The document discusses conformational isomerism in small organic molecules like ethane, propane, butane, and cyclohexane. It explains how to represent molecular conformations using Newman projections and sawhorse diagrams. It describes the different conformations of these molecules, including staggered, eclipsed, anti, gauche, chair, boat, twist-boat, and half-chair. The preferred chair conformation of cyclohexane is explained in detail, with distinctions made between axial and equatorial positions and bonds. Energy barriers for interconversions between cyclohexane conformations are provided.
Conformational isomerism
Conformations of Ethane:
Conformations of Cyclohexane
Representation of conformations:
Sawhorse projection:
Newman projection:
The conformational analysis of cyclohexane
CONFORMATION OF MONO SUBSTITUTED CYCLOHEXANE
STEREOSPECIFIC REACTION, STEREOSELECTIVE REACTION, OPTICAL PURITY, ENANTIOMERIC EXCESS.. all these topics are explained in this slide with examples and formula.
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
Conformational isomerism
Conformations of Ethane:
Conformations of Cyclohexane
Representation of conformations:
Sawhorse projection:
Newman projection:
The conformational analysis of cyclohexane
CONFORMATION OF MONO SUBSTITUTED CYCLOHEXANE
STEREOSPECIFIC REACTION, STEREOSELECTIVE REACTION, OPTICAL PURITY, ENANTIOMERIC EXCESS.. all these topics are explained in this slide with examples and formula.
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
An organic species which has a carbon atom bearing only six electrons in its outermost shell and has a positive charge is called carbocation.
The positively charged carbon of carbocation is sp2 hybridized.
The unhybridized p-orbital remains vacant.
They are highly reactive and act as reaction intermediate.
They are also called carbonium ion.
Unit II-Geometric isomerism and conformational isomer as PCI Syllabus of POC-IIIGanesh Mote
It Includes Cis-Trans Isomer, E& Z Nomenclature, Syn and Anti isomer, Determination of geometrical isomer, Conformations of ethane, Butane, Cyclohexane, Stereospecific and stereoselective addition reactions.
THIS SLIDE HAVE GOOD CONTENT. THIS SLIDE CONTAIN INTRODUCTION, STRUCTURE, RESONANCE, AROMATICITY, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF QUINOLINE.
Cyclohexane exists in different conformations viz chair, boat, twist boat and half chair. These conformations possess different energies. Therefore they differ in energy.
The video lecture for this presentation is available at the following link on YouTube
https://youtu.be/3sxal579RNM
The presenation will be useful for Ug/PG (Chemistry) students
An organic species which has a carbon atom bearing only six electrons in its outermost shell and has a positive charge is called carbocation.
The positively charged carbon of carbocation is sp2 hybridized.
The unhybridized p-orbital remains vacant.
They are highly reactive and act as reaction intermediate.
They are also called carbonium ion.
Unit II-Geometric isomerism and conformational isomer as PCI Syllabus of POC-IIIGanesh Mote
It Includes Cis-Trans Isomer, E& Z Nomenclature, Syn and Anti isomer, Determination of geometrical isomer, Conformations of ethane, Butane, Cyclohexane, Stereospecific and stereoselective addition reactions.
THIS SLIDE HAVE GOOD CONTENT. THIS SLIDE CONTAIN INTRODUCTION, STRUCTURE, RESONANCE, AROMATICITY, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF QUINOLINE.
Cyclohexane exists in different conformations viz chair, boat, twist boat and half chair. These conformations possess different energies. Therefore they differ in energy.
