The evolution of medicine: DNA
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This document summarizes and comments on three scientific articles about recent discoveries related to DNA regulation and replication. The first article discusses a discovery about how metabolism is linked to epigenetic regulation of DNA through an enzyme that transfers acetyl groups. The second article discusses reconstituting the DNA replication fork to study its process and regulation. The third discusses the medical importance of understanding DNA replication and regulation to develop new disease treatments.
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Folding Aleja Ramírez
A method of DNA repair called Break-induced Replication (BIR) is more likely to cause genetic mutations than normal DNA synthesis, being up to 2,800 times more mutagenic. BIR occurs when a broken DNA piece invades another chromosome during replication, which happens in the wrong place and time, losing accuracy. There are several changes to the replication machinery that make BIR highly mutagenic. Neutron scattering experiments provide information about how DNA strands separate at different temperatures during denaturation, observing the first stage of separation before the strands become disordered. Understanding DNA repair mechanisms and structure allows for medical advances in addressing genetic diseases and conditions like cancer.
Molecular biology
The document summarizes several studies on DNA replication and the molecular machinery involved. It describes how researchers used tools like molecular biology and biochemistry to slow down and "freeze" the replication process at intermediate steps. This allowed them to observe conformational changes in proteins like the origin recognition complex (ORC) as it recruits the helicase enzyme to unwind DNA. Cryo-electron microscopy was then used to capture 3D structures of the protein components and reveal how they interact during replication initiation. The studies provide new insights into this critical cellular process.
DNA replication
The document discusses two studies related to DNA replication and cancer. The first study found that certain enzymes in the APOBEC family can cause mutations during DNA replication by deaminating cytosines, potentially leading to cancer. The second study identified a protein pathway that some cancer cells use to replicate their DNA and which could be a target for new cancer therapies. Understanding the processes of DNA replication and how they can be disrupted provides insights into cancer development and new opportunities for diagnosis and treatment.
Plegable biomol
Researchers at the UT Southwestern Medical Center and the University of Geneva studied how certain genes and proteins involved in maintaining genetic stability can sometimes contribute to cancer development. They found:
1) Mutations in the p53 tumor suppressor gene, which normally restrains mobile genetic elements, were prevalent in cancer samples. This leads to genomic instability by allowing increased movement of these elements within chromosomes.
2) The APOBEC protein, intended to fight viruses by modifying single-stranded DNA, can exploit weaknesses during human DNA replication to introduce mutations, as detected in tumor cells. It acts on the single strands present during replication fork separation.
3) Understanding how p53 and APOBEC influence genetic
Folding
DNA sequencing has been successfully used to diagnose previously difficult to identify mitochondrial diseases. It allowed for diagnosis of 10 children with mitochondrial diseases out of 100 tested, finding genetic mutations much faster than traditional methods. Additionally, a form of Z-DNA, not normally found at sites other than where DNA is being copied, has been discovered on nucleosomes through a process involving SWI/SNF proteins and ATP. This Z-nucleosome structure may provide new opportunities for protein binding and regulation of gene expression. DNA sequencing is an important medical advancement that can lead to faster diagnosis and earlier treatment of hard to identify diseases like mitochondrial disorders.
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DNA repair mechanisms based on new technologies and findings, to combat diseases caused by DNA damage
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This document summarizes two scientific articles about DNA damage and repair mechanisms. The first article describes a discovery by University of Pennsylvania researchers about how DNA damage activates the immune system to target cancer cells. They propose using this knowledge to design new combination treatments. The second article discusses a new technique by University of North Carolina scientists to map DNA damage caused by cigarette smoking across the genome. This mapping revealed specific sites where repair was initiated following damage from cigarette carcinogens. Both advances could lead to improved cancer treatments and prevention strategies by deepening understanding of DNA replication and repair failures involved in disease.
Dna structure
The document discusses several studies related to DNA and cancer. A study identified a gene, NFIB, that is overexpressed in mouse and human lung tumors and appears to drive progression of small cell lung cancer. Another study revealed the molecular mechanism that promotes cancer development by characterizing regions of DNA that are more susceptible to breakage in early cancer development. A third study identified the molecular basis for DNA breakage in cancer cells.
