This document discusses cosmeceuticals, which are products that have both cosmetic and therapeutic effects intended to benefit skin health and beauty. Cosmeceuticals contain active ingredients that can affect skin cell function and are available over-the-counter without a prescription. However, the cosmeceutical industry is largely unregulated and products are not required to undergo clinical testing to substantiate their claims. Ideal cosmeceuticals should be tested to ensure they have proven benefits. The document provides several examples of plant extracts and compounds used in cosmeceuticals for their antioxidant properties.

2. A Category between cosmetic and drug

3.  Cosmeceutical term created in 1990s from cosm(etic) + (pharma)ceutic
 It’s a cosmetic product claimed to have medicinal
or drug-like benefits.
 Examples: Anti-aging creams, serums,
Moisturizers etc.
 These are marketed as cosmetics, but contain
biologically active ingredients.
 Majority of cosmeceutical products are not subjected
to review and approval process
 Fastest growing segment of Cosmetics & Personal Care.

4. Cosme ceutica
l
THE MARRIAGE OF COSMETICS
TO PHARMACEUTICALS

5. The term “cosmeceutical” was introduced by dermatologist
Dr Albert Kligman in 1984 and is derived from a
combination of the words cosmetic and pharmaceutical.
Cosmeceuticals are products that have both cosmetic and
therapeutic (medical or drug-like) effects, and are
intended to have a beneficial effect on skin health and
beauty. Like cosmetics, they are applied topically as
creams or lotions but contain active ingredients that have
an effect on skin cell function. In some cases, their action
is limited to the skin surface (such as exfoliants), while
others can penetrate to deeper levels, either enhancing or
limiting normal skin functions. Cosmeceuticals are
available “over-the-counter” (without prescription) and
are generally used as part of a regular skin care regime to
help improve skin tone and texture, pigmentation and fine
lines.

6. Ideally cosmeceuticals should be clinically tested
to ensure they have a proven benefit and can
substantiate their claims, however, the
cosmeceutical industry is largely unregulated.
Unlike medicines, cosmeceuticals are not
subject to review by the Food and Drug
Administration (FDA) in the United States or the
Therapeutic Goods Administration (TGA) in
Australia. Although they are usually tested for
safety, they do not have to undergo testing to
ensure the claims they make regarding efficacy
(effectiveness) are accurate. Unfortunately,
many creams do not live up to their advertised
hype.

7. Need for Cosmeceutical
 Products work at cellular level and treat
imperfections
 Avoid harsh chemicals associated with cosmetic
products
 Effectively counter the effect of changing
environmental conditions
 Single product can be used for multiple purposes
 Cost effective alternate to cosmetic surgery
 Ability to resolve the cause rather than covering

8.  The Federal Food, Drug, and Cosmetic
Act (FD&C Act) defines cosmetics by their
intended use, as "articles intended to be
rubbed, poured, sprinkled, or sprayed on,
introduced into, or otherwise applied to the
human body...for cleansing, beautifying,
promoting attractiveness, or altering the
appearance" [FD&C Act, sec. 201(i)]

9.  The FD&C Act defines drugs, in part, by their
intended use, as "articles intended for use in
the diagnosis, cure, mitigation, treatment,
or prevention of disease" and "articles (other
than food) intended to affect the structure
or any function of the body of man or other
animals" [FD&C Act, sec. 201(g)(1)].

10.  Some products meet the definitions of both cosmetics and
drugs. This may happen when a product has two intended
uses. For example, a shampoo is a cosmetic because its
intended use is to cleanse the hair. An antidandruff
treatment is a drug because its intended use is to treat
dandruff. Consequently, an antidandruff shampoo is both a
cosmetic and a drug. Among other cosmetic/drug
combinations are toothpastes that contain fluoride,
deodorants that are also antiperspirants, and moisturizers
and makeup marketed with sun-protection claims. Such
products must comply with the requirements for both
cosmetics and drugs.
Kalustian, P., 1985. Pharmaceutical and cosmetic uses of palm and lauric
products. Journal of the American Oil Chemists’ Society, 62(2), pp.431-433.

