This document discusses cosmetics, including their definition, common materials used, classification, microbiological aspects, product formulation, safety and toxicology, and legislation and regulations. It defines cosmetics as any article intended to be applied to the human body to cleanse, beautify or alter appearance. Common materials used include water, preservatives, oils and colors. Cosmetics are classified based on the area of the body they are used on, such as skin, hair, eyes and nails. Microbiological aspects and preventing contamination during manufacturing are also covered. The safety and toxicology section discusses irritation, sensitization and systemic effects. Legislation and regulations in India such as the Drugs and Cosmetics
cosmetic and cosmeceutical
Classification of cosmetic and cosmeceutical products
Definition of cosmetics as per Indian and EU regulations, Evolution of cosmeceuticals from cosmetics, cosmetics as quasi and OTC drugs
Cosmetic excipients: Surfactants, rheology modifiers, humectants, emollients, preservatives. Classification and application
Skin: Basic structure and function of skin.
Hair: Basic structure of hair. Hair growth cycle.
Oral Cavity: Common problem associated with teeth and gums
Classification of Sunscreens and SPF and Role of herbs in cosmetics:Priya Patil
Sun protection,
Classification of Sunscreens and SPF.
Role of herbs in cosmetics:
Skin Care: Aloe and turmeric
Hair care: Henna and amla.
Oral care: Neem and clove
cosmetic and cosmeceutical
Classification of cosmetic and cosmeceutical products
Definition of cosmetics as per Indian and EU regulations, Evolution of cosmeceuticals from cosmetics, cosmetics as quasi and OTC drugs
Cosmetic excipients: Surfactants, rheology modifiers, humectants, emollients, preservatives. Classification and application
Skin: Basic structure and function of skin.
Hair: Basic structure of hair. Hair growth cycle.
Oral Cavity: Common problem associated with teeth and gums
Classification of Sunscreens and SPF and Role of herbs in cosmetics:Priya Patil
Sun protection,
Classification of Sunscreens and SPF.
Role of herbs in cosmetics:
Skin Care: Aloe and turmeric
Hair care: Henna and amla.
Oral care: Neem and clove
Formulation and Manufacturing Process of Cosmetics with Packaging Ajjay Kumar Gupta
Formulation and Manufacturing Process of Cosmetics with Packaging (Antiperspirants and Deodorants, Cleansing Creams and Lotions, Emollient Creams and Lotions, Baby Toiletries, Face Powders, Eye Makeup, Aerosol Cosmetics, Hair Straighteners)
Indian consumers are becoming more and more knowledgeable about beauty and personal care. The beauty industry in India is growing at a break-neck pace, almost twice as fast as that of the markets in the United States and Europe. Beauty industry in India can be divided into some major segments like baby care, bath and shower, colour cosmetics, deodorants, depilatories, fragrances, hair care, men’s grooming, oral care, sets/kits, skin care, and sun care. The number of beauty salons in the country is increasing at a rate of almost 35 percent annually.
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Aerosol Cosmetics, Antiperspirants Formulations, Baby Products, Baby Toiletries manufacturing, Beauty Products You Can Make, Beauty Products, Best small and cottage scale industries, Bleaches, Body care Products, Body cream production process, Book on cosmetics, Business guidance for cosmetics industry, Cleansing Creams manufacturing, Colour cosmetics & Hair Products, Cosmetic & Oral Care Ingredients, Cosmetic business opportunities, Cosmetics and Beauty Products, Cosmetics and Personal Care Products, Cosmetics Based Profitable Projects, Cosmetics Based Small Scale Industries Projects, Cosmetics Business, Cosmetics business ideas, Cosmetics business in India, Cosmetics business plan, Cosmetics Handbook, Cosmetics Industry in India, Cosmetics products Business, Cosmetics Projects, Cosmetics Small Business Manufacturing, Could You Start Your Own Cosmetics Business?, Creams, Lotions, Gels -How to Make Cosmetics, Dental Products, Deodorants formulations, Dye Removers, Emollient Creams formulations, Emollient Creams manufacturing, Establishing Your Own Business Making Skin Care Products, Eye Makeup Formulation and Manufacture, Face Pack Manufacturing Process, Face Powders manufacturing process, Formulation of Cosmetic Products, Formulation of Cosmetics, Hair Colorings, Hair Straighteners manufacturing, How to Make Cosmetics Products, How to Manufacture Cosmetic Products, How to Start a Cosmetic Business, How to Start a Cosmetic Line Small Business, How to start a cosmetic store, How to Start a Cosmetics Production Business, How to start a makeup business, How to start a successful Cosmetics business, How to start cosmetics Industry in India, How to Start Cosmetics Manufacturing Business, How to Start Your Own Cosmetics line, I want to start a cosmetic line business in India, Lotion manufacturing process, Lotions formulations, Manufacturing Process of Cosmetics, Most Profitable Cosmetics Business Ideas, New small scale ideas in Cosmetics industry, Packaging of Cosmetics, Perfumes
Formulation and evaluation of a polyherbal face washMonika Targhotra
GEL- A gel is a solid jelly like material that can have properties ranging from soft and weak to hard and tough.
