NANOTECHNOLOGY comprises technological developments on the nanometer scale, usually 0.1 to 100 nm. Nanotechnology, the science of the small. Nano is Greek for dwarf, and nanoscience deals with the study of molecular and atomic particles.
NANOTECHNOLOGY comprises technological developments on the nanometer scale, usually 0.1 to 100 nm. Nanotechnology, the science of the small. Nano is Greek for dwarf, and nanoscience deals with the study of molecular and atomic particles.
Dendrimers may be defined as synthetic three-dimensional hyper branched, globular macromolecule, which is characterized by its highly branched 3D structure that provides a high degree of surface functionality.
Polymeric micelle formation , mechanism , Case study , applications , Factors affecting formation of Polymeric Micelle , Method of preparation , Types of polymers used in Polymeric micelle
Targeted Drug Delivery System Using NanoparticlesSelf
Targeted drug delivery, also known as smart drug delivery, is a method of treatment that involves the increase in medicament in one or few body parts in comparison to others.
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
MD. ABU JAR GIFARI
Ph.D. Student
Dept. of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences
Prince of Songkla University
Hat-Yai, Songkhla, Thailand 90110
Phone: +660969247553
Email: agifari50@gmail.com
Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous, and monodisperse structure consisting of tree-like arms or branches.
The second group called synthesized macromolecules ‘arborols’ means, in Latin, ‘trees’. Dendrimers might also be called ‘cascade molecules’
Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core
‘Dendrimer’ is only an architectural motif and not a compound. Dendrimers have gained a broad range of applications in supra molecular chemistry, particularly in host-guest reactions and self-assembly processes.
Dendrimers may be defined as synthetic three-dimensional hyper branched, globular macromolecule, which is characterized by its highly branched 3D structure that provides a high degree of surface functionality.
Polymeric micelle formation , mechanism , Case study , applications , Factors affecting formation of Polymeric Micelle , Method of preparation , Types of polymers used in Polymeric micelle
Targeted Drug Delivery System Using NanoparticlesSelf
Targeted drug delivery, also known as smart drug delivery, is a method of treatment that involves the increase in medicament in one or few body parts in comparison to others.
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
MD. ABU JAR GIFARI
Ph.D. Student
Dept. of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences
Prince of Songkla University
Hat-Yai, Songkhla, Thailand 90110
Phone: +660969247553
Email: agifari50@gmail.com
Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous, and monodisperse structure consisting of tree-like arms or branches.
The second group called synthesized macromolecules ‘arborols’ means, in Latin, ‘trees’. Dendrimers might also be called ‘cascade molecules’
Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core
‘Dendrimer’ is only an architectural motif and not a compound. Dendrimers have gained a broad range of applications in supra molecular chemistry, particularly in host-guest reactions and self-assembly processes.
COMPLETE DESCRIPTION ABOUT DENDRIMERS ALONG THEIR ROLE IN CURRENT MEDICAL SYSTEM,THEIR USEAGE IN CHEMOTHERAPUTIC PURPOSES ETC IS PROVIDED IN THIS PRESENTATION.
Dendrimer Polymers techniques is a controlled release system which helps to s...rita martin
Dendrimers are considered as the Polymers of 21st century, which ease the process of drug discovery, as we know that current drug discovery techniques takes years of time in inventing new drugs, this new Dendrimers technique help drug discovery companies and pharmaceutical industries to speed up their drug discovery process and provide better results
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...iosrphr_editor
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research paper publishing, where to publish research paper, journal publishing, how to publish research paper, Call for research paper, international journal, publishing a paper, call for paper 2012, journal of pharmacy, how to get a research paper published, publishing a paper, publishing of journal, research and review articles, Pharmacy journal, International Journal of Pharmacy, hard copy of journal, hard copy of certificates, online Submission, where to publish research paper, journal publishing, international journal, publishing a paper
This presentation contains an introduction to emerging healthcare Technologies. These emerging technologies include Data Analytics, AI, Blockchain, Telehealth, virtual reality, cloud computing, and IOT. The concept of Nanorobots as future medicine is also included in this presentation.