12.  The cosmeceuticals are mainly divided into
seven categories. In choosing an effective
Cosmeceuticals regimen it is critical to
match patients and their problems with the
appropriate products. Most patients have
multiple needs, and they should be
matched with products that offer
ingredients with multifunctional benefits.

14. Also It can be broadly classified into following
categories according to their daily life uses.
1 Creams, emulsions, lotions, gels and oils for the
skin (hands face, feet, etc.).
2 Face masks (with the exception of chemical
peeling products).
3 Tinted bases (liquids, pastes, powders).
4 Make-up powders, after-bath powders, hygienic
powders, etc.
6 Perfumes, toilet waters and eau de Cologne.
7 Bath and shower preparations (salts, foams,
oils, gels, etc.).
8 Depilatories.
9 Deodorants and anti-perspirants.

15. 10 Hair care products:
Hair tints and bleaches,
Products for waving, straightening and fixing,
Setting products,
Cleansing products (lotions, powders, shampoos),
Conditioning products (lotions, creams, oils),
Hair dressing products (lotions, lacquers, brilliantine).
11 Shaving products (creams, foams, lotions, etc.).
12 Products for making-up and removing make-up from the
face and the eyes.
13 Products intended for application to the lips.
14 Products for care of the teeth and the mouth.
15 Products for nail care and make-up.
16 Products for external intimate hygiene.
17 Sunbathing products.
18 Products for tanning without sun.
19 Skin-whitening products.
20 Anti-wrinkle products.

16. Mechanisms of current cosmeceutical agents. Alpha-hydroxyacid
(AHA), post-inflammatory hyperpigmentation (PIH), ultraviolet light
(UV).

17.  The main cutaneous function of
cosmeceuticals is to enhance the barrier
function of the skin following a resurfacing
procedure. Enhancing the barrier decreases
stinging and burning from a sensory
standpoint and improves the look and feel of
the skin. Moisturizers can smooth down
desquamating corneocytes and fill in the
gaps between the renaming corneocytes to
create the impression of tactile smoothness.
This effect is temporary, of course, until the

18.  moisturizer is removed from the skin surface by
wiping or cleansing. From a functional
standpoint. Moisturizers can create an optimal
environment for healing and rninirnize the
appearance of lines of dehydration by decreasing
transepidermal water loss. Trans epidermal
water loss increases when the brick-and-mortar
organization of the protein -rich corneocytes
held together by intercellular lipids is damaged.
A well-formulated cosmeceutical moisturizer can
decrease the water loss until healing occurs
following a resurfacing procedure. There are two
cosmeceutical ingredient categories that can
reduce transepidermal water loss post-
resurfacing: occlusive and humectants.
 The most common method for reducing
transepidermal water loss is the application of
occlusive ingredients in combination with
humectant ingredients in a thin moisturizer film.

19.  Many new developments have occurred in
the photoprotection cosmeceutical market to
increase both efficacy and cosmetic
acceptability. Higher sun protection factor
(SPF) formulations are more popular as new
sunscreen combinations arise that provide
better ultraviolet B (UVB) protection. New
methods of increasing the longevity of UVA
photoprotectants provide better broad-
spectrum protection. These advances have
improved the ability of sunscreens to prevent
post-inflammatory hyperpigmentation
following resurfacing.

20.  Sunscreen filters can be classified into two
major categoties. Chemical and physical.
Chemical sunscreens also known as organic
filters, undergo a chemical transformation
known as resonance delocalization to absorb UV
radiation and transform it to heat. This reaction
occurs within the phenol ring, which contains an
electron-releasing group in the ortho and/or
para position, and is irreversible, rendering the
sunscreen inactive once it has absorbed the UV
radiation. Physical sunscreens, also known as
inorganic filters, are usually ground particulates
that reflect or scatter UV radiation absorbing
relatively little of the energy. For this reason
they have longer activity on the skin surface.