Acne is the common disorder occurring due to the changes in the hormones such as androgens , corticosteroids.
Face and neck are more prone to the acne.
Acne can be prevented by removing the oil from the face.
To keep the skin free from acne, it should have antioxidants , smoothing and moisturizing property
The presentation contains brief explanation about the Emollients, its types with detailed examples. Brief classification of Rheological additives is also presented along with the applications in cosmeceuticals.
Formulation and Manufacturing Process of Cosmetics with Packaging Ajjay Kumar Gupta
Formulation and Manufacturing Process of Cosmetics with Packaging (Antiperspirants and Deodorants, Cleansing Creams and Lotions, Emollient Creams and Lotions, Baby Toiletries, Face Powders, Eye Makeup, Aerosol Cosmetics, Hair Straighteners)
Indian consumers are becoming more and more knowledgeable about beauty and personal care. The beauty industry in India is growing at a break-neck pace, almost twice as fast as that of the markets in the United States and Europe. Beauty industry in India can be divided into some major segments like baby care, bath and shower, colour cosmetics, deodorants, depilatories, fragrances, hair care, men’s grooming, oral care, sets/kits, skin care, and sun care. The number of beauty salons in the country is increasing at a rate of almost 35 percent annually.
See more
https://goo.gl/F3g8J9
https://goo.gl/rkg95P
https://goo.gl/w68h3b
Tags
Aerosol Cosmetics, Antiperspirants Formulations, Baby Products, Baby Toiletries manufacturing, Beauty Products You Can Make, Beauty Products, Best small and cottage scale industries, Bleaches, Body care Products, Body cream production process, Book on cosmetics, Business guidance for cosmetics industry, Cleansing Creams manufacturing, Colour cosmetics & Hair Products, Cosmetic & Oral Care Ingredients, Cosmetic business opportunities, Cosmetics and Beauty Products, Cosmetics and Personal Care Products, Cosmetics Based Profitable Projects, Cosmetics Based Small Scale Industries Projects, Cosmetics Business, Cosmetics business ideas, Cosmetics business in India, Cosmetics business plan, Cosmetics Handbook, Cosmetics Industry in India, Cosmetics products Business, Cosmetics Projects, Cosmetics Small Business Manufacturing, Could You Start Your Own Cosmetics Business?, Creams, Lotions, Gels -How to Make Cosmetics, Dental Products, Deodorants formulations, Dye Removers, Emollient Creams formulations, Emollient Creams manufacturing, Establishing Your Own Business Making Skin Care Products, Eye Makeup Formulation and Manufacture, Face Pack Manufacturing Process, Face Powders manufacturing process, Formulation of Cosmetic Products, Formulation of Cosmetics, Hair Colorings, Hair Straighteners manufacturing, How to Make Cosmetics Products, How to Manufacture Cosmetic Products, How to Start a Cosmetic Business, How to Start a Cosmetic Line Small Business, How to start a cosmetic store, How to Start a Cosmetics Production Business, How to start a makeup business, How to start a successful Cosmetics business, How to start cosmetics Industry in India, How to Start Cosmetics Manufacturing Business, How to Start Your Own Cosmetics line, I want to start a cosmetic line business in India, Lotion manufacturing process, Lotions formulations, Manufacturing Process of Cosmetics, Most Profitable Cosmetics Business Ideas, New small scale ideas in Cosmetics industry, Packaging of Cosmetics, Perfumes
Formulation and evaluation of a polyherbal face washMonika Targhotra
GEL- A gel is a solid jelly like material that can have properties ranging from soft and weak to hard and tough.