Introduction
Need of Nanosuspension
Advantages of Nanosuspension
Disadvantages of Nanosuspension
Method Of Preparation
Formulation Considerations
Characterization of Nanosuspension
Current Marketed Formulations
Pharmaceutical Applications
Introduction
Nanoparticle characterization techniques
Electron Microscope
Scanning electron microscope
Transmission electron Microscope
X-ray powder diffraction
Nuclear Magnetic Resonance
Introduction
Advantages & Disadvantages
Classification
Manufacturing of liposomes
Liposome characterization and control
Stability consideration for liposomal formulations
Regulatory science of liposome drug products
Drug release from liposomes
Applications
Recent innovations
Approved liposome products
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
This presentation contains
Introduction, Advantages & Disadvantages, Process of manufacturing, Evaluation and defects in Blister, strip & ALU ALU Packaging. Useful for pharmacy students to understand the concept of blister & strip packaging
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
3. • The name comes from Greek word “dendron” which means “tree”.
• Also called as “arborols/ cascade molecules’’
• They are family of nanosized, highly branched three dimensional molecules.
• Synthesis of polyamidoamine(PAMAM) dendrimer in 1985 was a turning
point.
What are Dendrimers
4. • In 2008 there were over 10 000 scientific reports and 1000 patents dealing with
dendritic structures.
• Tree-like polymers, branching out from a central core and subdividing into
hierarchical branching units
Not more that 15 nm in size, Mol. Wt very high
Very dense surface surrounding a relatively hollow core (vs. the linear
structure in traditional polymers)
What are Dendrimers
5. 1) An interior core
2) Interior layers composed of repeating units radically attached to cores.
3) Exterior layer (terminal functionality) attached to interior generations.
Structure of Dendrimers
8. Types of Dendrimers
Types of
Dendrimers
PAMAM
Dendrimer
PPI
Dendrimer
Chiral
Dendrimer
Multilingual
Dendrimer
Techto
Dendrimer
Hybrid
Dendrimer
Ampiphilic
Dendrimer
Frechet type
Dendrimer
Peptide
Dendrimer
PAMAMOS
Dendrimer
9. • PAMAM Dendrimer – PAMAM or Poly (Amido Amine)
dendrimers are spheroidal or ellipsoidal in shape.
• These are synthesized by the divergent method using
ammonia or ethylenediamine as a starting material.
• The high solubility and reactivity of these are due to
presence of a number of functional end groups and
empty internal cavities.
• PAMAM dendrimers are commercially available,
usually as methanol solutions.
• Starburst dendrimers is applied as a trademark name
for a sub-class of PAMAM dendrimers based on a
trisaminoethylene-imine core. The name refers to the
star like pattern observed when looking at the
structure of the high generation dendrimers of this
type in two-dimensions
PAMAM Dendrimer
10. • PAMAMOS Dendrimer – PAMAMOS or Poly
(Amido Amine Organosilicon) are silicon
containing first commercial dendrimers.
• These are inverted unimolecular micelles
that consist of hydrophilic, nucleophilic
polyamidoamine (PAMAM) interiors and
hydrophobic organosilicon (OS) exteriors.
• These dendrimers are exceptionally useful
precursors for the preparation of
honeycomb-like networks with nanoscopic
PAMAM and OS domains.
PAMAMOS Dendrimer
11. • PPI Dendrimer – PPI or Poly (Propylene Imine)/
Poly (Propylene Amine) is one of the oldest known
dendrimer developed initially by Vogtle.
• Its core structure is based on diamino butane with
primary amines as end groups and tertiary
propylene amines as interior.
• Thus, these dendrimers are also sometimes
referred to as “DAB-dendrimers” where DAB refers
to the core structure, which is usually based on
Diamino butane.
• PPI dendrimers are commercially available up to
G5, and has found widespread applications in the
field of material science and biology. These are
widely available as Astramol TM.
PPI Dendrimer
12. • Tecto Dendrimer – These are composed of a core
dendrimer, surrounded by other dendrimers, each
one of which perform a specific function leading
to a smart therapeutic system which can
simultaneously diagnose the diseased state and
deliver API to the recognized diseased cell.
• Different compounds perform varied functions
ranging from diseased cell recognition, diagnosis
of disease state, drug delivery, reporting outcomes
of therapy.
Tecto Dendrimer
13. • Frechet-Type Dendrimers – It is a more recent type of dendrimer
developed by Hawker and Frechet based on polybenzyl ether hyper
branched skeleton.
• These dendrimers usually have carboxylic acid groups as surface
groups, serving as a good anchoring point for further surface
fictionalization, and as polar surface groups to increase the solubility
of this hydrophobic dendrimer type in polar solvents or aqueous
media.
Frechet Type Dendrimer
14. • Amphiphilic Dendrimers – These are composed of two segregated
sites of chain end, one half is electron donating and the other half is
electron withdrawing.