21.  L. cylindrica (Linn) M. Roem. is a climber with a
slender, slightly hairy stem with little
furrowing. The seeds of L. cylindrica contain oil
in which the fatty acids are stearic and linoleic
acids - are unsaturated fatty acids. It has been
reported that naturally occurring unsaturated
fatty acids and phenolic compounds have free
radical scavenging properties In a study by
Yoganandam et al , it was concluded that the
fixed oil isolated from the seed kernels of the
plant not only scavenges off the free radicals
but also inhibits generation of free radicals. 7 |
P a g e

22.  Portulaca oleracea (Common Purslane; also known as Verdolaga,
Pigweed, Little Hogweed or Pusley) is an annual succulent in the
family Portulacaceae, which can reach 40 cm in height. It is
found throughout India and the Middle East, but is naturalized
elsewhere, and in some regions, is considered an invasive weed.
The whole plant is considered antiphlogistic (takes the heat
out), a bactericide, antidiabetic, anaphrodisiac (opposite to
aphrodisiac), emollient, calmative, diuretic, and refreshing
agent. Sanja et al has proved the antioxidant activity of the
methanol extract using methods such as DPPH free radical
scavenging, reducing power estimation by FeCl3, nitric oxide
free radical scavenging superoxide scavenging activity. The
extract has a tendency to scavenge the free radicals involved in
the ageing process and skin wrinkling and thus may provide some
photoprotective action rejuvenate the skin. The fresh gel, juice
or formulated products have been used for medical and cosmetic
purposes and to enhance general health.

23.  Terminalia chebula, also called Harde,
belongs to the family Combretaceae. It is
used commonly in many Ayurvedic
preparations as laxative, diuretic and
cardiotonic, as well as in some health
supplements. Its chemical constituents
include ascorbic acid, gallic acid and ellagic
acid, which are well known to exert free
radical scavenging properties.

24.  Piper longum L. belonging to the family
Piperaceae, is commonly found in Indonesia,
India and the Phillipines. It consists of a spike of
fruits forming a structure about 4 cm long and 6
mm in diameter. The fruit (pepper) contains 1 -
2.5 % volatile oil, 5 – 95 % of crystalline alkaloid
piperine and piperettine, and a resin. Piperine
extracted from this plant has been used as an
ingredient in Ayurvedic formulations because of
its antioxidant potency both in vitro and in vivo
in mice. Piperine, due to this antioxidant
property, is used topically in a cream base to
treat sunburn diseases.

25.  The leaves of Aloe vera (A. barbadensis) (Fam.
Liliaceace) are the source of aloe vera gel. The
gel does not include the sap of Aloe vera, which
contains anthraquinones. Aloe vera gel is widely
used in cosmetics and toiletries for its
moisturizing and revitalizing action. The whole
leaf of Aloe vera is known to aid cellular repair
as well as digestion, assimilation of foods,
vitamins, minerals and other vital nutrients to
rejuvenate the skin. The fresh gel, juice or
formulated products have been used for medical
and cosmetic purposes and to enhance general
health.

26.  Use of sunscreen agents and limiting the exposure to
sun prevents early wrinkling and skin cancer.
Sunscreen agents are used to prevent sunburns.
There are two kinds of sunscreen agents: chemical
and physical. Chemical sunscreen agents protect the
skin from the sun by absorbing the ultraviolet (UV)
and visible sun rays, while physical sunscreen agents
reflect, scatter, absorb, or block the rays.
 Sunscreen agents often may comprise more than one
ingredient. For example, products may contain an
ingredient that provides protection against the
ultraviolet A (UVA) sun rays and another ingredient
that protects from the ultraviolet B (UVB) sun rays,
which are more likely to cause sunburns than the UVA
sun rays. Ideally, coverage should include protection
against both UVA and UVB sun rays.

27.  The sun protection factor (SPF) that is present
on the label of these products reflects the
minimum amount of UVB sunlight that is needed
with that product to produce redness on
sunscreen protected skin as compared with
unprotected skin. Sunscreen products with high
SPFs provide more protection against the sun.
The following sunscreen agents have been
recommended by the U.S. Department of Health:
 Cycloform (isobutyl p‐amino benzoate)
 • Propylene glycol p‐amino benzoate
 • Monoglyceryl p‐amino benzoate
 • Digalloyl trioleate
 • Benzyl salicylate and benzyl cinnamate (2%
each)

28.  Besides these, chemical sunscreens mainly based
on para‐amino benzoic acid, its deivatives,
cinnamates, various salicylates and
benzophenones, dibenzoylmethanes, anthraline
derivatives, octocrylene and homosalate are
frequently employed as sun blocking agents.
Direct physical blockers include metal containing
compounds such as iron, zinc, titanium, and
bismuth. Zinc oxide and titanium dioxide are
highly reflective white powders, but submicron
zinc oxide or titaniumdioxide powder particles
transmit visible light while retaining their UV
blocking properties, thus rendering the sun block
invisible on the skin.