Recommended
Folding Aleja Ramírez
A method of DNA repair called Break-induced Replication (BIR) is more likely to cause genetic mutations than normal DNA synthesis, being up to 2,800 times more mutagenic. BIR occurs when a broken DNA piece invades another chromosome during replication, which happens in the wrong place and time, losing accuracy. There are several changes to the replication machinery that make BIR highly mutagenic. Neutron scattering experiments provide information about how DNA strands separate at different temperatures during denaturation, observing the first stage of separation before the strands become disordered. Understanding DNA repair mechanisms and structure allows for medical advances in addressing genetic diseases and conditions like cancer.
Molecular biology
The document summarizes several studies on DNA replication and the molecular machinery involved. It describes how researchers used tools like molecular biology and biochemistry to slow down and "freeze" the replication process at intermediate steps. This allowed them to observe conformational changes in proteins like the origin recognition complex (ORC) as it recruits the helicase enzyme to unwind DNA. Cryo-electron microscopy was then used to capture 3D structures of the protein components and reveal how they interact during replication initiation. The studies provide new insights into this critical cellular process.
DNA replication
The document discusses two studies related to DNA replication and cancer. The first study found that certain enzymes in the APOBEC family can cause mutations during DNA replication by deaminating cytosines, potentially leading to cancer. The second study identified a protein pathway that some cancer cells use to replicate their DNA and which could be a target for new cancer therapies. Understanding the processes of DNA replication and how they can be disrupted provides insights into cancer development and new opportunities for diagnosis and treatment.
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Researchers at the UT Southwestern Medical Center and the University of Geneva studied how certain genes and proteins involved in maintaining genetic stability can sometimes contribute to cancer development. They found:
1) Mutations in the p53 tumor suppressor gene, which normally restrains mobile genetic elements, were prevalent in cancer samples. This leads to genomic instability by allowing increased movement of these elements within chromosomes.
2) The APOBEC protein, intended to fight viruses by modifying single-stranded DNA, can exploit weaknesses during human DNA replication to introduce mutations, as detected in tumor cells. It acts on the single strands present during replication fork separation.
3) Understanding how p53 and APOBEC influence genetic
Folding
DNA sequencing has been successfully used to diagnose previously difficult to identify mitochondrial diseases. It allowed for diagnosis of 10 children with mitochondrial diseases out of 100 tested, finding genetic mutations much faster than traditional methods. Additionally, a form of Z-DNA, not normally found at sites other than where DNA is being copied, has been discovered on nucleosomes through a process involving SWI/SNF proteins and ATP. This Z-nucleosome structure may provide new opportunities for protein binding and regulation of gene expression. DNA sequencing is an important medical advancement that can lead to faster diagnosis and earlier treatment of hard to identify diseases like mitochondrial disorders.
Dna repair mechanism
DNA repair mechanisms based on new technologies and findings, to combat diseases caused by DNA damage
Dna Repair Mechanisms
This document summarizes two scientific articles about DNA damage and repair mechanisms. The first article describes a discovery by University of Pennsylvania researchers about how DNA damage activates the immune system to target cancer cells. They propose using this knowledge to design new combination treatments. The second article discusses a new technique by University of North Carolina scientists to map DNA damage caused by cigarette smoking across the genome. This mapping revealed specific sites where repair was initiated following damage from cigarette carcinogens. Both advances could lead to improved cancer treatments and prevention strategies by deepening understanding of DNA replication and repair failures involved in disease.
Dna structure
The document discusses several studies related to DNA and cancer. A study identified a gene, NFIB, that is overexpressed in mouse and human lung tumors and appears to drive progression of small cell lung cancer. Another study revealed the molecular mechanism that promotes cancer development by characterizing regions of DNA that are more susceptible to breakage in early cancer development. A third study identified the molecular basis for DNA breakage in cancer cells.
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The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
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The document discusses recent advances in understanding DNA regulation and replication. A key finding was the discovery of an enzyme thought to reside only in mitochondria, but is also found in the nucleus and may be involved in epigenetic regulation of DNA. Additionally, researchers created the first model of the eukaryotic DNA replication fork using yeast enzymes. This model allows study of the replication process and its regulation in fine detail. These discoveries provide insights into normal biological functions and disease states, aiding medical research and potential new treatments.
