This document discusses environmentally friendly synthetic strategies, specifically non-conventional methods like microwave irradiation and ultrasonication. It notes that these methods have advantages over conventional methods in being cleaner with higher yields and being more eco-friendly. The document outlines a strategy to synthesize new heterocyclic compounds by combining moieties like pyrazole, benzo-γ-pyrone, and quinoline, and studying the biological activity of the resulting products. It provides details on sonochemistry and microwave-assisted organic reactions, giving examples of reactions that can be performed using these techniques. The aims are to synthesize and characterize new heterocycles and evaluate their therapeutic potential, attempting the syntheses using both conventional and non-conventional

1. 1
“Environmentally Benign Synthetic Strategies
For Potentially Active Compounds.”
• Dr.Gurumeet C Wadhawa ,Assistant Professor,
Department of Chemistry.
Rayat Shikshan sansthas Veer Wajekar ASC
College,Phunde,Uran

2. 2
Advantages of Non-conventional methods over
Conventional
• The non-conventional methods like Microwave induced
reactions, Ultrasound assisted synthesis, grinding etc. are now
a days used in Organic synthesis. These methods are preferred
owing to their various advantages e.g.
1) Cleaner Methods
2) Yields are higher
3) Eco-friendly.

3. 3
• The heterocyclic compounds like chromone and their derivatives are
found to possess excellent physiological activities.
• Our strategy will be to combine various heterocycles with pyrazole,
benzo- -pyrone and quinoline moiety and study the combined effect
of the resulting products.

4. 4
Sonochemistry- Green approach for Organic Synthesis
• What is Sonochemistry?
Study of chemical changes that occur in presence of sound or
ultra-sound.
• Some properties of sonochemical / Ultrasound radiations
. Frequency ranges from 20 KHz to 10 MHz
(Human hearing upper limit is 18 KHz)
. Region 20-100 KHz is best for chemical transformation
. Frequency range 1-10 MHz are suitable for ultrasound
imaging of body organs

5. 5
• Various Organic transformations using Ultrasound radiations was reported those are
• Esterification
• Saponification
• Hydrolysis
• Substitution
RCOOH + R-OH RCOOR'
H2SO4,rt
))))))))
COOCH3 COOH
-
OH/ H2O
)))))) ,60 min.
Ar CN Ar COOH
-
OH/ H2O
)))))) ,60 min.
R Cl
O
R CN
O
KCN, MeCN
)))))))),50 C

6. 6
Microwave assisted reactions as an greener approach in
Organic Chemistry
• Microwave induced organic reaction enhancement (MORE) chemistry are
extremely fast cleaner than conventional reactions and lead to higher atom
economy, because of -
• Short reaction time
• Ease of workability
• Eco-friendly
• Greener technique
• Higher Selectivity

7. 7
Various Organic transformations using Microwave radiations
OR1
O O
+ H2N NH2
X
N
H
NH
R
R1O
O
X
MW, 300 Mz
X = O, S.
RCHO
(1) (2) (3) (4a-t)
Zn (OAC)2
•Biginelli reaction Under Microwave Irradiation
•Knoevenagel reaction Under Microwave Irradiation
R1
R2
R3
R4
O
O
CHO N
N
C
H3
O Ph
O
R1
R2
R3
R4 O H
N
N
CH3
O
Ph
MW
Basic alumina
+
R1
R2
R3
R4
O
O
CHO N
N
C
H3
O Ph
O
R1
R2
R3
R4 O H
N
N
CH3
O
Ph
MW
+ Acidic alumina

8. 8
Aims
The present investigation is aimed at
• Synthesizing some new heterocycles
• Establishing their structures and stereochemistry
• Evaluating their therapeutic values
• An attempts will be made to synthesize these
compounds by conventional as well as by non –
conventional methods like MWI, Ultrasonication etc..

9. 9