29.  Exposure to the UV radiations accelerates the aging effect of the skin.
The progressive telomere shortening and finally its disruption by
low‐grade oxidative damage are related to the aging. Damage is initiated
by the generation of reactive oxygen species (free radicals). It is a
progressive process whose consequences are damage to DNA. The topical
treatment of acne vulgaris with vitamin A, is very well supported by
evidence. Vitamin B3, commonly known as nicotinamide or niacinamide,
is available in cosmetic and cosmeceutical products and can be used as a
complementary agent for some types of acne, as well as aging skin.
Activation of toll‐like receptors may also be involved in the scarring
process by activating the metalloproteinases the retinoids arem vitamin A
derivatives constituting the most effective comedolytic agents.
 They function by normalizing desquamation of the follicular epithelium,
preventing the formation of new microcomedo, and minimiz the
formation of comedones and inflammatory lesions. Nicotinamide is useful
as a complementary drug because of its mild anti‐inflammatory activity
and its possible action in the reduction of sebum production and
improvement of the skin barrier.

30.  Hyperpigmentation is the changing of colour intensity of the skin
to darker hue, which is due to an increased amount of melanin in
the epidermis, the dermis, or both. This change can be due to 2
pathophysiologic processes: melanocytosis (increased number of
melanocytes) and melanosis (increased amount of melanin). Skin
lightening agents work best when melanosis or melanocytosis is
confined to the epidermis. Patients with Fitzpatrick skin types III
have advantage over type‐ IV such as type I‐III benefit from local
pigment lightening for the treatment of hormonally induced
melasma and postinflammatory hyperpigmentation caused by
acne and trauma, whereas those with Fitzpatrick skin types IV
and darker may also seek therapy for pigmentary changes that
occur around the eyes, in the intertriginous areas, following
dermatitis, or with acne and trauma.
 Standard dermatologic agent for skin lightening is hydroquinone
but its safety is questionable, leading to the use of alternative
agents such as retinoids, mequinol, azelaic acid, arbutin, kojic
acid, aleosin, licorice extract, ascorbic acid, soy proteins, and N
‐acetyl glucosamine.

31.  Antioxidants form one of the most popular categories
of cosmeceutical ingredients. This is due tGthe fact
that the major cause of cutaneous aging is oxidation
of skin structures from highly reactive oxygen
molecules present in our oxygen-rich environment. It
is amazing tG think that the life-giving oxygen
required to survive is also the same oxygen
responsible for aging the human body. The primary
souree of cosmeceutical antioxidant ingredients is
botanical extracts, since all plants must protect
themselves from oxidation following UV exposure.
Antioxidant botanieals function by quenching singlet
oxygen and reactive oxygen species, such as
superoxide anions. hydroxyl radicals fatty peroxy
radicals and hydroperoxides.

32.  There are many botanical antioxidants available. Both
from raw-material suppliers and from the cosmeceutical
industry and they can be classified in three categones,
Carotenoids, flavonoids and polyphenols. Carotenoids are
chemically related to retinoids, while flavonoids possess a
polyphenolic structure that accounts for their antioxidant,
UVprotectant, and metal chelation abilities. Lastly,
polyphenols represent a chemical subset of flavonoids.
Antioxidants are found in many skin lines for use following
resurfacing procedures. They are typically placed in
moisturizing vehicles that may aid in healing through the
prevention of transepidermal water loss. Whether
Cosmeceuticals the antioxidant formulation extends the
effect of a resurfacing procedure has never been
documented, yet their frequent use demands a thorough
understanding of their function.