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1) Scientists have reconstituted the DNA "replication fork" for the first time, allowing them to study the complex process of DNA duplication.
2) Researchers discovered that an enzyme involved in metabolizing carbohydrates, pyruvate dehydrogenase complex (PDC), is present in the nucleus and can acetylate histones to regulate DNA replication and gene expression.
3) Understanding how DNA replicates and is regulated could help scientists develop treatments for diseases like cancer by controlling genetic and epigenetic processes involved in uncontrolled cell growth.
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Jack Reifert's Resume
Jack Ryan Reifert has extensive experience in neuroscience research and industrial research. He received his Ph.D. in Molecular, Cellular, and Developmental Biology from UCSB, focusing on amyloid beta induced neurodegeneration and the involvement of tau. He has held postdoctoral positions at UCSB studying bacterial peptide display to inhibit ovarian cancer metastasis and at UCSD investigating wnt/β-catenin signaling in rheumatoid arthritis. Reifert has worked at several companies, contributing to FDA approval of Bendamustine and coordinating product releases. He is currently a postdoctoral fellow at UCSB studying targeted inhibition of proteases in ovarian cancer metastasis.
Folding maria
1. The document discusses how trigger mechanisms in cell division provide quality control by monitoring nuclear structure and delaying cell division if not correct.
2. It also discusses how unnatural genes designed in a lab can be used to replace missing DNA in cells to keep them alive by fixing mutations.
3. Introducing these artificial DNA sequences allowed previously non-viable E. coli cells to survive, demonstrating how engineered genes can rescue cells.
Dna Repair Mechanisms
This document discusses DNA repair mechanisms and two related studies. It first provides an introduction to how cells use DNA repair mechanisms to detect and correct damage to prevent mutations. It then summarizes two studies: one identifying the FAN1 gene which may be involved in repairing DNA damage in the Fanconi anemia pathway, and another finding that the drug Olaparib, which inhibits the DNA repair enzyme PARP, caused tumors to shrink in women with BRCA gene mutations and breast or ovarian cancer. It concludes by discussing the potential medical applications of further understanding DNA repair mechanisms and using drugs like Olaparib to treat cancer.
Aziz Sancar 2015 Nobel Prize in Chemistry
Gary's Ph.D. adviser, Aziz Sancar, is awarded the Nobel Prize in Chemistry for his work ion nucleotide excision repair.
Genetic engineering 34
Genetic engineering is the process of manipulating genes to introduce desirable traits. It involves combining DNA from different organisms, such as inserting a gene for insulin into bacteria. The gene is inserted into a plasmid or virus vector and introduced into a host cell. This allows the production of proteins like insulin to treat diseases. While genetic engineering holds promise to treat diseases, some argue it could disrupt nature in unintended ways. Regulatory issues also exist regarding its applications and effects.
Cloning ppt
Cloning involves producing genetically identical copies of biological entities. In the 1950s, embryologists Briggs and King developed nuclear transplantation, a technique where the nucleus is transferred from one cell to an egg cell with its original nucleus removed. This revealed that nuclei from older embryos and tadpoles, when transplanted, can affect the developmental potential of the recipient egg cell. Cloning describes processes used to copy genetic material and produce clones that are identical to the original biological entity.
Molecular genetics
DNA carries genetic information in cells and is made of two strands that are coiled in a double helix. DNA replicates itself during cell division and then transcription and translation are used to create proteins from DNA code. Genetic engineering techniques can manipulate genetic material to change traits while biotechnology applies biology to areas like medicine, agriculture, and industry.
Folding molecular biology
The document discusses how identifying mutations in human genes through advances in biotechnology can help prevent and treat cancers and genetic diseases. As more is learned about the human genome and specific gene mutations, new arguments emerge to support gene therapy as a potential treatment method, especially as it becomes better understood and can be implemented safely and ethically. The knowledge of the human genome continues to grow each year through investigations like those mentioned.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
Dna finger printing
The term DNA Finger printing is also known as DNA Typing, Genetic Profiling or Genotyping, it is a process in which the DNA characteristics of a person is determined by isolating and identifying variable elements in the base-pair sequence of DNA.