Acne is the common disorder occurring due to the changes in the hormones such as androgens , corticosteroids.
Face and neck are more prone to the acne.
Acne can be prevented by removing the oil from the face.
To keep the skin free from acne, it should have antioxidants , smoothing and moisturizing property
The presentation contains brief explanation about the Emollients, its types with detailed examples. Brief classification of Rheological additives is also presented along with the applications in cosmeceuticals.
Factors affecting action of Disinfectants and Factors Affecting Choice Of Ant...Ms. Pooja Bhandare
PHARMACEUTICAL MICROBIOLOGY (BP303T)Unit-III. Factors affecting action of Disinfectants and Factors Affecting Choice Of Antimicrobial Agent: Concentration of the disinfectant.
Chemical Structure of the disinfectant.
Formulation of the disinfectant.
Interfering substances in the environment.
pH of the surrounding.
Potentiation and antagonism of the disinfectants.
Surface Tension.
Temperature.
Time of Contact.
Type and no. of microbes present.
FACTORS AFFECTING CHOICE OF ANTIMICROBIAL AGENT:
Properties of chemical agents
Environment
Types of microorganisms
Intended application
Toxicity agents
Culture state
Preservation of pharmaceutical products using antimicrobial agents. PHARMACEU...Ms. Pooja Bhandare
PHARMACEUTICAL MICROBIOLOGY (BP303T)Unit-VPart-3
Preservation of pharmaceutical products using antimicrobial agents.
Introduction. Ideal Properties of Preservatives:
Antimicrobial Chemical Preservatives
Development of a Preservative System.
Factors affecting efficacy of a preservative: 1. Interaction With components of the formulation
2. Properties of the Preservatives:
3) Effect of Containers.
4) Type of microbes:
5) Influence of pH:
Challenge Test: Efficacy Test of Preservative : Medium used, Choice of test organism:
Preparation of the inoculum:
Procedure:
Interpretation of Results:
Infection control prevents or stops the spread of infections in healthcare settings
sterilization is a process which kills all forms of microbial life including transmissible agents such as virus, bacteria, fungi and spore forms
disinfection is define as a destruction or inhibition of most pathogenic agent on the surface of inanimate object by chemical or physical means.
Methods of Handwashing are
A.Short Scrub
B. Short Standard Handwash
C. Surgical Hand Scrub
Introduction
Definition
Features desired in pharmaceutical suspension
Advantage/Disadvantages of pharmaceutical suspension
Flocculated and deflocculated suspension
Interfacial properties of suspending particles
Settling in suspensions
Effect of Brownian movement,
Sedimentation of flocculated particles,
Sedimentation parameters
Formulation of suspensions
Wetting of Particles,
Controlled flocculation,
Flocculation in structured vehicle
surface & interfacial tension, surface free energy, Gibb’s equation, thermodynamic & kinetic stability of disperse systems
Definition, advantages and disadvantages, desirable features and pharmaceutical dispersions
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
SURFACE TENSION, INTERFACIAL TENSION, SURFACE FREE ENERGY, Measurement of surface and interfacial tension-capillary rise method, drop number method, drop weight method, Du Nuoy tensiometer method, Spreading of liquids, spreading coefficient, surface active agents, hydrophilic-lipophilic balance, soluble monolayers, Adsorption on solid surface, Isotherms
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Definition
“Any article intended to be
rubbed, poured, sprinkled or
sprayed on, or introduced into,
or otherwise applied to, the
human body or any part thereof
for cleansing, beautifying,
promoting attractiveness, or
altering the appearance is
known as cosmetic.”