33.  Carotenoids are derivatives of vitamin A and
have found widespread use in cosmeceuticals
due to the established topical anti-aging
benefits associated with the prescription
retinoid tretinoin. The carotenoids are a
large family of orange, red, and yellow
substances that perform vital antioxidant
roles when ingested and are less well
established as topical antioxidants. The
carotenoids are discussed in detail here.

34.  Astaxanthin is a pink carotenoid found in high
concentration in salmon accounting for the characteristic
pink color of the fish. This is the rationale for anti-aging
diets recommending the ingestion of a serving of salmon
fivemtimes weekly. For topical application purposes.
Astaxanthin is obtained from the marine rnicroalgae
Haematococcus pluvialis. The efficacy of astaxanth in is
attributed to its cell mernbrane composed of two external
lipid layers, which has been touted to possess stronger
antioxidant abilities than vitamin E. Few studies exist to
confirm the topical effect of astaxanthin, but it has been
studied extensively as an oral supplement. Astaxanthin in
concentrations of 0.03-0.07% produces a pink-colored
cream. This limits the concentration that can be used, but
no topical adverse reactions have been associated with
this carotenoid. The topical antioxidant benefits of
astaxanthin have not been established.

35.  Another carotenoid found in topical cosmeceuticals is
lutein. It is naturally found in green leafy vegetables.
Such as spinach and kale. Lutein is an antioxidant in
the plant kingdom, also being used for blue light
absorption, in the animal kingdom, lutein is found in
egg yolks, animal fats and the corpus luteum. It is a
lipophilic molecule, not soluble in water,
characterized bya long polyene side chain composed
of conjugated double bonds. These double bonds are
degraded by light and heat, a universal characteristic
of carotenoids to a greater or lesser degree. The
topical value of lutein in wound healing has never
been evaluated.

36.  Hydroxy acids are organic carboxylic acids
classified into alphahydroxy acids (AHA),
beta‐hydroxy acids (BHA), polyhydroxy acids,
and bionic acids on the basis of their
molecular structure. Hydroxy acids are found
in most of the marketed cosmetic
preparation but are used in very low
concentration.

37.  The AHAs are organic carboxylic acids with one hydroxyl
group attached to the α-position of the carboxyl group.
The hydroxyl and carboxyl groups are both directly
attached to an aliphatic or alicyclic carbon atom. The
hydroxyl group in the AHA is neutral, and only the carboxyl
group provides an acidic property. Many AHAs are present
in foods and fruits and, therefore, are called fruit acids.
Glycolic acid, the smallest AHA, occurs in sugar cane and is
the most widely used HA in skin care. Lactic acid, the next
smallest AHA, is also widely used in topical formulations to
exfoliate and provide antiaging effects. Some AHAs contain
a phenyl group as a side-chain substituent. This changes
the solubility profile of the AHA, providing increased
lipophilicity over conventional water-soluble AHAs and can
be used to target oily and acne-prone skin. Examples
include mandelic acid (phenyl glycolic acid) and benzilic
acid (diphenyl glycolic acid).

39.  The BHAs are organic carboxylic acids having one
hydroxyl group attached to the β-position of the
carboxyl group. The hydroxyl group in the BHA is
neutral in nature and the carboxyl group
provides the acidic property. Some BHAs, such as
β-hydroxybutanoic acid, are present in body
tissues as metabolic intermediates and energy
sources; however, they have not yet been
commercialized in dermatologic formulations.
Some molecules are both an AHA and BHA
because they contain a hydroxyl group in the α-
position to one carboxyl group and in the β-
position to another carboxyl group.

40.  Malic acid (apple acid), for example, contains
one hydroxyl and two carboxyl groups, and citric
acid contains one hydroxyl and three carboxyl
groups, making both molecules an AHA and a
BHA. Citric acid is widely used in topical
formulations as an antioxidant and pH adjustor,
and its antiaging benefits are well established.5
Although some have termed salicylic acid a BHA,
we do not consider it to be a BHA; for that
reason, it is not included in this discussion.
Salicylic acid behaves differently on skin than
other HAs, presumably due to its phenolic
hydroxyl attachment that renders the hydroxyl
acidic rather than neutral.