By developing this method in 1984 the British geneticist Alec Jeffery found that some sequence area unit extremely variable Deoxyribonucleic acid called as minisatellites. These minisatellites do not have contribution in functioning of DNA and are repeated in the genes. Geneticist found that in every person there is a unique pattern of these minisatellites except the identical twins.
Genetic Mapping
The document discusses two separate but related discoveries. The first is that researchers discovered the PARK2 gene, which links lung cancer to early-onset Parkinson's disease. This discovery could allow for more targeted therapies to prevent both lung cancer and Parkinson's. The second discovery discussed is that researchers developed a new technique for positional cloning that allows mapping the large and complex genome of maize. This new approach could enable more efficient identification and study of genes associated with human diseases. Both discoveries may contribute to future gene therapy and treatments by improving understanding of gene locations and relationships to diseases.
Plegable Biología Molecular
Geneticists from the USA and Japan used iPSC to replace ring chromosomes, which cause short stature and mental retardation, with normal chromosomes in cell cultures from 5 patients. The therapy was successful in replacing ring chromosomes from chromosomes 13 and 18, but not other defects. Additionally, a study found variations in non-coding DNA, not just known risks like age and weight, increase risk of type 2 diabetes. Over 300 million people worldwide have diabetes, so further study of non-coding DNA could help understand disease development and identify new treatment approaches. Both studies provide potential ways to address genetic defects and help patients through stem cell therapy or risk assessment.
D.n.a.
D.N.A. replication is the process by which a cell makes an identical copy of its DNA before cell division. It is essential for reproduction as it allows transfer of genetic traits from parents to offspring. D.N.A. replication ensures the basic characteristics are passed down, while occasional small variations that occur may provide advantages to offspring. Abnormal D.N.A. replication due to environmental factors like radiation can lead to mutations and genetic abnormalities in offspring.
Plegable UPB Biomol
The document discusses two scientific articles about discoveries linking metabolism and gene regulation. The first found that the enzyme pyruvate dehydrogenase complex, which normally resides in mitochondria, can also enter the nucleus and generate acetyl-CoA to acetylate histones and regulate DNA replication and expression. The second discovered a protein, TARBP2, that promotes cancer metastasis but also inhibits genes linked to neurodegeneration by binding to mRNA. This reveals connections between cancer and neurodegenerative diseases. Further research on these newly discovered mechanisms could lead to new treatment and prevention strategies through genetic therapy.
Plegable biomol Ana Maria Parada Pérez.
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GENETIC MAPPING
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
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This document summarizes two scientific articles. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CpG methylation, rather than CpG methylation, dominates DNA methylation patterns in mature human neurons and is important for brain development and function. Abnormal epigenetic changes may also contribute to psychiatric disorders.
Chenimineni_Gayathri_Poster_Version6
This document discusses a study on the effects of calcium on neuroblastoma cell growth and differentiation. The purpose is to use calcium to induce extensive neurite outgrowth in neuroblastoma cells and determine if the effect is intracellular or extracellular. Calcium concentrations of 1M will be tested at different dilution rates (0 mM, 10mM, 20 mM) on neuroblastoma cells over multiple days. Successful calcium treatments may reduce costs and time for neuroblastoma cell research by inducing differentiation and faster confluency.
Brown - CV
This document provides a curriculum vitae for Elvin Brown, Ph.D., who is a term professor of chemistry at the University of Alaska Anchorage. It details his education, including a Ph.D. in biochemistry from the University of Alaska Fairbanks and a B.S. in genetics from UC Berkeley. It also outlines his biomedical and teaching experience, published works, presentations, awards, and grants received for his research focusing on chromatin remodeling complexes.
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HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
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“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
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Plegable Biología Molecular
The document discusses recent advances in understanding DNA regulation and replication. A key finding was the discovery of an enzyme thought to reside only in mitochondria, but is also found in the nucleus and may be involved in epigenetic regulation of DNA. Additionally, researchers created the first model of the eukaryotic DNA replication fork using yeast enzymes. This model allows study of the replication process and its regulation in fine detail. These discoveries provide insights into normal biological functions and disease states, aiding medical research and potential new treatments.