3. Common material used In cosmetics
• Water
• Preservatives: Anti-microbial agents
• Anti-oxidants
• Humectants
• Surfactants
• Oils, fats & waxes
• Perfumes
• Colors
• Some functional raw materials (active ingredients)
• Herbal or plant materials
4. Classification of Cosmetic Products
Cosmetics for skin:
• Skin cream
• Skin bleach cream
• Sunscreen cream
• Body powder (talcum powder)
• Antiperspirants & deodorants
5. Cosmetics for face:
• Face powders
• Compact powders
• Foundation
• Lipsticks
• Astringents & skin tonics
• For the rapid coagulation of blood from a flesh wound, skin healing, the
promotion of tissue growth and other, more subjective sensations such as a
refreshing or invigorating
Classification of Cosmetic Products
7. Cosmetics for eye:
• Eye shadows
• Eyebrow pencils
• Mascara
• Eye liners
Classification of Cosmetic Products
8. Cosmetics for nails:
• Cuticle creams (for dry cuticles, nails)
• Nail Polish
• Nail lacquers & removers
Classification of Cosmetic Products
9. According to their function:
• Curative or therapeutic
• Antiperspirants
• Hair preparations
• Protective
• Sunscreen cream
• Corrective
• Face powder
• Decorative
• Lipstick
• Nail polishes
• Eye lashes
Classification of Cosmetic Products
(Antiperspirants: A substance that is applied to the skin,
especially under the arms, to prevent or reduce perspiration)
11. Microbiological aspects of cosmetics
• Many cosmetics, particularly emulsion-type formulations, provide
good media for the growth of bacteria and fungi (the latter group
includes moulds and yeasts).
• Means of inhibiting their growth are therefore essential to prevent
deterioration of the product and to ensure the safety of the consumer
during its use.
• Spoilage of product in time by the formation of bad odours, changes
of colour or texture and separation of phases quite often indicates
contamination.
12. Microbiological
aspects of cosmetics
• Presence of microorganisms
is not readily apparent, but it
can be demonstrated by
sampling and growing on
enriched culture media
• Counting the colonies so
formed, the original numbers
can be assessed.
13. Pathogen
• Pathogen can give rise to disease, most often under the following
circumstances
• If broken or abraded, skin allows invasion through to the underlying
tissue, as when Staphylococcus aureus gives rise to septicaemia.
• During illness when general resistance may be lowered.
• If the skin is delicate, as in the very young whose immunity is
undeveloped, or in the elderly where it is impaired or weakened by age.
• The eyes are especially vulnerable, mainly because they are so moist;
Pseudomonas aeruginosa flourishes in moist conditions.
• If the consumer is undergoing antibiotic or steroid therapy.
17. Sterilization
• Sterilization is an absolute term indicating the complete destruction or
removal of all microorganisms including the most resistant bacterial spores
• Moist heat: Autoclaving is the application of steam heat for 15-20min. It is
useful for culture media, glassware, distilled water and instruments. At a
pressure of 10 Pa (15 Ib in~2) water boils at 1210C and both spores and
vegetative organisms are destroyed.
• Dry heat: Some materials such as cotton wool and paper can be sterilized in
a hot-air oven, thermostatically controlled, and maintained at 1800C for 1 h.
All open-ended apparatus should be plugged with cotton wool to prevent
aerial contamination before sterilization and plugged again immediately
after use. Heating to 1400C for 3 h may be used in some cases. Dry heat
kills by oxidation.
18. Sterilization
• Membrane filtration Vegetating organisms and spores may be
physically removed from liquids by filtration. This is useful for culture
media, enzyme preparations, water and solutions of antibiotics.
• Several types of filter are available and all are used over slight
negative pressure achieved by means of a vacuum pump.
• They must be changed frequently or sanitized with water containing
200 ppm of chlorine, or 2% formalin with a final flushing with sterile
water which should be tested for sterility.
19. Sterilization
• Hygiene in the microbiological laboratory
• After contact with microorganisms every piece of disposable equipment,
including used Petri dishes containing discarded media, must be disinfected,
e.g. with 2% phenol, before being destroyed.
• Aseptic precautions to take are as follows:
• 1. The external neck of the receiver, when samples are taken, should be
wiped
• with ethanol; for example, batch samples.
• 2. Disposable plastic gloves should be used once only when testing samples.
• 3. Distilled, freshly sterilized water must be used in preparing media and
whenever
• water is called for in a test.
20. Product formulation and development
Choice of raw materials.
• If the raw materials are of natural origin there is a possibility that they will
be heavily contaminated; suspect ingredients are talc, bentonite, kaolin,
pigments and natural gums
Choice of preservatives:
• For example, hexachlorophane is active against the Gram-positive
Staphylococcus spp. but less so against Gram-negative spp.