41.  The BAs are chemically classified as aldobionic
acids. They consist of one carbohydrate
monomer chemically linked to an aldonic acid
PHA; examples are lactobionic acid,
maltobionic acid, and cellobionic acid. BAs are
commonly obtained from their disaccharide
through chemical or enzymatic oxidation; for
example, lactobionic acid is obtained from
lactose, maltobionic acid from maltose, and
cellobionic acid from cellobiose. Although the
BAs are larger molecules than traditional AHAs,
they are small enough to penetrate skin at
approximately 358 daltons, and their pKa is
roughly equivalent to smaller AHA molecules;
for example, the pKa of lactobionic acid is 3.8,
which matches that of glycolic acid.

42.  BAs are hygroscopic materials that readily
attract and retain water, forming a gel matrix
when their aqueous solution is evaporated at
room temperature. The transparent gel contains
certain amounts of water, forming a clear gel
matrix. Formation of a gel matrix may add
protective and soothing effects for inflamed
skin. Indeed, formulations containing BA are well
tolerated and help calm skin when applied after
cosmetic procedures that weaken the skin’s
barrier, including superficial HA peels and
microdermabrasion. One notable protective use
of lactobionic acid, a BA used in some
commercial skin care formulations, is as an
antioxidant chelator in organ transplantation
preservation solutions.

43.  Growth factors act as regulators in wound healing
and on exogenous application can modify the
process. Two peptide growth factors which play a
pivotal role in normal wound healing in tissues such
as skin, cornea and the gastrointestinal (GI) tract are
the structurally related peptides epidermal growth
factor (EGF) and transforming growth factor alpha
(TGF-a). Other peptides such as basic and acidic
fibroblast growth factors (bFGF and aFGF), platelet
derived growth factors (PDGF-AA, -AB and -BB) and
insulin-like growth factor (IGF-I) have been identified
as potential wound-healing agents. EGF/TGF-a
receptors are expressed by many types of cells
including skin keratinocytes, fibroblasts, vascular
endothelial cells and epithelial cells of the GI tract.

44.  Healing of a variety of wounds in animals and
patients has been enhanced by treatment
with EGF or TGF-a. EGF also increased the
tensile strength of skin incisions in rats and
corneal incisions in rabbits, cats and
primates. Sorensen et al. demonstrated that
two of the important growth factors in
wound healing, IGF-I and TGF-a, induce the
expression of the AMPs/polypeptides hCAP-
18, hbD-3, NGAL and SLPI in human
keratinocytes.

46. Glutathione (γ-glutamyl-cysteinylglycine) is a
small, low-molecular weight, water-soluble
thiol-tripeptide formed by three amino acids
(glutamate, cysteine and glycine). It is a
ubiquitous compound with a biologically
active sulfhydryl group contributed by the
cysteine moiety that acts as the active part
of the molecule.[ This sulfhydryl group allows
for interaction with a variety of biochemical
systems, hence the abbreviation “GSH” for
its active form. Glutathione is one of the
most active antioxidant systems in human
physiology

47. Melanin in human skin is a polymer of various
indole compounds synthesized from L-
tyrosine by the Raper–Mason pathway of
melanogenesis [Figure 2] with tyrosinase
being the rate limiting enzyme. The ratio of
the two different types of melanin found in
skin, black-brown colored eumelanin and
yellow-red pheomelanin, determines the skin
colour. An increased proportion of
pheomelanin is associated with lighter skin
colour.

48. Due to the low bioavailability of oral glutathione, intravenous
injections are being promoted to provide desired therapeutic
levels in the blood and skin and to produce “instant” skin-
lightening. Interestingly, intravenous injections of glutathione
have been used for years but there is not even a single clinical
trial evaluating its efficacy. Manufacturers of intravenous
glutathione injections recommend a dose of 600–1200 mg for skin
lightening, to be injected once to twice weekly. The duration for
which they should be continued is not specified. Intravenous
administration is expected to deliver 100% bioavailability of
glutathione, much more compared to that achieved by oral
administration. However, there are no studies to support this
hypothesis. Although intravenous glutathione delivers a much
higher therapeutic dose that enhances its efficacy, it also
provides a narrower margin of safety due to the possibility of
overdose toxicity.

