DNA replication is a semiconservative process. It means that each strand acts as a template for the synthesis of a new complementary strand. Therefore, this process takes us from one parent molecule to two daughter molecules, with each newly formed double helix containing one new and one old strand.

1. Isabella Montoya Botero.
Medicine Student.
UPB.

4. DNA is
composed of two
strands.
DNA replication
occurs in the S
phase of the cell
cycle.
There are
human diseases
associated with
defects in DNA
replication.

5. NEW STUDY REVEALS THENEW STUDY REVEALS THE
STRUCTURE OF DNA HELICASESTRUCTURE OF DNA HELICASE
AT THE REPLICATION FORK.AT THE REPLICATION FORK.
Van Andel Research Institute.
(2017, January 16).

6. NEW STUDY REVEALS THENEW STUDY REVEALS THE
STRUCTURE OF DNA HELICASE ATSTRUCTURE OF DNA HELICASE AT
THE REPLICATION FORKTHE REPLICATION FORK
Helicase activity has long been
recognized as a critical part of
DNA replication. It separates
double-stranded DNA into
single strands.

7. NEW STUDY REVEALS THENEW STUDY REVEALS THE
STRUCTURE OF DNA HELICASE ATSTRUCTURE OF DNA HELICASE AT
THE REPLICATION FORKTHE REPLICATION FORK
Scientists at the Van Andel
Research Institute have
successfully described how the
CMG helicase works from a
purified sample of Saccharomyces
cerevisiae.

8. NEW STUDY REVEALS THENEW STUDY REVEALS THE
STRUCTURE OF DNA HELICASE ATSTRUCTURE OF DNA HELICASE AT
THE REPLICATION FORKTHE REPLICATION FORK
This investigation showed that helicase
presents a different orientation to the
commonly accepted model, which
helps us to understand how it acts in
DNA replication.

9. OPINIONOPINION
This discovery is important to know the
orientation and mechanism of action of
this enzyme, because it has important
implications in understanding the
replication process. Also, helicase
activity has been recognized as a
fundamental part in the propagation of
life.

10. DNA DUPLICATOR SMALLDNA DUPLICATOR SMALL
ENOUGH TO HOLD IN YOURENOUGH TO HOLD IN YOUR
HAND.HAND.
Vanderbilt University.
(2017, January 11).

11. DNA DUPLICATOR SMALL ENOUGHDNA DUPLICATOR SMALL ENOUGH
TO HOLD IN YOUR HANDTO HOLD IN YOUR HAND
Engineers at Vanderbilt
University have developed a
prototype adaptive PCR device,
which is used to control the
DNA duplication process.

12. DNA DUPLICATOR SMALL ENOUGHDNA DUPLICATOR SMALL ENOUGH
TO HOLD IN YOUR HANDTO HOLD IN YOUR HAND
This prototype uses
fluorescently labeled L-DNA
which provides information
about molecular reactions that
take place during the PCR
process.

13. DNA DUPLICATOR SMALL ENOUGHDNA DUPLICATOR SMALL ENOUGH
TO HOLD IN YOUR HANDTO HOLD IN YOUR HAND
The prototype adaptive PCR
device is easy to handle and has
less sensitive to environmental
conditions.

14. OPINIONOPINION
This prototype is an important
breakthrough that could help to identify
more effectively when bacteria or viruses
are causing an infection, and allow us to
detect tumor cells, mutations, and
polymorphisms. In addition, it can make
molecular and genetic analysis with less
margin of error.

15. MEDICAL UTILITYMEDICAL UTILITY

16. MEDICAL UTILITY: NEWMEDICAL UTILITY: NEW
STUDY REVEALS THESTUDY REVEALS THE
STRUCTURE OF DNASTRUCTURE OF DNA
HELICASE AT THEHELICASE AT THE
REPLICATION FORKREPLICATION FORK
Several human genetic
syndromes are associated
with defects in DNA
replication mechanisms.
It’s necessary to know the
helicase activity, which has
an important role in DNA
replication, because this
allows us to understand the
origin of the disease to
perform a timely
intervention.

17. MEDICAL UTILITY:MEDICAL UTILITY:
DNA DUPLICATORDNA DUPLICATOR
SMALL ENOUGHSMALL ENOUGH
TO HOLD IN YOURTO HOLD IN YOUR
HANDHAND
This discovery will allow us to
perfect the different applications of
PCR, such as establishment of
polymorphisms, mutation tracking,
prenatal diagnosis of genetic
diseases, detection of infectious
microorganisms and tumor cells,
etc.

18. Both researches offer information
that helps us to understand the
phenomenon that guarantees the
succession of life and the basic
mechanism of conservation of
species.

19. BIBLIOGRAPHYBIBLIOGRAPHY
◦ Van Andel Research Institute. (2017, January 16). New study reveals the structure of
DNA helicase at the replication fork. ScienceDaily. Retrieved February 06, 2017 from
https://www.sciencedaily.com/releases/2017/01/170116160548.htm.
◦ Vanderbilt University. (2017, January 11). DNA duplicator small enough to hold in
your hand. ScienceDaily. Retrieved February 06, 2017 from
https://www.sciencedaily.com/releases/2017/01/170111131101.htm.
◦ Martínez Sánchez, Lina María. Biología Molecular. 8 ed. Medellín: UPB.
School of Medicine, 2015.