• A mixture of methyl, ethyl, propyl and butyl /7-hydroxybenzoates is
effective against a wide range of fungi and some bacteria since their
different solubilities enable them to be well distributed between the various
phases in an emulsion
21. Prevention of contamination during
manufacture
• Control of environment of manufacturing premises
• Control of personal hygiene
• Development of an effective cleaning & sterilization programme
• Monitoring of quality of water supply
• Observation of quality of water supply
• Use of adequate preservatives
• Monitoring of microbial quality of cosmetics during manufacturing
stages.
23. Safety & Toxicology
• Skin irritation
• Irritation can be likened to a direct chemical attack on the skin. This may either be
directly on the surface horny layer resulting in dry, flaky or rough skin or the material
may penetrate into the skin and cause inflammation and reddening. A secondary
process may result in a disturbance of keratinization so that the new horny layer is
affected and becomes dry, flaky or rough.
• There is normally a threshold concentration below which the product is safe. It is
clearly important for an estimate of this threshold concentration to be available for risk
assessment, and it follows that more irritant materials may be acceptable as minor
ingredients in a product, while the major ingredients must have a low irritation
threshold.
• Methods of determining skin irritation are in general comparative, with the objective
being to show whether or not a new ingredient is more irritant than existing ingredients
with the same degree of exposure to the skin. A conclusion that a new ingredient is of
less or equal irritancy can be used directly in the risk assessment procedure.
24. Safety & Toxicology
• Eye irritation
• Damage to the eye is of course a potentially greater hazard than skin irritation
because of possible effects on vision. Great care must be taken particularly with
cosmetics intended for use around the eyes.
• There is an increasing pressure on the cosmetic industry to avoid testing on
animals. An increasing number of alternative testing methods are under
development and coming into use within the industry.
• HET CAM instead of Draize test
25. Safety & Toxicology
• Mucous membrane irritation
• The area around the eye and the ano-genital region have mucous
membrane tissues which cosmetic products may contact either accidentally
• Mucous membranes do not have the protective horny layer of the skin and
are therefore more susceptible to irritants.
• Some ingredients may be acceptable for use on skin but not for use in
products which are likely to contact mucous membranes.
• Again the principles of concentration limits and comparison with existing
ingredients are used in risk assessment procedures for mucous membrane
contact.
26. Safety & Toxicology
• Skin sensitization
• One of the adverse effects of cosmetics is that of skin sensitization or allergy.
• Allergy differs from irritation not in the reaction itself but in the mechanism
that produces the reaction. The immune system is involved
• Chemicals differ in their allergenic potential and vary from materials such as
poison ivy or chemicals
• Sensitization is concentration-dependent
• It is frequently said that any chemical will sensitize someone somewhere, and
the object of cosmetic safety evaluation is to reduce the number of sensitized
people to a minimum because Zero reactions are impossible target.
• The available test methods aim to determine the relative potential to
sensitization.
27. Safety & Toxicology
• The effect of ultraviolet light
• Some chemicals cause skin irritation or allergy only in the presence of
ultraviolet light, known as photoirritation
• It has become routine to consider all new ingredients for their potential to
cause of photoirritation
• Ingredients which do not absorb ultraviolet light are not considered to show a
problem
• Particular care is therefore required in the safety evaluation of sunscreen
agents as they are a potential problem and new ones are thoroughly evaluated
before use
28. Safety & Toxicology
• Miscellaneous skin reactions
• Occasionally there are skin reactions which do not fit neatly into any of
the categories outlined above.
• The first is known as an urticarial response (nettle rash) and is
characterized by a direct release of histamine, and possibly other
mediators of inflammation, into the skin.
• Some ingredients used in cosmetics, e.g. cinammic aldehyde, have been
shown to have this effect.
• The second phenomenon is that of skin stinging. A small (around 10%)
proportion of people suffer a severe stinging sensation
29. Safety & Toxicology
• Systemic effects
• Cosmetic ingredient may enter the body through the skin or mucous
membranes, by swallowing or by inhalation. Almost any chemical in
contact with the skin can penetrate to some extent and enter the
bloodstream so that effects anywhere in the body are possible
• There can be several types of systemic toxicity which need to be
considered during safety evaluation, and information on each needs to
be available.
• Specific effects such as cancer (carcinogenicity), birth defects
(teratology) or toxic effects on the nervous system (neurotoxicity)
31. BIS
Bureau of Indian Standards
• BIS –The National Standards Body Of India Functioning Under
Ministry Of Consumer Affairs and leaders in all matters concerning
standardization, certification & quality.