The video lecture for this presentation is available at the following link on YouTube
https://youtu.be/3sxal579RNM
The presenation will be useful for Ug/PG (Chemistry) students
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This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Conformational isomers
1. Conformational Isomerism
1
• Dr. Gurumeet C Wadhawa
• Department of Chemistry
• Karmaveer Bhaurao Patil ,College
• Vashi, Navi Mumbai
2. Representing Conformations
• Sawhorse representations show
molecules at an angle, showing a
molecular model
– C-C bonds are at an angle to
the edge of the page and all C-
H bonds are shown
• Newman projections show how the
C-C bond would project end-on
onto the paper
– Bonds to front carbon are lines
going to the center
– Bonds to rear carbon are lines
going to the edge of the circle
2
5. Ethane’s Conformations
• There barrier to rotation between conformations is small (12 kJ/mol; 2.9
kcal/mol) The most stable conformation of ethane has all six C–H bonds
away from each other (staggered)
• The least stable conformation has all six C–H bonds as close as possible
(eclipsed) in a Newman projection – energy due to torsional strain
5
7. Conformations of Propane
• Propane (C3H8) torsional
barrier around the carbon–
carbon bonds 14 kJ/mol
• Eclipsed conformer of propane
has two ethane-type H–H
interactions and an interaction
between C–H and C–C bond
7
9. Conformations of Butane
• anti conformation has two methyl groups 180° away from each other
• Rotation around the C2–C3 gives eclipsed conformation
• Staggered conformation with methyl groups 60° apart is gauche
conformation
9
14. Stability of Cycloalkanes: The Baeyer
Strain Theory
• Baeyer (1885): since (sp3) carbon
prefers to have bond angles of
approximately 109°, ring sizes other
than five and six may be too strained
to exist
• Rings from 3 to 30 C’s do exist but
are strained due to bond bending
distortions and steric interactions
14
15. The Nature of Ring Strain
• Rings larger than 3 atoms are not flat (planar)
• Cyclic molecules can assume nonplanar conformations to
minimize angle strain and torsional strain by ring-puckering
• Larger rings have many more possible conformations than
smaller rings and are more difficult to analyze
15
17. Types of Strain
• Angle strain - expansion or compression of bond angles
away from most stable
• Torsional strain - eclipsing of bonds on neighboring
atoms
• Steric strain - repulsive interactions between nonbonded
atoms in close proximity
17
20. Cyclopropane: An Orbital View
• 3-membered ring must have planar structure
• Symmetrical with C–C–C bond angles of 60°
• Requires that sp3 based bonds are bent (and weakened)
• All C-H bonds are eclipsed
20
21. Conformations of Cyclobutane and
Cyclopentane
• Cyclobutane has less angle strain than cyclopropane but more torsional
strain because of its larger number of ring hydrogens
• Cyclobutane is slightly bent out of plane - one carbon atom is about 25°
above
– The bend increases angle strain but decreases torsional strain
21
22. Cyclopentane
• Planar cyclopentane would have no angle strain but very high torsional
strain
• Actual conformations of cyclopentane are nonplanar, reducing torsional
strain
• Four carbon atoms are in a plane
– The fifth carbon atom is above or below the plane – looks like an envelope
22
24. Conformations of Cyclohexane
• Substituted cyclohexanes occur widely in nature
• The cyclohexane ring is free of angle strain and torsional strain
• The conformation is has alternating atoms in a common plane and
tetrahedral angles between all carbons
• This is called a chair conformation
24
27. Axial and Equatorial Bonds in Cyclohexane
• The chair conformation has two
kinds of positions for substituents
on the ring: axial positions and
equatorial positions
• Chair cyclohexane has six axial
hydrogens perpendicular to the ring
(parallel to the ring axis) and six
equatorial hydrogens near the
plane of the ring
27
29. Axial and Equatorial Positions
• Each carbon atom in cyclohexane has one axial and one equatorial
hydrogen
• Each face of the ring has three axial and three equatorial hydrogens
in an alternating arrangement
29
33. Chair Conformation of Cyclohexane
• Chair conformations readily interconvert, resulting in the exchange of axial
and equatorial positions by a ring-flip
33
34. Boat Cyclohexane
• Cyclohexane flips through a boat
conformation
• Less stable than chair cyclohexane
due to steric and torsional strain
• C-2, 3, 5, 6 are in a plane
• H on C-1 and C-4 approach each
other closely enough to produce
considerable steric strain
• Four eclipsed H-pairs on C- 2, 3, 5,
6 produce torsional strain
• ~29 kJ/mol (7.0 kcal/mol) less
stable than chair
34
39. Conformations of Cyclohexane
* Sachse’s suggestion(1890) : CH exists in
Folded form. All nuclear carbons do not lie
in one plane.
1. Chair Conformation
2. Boat Conformation
3. Twist Conformation or Skew Boat Conformation
4. Half Chair Conformation
40. Chair Conformation
• Shape : Like a
Chair
• No. of Carbon
atoms
• All Carbon atoms
: 06
: sp3
hybridised
• Bond angle between any two bonds : 1090 28’
• No. of Hydrogen atoms : 12
• Two sets of Hydrogen atoms : 06 + 06
a)Axial hydrogen atoms
b) Equatorial hydrogen atoms
42. Axial and Equatorial Bonds in Cyclohexane
There are two kinds of positions for substituents on the
cyclohexane ring
Axial positions – 6 axial positions perpendicular to ring
and parallel to ring axis. Bonds in these positions are axial
bonds and atoms/grs. are axial
Equatorial positions – 6 equatorial positions are in
rough plane of the ring around the equator, i. e. Projecting
outwards the ring. Bonds in thesepositions are equatorial
bonds and atoms /grs are equatorial