49.  Anti-aging creams may include conventional moisturising
ingredients. They also usually contain specific anti-aging
ingredients, such as:
 Retinol (for instance, in the form of retinyl palmitate). In
various formulations it has been shown to reduce fine lines
and pores.Epidermal growth factor, to stimulate cell
renewal and collagen production in the skin, and
strengthen elasticity and structure.
 Alpha hydroxy acids (AHAs) and beta hydroxy acids or
other chemical peels. These help to dissolve the
intracellular "glue" that holds dead cells together on the
skin. The use of this type of product on a daily basis
gradually enhances the exfoliation of the epidermis. This
exposes newer skin cells and can help improve
appearance. AHAs may irritate some skin, causing redness
and flaking.
 Peptides, such as Matryxil and copper peptides.
 Coenzyme Q10

50. Botulinum toxin (BTX) has no effect on skin
texture and cannot discontinue the skin aging
process. However, regular BTX injections can
slow down the visible aging process by
helping in the management of certain
dynamic facial lines and wrinkles. The
mechanism of action of BTX makes it an ideal
agent to target the major cause of these
dynamic lines.

51.  beeswax and candelilla wax.
 Various oils and fats
 olive oil
 mineral oil
 cocoa butter
 lanolin
 petrolatum.

52. Common ingredients in anti-wrinkle creams
 Retinol. ...
 Vitamin C. Another potent antioxidant,
vitamin C may help protect skin from sun
damage. ...
 Hydroxy acids. ...
 Coenzyme Q10. ...
 Peptides. ...
 Tea extracts. ...
 Grape seed extract. ...
 Niacinamide.

53. COSMETIC DRUGS
Moistening shampoo Anti dandruff shampoo
Mustering creams whitening creams
Lipstick Anti-aging
Eye shadow Anti-wrinkle cream
Hair dye and colorant Acne Aiad soap

54.  Bithionol: photocontact sensitization
 Chlorofluorocarbon propellants
 Chloroform: cancer
 Halogenated salicylanilides: skin disorders
 Hexachlorophene:
 Mercury compounds: allergic reactions, skin
irritation, or neurotoxic problems

55.  Address the root-causes
 Safe for long-terms use
 Complementary role
 Promote beauty through health & wellness of
skin
 Cosmeceutical with natural ingredients are
preferred

56.  Improving Skin Complexion
 Preventing Visible Effects of Ageing
 Controlling/Reducing Wrinkles
 Freckle & Black Spot
 Acne & Pimple scars
 Controlling Sebum
 Reducing Cellulite

57.  Use of plant stem cell technology in anti
aging products, a new trend in the market
 Use of active ingredients is another trend
witnessed by the market
 Increasing usage of cosmeceutical by men
segment will contribute to the growth of
the market

58.  Most of the cosmetic or personal care
players are sifting towards
cosmeceutical
 The Asian markets dominated by
domestic players
 In Asia, especially China,
pharmaceutical companies are
shifting towards cosmeceutical
industry

59.  It is very heartening to note, that a comparatively
newer concept of Cosmeceuticals has already been
introduced in Pakistan which will surely provide
Cosmetic Surgeons, Dermatologists, Beauticians,
and Consumers a safe and effective alternative for
maintaining a healthy and beautiful skin. “LEGAL
Aspects” The term ‘cosmeceutical’ has no meaning
under law. They are not subject to review by the
Food, Drug and Cosmetic Act. Although some
cosmeceuticals are tested for safety, testing to
determine whether active ingredients actually live
up to a manufacturer’s claim is not mandatory.

