they produce halfwave
rectification .
38. Full-wave rectifier
• Both halves of the alternating voltage are used to produce x rays, so
the x-ray output per unit time is twice as large as it is with half-
wave rectification .
43. Six pulse, six-rectifier
• This design employs a delta-wound primary transformer with a
wye-wound secondary transformer. The output of the secondary
windings is rectified with six solid-state rectifiers.
• There are three maximum and three minimum voltages in one
complete cycle (1/60 sec). When rectified, there will be six positive
maximum voltages per cycle. Thus the term "six pulse."
45. Six pulse, twelve-rectifier
• This circuit is still a six-pulse circuit
• This circuit has a fixed potential to ground, an advantage over the
six-rectifier circuit.
47. Twelve-pulse rectifier
• Looks similar to the six-pulse, the difference is that the secondary is
not a double wye connection; it is a wye and a delta connection.
• When a delta and a wye winding are connected together in the
secondary, the output of the delta will lag the wye by 30°. The
result of this is that the output of one winding will fill in the ripple
of the other, resulting in a twelve-pulse rather than a sixpulse
output
49. Ripple factor
• The ripple factor is the variation in the voltage across the x-ray tube
expressed as a percentage of the maximum value.
• With a single-phase circuit the ripple factor is 100% because the
voltage goes from zero to a maximum value with each cycle.
• A six-pulse circuit has a ripple factor of 13.5%.
• A twelve-pulse circuit has a theoretical ripple factor of 3.5%.
51. • When three-phase generators are operated under load, the ripple
factor is accentuated.
• This is known as the load ripple-factor, and is always greater than
the theoretical ripple.
• The load ripple-factor of a twelve-pulse, three phase system is
about 5%.