• OBJECTIVES:
• Harmonious development of activities of standardization, marking
and quality certification
• Providing new thrust to standardization and quality control
• Evolving the national strategy for according recognition to standards
and integrating them with growth and development of industrial
production and exports
• Product specification, method of test, codes of practices,
terminologies, basic standards (17000 standards )
32. BIS
• MAIN ACTIVITIES
• Standards Formulation Certification Product
Hallmarking of Gold Jewelry Quality Management System
Environmental Management Systems Occupational Health
and Safety Management System Hazard Analysis and Critical
Control Points Imported Products FMCS Laboratory
Management International Activities Training Services
Others Information Services Consumer Affairs & Standards
Promotion Sale of Standards
33. ICH
• The complete name of ICH is the "International Conference on
Harmonisation of Technical Requirements for Registration of
Pharmaceuticals for Human Use“ April 1990 in Brussels ICH
is a joint initiative involving both regulators and research-based
industry representatives of the European Union, Japan and the
USA in scientific and technical discussions of the testing
procedures required to assess and ensure the safety, quality
and efficacy of medicines. The objective of ICH is to increase
international harmonisation of technical requirements to ensure
that safe, effective, and high quality medicines are developed
and registered in the most efficient and cost-effective manner
34. Regulation in India
• The Objective of a Drug Regulatory in India are to ensure the
Medicinal, Medical Devices and Cosmetics products are acceptable on
their Quality, Safety and Efficacy.
• Drug Controller General of India is the head of Central Drug Standard
Control Organisation.[CDSCO] He Regulates Cosmetics, Devices &
Drugs in India.
• The Drugs & Cosmetics Act and Rules are the governing regulations
in India.
35. Cosmetic
• Drugs & Cosmetic Act defines “cosmetic” means any article intended
to be rubbed, poured, sprinkled or sprayed on, or introduced into, or
otherwise applied to the human body or any part thereof for cleansing,
beautifying, promoting attractiveness, or altering the appearance, and
includes any article intended for use as a component of cosmetic.
36. Import of cosmetics
• Domestic Manufacturing of Cosmetic already regulated in India As
per Notification GSR 426(E) in 2010 the Drugs &
• Cosmetics Act amended required Registration prior to importation of
Cosmetics to India.
• Though it is extended for some time now it is mandatory from 1st
April 2013
37. Documents
• Other Documents required are Manufacturing License, GMP if any,
Free Sale Certificate, etc.
• The products should not contain prohibited items (such as mercury,
lead & prohibited colors) & it should comply to the standards of either
Bureau of Indian Standards or of International Cosmetics Standards.
• Government Fee by TR Challan as applicable
38. Documents
• Documents To be submitted by Indian agent
• Form 42- It should be signed and stamped by Indian agent.
• Documents To be submitted by Manufacturer:
• POA- Power of attorney should be Appostilised or Consularized from
• Indian embassy of the country of the origin and should be co-jointly signed by
both the parties i.e. Manufacturer and Indian Agent in the given format.
• Schedule DIII- They should be signed and stamped by Manufacturer in the given
format.
39. Labels and inserts
• Product labels should show the address of manufacturer,
manufacturing & expiry date, importer name and address, import
license no., indications & cautions or contra-indications (if any)
• Product inserts should describe the brief description of the product and
its intended use.
• Company Profile
• Product specification and testing protocol
• List of Ingredients with details of strength of each ingredient used in
the products to be registered
40. Timeline
• After ensuring all documents correctly as per the requirements of
FDA, they are submitted. It generally takes about 2-3 months to
scrutinize these documents by Technical Data Associates/Drug
inspectors of CDSCO.
• During this period clarification if any, required by them are answered
and thereafter we get the Registration Certificate (RC) in Form 43
41. Timeline
• State Drug authorities of Respective States are responsible to issue manufacturing
Licenses.
• Application in Form 31 with Govt. Fees …...
• List of Equipment
• Manufacturing Facility details with minimum area of 15 Sq. Meters,
• Technical Competent personnel details,
• Relevant Sops are required for obtaining manufacturing permissions.
• The specifications should comply the BIS standards if applicable or else
acceptable International Standards.
• Presently Trials are not required. A proposal to include the definition of
• New cosmetics are on cards.