nano components used in drug delivery system

1. NANOTECHNOLOGY IN DRUG
DELIVERY SYSTEM
By
SATHISHKUMAR G
(sathishsak111@gmail.com)

2. IINTRODUCTION
Nanotechnology is the engineering and
manufacturing of materials at the atomic and molecular
scale resulting into the construction of structures in the
nanometre scale size range (often 100 nm or smaller),
without changing unique properties.

3. Applications of Nano-biotechnology
in therapeutics
 Medical diagnostic tool and sensors
 Drug delivery
 Pharmacocatalysis
 Medical imaging

4. Nanoparticles for Drug Delivery
Different types of nanoparticles drug delivery
system:
 Metal based nanoparticles –Au, Ag, Cd-Se, Zn-
S
 Lipid based nanoparticles-liposomes and
neosome
 Polymer based nanoparticles- Dendrimer,
Micelle
 Biological nanoparticles-Bovine-albumin
serum based

5. Brain-The ultimate target for
drug delivery
 Blood Brain Barrier –layer of endothelial cell(over surface
brain capillaries)
 Endothelial cell fit tightly together and substances cannot pass
out of the bloodstream
 Such obstacles can be overcome by nanotechnology

7. Lipid nanoparticles
It is a colloidal drug carrier ranges from(10-
1000nm)
Unique properties
 Small size, large surface area
 High drug loading
 Less toxicity and more biocompatible
 Protection of drug from degradation

8. Liposomes
Liposomes are cells assembling spherical close colloidal
structure composed of lipid bilayers that surround a central
aqueous space
 Encapsulation of hydrophilic & hydrophobic drugs
 Less toxicity &immunogenicity

9. Dendrimer
Dendrimers have a tree-like structure with
many branches where a variety of
molecules,including drug can be attached

10. Nanoshells
Absorption of light by nanoshells creates an
intense heat that is lethal
 Fluorescent diagnostic labels
 Enhancing photo luminescence
 Preparation of bio conjugates
 Gold nanoshells used in cancer therapy

11. Nanofibres
Nanofibres are carbon vapour
grown, self-assembled from peptide
amphiphiles or electrospun from most polymer
materials.
 Electrospun continuous nanofibres are unique
and safety to manufacture

12. Micelles
They have a nanosize,easy manipulation of
surface chemistry,core functionalities,as well as
ease of fabrication,making them suitable as
carriers for encapsulation and delivery of water
polymeric micelles used in
cancer treatment

13. Nano capsules
Nano capsules are dispersed polymer.
Nano capsules can serve as nano-sized drug
carriers to achieve controlled release as well as
efficient drug targeting.

14. Advantages
By these drug carrier
 Uniform delivery of drug
 Ability to sustain the release of drug
 Prevent the drug from biological degradation
 Delivery of drugs at cellular & nuclear level

15. Problems faced in drug delivery
 Poor oral bioavailability related to
physicochemical problems
 Limitation to inhalation were dose molecular
weight and cost of sophisticated dose form