Amphiphilic Dendrimer
15. • Hybrid Dendrimers – These are hybrids (block or graft polymers) of
dendritic and linear polymers having characters of both.
• Hybrid dendrimers are obtained by complete mono functionalization of
the peripheral amines of a "zero generation” polyethyleneimine
dendrimer; provide structurally diverse lamellar, columnar, and cubic self
organized lattices that are less readily available from other modified
dendritic structures.
Hybrid Dendrimer
16. • Chiral Dendrimers – The chirality in
these dendrimers is based upon the
construction of constitutionally
different but chemically similar
branches to the chiral core.
• Their potential use as chiral hosts
for enantiomeric resolutions and as
chiral catalysts for asymmetric
synthesis has been recognized.
Chiral Dendrimer
17. • Peptide Dendrimers – These dendrimers consists of amino acids as
branching or interior unit. It is a dendron like molecular construct based
upon a polylysine skeleton.
• This type of dendrimer was introduced by J. P. Tam in 1988, has
predominantly found its use in biological applications, such as in vaccine
and diagnostic research.
Peptide Dendrimer
18. Divergent method
Convergent method
Double Exponential and Mixed Growth
Hypercores and Branched Monomers Growth
Synthesis of Dendrimers
19.
20. • Dendrimer grows from core to periphery.
• The core molecule reacts with the monomer molecule having two
dormant and one reactive group.
Divergent method
21. • Dendrimer grows starting from end groups and progresses inward.
• Method makes impurity removal easier monodisperse dendrimers are
obtained.
• But stearic effects along the core limits the size.
• Small molecules come together and reaction proceeds inward.
• Eventually the molecules become attached to the core.
Convergent method
22.
23. • In this approach two products (monomers for both convergent and
divergent growth) are reacted together to give an orthogonally protected
trimer, which may be used to repeat the growth process again.
• Strength of double exponential growth is more subtle than the ability to
build large dendrimers in relatively few steps.
Double Exponential and Mixed Growth
24. • This method involves the pre-assembly of oligomeric species which can be linked
together to give dendrimers in fewer steps or higher yields in a radial, branch-
upon-branch.
• Core is reacted with two or more moles of reagent containing at least two
protecting branching sites, followed by removal of the protecting groups.
• The subsequent liberated reactive sites lead to the first generation Dendrimers.
Hypercores and Branched Monomers Growth
25. • Inert and non-toxic;
• Biodegradable;
• Non-immunogenic;
• Able to cross barriers such as intestine, blood-tissue barriers, cell membranes etc;
• Able to stay in circulation for the time needed to have a clinical effect;
• Able to target to specific structures;
• Compatible with guest molecules;
• Must protect the drug until it reaches to the desired site of action and release the
drug.
Ideal Properties of Dendrimers
27. Improved efficacy of drugs
Extension of drug half-life
Reduced toxicity
Active or passive targeting
Product lifecycle management
Improved solubility of drugs
Drug “rescue”
Applications in drug delivery
28. • Utilizing a dendrimer construct the aqueous solubility of
the drug Paclitaxel was increased >9,000X.
Paclitaxel aqueous solubility 0.8 mg/mL
Improved Drug Solubility
29. • Dendrimers are particularly attractive as they offer a high
drug-loading capacity.
• Methods of dendrimer drug delivery are
Encapsulation of drugs
Dendrimer –drug conjugates
Mechanism of drug delivery: Dendrimer
30. Interactions between the dendrimer and drug to trap the drug inside
the dendrimer. Such a system can be used to encapsulate drugs and
provide controlled delivery.
eg: DNA was complexed with PAMAM dendrimers for gene delivery
applications, and hydrophobic drugs and dye molecules were
incorporated into various dendrimer cores.
Mechanism of drug delivery: Dendrimer
Encapsulation of drugs
31. Dendrimer–Drug Conjugates
In dendrimer–drug conjugates, the drug is attached through a
covalent bond either directly or via a linker/spacer to the
surface groups of a dendrimer.
Dendrimers have been conjugated to various biologically
active molecules such as drugs, antibodies, sugar moieties
and lipids
Mechanism of drug delivery: Dendrimer
32. The drug loading can be tuned by varying the generation number of
the dendrimer
Release of the drug can be controlled by incorporating degradable
linkages between the drug and dendrimer
Conjugates of PAMAM dendrimers with cisplatin, a potent anticancer
drug with non-specific toxicity and poor water solubility.
The conjugates show increased solubility, decreased systemic toxicity
and selective accumulation in solid tumors
Mechanism of drug delivery: Dendrimer