Plegable ana cristina
1) Scientists have reconstituted the DNA "replication fork" for the first time, allowing them to study the complex process of DNA duplication.
2) Researchers discovered that an enzyme involved in metabolizing carbohydrates, pyruvate dehydrogenase complex (PDC), is present in the nucleus and can acetylate histones to regulate DNA replication and gene expression.
3) Understanding how DNA replicates and is regulated could help scientists develop treatments for diseases like cancer by controlling genetic and epigenetic processes involved in uncontrolled cell growth.
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2) Researchers discovered that an enzyme involved in metabolizing carbohydrates, pyruvate dehydrogenase complex (PDC), is present in the nucleus and can acetylate histones to regulate DNA replication and gene expression.
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A group of Swedish and Russian scientists led by Sergey Nikolaev argue that the APOBEC protein, which normally protects against viruses, takes advantage of DNA replication weaknesses to insert mutations into the genome. The APOBEC protein acts when the lagging strand is single-stranded, causing early mutations in important genes. Studying yeast cells provided new insights into how replication can go wrong and when. Understanding DNA replication could help intervene in copying errors to ensure proper genome replication and improve patient quality of life. Further research on proteins influencing replication errors may help prevent cancers.
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This document discusses DNA replication and the role of various enzymes in the process. It then summarizes two scientific articles about research on DNA breakage and cancer development. The first article describes research from Hebrew University scientists that identified the molecular basis for DNA breakage. The second discusses proteins called Cks1 and Cks2 that allow cancer development by overriding checkpoints during cell division. The document concludes that these discoveries may help develop new cancer treatments and prevention strategies by targeting these proteins or DNA breakage processes early in cancer development.
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Unveiling the Miracle of Life.pdf
DNA replication, the fundamental process that underpins the perpetuation of life, serves as the cornerstone of biological inheritance and the continuity of genetic information across generations. In this blog post, we embark on an illuminating journey through the intricate world of DNA replication, unraveling its mechanisms, significance, and the profound implications it holds for the perpetuation of life and the diversity of living organisms.
Trabajo plegable biomol
Researchers have discovered two new mechanisms related to DNA replication and gene expression. First, they found an enzyme called NEIL1 that repairs damaged DNA and could enhance cancer treatments if inhibited in cancer cells. Second, they uncovered a new mechanism where a fragment of the CACNA1A gene causes spinocerebellar ataxia type-6 by producing toxic proteins, offering potential treatment by inhibiting production of the mutant fragment. The discoveries provide insights into cellular processes that could be targeted to develop new disease treatments.
DNA structure
DNA is a long polymer of simple units called nucleotides. Each one contains a phosphate group (acid component), a sugar group (neutral component) and a nitrogen base (basic component).
Plegable biologia molecular
The document discusses several topics related to DNA replication and repair:
1) A study found that faulty proteins involved in DNA repair may be linked to ovarian cancer recurrence and response to PARP inhibitor drugs.
2) PARP inhibitors are being tested for ovarian cancer patients with BRCA1/BRCA2 mutations or other damaged DNA repair proteins.
3) Research is exploring an earlier genetic molecule called TNA that may have preceded DNA and RNA due to its simpler structure and ability to self-replicate, providing insights into the origins of life.
4) Understanding DNA repair mechanisms and how they relate to disease could help develop new treatments, such as genomic therapies that insert missing genes.
Molecular biology
The document discusses two scientific articles about DNA replication. The first article describes an enzyme called NEIL1 that acts as a "cowcatcher" by binding to single-stranded DNA damage before replication to stop the process and allow for repair. The second article reveals new details about the mechanism of DNA unwinding during replication through cryo-electron microscopy images of protein complexes involved. Studying these replication processes has implications for understanding and treating cancer.
Cowcatcher' enzyme fixes single strand dna and key
The document discusses two scientific articles about DNA replication. The first article describes an enzyme called NEIL1 that acts as a "cowcatcher" by binding to single-stranded DNA damage before replication to stop the process and allow for repair. The second article reveals new details about the mechanism of DNA unwinding during replication through cryo-electron microscopy images of protein complexes involved. Studying these replication processes has implications for understanding and treating cancer.