60. LATEST MARKETING
TRENDS OF
COSMACEUTICALS

61. Cosmeceutical in Cosmetics
Market Penetration (2015 & 2020)
Cosmeceutical penetration expected to grow 30% by 2020
Cosmeceutical
Cosmetics
87%
13%
Cosmeceutical
Cosmetics
83%
17%

62. Skin Care Cosmeceutical Market
 Anti-aging cosmeceutical are the star performers
 Sun protection and anti acne other widely used
products
 The 35+ age group a major opportunity
 BB and CC creams are the latest trend
 Use of technologically sophisticated
ingredients growing
 In Asia, skin whitening products posses
huge opportunity
 China and India focal point for growth
By Application (2015e)
Skin Whitening
Sun Protection
Professional
Skin Care
Anti - Acne
Others
Anti Aging41%
17%
16%
14%
9%
3%
Market (Billion US$)
CAGR 8%
2015e 2020f
25
37

63.  Developed region major market for hair
growth
 Anti Dandruff is the fasted growing segment
 High demand of hair care products from men
 Active ingredients based products
being launched
 Emerging economies are the focal
point for growth
Hair Care Cosmeceutical Market
By Application (2015e)
Anti -
Dandruff
Others
Hair Growth
52%
40%
8%
Market (Billion US$)
CAGR 8%
2015e 2020f
6
9

64. Injectable Cosmeceutical Market
 Botox most widely used botulinum toxin
 Dermal fillers segment fastest growing
 Affluent section is the major user of dermal fillers
 Hyaluronic acid (HA) based fillers are most
extensively used
 Solid HA filler an advanced version
 Other dermal filler materials - Collagen and
Calcium hydroxylapatite
By Application (2015e)
Dermal
Fillers
Others
Botulinum
Toxin
65%
23%
12%
Market (Billion US$)
CAGR 10%
2015e 2020f
2
3

65. • Lip balms, most widely used lip care
product
• Tooth whitening highest growing segment
• Aging population major consumer of anti
cellulite products
• Launch of low priced products in Asian
regions
• The Asian countries focal point for growth
Others Cosmeceutical Market
By Application (2015e)
Others
Anti-Cellulite/
Body Slimming
Preparations Tooth
Whitening
Lip Care
30%32%
10% 28%
Market (Billion US$)
CAGR 9%
2015e 2020f
8
13

66. Cosmeceutical Market: Regions
 Asia Pacific is the largest market
 Rising disposable income major factor for
the growth of Asia Pacific market
 Anti agers and skin whitening high growth
segments in Asia Pacific market
 Players investing in emerging economies
 North America and Europe are expected
to witness moderate growth.
 Anti agers are leading the North
American and European market
2020f
Asia
Pacific
Rest of
the World
North
America
Europe
24%
13%57%
6%
2015e
Asia
Pacific
Rest of
the World
North
America
Europe
29%
16%
49%
6%

67. Asia Pacific Cosmeceutical Market
 Skin care is the major segment
 Injectable segment is the fastest growing
 High demand for herbal and less expensive
cosmeceutical
 30 + age group women- Major consumer
of skin care cosmeceutical
 The growth of the market will be focused
on India and China
 India is becoming a hub for cosmeceutical
based clinical studies in South East Asia
By Country (2015e)
Rest of
the Asia
India
China
Japan
40%
30%
16%
14%
Market (Billion US$)
CAGR 11%
2015e 2020f
20
35

68. Rest of theWorld Cosmeceutical Market
 Latin America especially Brazil is the major market
 Brazil is the third largest consumer market for
cosmetics and other products related to beauty
 Hair care is the largest segment in Latin America
 Skin care products are extensively used in
African countries
 High demand for natural and low priced
products in the market
 Foreign players are focusing on RoW
market
Market (Billion US$)
CAGR 10%
2015e 2020f
2
4

69. •The usage of cosmeceuticals has drastically
hiked in recent years, which in turn has
increased the spectrum of the physician to
broaden their range of products to enhance
the comeliness of the patients associated
with dermal problems.
•However, at times, where generations are
keenly worried for their beauty, lots of
manufacturing companies are competing and
working hard to provide convincing results to
meet requirements of the patients.
CONCLUSION

70. • Claims of effectiveness lack
convincing evidence, thus the industry
is challenged to provide evidence on
the effectiveness of these compounds.
• Cosmeceuticals like vitamins,
sunscreens, hydroxyl acids & many
more have diseases thus enhancing the
skin texture.
• Clinical trials of cosmeceuticals are
important to know the interaction skin
and cosmeceuticals which could even
be influenced by environmental fact.