Importance of dna s
DNA, or deoxyribonucleic acid, is the hereditary material found in humans and most organisms that contains the genetic instructions used in the development and functioning of living beings. DNA is located in the cell nucleus for eukaryotic cells like humans, but in the cytoplasm for prokaryotic cells like bacteria. DNA is composed of nucleotides containing phosphate, sugar, and nitrogen bases that form the signature double helix structure. The sequence of these bases determines the organism's traits and functions. DNA analysis has various important applications in fields like genetics, medicine, agriculture, law, and archaeology.
“Clever” DNA may help bacteria survive and How DNA is “edited” to correct gen...
The document discusses two main topics:
1) Research showing that bacterial DNA can change structure from a double helix to a more compact form to help bacteria survive adverse conditions like dehydration. This structural change may help explain how bacteria can become active in the human body.
2) Studies observing how enzymes called CRISPR can edit DNA sequences, which could help develop treatments for genetic diseases by correcting mutations. Understanding how these enzymes target DNA may allow engineering them to increase accuracy and minimize unintended effects.
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The evolution of medicine: DNA
- 1. Daniela Márquez Obando Universidad Pontificia Bolivariana
- 2. FOLDING
- 3. FOLDING
- 4. INTRODUCTION DNA Double strand macromolecule (D Watson y F Crick) Components: Phosphates + Sugar + nitrogenous bases Medical importance: Genetic theraty
- 5. SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA Science Daily (July 4, 2014)
- 6. SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA “Epigenetic regulation of DNA” is an important mechanism by which the PDC enzyme transfers an acetyl group from acetyl Co-A molecule to a histone. It has importance in the normal functions of cells like growth
- 7. SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA Despite the great importance of histone acetylation in the struggle to develop medical treatments, before this discovery the source of the acetyl group was unknown in the nucleus.
- 8. SWEET GENES: NEW WAY FOUND BY WICH METABOLISM IS LINKED TO THE REGULATION OF DNA With new knowledge about the work that the PDC enzyme in the nucleus, scientists and people with great knowledge of the subject, will be able to conduct research on potential treatments against diseases such as the fast growth of cancer cells.
- 9. OBSERVATION This discovery has much importance in medicine because, as is known beforehand, the cancer a disease that is more prevalent in the world and this finding may have a clear choice of therapy and healing.
- 10. DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME Science Daily (July 9, 2014)
- 11. DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME The replication fork has much similarity to a zipper opening system. The CMG has an important role in the course of the rack and as a result of this system, are obtain two separate strands of DNA that become templates for daughters copies.
- 12. DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME O'Donnell and a group of investigators purified and formed for the first time, the central components involved in the eukaryotic replication fork, allowing detailed study of this process and who is the regulation by the cell.
- 13. DNA 'REPLICATION FORK' RECONSTITUTED FOR THE FIRST TIME Repeatedly cancer is caused by a malfunction at the cellular level and much of this responsibility may be due to damage in the processes of replication, transcription and translation. With this invention, researchers will be able to more easily study the replication process and generate alternative treatment of some diseases.
- 14. OBSERVATION Rebuilding the biochemical events at the molecular level what happens in the replication of DNA is very important not only to learn more about this process, also in diseases such as cancer, which often arise from damage to DNA inheritance.
- 15. MEDICAL UTILITY
- 16. MEDICAL UTILITY Today procedures such as gene therapy so it is very useful to know and study the processes involved are made, such as the replication of DNA
- 17. MEDICAL UTILITY Understand the causes of disorders today have no clear explanation.
- 18. MEDICAL UTILITY With new knowledge, try to develop treatments for multiple diseases.
- 19. BIBLIOGRAPHY MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p. “Sweet genes: New way found by which metabolism is linked to the regulation of DNA” Science Daily. Science Daily, 4 July 2014. “DNA 'replication fork' reconstituted for the first time” Science Daily. Science Daily, 9 July 2014
- 20. THANKS